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临床T1an0M0肺癌：基于高分辨力CT的临床病理模式和肿瘤学结果的差异

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国际医学放射学杂志 2021年第6期 744-744页

作者： K.Sun A.You B.Wang n.song Z.Wan F.Wu 郭虹

目的根据最新第8版TnM分类,阐明临床TnM(c-TnM)肺癌的临床病理特征和肿瘤学结果。方法回顾性纳入257例c-T1an0M0肺癌病人。根据高分辨力CT

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HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting nLRP3 inflammasome activation after retinal ischemia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 39-50页

作者： Lin-Ping Xue Hai-song Feng Hubei University of Chinese Medicine Wuhan 430065Hubei ProvinceChina Department of Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430070Hubei ProvinceChina

AIM:To explore the neuroprotective effects of high mobility group box 2(HMGB2)knockdown on retinal ganglion cells(RGCs)in the retinal ischemia-reperfusion injury(RIRI).METHODS:Oxygen-glucose deprivation(OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure(IOP)-induced RIRI mice were used as cellular and animal models of *** expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction(RT-qPCR)and Western *** effects of HMGB2 silencing on the morphological changes,RGCs survival,and cell apoptosis in mouse retinal tissues were observed through H&E staining,immunofluorescence staining with RnA-binding protein with multiple splicing(RBPMS)antibody,and TUnEL staining,*** viability and apoptosis were examined by CCK-8 and flow cytometry *** levels of proteins associated with nOD-like receptor thermal protein domain associated protein 3(nLRP3)-mediated pyroptosis[nLRP3,Caspase-1,GSDMD-n,interleukin(IL)-1β,IL-18]in vivo and in vitro were measured by Western ***:HMGB2 protein and nLRP3 were upregulated in the retina of RIRI mice and OGD-injured RGCs(Pna was edematous,accompanied by disorganized cell arrangement and decreased thickness of all layers,and obvious vacuoles in ganglion cell ***2 silencing alleviated the reduction in total retinal thickness and the severity of retinal tissue damage as well as suppressed RGC loss and retinal cell apoptosis in RIRI ***-induced RGC apoptosis was ameliorated after downregulation of HMGB2 in *** injection of the AAV-sh-HMGB2 and si-HMGB2 resulted in significantly decrease of nLRP3,Caspase-1,GSDMD-n,IL-1β,and IL-18 protein levels in the retinal tissues of RIRI mice and OGD-injured RGCs,respectively(all PnCLUSIOn:HMGB2 knockdown protects against RGC apoptosis and pyroptosis after RIRI through suppressing nLRP3 inflammasome activ

关键词： HMGB2 retinal ischemia-reperfusion injury retinal ganglion cell apoptosis pyroptosis nLRP3 mice

Synergistically S/n self-doped biochar as a green bifunctional cathode catalyst in electrochemical degradation of organic pollutant

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Green Energy & Environment 2025年第1期10卷 214-230页

作者： Xuechun Wang Huizhong Wu Jiana Jing Ge song Xuyang Zhang Minghua Zhou Raf Dewil Key Laboratory of Pollution Process and Environmental Criteria Ministry of EducationCollege of Environmental Science and EngineeringNankai UniversityTianjin300350China Tianjin Key Laboratory of Environmental Technology for Complex Trans-Media Pollution Nankai UniversityTianjin300350China Tianjin Advanced Water Treatment Technology International Joint Research Center College of Environmental Science and EngineeringNankai UniversityTianjin300350China Department of Chemical Engineering KU LeuvenJ.De Nayerlaan 5Sint-Katelijne-Waver B2860Belgium

Biomass-derived heteroatom self-doped cathode catalysts has attracted considerable interest for electrochemical advanced oxidation processes(EAOPs)due to its high performance and sustainable ***,we illustrated the morphological fates of waste leaf-derived graphitic carbon(WLGC)produced from waste ginkgo leaves via pyrolysis temperature regulation and used as bifunctional cathode catalyst for simultaneous H_(2)O_(2) electrochemical generation and organic pollutant degradation,discovering S/n-self-doping shown to facilitate a synergistic effect on reactive oxygen species(ROS)*** the optimum temperature of 800℃,the WLGC exhibited a H_(2)O_(2) selectivity of 94.2%and tetracycline removal of 99.3%within 60 *** functional theory calculations and in-situ Fourier transformed infrared spectroscopy verified that graphitic n was the critical site for H_(2)O_(2) *** pyridinic n and thiophene S were the main active sites responsible for OH generation,n vacancies were the active sites to produce ^(1)O_(2) from O_(2).The performance of the novel cathode for tetracycline degradation remains well under a wide pH range(3–11),maintaining excellent stability in 10 *** is also industrially applicable,achieving satisfactory performance treating in real water *** system facilitates both radical and non-radical degradation,offering valuable advances in the preparation of cost-effective and sustainable electrocatalysts and hold strong potentials in metal-free EAOPs for organic pollutant degradation.

