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Approaching lean product development using system dynamics:investigating front-load effects

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Advances in Manufacturing 2014年第2期2卷 130-140页

作者： Alemu Moges Belay Torgeir Welo petri Helo Department of Engineering Design and Materials Norwegian University of Science and TechnologyRichard Birkelands Vei 2BN-7491 TrondheimNorway Department of Production Technology University of Vaasa P.O.Box 700FI-65101 VaasaFinland

Competing with successful products has become perplexing with several uncertainties and transmutes from time to time as customers＇ expectations are *** is why manufacturing firms exhaustively strive to look for a better competitive frontier using wellestablished and innovative product development（PD）*** this paper,we would like to answer three research questions：（i）What would be the effects of frontloading in PD？（ii）Can we improve our PD process endlessly？（iii）When is the critical time that the firm should take remedial action for improvements？As a contribution to the vast numbers of improvement methods in new product development（nPD）,this paper investigates the effects of front-loading using set-based concurrent engineering（SBCE）on cost and lead *** are developed and treated using a system dynamics（SD）*** assign a hypothetical upfront investment for SBCE and compare its effects on total cost and lead time of the development *** the research,it is found that the total cost of PD is reduced almost by half-although the front loading is higher in order to encompass multiple design *** total product lead time is reduced by almost 20%.The model reveals the critical time for improvement of the PD *** use SD tool（e.g.,STELLA）for simulation and visualization of the complex PD model,using SBCE as one of several strategies to frontload activities in the nPD process.

关键词： Front-loading Set-based concurrent engineering(SBCE) Innovation Lean product development(LPD) System dynamics(SD)

Fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival, differentiation following inplantation into the adult scala tympani and estibulocochlear nerve

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Fetal dorsal root ganglion, embryonic stem cell and adult ne...

Towards electrochemical hydrogen storage in liquid organic hydrogen carriers via proton-coupled electron transfers

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Christine Regala Jonas Frisén Mats Ulfendahl petri Olivius Department of Clinical neuroscience Department of Clinical neuroscience Department of Otolaryngology Department of Clinical neuroscience Department of Otolaryngology Center for Hearing and Communication Research

＜正＞Either sensory hair cell or spiral ganglion neuron plays critical role in hearing. Loss or degeneration of hair cell and/or spiral ganglion neuron causes peripheral sensorineural hearing loss. Unfortunately, neither of them can be regenerated after loss in mammalian. We implanted fetal dorsal root ganglion （DRG） neurons, embryonic stem cell （ESC） and adult neural stem cell （AnSC） into adult animal cochlea. DRG neuron, ESC and AnSC have either lacZ or GFP reporter genes when implanted. We found that DRG neurons, ESCs and AnSCs could survive, migrate and differentiate transplantation into various species （rat and guinea pig）. The results suggest that new potential treatment using DRG, ESC and AnSC might be the case in near future in clinical patient.

关键词： embryonic stem cell adult neural stem cell

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Journal of Energy Chemistry 2022年第10期31卷 292-300,I0007页

作者： Hamid Ghorbani Shiraz Mikhail Vagin Tero-petri Ruoko Viktor Gueskine Krzysztof Karon Mieczystaw tapkowski Tobias Abrahamsson Thomas Ederth Magnus Berggren Xavier Crispin Laboratory of Organic Electronics Department of Science and Technology(ITN)Linkoping UniversitySE-60174 NorrkopingSweden Smart Photonic Materials Facuty of Engineering and Natural SciencesTampere UniversiyPBox 541.Tampere Fl-33101Finland Silesian University of Technology.Faculty of Chemistry Deparment of Physical Chemistry and Technology of PolymersM.Strzody 9.44-100 GliwicePoland dDepartment of Physics Chemistry and Biology(IFM)Linkoping UniversiySE-58183 LinkopingSweden

