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Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

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Advances in Breast Cancer Research 2013年第3期2卷 51-55页

作者： T. S. Balmukhanov A. K. Khanseitova V. G. nigmatova S. P. Varchenko sh. Zh. Talaeva n. A. Aitkhozhina Structural and Functional Genomics Laboratory Institute of Molecular Biology and Biochemistry Almaty Kazakhstan

Associations of polymorphisms in rs4646903 site of CYP1A1 and rs1056836 site of CYP1B1 genes with the breast cancer (BC) were studied in two main ethnic groups of Kazakhstan Republic (Kazakhs and Russians). Total number of BC patients was 181, controls—397. The statistically significant differences were revealed in allele frequencies (χ2 = 5.93, р = 0.004) and in genotypes distribution (χ2 = 8.71, р = 0.015) in rs4646903 site of CYP1A1 gene in Kazakh but not in Russian group. The study of CYP1В1 rs1056836 site demonstrated differences in genotype distributions (χ2 = 7.48, р = 0.023) between BC patients and controls in Russian but not in Kazakh ethnic group.

关键词： Breast Cancer Gene Polymorphism CYP1A1 CYP1B1 Kazakhstan

The Electrode for Potentiometric Determinаtion of Chromium (III, VI) in Wаter Solutions

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Journal of Materials Science and Chemical Engineering 2014年第1期2卷 52-56页

作者： shаmshiyа Аmerkhаnovа Dana Belgibayeva Rustаm shlyаpov Аitolkyn Uаli Depаrtment of Chemicаl Engineering аnd Petroleum Chemistry Buketov Kаrаgаndy Stаte University Kаrаgаndy Kаzаkhstаn Depаrtment of Physicаl аnd Аnаlyticаl Chemistry Buketov Kаrаgаndy Stаte University Kаrаgаndy Kаzаkhstаn

The possibility of determining of chromium (III, VI) ions was investigated in this paper. It is shown that the electrode on а basis of heаzlewoodite has high selectivity to chromium (III) ions. Also the stability constants of complexes, forming in system “Cr3+-Mohr’s salt-Ca(oH)2-PVA ÷ PAA” were determined by potentiometric titration with ion-selective electrode.

关键词： Heаzlewoodite Chromium (III VI) Ions Potentiometric Method

The Transformation of the Heterogeneous Materials under the Fatigue Deformation

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Materials Sciences and Applications 2012年第6期3卷 398-407页

作者： S. Kh. shamirzaev J. K. Ziyovaddinov sh. B. Karimov Physical Technical Institute of Uzbek Academy of Sciences Tashkent Republic of Uzbekistan

The objects of our paper are aluminum alloy samples (AASs) contained the different amount of Cu, Mn, Mg, Si and Li. We are modeling the features of microstructure of potential relief of an AAS and studying its transformation under both imposed fatigue deformation and wetted by liquid metals (Ga;or Hg;Li;In). We illustrate the main ideas by using only the “time series” allied with effective internal friction Q-1eff of an AAS. AASs like B-95 or 7075 are heterogeneous materials for which the more energy can be absorbed by selected micro-regions of a tested sample. So micro-crack in the space of AAS and alarm state of AAS arises. Each micro-region will to contribute the Q-1k (the internal friction Q-1k belong to k-th micro-region) to the effective internal friction— Q-1eff accordance with fit statistic . We find a number of micro-regions—L and series gk & Qk from the experimental data like as the internal friction (Q-1)eff versus both the number of cycles—n and the deformation—е. Series gk & Qk (k=1,2,3,...,L) present the microstructures of AASs. In this paper also is presented the original technology to forecast fatigue damage of an AAS. Here the fatigue sensitive element (FSE) used. We made multiphase heterogeneous mixtures (MHMs) which contents a variable volume of initial components. It is selected MHMs are using for produce FSEs. The present paper is aimed to establish the correlation of the FSEs microstructures changes and corresponding changes of the aluminum alloy microstructures at imposing the same spectra deformation on both of them. A change of FSEs microstructure investigated by using their effective electrical resistance Reff data.