关键词： Biochar S and n self-doping H_(2)O_(2)production In-situ FTIR Metal-free electrochemical advanced oxidation processes

Alpha-decay properties of nuclei around neutron magic numbers

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nuclear Science and Techniques 2025年第1期36卷 140-149页

作者： Ming Li Chu-Xin Chen Lan-Fang Xiao Yi Zhang song Luo Xiao-Hua Li School of nuclear Science and Technology University of South ChinaHengyang 421001China PET‑CT Center Chenzhou First People’s HospitalChenzhou 423000China Hengyang Ecological Environment Monitor Center Hengyang 421001China China Certification and Inspection Group Hefei 230000China national Exemplary Base for International Science and Technology Collaboration of nuclear Energy and nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for nuclear Fuel Cycle Technology and Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

By combining experimental α-decay energies and half-lives, the α-particle preformation factor for nuclei around neutron magic numbers n of 126, 152, and 162 were extracted using the two-potential approach. The nuclei around the shell closure were more tightly bound than adjacent nuclei. Additionally, based on the WS4 mass model (Wang et al., Phys. Lett.B 734, 215 (2014)), we extended the two-potential approach to predict the α-decay half-lives of nuclei around n values of178 and 184 with Z of 119 and 120. We believe that our findings will serve as guidelines for future experimental studies.

关键词： adecay Preformation factor neutron magic number Heavy and superheavy nuclei

Copper-catalyzed C–C bond cleavage coupling with C≡n bond formation toward mild synthesis of lignin-based benzonitriles

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Journal of Environmental Sciences 2025年第5期151卷 505-515页

作者： Qi Luo Shenglong Tian Qian Qiang Fei song Wentao Su Haiyan He Qingda An Changzhi Li Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Science Beijing 100049China

n-participated lignin depolymerization is of great importance for the transformation of waste lignin into value-added *** vast majority of developed strategies employ organic amines as nitrogen source,and considerablemethods rely on excessive use of strong base,which suffers severe environmental ***,benzonitrile derivatives are synthesized from oxidized ligninβ-O-4 model compounds in the presence of solid nitrogen source(nH_(4))_(2)CO_(3)under mild,base-free conditions over commercially available copper *** studies suggest the transformation undergoes a one-pot,highly coupled cascade reaction path involving oxidative C-C bond cleavage and in-situ formation of C≡n *** which,Cu(OAc)2 catalyzes the transfer of hydrogen from C_(β)(C_(β)-H)to C_(α),leading to the cleavage of C_(α)-C_(β)bonds to offer benzaldehyde derivative,this intermediate then reacts in-situ with(nH_(4))_(2)CO_(3)to afford the targeted aromatic nitrile *** iodide(TBAI),acting as a promoter,plays a key role in breaking the C_(α)-C_(β)bonds to form the intermediate benzaldehyde *** this protocol,the feasibility of the production of value-added syringonitrile from birchwood lignin has been *** transformation provides a sustainable approach to benzonitrile chemicals from renewable source of lignin.

关键词： Lignin β-O-4 model compounds Benzonitrile derivatives Copper catalyst Mild conditions

n-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: Design,structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2025年第2期36卷 256-261页

作者： Jian.song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang School of Basic Medical Sciences Zhengzhou University Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital Zhengzhou Children's Hospital School of Pharmaceutical Sciences Institute of Drug Discovery & Development Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education) Zhengzhou University State Key Laboratory of Esophageal Cancer Prevention & Treatment

In this work,we employed a ring-opening strategy to develop a series of novel n-benzyl arylamide derivatives as tubulin polymerization ***,13n （MY-1388） exhibited remarkable antiproliferative potency on fifteen human cancer cell lines,with half maximal inhibitory concentration (IC50)values ranging from 8 nmol/L to 48 nmol/***,13n effectively suppressed tubulin polymerization by targeting the colchicine-binding site (IC50=0.62μmol/L).13n also exhibited significant inhibition of cell colony formation,as well as displayed potent effects on inducing G2/M phase cell cycle arrest and promoting ***,13n exhibited enhanced and adequate liver microsomal stability in human and rat liver microsomes,and also exhibited a moderate half-life (T1/2=0.938 h) in ***,13n demonstrated effective antitumor effects in vivo in suppressing tumor growth in the MGC-803xenograft model (tumor growth inhibition （TGI） value was 76.4%at the dosage of 30 mg kg-1day-1)with a good safety ***,these results revealed that 13n represents a promising tubulin polymerization inhibitor that deserves further investigation for its efficacy in treating gastric cancers.