Green hydrogen is identified as one of the prime clean energy carriers due to its high energy density and a zero emission of CO_(2).A possible solution for the transport of H_(2)in a safe and low-cost way is in the form of liquid organic hydrogen carriers(LOHCs).As an alternative to loading LOHC with H_(2)via a two-step procedure involving preliminary electrolytic production of H_(2)and subsequent chemical hydrogenation of the LOHC,we explore here the possibility of electrochemical hydrogen storage(EHS)via conversion of proton of a proton donor into a hydrogen atom involved in covalent bonds with the LOHC(R)via a protoncoupled electron transfer(PCET)reaction:2nH^(+)+2ne^(-)+Rox■n H_(2)^(0)*** chose 9-fluorenone/fluorenol(Fnone/Fnol)conversion as such a model PCET *** electrochemical activation of Fnone via two sequential electron transfers was monitored with in-situ and operando spectroscopies in absence and in presence of different alcohols as proton donors of different reactivity,which enabled us to both quantify and get the mechanistic insight on *** possibility of hydrogen extraction from the loaded carrier molecule was illustrated by chemical activation.

关键词： Proton-coupled electron transfer Electrochemical hydrogen storage Hydrogen bonding agent Anion-radical Comproportionation

Relationships between native tree species and soil properties in the indigenous forest fragments of the Eastern Arc Mountains of the Taita Hills, Kenya

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Forestry Studies in China 2011年第3期13卷 198-210页

作者： Loice Mildred Akinyi OMORO Raija LAIHO Michael STARR petri K.E.PELLIKKA Viikki Tropical Resources Institute Department of Forest Sciences University of HelsinkiP.O.Box 27 (Latokartononkaari 7) Helsinki FIN-00014 Finland Department of Forest Sciences University of HelsinkiP.O.Box 27 (Latokartanonkaari 7) Helsinki FI-00014 Finland Department of Geography University of HelsinkiP.O.Box 64 (Gustaf H llstr min katu 2) Helsinki FI-00014 Finland

The relationship between soil properties and spatial distribution of native woody species was studied in three Taita Hills forest fragments which, although degraded, are ranked among 34 biodiversity hotspots of the world due to their high biodiversity of both plant and animal species. This relationship was assessed by using Spearman correlation and principal component analyses （PCA）. The results of these analyses should be useful in instituting forest restoration programs that are crucial for the forests. Both the soil and vegetation studied were sampled from 17 subplots in the natural forest fragments of ngangao （120 ha）, Chawia （86 ha） and Mbololo （185 ha）. The soil variables measured were： pH, texture, soil nutrients of C, n, Ca, P, K, Mg and na. In total 36 native tree species from 13 families were identified from the three forest fragments. Ordination results show that axis 1 accounted for 35% and axis 2 for 25% of the total variation in species composition, indicating that the structure of vegetation is related to two major environmental gradients. The correlation analyses of species and soil properties showed that na and clay particles were the most important determinants of species distribution; pH and soil variables such as C, n, Ca and P also played minor roles. Unexpectedly, some species （e.g. Psychotria petitii） showed positive relationships with na attributed to possible substitution for K. Relationships with P were both positive （e.g. Craibia zimmermannii） and negative （e.g. Albizia gummifera） with some species, attributable to pH levels. An AnOVA for soil variables showed that there were differences in the Ca content in Mbololo （due to the parent material） and P in ngangao where a special relationship was observed between some of the species. The presence of gaps accounted for the distribution of seedlings but not for the saplings, whose distribution responded more to factors similar to those to which mature trees respond. Soil-species relationships

关键词： Eastern Arc Mountains forests principal component analysis soil variables native woody species

Effects of exercise and dietary interventions on serum metabolites in men with insomnia symptoms:A 6-month randomized controlled trial

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Sports Medicine and Health Science 2020年第2期2卷 95-101页

作者： Xiaobo Zhang Xiuqiang Wang Shenglong Le Xiaowei Ojanen Xiao Tan.petri Wiklund Sulin Cheng School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghaiChina Key Laboratory of Systems Biomedicine Ministry of Education and Exercise Translational Medicine CenterShanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghaiChina Exercise Healthand Technology CenterDepartment of Physical EducationShanghai Jiao Tong UniversityShanghaiChina Faculty of Sport and Health Sciences University of JyvaskylaJyvaskylaFinland Department of neuroscience Uppsala UniversityUppsalaSweden