关键词： Amplitude-Dependent Internal Friction Fatigue Cracking Process Alarm State Fatigue Sensitive Element

外源性肾上腺髓质素对肾脏创伤大鼠Th1/Th2的调节作用

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中国组织工程研究与临床康复 2007年第16期11卷 3078-3081页

作者：张希炯孙少华兰州大学基础医学院法医学研究室甘肃省兰州市730000

目的:观察外源性肾上腺髓质素(adrenomedullin,ADM)对大鼠肾脏创伤后外周血Th1/Th2的调节作用,并了解给药时间对此作用的影响。方法:实验于2005年在兰州大学实验中心进行。将104只Wistar大鼠随机分为4大组:①正常对照组(8只);不打击。... 详细信息

目的:观察外源性肾上腺髓质素(adrenomedullin,ADM)对大鼠肾脏创伤后外周血Th1/Th2的调节作用,并了解给药时间对此作用的影响。方法:实验于2005年在兰州大学实验中心进行。将104只Wistar大鼠随机分为4大组:①正常对照组(8只);不打击。②创伤组(32只);自由落体生物撞击仪撞击大鼠脊肋区,间接打击双侧肾脏造成肾脏Ⅰ级损伤。③创伤前注射ADM组(32只);打击同创伤组,打击前10min腹腔注射肾上腺髓质素0.1nmol/kg(终体积0.5mL)。④创伤后注射ADM组(32只):打击同创伤组,打击后10min腹腔注射肾上腺髓质素0.1nmol/kg(终体积0.5mL)。后3组分别在打击后1,6,12,24h各处死8只。采用酶联免疫斑点法测定Th1与Th2阳性率。结果:82只大鼠进入结果分析。①创伤组:Th1细胞在创伤后6h显著增加并达峰值,高于创伤后1h及正常对照组[(0.32±0.07)%,(0.13±0.06)%,(0.16±0.07)%,P<0.05,0.01];Th2各时间点比较均无差异;Th1/Th2在创伤后6h达高峰,创伤后24h降至正常对照组水平。②创伤前注射ADM组:Th1在创伤后6h低应答,在创伤后12h增高并达峰值,高于创伤后6h及正常对照组[(0.32±0.08)%,(0.08±0.06)%,(0.16±0.07)%,P<0.05,0.01];Th2在创伤后6-12h的变化趋势与Th1相同;Th1/Th2创伤后6h达最低,低于该时点创伤组(4.58±3.81,23.44±6.19,P<0.01),随后上升,至创伤后24h达高峰。③创伤后注射ADM组:Th1自创伤后1h逐渐上升,至24h达高峰,高于创伤后1,6h[(0.32±0.10)%,(0.10±0.04)%,(0.17±0.07)%,P<0.05,0.01],Th2细胞各时间点比较均无差异;Th1/Th2于创伤后1,6h接近正常对照组,然后逐渐上升,至创伤后24h达最高,高于正常对照组及该时点创伤组(22.49±12.64,5.33±4.55,4.78±3.15,P<0.01)。结论:①急性创伤早期(以创伤后6h为著),外源性肾上腺髓质素通过抑制Th1优势应答,具有校正Th1/Th2比例失衡的免疫调节作用。②急性创伤后最初6h内,创伤后给予肾上腺髓质素调节Th1/Th2平衡作用明显优于创伤前给药。

关键词：肾脏创伤肾上腺髓质素 Th1细胞 Th2细胞

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试论吐蕃时期拉萨城市的形成及原因

乐山师范学院学报 2015年第7期30卷 75-79页

作者：陈姗姗朱普选西藏民族学院民族研究院陕西咸阳712082 西藏民族学院管理学院陕西咸阳712082

拉萨,作为我国西藏自治区的首府,最初发展始于吐蕃王朝时期,后历代经历了不同程度的发展,其古老的历史文化在中国历史上占据着独特的地位。而吐蕃时期拉萨城市的发展又为历代的发展奠定了基础,故研究这一时期拉萨城市的变迁,对历代的拉... 详细信息

拉萨,作为我国西藏自治区的首府,最初发展始于吐蕃王朝时期,后历代经历了不同程度的发展,其古老的历史文化在中国历史上占据着独特的地位。而吐蕃时期拉萨城市的发展又为历代的发展奠定了基础,故研究这一时期拉萨城市的变迁,对历代的拉萨城市研究和拉萨城市的规划都有重要的意义。文章试图利用历史地理的相关研究方法,分析了吐蕃时期拉萨古城的形成,认为其形成的原因主要是优越的地理条件,城市经济的发展,军事的促进和佛教的作用。