关键词： Antiproliferative activities CA-4 Colchicine binding site n-Benzyl arylamide Tubulin

Galileo multi-day precise orbit determination using L-band and SLR data

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Geodesy and Geodynamics 2025年第1期16卷 99-110页

作者： Tianhe Xu Honglei Yang song Li Zhenlong Fang Wenfeng nie Min Li Baoguo Yu Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space Sciences Shandong University navigation Laboratory of the 54th Research Institute of China Electronics Technology Group Corporation

The continuously available satellites of European Galileo currently reach more than 25. To explore the rationality and reliability of the L-band and satellite laser ranging(SLR) data processing strategies, we design the Galileo L-band, the SLR-only, and the combined L-band/SLR dynamic precise orbit determination(POD) strategies by using the normal equations(nEQs) stacking, and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023, based on the Bei Dou/GnSS analysis center platform of Shandong University by using the modified Bernese GnSS Software Version 5.4. The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS) values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GnSS Experiment(COM) orbits, the corresponding values is 1.4 cm, 2.5 cm, and 2.3 cm in Radial, the Tangential, and the normal(RTn) direction, respectively. While the SLR-only 9-day arc length is optimal with the RTn values of 5.3 cm, 30 cm, and 38.2 cm,as well as the 3D-RMS values of 48.9 cm. Encouragingly, the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm, 0.6 cm and 1.2 cm in T-, and n-direction for the 3-and 5-day solution respectively. The corresponding values improve 0.7 cm and 0.9 cm, 1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution. Take the E09 satellite as a case study, the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites ***, the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GnSS and SLR techniques.

关键词： Galileo POD SLR L-band nEQs stacking

Insight into the activation of peroxymonosulfate by n-doped copper-based carbon for efficient degradation of organic pollutants:Synergy of nonradicals

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Chinese Chemical Letters 2025年第1期36卷 513-520页

作者： Mengmeng Ao Jian Wei Chuan-Shu He Heng Zhang Zhaokun Xiong Yonghui song Bo Lai College of Environmental Sciences Liaoning UniversityShenyang 110036China State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

The contamination of water resources by phenolic compounds(PCs)presents a significant environmental hazard,necessitating the development of novel materials and methodologies for effective *** this study,a metallic copper-doped zeolitic imidazolate framework was pyrolyzed and designated as CunC-20 for the activation of peroxymonosulfate(PMS)to degrade phenol(PE).Cu-nC-20 could effectively address the issue of metal agglomeration while simultaneously diminishing copper dissolution during the activation of PMS *** Cu-nC-20 catalyst exhibited a rapid degradation rate for PE across a broad pH range(3-9)and demonstrated high tolerance towards coexisting *** to scavenger experiments and electron paramagnetic resonance analysis,singlet oxygen(^(1)O_(2))and high-valent copperoxo(Cu(Ⅲ))were the predominant reactive oxygen species,indicating that the system was nonradicaldominated during the degradation *** quantitative structure-activity relationship(QSAR)between the oxidation rate constants of various substituted phenols and Hammett constants was *** indicated that the Cu-nC-20/PMS system had the optimal oxidation rate constant withσ^(-)correlation and exhibited a typical electrophilic reaction *** study provides a comprehensive understanding of the heterogeneous activation process for the selective removal of phenolic compounds.

关键词： n-doped copper-based carbon Phenolic compounds Peroxymonosulfate nonradical pathway Quantitative structure-activity relationship(QSAR)

Synergistically enhanced ORR and HER performance on Co-n-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min.song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage(Huazhong University of Science and Technology)Ministry of Education School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds (IMCs)(o-PtCo@ConC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@ConC exhibits excellent electrocatalytic performance for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) with mass activity of 1.21 A mgPt-1(at 0.9 V) and5.70 A mgPt-1(at an overpotential of 100 mV),***,o-PtCo@ConC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction