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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål nicolas GBazan Shuai Tan nailin Li Makiko ohshima Marianne Schultzberg Xiaofei Li Department of neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and nutrition Karolinska InstitutetHuddingeSweden neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RnA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RnA-sequencing specialized pro-resolving lipid mediator

α,β-Dehydroamino Acid Synthesis through Proline-Catalyzed Aldol Condensation with a Glycine Schiff Base

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Precision Chemistry 2024年第1期2卷 14-20页

作者： Jun Sawamura Daikan Ieiri Ryo Yazaki Takashi ohshima Graduate School of Pharmaceutical Sciences Kyushu UniversityFukuoka 812-8582Japan

A general protocol for the synthesis ofα,β-dehydroamino acids and their peptides was *** efficiently catalyzed an aldol condensation reaction of a glycine Schiff base with a variety of *** hydroxy group on the benzophenone imine was crucial for high Z/E selectivity and further transimination for protecting group-freeα,β-dehydroamino *** elongation of both the C-and n-terminals highlighted the usefulness of our present protocol.

关键词： α β-dehydroamino acid peptide proline aldol condensation glycine Schiff base transimination

In vitro evaluation of the anti-diabetic potential of soymilk yogurt and identification of inhibitory compounds on the formation of advanced glycation end-products

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Food Bioscience 2022年第6期50卷 668-675页

作者： Yuki nakashima naoki Yamamoto Ryosuke Tsukioka Hikari Sugawa Rina ohshima Kaede Aoki Tomoyuki Hibi Kotone Onuki Yudai Fukuchi Shin Yasuda Ryoji nagai Hideki Kinoshita Graduate School of Bioscience Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Graduate School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Probio LLC. 1330-1 FutaNishihara-muraAso-gunKumamotoJapan

In this study, we aimed to identify starter strains of lactic acid bacteria (LAB) to produce soymilk yogurt that can decrease the risk of diabetes mellitus (DM) and its complications. The inhibition assays of the dipeptidyl peptidase IV (DPP- IV) and advanced glycation end products (AGEs) formation were conducted using 70% ethanol (EtOH) extraction of freeze-dried soymilk yogurt. Soymilk yogurt produced using Weissella confusa TOKAI 2 showed the highest inhibition rate in the α-amylase inhibition assay, while soymilk yogurt produced using Lactiplantibacillus plantarum TOKAI 17 showed the highest inhibition rates in the α-glucosidase and DPP-Ⅳ inhibition assays, respectively. Soymilk yogurt produced using Streptococcus macedonicus TOKAI 4 showed the highest inhibitory activities in nω-(carboxymethyl) arginine (CMA) and nε-(carboxymethyl) lysine (CML) formation, respectively. Furthermore, soymilk yogurt prepared using Lb. plantarum TOKAI 17 and Lactiplantibacillus pentosus TOKAI 35 exhibited higher proportions of aglycone isoflavones than soymilk and showed a higher fluorescent AGEs inhibitory activity than that of soymilk (p nterestingly, the inhibition assay assessing fluorescent AGEs formation using isoflavones indicated that aglycone-type isoflavones, such as genistein and daidzein, had higher inhibitory activities than that of glycosides (p ndicate that soymilk yogurt produced using Lb. plantarum TOKAI 17 and Lb. pentosus TOKAI 35 had inhibitory effects on α-glucosidase, DPP-Ⅳ, and AGEs formation in vitro, and that aglycone isoflavones might inhibit the formation of fluorescent AGEs.