Accumulating evidence show that exercise and diet interventions are associated with improved sleep *** investigating the effects of exercise and dieting on circulating metabolomics in people with sleep disorders,particularly insomnia,are *** 6-month randomized study aimed to assess the effects of exercise and dietary interventions on serum metabolites in men with insomnia ***-two Finnish men(age:51.6±10.1 years)with chronic insomnia symptoms who were assigned to different intervention groups completed this study(exercise,n=24;diet,n=27;and control,n=21).The Shapiro-Wilk W-test,Levene test,Spearman correlation analysis,and analysis of variance were used for data *** found that exercise and diet intervention were associated with improved sleep quality and with a number of metabolites across different biochemical *** we could not show causality,our findings provide new insight into the biological mechanisms underlying the health effects of physical activity,diet,and sleep *** investigation is needed to better understand the link among lifestyle,sleep quality,and metabolic health.

关键词： Diet Exercise Insomnia Metabolomics

The effect of ensiled paulownia leaves in a high-forage diet on ruminal fermentation,methane production,fatty acid composition,and milk production performance of dairy cows

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Journal of Animal Science and Biotechnology 2023年第1期14卷 339-357页

作者： Haihao Huang Dorota Lechniak Malgorzata Szumacher‑Strabel Amlan Kumar Patra Martyna Kozłowska Pawel Kolodziejski Min Gao Sylwester Ślusarczyk Daniel petrič Adam Cieslak Department of Animal nutrition PoznańUniversity of Life SciencesWołyńska 3360‑637 PoznańPoland. Department of Genetics and Animal Breeding PoznańUniversity of Life SciencesWolynska 33Poznań60‑637Poland. Department of Animal nutrition West Bengal University of Animal and Fishery Sciences37 K.B.SaraniKolkataIndia. Institute of Genetics and Animal Biotechnology Polish Academy of SciencesPostępu 36A05‑552MagdalenkaWarsawPoland. Department of Animal Physiology Biochemistry and BiostructurePoznan University of Life SciencesWolynska 35Poznan 60‑637Poland. Department of Pharmaceutical Biology and Botanic Garden of Medicinal Plants Wrocław Medical UniversityWrocław 50‑556Poland. Institute of Animal Physiology Centre of Biosciences of Slovak Academy of SciencesŠoltesovej 4‑6040‑01 KošiceSlovak Republic. Department of Animal nutrition Faculty of Veterinary Medicine and Animal SciencePoznańUniversity of Life SciencesPoznań60‑637Poland.

Background:The use of industrial by-products rich in bioactive compounds as animal feeds can reduce greenhouse gas *** leaves silage(PLS)was supplemented to dairy cows'diet and evaluated in vitro(Exp.1;Rusitec)and in vivo(Exp.2,cannulated lactating dairy cows and Exp.3,non-cannulated lactating dairy cows).The study investigated the PLS effect on ruminal fermentation,microbial populations,methane production and concentration,dry matter intake(DMI),and fatty acid(FA)proportions in ruminal fluid and ***:Several variables of the ruminal fluid were changed in response to the inclusion of *** Exp.1,the p H increased linearly and quadratically,whereas ammonia and total volatile fatty acid(VFA)concentrations increased linearly and cubically.A linear,quadratic,and cubical decrease in methane concentration was observed with increasing dose of the ***.2 revealed an increase in ruminal p H and ammonia concentrations,but no changes in total VFA *** of PLS increased ruminal propionate(at 3 h and 6 h after feeding),isovalerate,and valerate *** of PLS also affected several populations of the analyzed *** abundances of protozoa and bacteria were increased,whereas the abundance of archaea were decreased by *** production decreased by 11%and 14%in PLS-fed cows compared to the control in Exp.2 and 3,***.3 revealed a reduction in the milk protein and lactose yield in the PLS-fed cows,but no effect on DMI and energy corrected milk ***,the PLS diet affected the ruminal biohydrogenation process with an increased proportions of C18:3 cis-9 cis-12 cis-15,conjugated linoleic acid,C18:1 trans-11 FA,polyunsaturated fatty acids(PUFA),and reduced n6/n3 ratio and saturated fatty acids(SFA)proportion in *** relative transcript abundances of the 5 of 6 analyzed genes regulating FA metabolism ***:The dietary PLS replacing the alfalfa silage at 60 g/kg diet can red

