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Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第7期7卷 87-94页

作者： Devulapalli Krishnaveni Bhayal Amar Chand Porika shravan kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy nallari Pratibha n Balakrishna Ananthapur Venkateshwari Department of Cell Biology Institute of Genetics and Hospital for Genetic DiseasesOsmania University Department of Gastroenterology Gandhi Hospital Department of Genetics Osmania University Department of Biostatistics National Institute of NutritionHyderabad

AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DnA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P nts with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. no significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).COnCLU

关键词： Genetics Helicobacter pylori nutrition Oncology Endoscopy Gastro duodenal nitric oxide Single nucleotide polymorphism rs2070744 Agarosegel electrophoresis Allele specific polymerase chainreaction

Uncertainty-quantified parametrically homogenized constitutive models (UQ-PHCMs) for dual-phase α/β titanium alloys

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npj Computational Materials 2020年第1期6卷 677-696页

作者： shravan Kotha Deniz Ozturk Somnath Ghosh Departments of Civil Mechanical and Materials Science&EngineeringJohns Hopkins University3400 N.Charles StreetBaltimoreMD 21218USA

This paper develops an uncertainty-quantified parametrically homogenized constitutive model(UQ-PHCM)for dual-phase α/βtitanium alloys such as *** microstructures are characterized by primaryα-grains consisting of hcp crystals and transformedβ-grains consisting of alternating laths ofα(hcp)and β(bcc)*** PHCMs bridge length-scales through explicit microstructural representation in structure-scale constitutive *** forms of equations are chosen to reflect fundamental deformation characteristics such as anisotropy,length-scale dependent flow stresses,tension-compression asymmetry,strain-rate dependency,and cyclic hardening under reversed loading *** coefficients are functions of representative aggregated microstructural parameters or RAMPs that represent distributions of crystallographic orientation and morphology.

关键词： alloys deformation constitutive

Vibration Control of Vertical Turbine Pump by Optimization of Vane Pitch Tolerances of an Impeller Using Statistical Techniques

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Sound & Vibration 2021年第4期55卷 305-327页

作者： Ravindra Birajdar Appasaheb Keste shravan Gawande Kirloskar Brothers Limited Corporate R&DPune411045India Department of Mechanical Engineering MES College of EngineeringPune411001India

The objective of the study is to find the tolerance on vane pitch dimensions of a Vertical Turbine(VT)pump *** this purpose,the study is divided into two parts *** find the critical hydraulic eccentricity of a VT pump impeller by way of numerical simulations and design of experiments to find the vane pitch tolerance using critical hydraulic *** effect of impeller vane pitch deviations on hydraulic unbalance is examined for a vertical turbine pump using Design of Experiments(DOE).A suitable orthogonal matrix has been selected with vane pitch at different axial locations of an impeller as the control *** eccentricity,which is the output of the DOE experiments is analyzed using S/n ratio,AnOM and regression analysis to find the significant control factor effecting the hydraulic unbalance and hence *** vane pitch deviation at outlet and inlet of impeller shroud geometry are found to be the most critical factor affecting the pump vibrations.

关键词： Vertical turbine pump vibrations design of experiments hydraulic eccentricity

Finite Element Analysis of Dynamic Damper for CV Joint

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Energy and Power Engineering 2012年第4期4卷 241-247页

作者： Rahul n. Yerrawar Vinod B. Tungikar shravan H. Gawande Dept. of Mechanical Engineering M.E.S. College of Engineering Pune India Dept. of Production Engineering S.G.G.S. Institute of Engineering and Technology Nanded India

Constant Velocity [CV] Joints are one of the most important components of front wheel drive axles. It is subjected to various stresses such as bending stress, shear stress and bearing stress. Apart from these stresses, it is also subjected to vibrations, due to out of balance tire or wheel and an out of round tire or wheel, or a bent rim. The main objective of this work is to reduce the stiffness of the damper, so that the damper can withstand within the required constraints [i.e. the forced frequency range of 80 Hz to 150 Hz]. The free vibrational and forced vibrational effects are investigated to predict the resonance phenomenon of the damper. Finite Element Analysis in AnSYS-11 software was performed to predict the dynamic behavior of the system under the required vibrational frequencies ranging from 80 Hz to 150 Hz at given loading conditions.