关键词： Lactic acid bacteria Soymilk yogurt Diabetes Advanced glycation end products

Development of a Heavy Ion Bearn Probe for Measuring Electrostatic Potential Profile and Its Fluctuation in LHD

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Plasma Science and Technology 2009年第4期11卷 460-464页

作者： TakeshiI DO Akihiro SHIMIZU Masaki nISHIURA Haruhisa nAKAnO Shinji KATO Shinsuke ohshima Yasuo YOSHIMURA Shin KUBO Takashi SHIMOZUMA HiroeI GAMI Hiromi TAKAHASHI Kazuo TOI Fumitake WATAnABE Kazumichi nARIHARA Ichihiro YAMADA national Institute for Fusion Science

A heavy ion beam probe （HIBP） using a 3-MV tandem accelerator has been installed on large helical device （LHD）. Electrostatic potential in core plasma can be measured under the toroidal magnetic field strength of up to 3 T. By using the HIBP, the transition of potential profiles from electron-root to ion^root is observed in core plasmas during ramp-up of the electron density. Potential fluctuations are also measured electron cyclotron current drive （ECCD）. Two kind of characteristic fluctuations are observed. One is a reversed-shear-induced Alfv^n eigenmode （RSAE）, whose frequency varies during the evolution of the rotational transform profile, and the other is with a constant geodeisc acoustic mode （GAM） frequency.

关键词： electrostatic potential measurement HIBP GAM RSAE

Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions

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World Journal of Gastroenterology 2009年第46期15卷 5805-5812页

作者： naoto Koike Akihiro Cho Katsuhiro nasu Kazuhiko Seto Shigeyuki nagaya Yuji ohshima nobuhiro Ohkohchi Department of Surgery Seirei Sakura Citizen Hospital Department of Surgery Chiba Cancer Center Department of Radiology Institute of Clinical MedicineUniversity of Tsukuba Department of Radiology Seirei Sakura Citizen Hospital Department of Radiology Seirei Mikatabara Hospital Department of Surgery Institute of Clinical MedicineUniversity of Tsukuba

AIM： To evaluate the utility of diffusion-weighted imaging （DWl） in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS： Magnetic resonance imaging （MRI） examinations were performed using the Signa Excite Xl Twin Speed 1.5T system （GE Healthcare, Milwaukee, Wl, USA）. Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas （HCC）, four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio （RCR）, and apparent diffusion coefficient （ADC） were compared between benign and malignant lesions on DWl. Su- perparamagnetic iron oxide （SPIO） was administered to 59 patients, and RCR was compared pre- and ***： DWI showed higher contrast between malignant lesions （especially in multiple small metastatic cancers） and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs （mean±SD × 10^-3 mm2/s） were significantly lower （P 〈 0.05） in malignant lesions （HCC： 1.31 ± 0.28 and liver metastasis： 1.11 ± 0.22） and were significantly higher in benign lesions （hemangioma： 1.84 ± 0.37 and cyst： 2.61 ± 0.45） than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding he- patic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not ***： DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis.

关键词： Hepatic tumor Liver imaging Magneticresonance imaging Diffusion-weighted imaging Apparent diffusion coefficient

Observation of Edge Plasma Fluctuations with a Fast Camera in Heliotron J

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Plasma Science and Technology 2013年第3期15卷 213-216页

作者：臧临阁 M.TAKEUCHI n.nISHInO T.MIZUUCHI S.ohshima K.KASAJIMA M.SHA K.MUKAI H.Y.LEE K.nAGASAKI H.OKADA T.MInAMI S.KOBAYASHI S.YAMAMOTO K.HAnATAnI Y.nAKAMURA S.KOnOSHIMA F.SAnO Graduate School of Energy Science Kyoto University naka Fusion Institute Japanese Atomic Energy Agency Graduate School of Engineering Hiroshima University Institute of Advanced Energy Kyoto University

A fast video camera is verified to be a powerful t0ol for observation of filaments/blobs near the last closed flux surface （LCFS）. In order to extract the fluctuation component from the raw data of the fast camera, a pre-processing technique, sliding time window averaging subtraction （STWAS） has been developed to remove the background of slowly varying emission from the bulk plasma. By using this pre-processing technique, the fast camera data are analyzed. A method to identify the filaments in the pre-processed image is also discussed.

关键词： edge plasma fluctuation fast camera Heliotron J

A new High-Spin Level Scheme of ^128I

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Chinese Physics Letters 2010年第8期27卷 58-61页

作者：王海霞张玉虎丁兵周小红张宁涛柳敏良马英君 Y. Sasakiz K. Yamada H. ohshima S. Yokose M. Ishizuka T. Komatsubara K. Furuno Insititute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 Graduate School of the Chinese Academy of Sciences Beijing 100049 Department of Physics Jilin University Changehun 130021 Institute of Physics and Tandem Accelerator Center University of Tsukuba Ibaraki 305-0006 Japan

High-spin states in the beam energies. A new and 72 γ transitions odd-odd nucleus ^128I are investigated via the ^124 Sn（^7 Li,3n）^128 I reaction at 28 and 32 Me V level scheme of 12sI is established up to high-spin states at I^π = 16, including 48 levels The present level scheme is largely different from the one in a recent publication due to identification of several doublet and triplet γ transitions and their proper placements in the level scheme. The high-spin level structure exhibits no obvious collective properties and is possibly associated with two and multi-quasiparticle configurations.

关键词： EnERGY levels (Quantum mechanics) PHASE transformations (Physics) nUCLEAR reactions PARTICLE beams QUASIPARTICLES (Physics)

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双奇核^(128)Ⅰ的高自旋态

中国科学：物理学、力学、天文学 2011年第3期41卷 256-266页

作者：丁兵张玉虎王海霞周小红张宁涛柳敏良王世陶马英君 SASAKIZ Y YAMADA K ohshima H YOKOSE S ISHIZUKA M KOMATSUBARA T FURUnO K 中国科学院近代物理研究所兰州730000 中国科学院研究生院北京100049 吉林大学物理学院长春130021 Institute of Physics and Tandem Accelerator Center University of Tsukuba

利用重离子熔合蒸发反应124Sn(7Li,3n)布居了双奇核128I的激发态.基于标准在束γ谱学实验测量结果,扩展并更新了128I原有能级纲图.根据已有的高自旋态核结构知识,通过系统学比较和分析,指出了基于π(g7/2/d5/2)vh11/2组态的负宇称能... 详细信息

利用重离子熔合蒸发反应124Sn(7Li,3n)布居了双奇核128I的激发态.基于标准在束γ谱学实验测量结果,扩展并更新了128I原有能级纲图.根据已有的高自旋态核结构知识,通过系统学比较和分析,指出了基于π(g7/2/d5/2)vh11/2组态的负宇称能级结构和πh11/2πh11/2组态的正宇称能级结构.

关键词：双奇核^(128)I 在束γ谱学能级纲图

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^(134)Ba能级结构的在束γ谱学研究

高能物理与核物理 2004年第3期28卷 268-273页

作者：骆鹏柳敏良刘忠张玉虎周小红郭应祥马英君 Y.Sasaki K.Yamada H.ohshima S.Yokose M.Ishizuka T.Komatsubara K.Furuno 中国科学院近代物理研究所吉林大学长春130012 Institute of Physics and Tandem Accelerator Center University of Tsukuba

利用在束γ谱学技术 ,通过 12 8Te(10 B ,1p3n) 13 4 Ba反应研究了 13 4 Ba的中、高自旋激发态 .实验中采用 9套BGO(AC)HPGe探测器进行了γ γ t符合测量 .基于γ γ符合关系、γ射线的相对强度和各向异性度的测量结果建立了 13 4 Ba的... 详细信息

利用在束γ谱学技术 ,通过 12 8Te(10 B ,1p3n) 13 4 Ba反应研究了 13 4 Ba的中、高自旋激发态 .实验中采用 9套BGO(AC)HPGe探测器进行了γ γ t符合测量 .基于γ γ符合关系、γ射线的相对强度和各向异性度的测量结果建立了 13 4 Ba的能级纲图 .比较n =78的同中子素链的负宇称能级结构的系统性 ,发现激发能位于 4 14 2keV ,Jπ 值为 11-的能级很可能是与 13

关键词：各向异性度能级纲图钡能级结构束γ谱学自旋激发态 γ-γ-t符合测量高能物理实验