关键词：吐蕃时期拉萨形成原因

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基础统计热力学解题方法

丛书名：书名原文:Elementery statistical ther modynamics

1989年

作者：（美）史密斯（Smith n.o.）鲍银堂译

本书以解题方式阐述了统计热力学的基本原理和应用，内容浅要，结构严谨，阐述简明，引用了许多例题，每章末有许多习题并附有习题解答。

ISBN: (纸本)704000285X

本书以解题方式阐述了统计热力学的基本原理和应用，内容浅要，结构严谨，阐述简明，引用了许多例题，每章末有许多习题并附有习题解答。

关键词：统计热力学学科:解题学科:高等教育

来源：汇雅图书（南通市图书馆... 评论

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神经递质受体结合与发现新药

国际药学研究杂志 1985年第1期 9-13页

作者： Snyder sh 檀东平

许多精神药物和心血管药物都是通过影响突触机制显示疗效。但由于药物作用的分子机制仍未阐明,至今这些领域中的新药筛选方案尚未能与神经递质的基础研究紧密相联,因而,在许多方面,还不能通过体外生化活性的检测来建立鉴定新药的系统方... 详细信息

许多精神药物和心血管药物都是通过影响突触机制显示疗效。但由于药物作用的分子机制仍未阐明,至今这些领域中的新药筛选方案尚未能与神经递质的基础研究紧密相联,因而,在许多方面,还不能通过体外生化活性的检测来建立鉴定新药的系统方法。药物可通过多种途径影响神经递质系统,如可干扰递质的合成或降解的酶,改变递质的贮存或释放、或在受体位点上拟似或阻滞递质的作用。许多精神药物和心血管药物作用于受体。因此采用分子策略来发现新药需要简便的生化检测方法以识别受体位点。如在电器官中烟碱（n）-胆碱受体的成功鉴定是由于发现了极强的毒素,如[;I]-α-银环蛇毒素和密度高达膜蛋白20%的n-胆碱受体。仅占脑或心脏重量百万分之一的阿片受体已能成功地用简

关键词：受体亚型 GABA BZ 拮抗剂激动剂受体结合巴比妥类阿片受体新药

Research on the degradation mechanism of dimethyl phthalate in drinking water by strong ionization discharge

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Plasma Science and Technology 2018年第3期20卷 112-121页

作者：赵红依成武依蓉婕王慧娟尹兰兰 I n MUHAMMAD 马中飞 School of the Environment and Safety Engineering Jiangsu University

The degradation mechanism of dimethyl phthalate（DMP） in the drinking water was investigated using strong ionization discharge technology in this study. Under the optimized condition, the degradation efficiency of DMP in drinking water was up to 93% in 60 min. A series of analytical techniques including high-performance liquid chromatography, liquid chromatography mass spectrometry, total organic carbon analyzer and ultraviolet–visible spectroscopy were used in the study. It was found that a high concentration of ozone（o_3） produced by dielectric barrier discharge reactor was up to 74.4 mg l^（-1） within 60 min. Tert-butanol, isopropyl alcohol,carbonate ions（Co_3^（2-）） and bicarbonate ions （HCo_3^-） was added to the sample solution to indirectly prove the presence and effect of hydroxyl radicals（·oH）. These analytical findings indicate that mono-methyl phthalate, phthalic acid（PA） and methyl ester PA were detected as the major intermediates in the process of DMP degradation. Finally, DMP and all products were mineralized into carbon dioxide（Co_2） and water（H_2o） ultimately. Based on these analysis results, the degradation pathway of DMP by strong ionization discharge technology were proposed.

关键词： strong ionization discharge dimethyl phthalate active particles

A hydrochemical and Dye-tracing Investigation in the Posht-e-naz Karstic Aquifer,Alburz Mountain,northern Iran

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Journal of Mountain Science 2011年第1期8卷 37-45页

作者： Kalantari n. Alizadeh B. Mohammadi A.R. Keshavarzi.M.R. Geology Department Shahid Chamran University WaterResource organization

A hydrochemical and tracer study （uranine injection） was conducted in Jurassic limestone of the Posht-e-naz area in the Alborz belt to evaluate hydraulic relations between a large diameter （about 100m） sinkhole and springs and aquifer parameters. A main goal of the project was to find out the source of turbidity of the Emarate drinking water supply spring （SP4） in rainy season. Springs discharge were measured and hydrochemical investigation were carried out. The uranine tracer was injected and eight springs, three wells and the neka River were selected and totally 989 samples in 107 days were collected. Hydrochemical data demonstrated a relative connection between sinkhole （shl） and spring （SP4）. The results of the tracing by sampling water indicated only a hydraulic connection between Sange- nou spring （SP8） and injection point, while the charcoal packets analysis revealed tracer exits from spring numbers SP1, SP3, SP4, SP5, SP8, in wells W1 and W2, and in the neka River. The concentration - time curves of charcoal packets for qualitative analysis and exit tracer for quantitative analysis is also assessed.

关键词： Posht-e-naz Tracing Spring Sinkhole Charcoal packet