关键词： Constant Velocity (CV) Finite Element Analysis (FEA)

Epizootic, Endemic and Pandemic Zoonotic Viral Infections

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Journal of Biosciences and Medicines 2022年第3期10卷 90-96页

作者： shravan Singh Rathore Hem Singh Gehlot Gyan Prakash Jayashree S. nandi Wildlife Institute of India GIB-CB Project Sam-Jaisalmer India Department of Zoology JNV University Jodhpur India Machiya Biological Park Post Office Saran Nagar Jodhpur India national Institute of Virology (Past) Pune India Department of Microbiology and Immunology Albert Einstein College of Medicine (Past) Bronx New York USA

More than 60% human infectious diseases have zoonotic origin. Cross species transmission of pathogens is a continuous, dynamic process that occurs throughout the world, giving rise to epizootic (temporary, limited infection), endemic (on-going infection limited to a defined geographic region) and pandemic viral infections (infection spreading to every part of the world) like the current COVID-19 pandemic, which depends on the existing conditions on the ground. In nov 2021, sudden mortality of numerous migrating demoiselle cranes was reported from their resting site near Jodhpur, Rajasthan. The symptomatic cranes became gradually weak and were unable to fly. They eventually fell dead which caused concern locally, given the current prevailing SARS-CoV-2 pandemic situation the world over. By the end of Dec 2021, the number of cranes with mortality and morbidity reduced, making it a temporary “epizootic infection”. Molecular diagnosis carried out at a specialized laboratory identified the etiological agent to be the highly pathogenic Avian Influenza Virus H5n1 (HPAIV), which has been responsible for morbidity of avian species from different parts of the world. There was no report of spreading the H5n1 AIV infection from the infected migratory cranes to nearby chicken farms or pig farms for now. In the absence of vaccines against the highly pathogenic H5n1 AIVs, and the inherent ability of influenza viruses, both avian AIV and human IAVs to constantly mutate its envelope gene or the surface antigens, resulting from the error-prone nature of the viral RnA Polymerase enzyme are the roadblocks for development of a universal, broad-spectrum influenza vaccine. Even when such a universal vaccine against H5n1 is available, vaccinating a large number of wild migratory cranes would be difficult. However, it is possible and indeed necessary to vaccinate chickens in poultry farms and pigs in farms that raise pigs for human consumption.

关键词： Zoonotic Pathogens natural Infection Anthroponosis Migratory Birds Across Countries Aquatic Demoiselle Cranes Viral Infectious Diseases

Design and Development of Shell &Tube Heat Exchanger for Beverage

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Modern Mechanical Engineering 2012年第4期2卷 121-125页

作者： shravan H. Gawande Sunil D. Wankhede Rahul n. Yerrawar Vaishali J. Sonawane Umesh B. Ubarhande Department of Mechanical Engineering M. E. Society’s College of Engineering Pune India Dy. Manager PEM Design (R&D) Alfa Laval (India) Ltd. Pune India

In the first part of this paper, a simplified approach to design a Shell & Tube Heat Exchanger [STHE] for beverage and process industry application is presented. The design of STHE includes thermal design and mechanical design. The thermal design of STHE involves evaluation of required effective surface area (i.e. number of tubes) and finding out log mean temperature difference [LMTD]. Whereas, the mechanical design includes the design of main shell under internal & external pressure, tube design, baffles design gasket, etc. The design was carried out by referring ASME/TEMA standards, available at the company. The complete design, fabrication, testing and analysis work was carried out at Alfa Laval (India), Ltd., Pune-12. In the second part of this paper detail view of design optimization is presented by flow induced vibration analysis [FVA].

关键词： Heat Exchanger LMTD TEMA HTRI