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Secondary metabolites from an endophytic fungus Aspergillus fumigatus from Solanum insanum L.

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Asian Journal of Traditional Medicines 2021年第2期16卷 76-82页

作者： Vindya Kanthi Munasinghe n.savitri kumar nimal Adikaram Lalith Jayasinghe Hiroshi Araya Yoshinori Fujimoto national Institute of Fundamental Studies Hantana RoadKandySri Lanka School of Agriculture Meiji UniversityKawasakiKanagawa214-8571Japan

An endophytic fungus Aspergillus fumigatus,isolated from the fruits of Solanum insanum L.,was cultured in potato dextrose broth *** separation of the EtOAc extract led to the isolation of six secondary metabolites,identified as pseurotin A(1),fumigaclavine C(2),monomethylsulochrin(3),trypacidin(4),fumiquinazoline C(5)and guignasulfide(6)by spectral *** 2 and 3 showed brine shrimp toxicity with IC50 values of 147 and 74.2μM,respectively,while compounds 4 and 5 showed slight inhibition on the growth of fungal pathogen Cladosporium *** is the first report of the isolation of guignasulfide(6)from ***,which has been previously isolated only from an endophytic fungus Guignardia sp.

关键词： Aspergillus fumigatus Endophytic fungi Solanum insanum Guignasulfide

Synthesis and Biological Study of Some 4-oxo-Thiazolidine Derivatives of 2-Aminothiazole

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Chinese Journal of Chemistry 2011年第5期29卷 1001-1010页

作者： Samadhiya Pushkal Sharma Ritu Srivastava Santosh K. Srivastava savitri D. Synthetic Organic Chemistry Laboratory Department of Chemistry Dr. H.S. Gour University (A Central University) Sagar M.P. 470003 India

Conventional and microwave assisted synthesis of new series of n-[2-{2-（substituted phenyl）-4-oxo- 5-（substituted benzylidene）-1,3-thiazolidine}-iminoethyl]-2-aminothiazole 5a-Sin have been developed. The cycloaddition reaction of thioglycolic acid with n-{2-（substituted benzylidenehydrazino）-ethyl}-2-aminothiazole 3a--3m in the presence of anhydrous ZnC12 afforded new heterocyclic compounds n-[2-{2-（substituted phenyl）- 4-oxo-l,3-thiazolidine}-iminoethyl]-2-aminothiazole 4a---4m. The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2HsOna undergoes Knoevenagel reaction to yield 5a--Sin. The structures of compounds 1, 2, 3a--3m, 4a---4m and 5a--Sm were confirmed by IR, IH nMR, 13C nMR, FAB-Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis.

关键词： conventional microwave synthesis 2-aminothiazole 4-oxo-thiazolidine antimicrobial antitubercular

Synthesis of n1-3-{（4-Substituted aryl-3-chloro-2-oxo- azetidine）-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance

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Chinese Journal of Chemistry 2011年第8期29卷 1745-1752页

作者： Samadhiya, Pushkal Sharma, Ritu Srivastava, Santosh K. Srivastava, savitri D. Synthetic Organic Chemistry Laboratory Department of Chemistry Dr. H. S. Gour University (A Central Univer- sity) Sagar M.P. 470003 India

Synthesis of n1-3-{（4-substitute daryl-3-chloro-2-oxo-azetidine）-iminocarbamyl}-propyl-6-nitroindazole 4a-- 4s was conducted by a conventional method. All the compounds were synthesized and characterized by IR, 1H nMR, 13C nMR, FAB-Mass techniques and chemical methods. All the final synthesized compounds were evaluated for their antimicrobial activity and antitubercular activity with MIC values against some selected microorganisms.

关键词： synthesis 6-nitroindazole 2-azetidinone biological activity

Permeable Reactive Barrier for the treatment of contaminated surface water in Katedan industrial development area, Hyderabad, India

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Chinese Journal Of Geochemistry 2006年第B8期25卷 117-118页

作者： savitri Tripathi Vandana Parth Phani Homeshwari M. Vittal Babu n. Murthy n.n. Sorlie J.E. Govil P.K. national Geophysical Research Institute Hyderabad India norwegian Geotechnical Institute Oslo Norway