关键词： Dairy cow Fatty acid composition in milk Methane emission Paulownia leaves

The Effects of Mustard Protein Concentrate on nutrient Digestibility and Performance of Broiler Chickens

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Journal of Animal Science and Biotechnology 2010年第2期1卷 85-92页

作者： P.A.Thacker D.petri Department of Animal and Poultry Science University of Saskatchewan51 Campus DriveSaskatoonSaskatchewanCanadaS7N 5A8

This experiment was conducted to de- termine the effects of feeding mustard protein concen- trate on nutrient digestibility and the performance of broiler chickens. A total of 180, day-old, male broiler chickens, weighing an average of 52.8±0.6 g, were randomly assigned to one of six dietary treatments in a randomized block design. The control diet was based on wheat and soybean meal and contained 15% cano- la meal. The experimental diets contained 3 %, 6%, 9% ,12% or 15% mustard protein concentrate added at the expense of canola meal. The digestibility of crude protein and energy declined linearly （ P 〈 0.01 ） with increasing levels of mustard protein concentrate. In addition, weight gain and feed intake were linearly （P 〈 0.01 ） reduced as the level of mustard protein concentrate in the diet increased. Feed conversion wasalso negatively affected （ P 〈 O. O1 ） by mustard pro- tein concentrate while mortality did not differ among treatments. The results of the present experiment pro- vide a strong indication that there is a factor or factors present in mustard protein concentrate which negative- ly affects broiler performance. The process through which the protein in mustard seed is concentrated from mustard meal may concentrate some of the anti-nutri- tional factors found in mustard. Previous research has reported an increase in the concentration of phenolic compounds in protein isolates from mustard and this may be the cause of the reduction in performance as the level of mustard protein concentrate in the diet in- creased. Further research should be conducted to test this hypothesis.

关键词： digestibility mustard protein concentrate performance phenolics poultry

Early graft dysfunction following adult-to-adult livingrelated liver transplantation:Predictive factors and outcomes

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World Journal of Gastroenterology 2009年第36期15卷 4556-4560页

作者： Salvatore Gruttadauria Fabrizio di Francesco Giovanni Battista Vizzini Angelo Luca Marco Spada Davide Cintorino Sergio Li petri Giada Pietrosi Duilio Pagano Bruno Gridelli Department of Surgery University of PittsburghCoordinator Abdominal Adult Transplant.ISMETT (Mediterranean Institute for Transplant and Advanced Specialized TherapiesUniversity of Pittsburgh Medical Center in Italy)Via E. Tricomi N.190127 PalermoItaly Thomas Starzl Transplantation Institute University of Pittsburgh Medical CenterPittsburgh15213 PAUnited States

AIM:To describe a condition that we define as early graft dysfunction(EGD)which can be identified preoperatively. METHODS:Small-for-size graft dysfunction following living-related liver transplantation(LRLT)is characterized by EGD when the graft-to-recipient body weight ratio(GRBWR)is below 0.8%.However, patients transplanted with GRBWR above 0.8%can develop dysfunction of the *** 73 recipients of LRLT(GRBWR>0.8%),we identified 10 patients who developed *** main measures of outcomes analyzed were overall mortality,number of re-transplants and length of stay in days(LOS).Furthermore we analyzed other clinical pre-transplant variables,intraoperative parameters and post transplant ***:A trend in favor of the non-EGD group(3-mo actuarial survival 98%vs 88%,P=0.09;3-mo graft mortality 4.7%vs 20%,P=0.07)was observed as well as shorter LOS(13 d vs 41.5 d;P=0.001)and smaller requirement of peri-operative Units of Plasma (4 vs 14;P=0.036).Univariate analysis of pre- transplant variables identified platelet count,serum bilirubin,InR and Meld-na score as predictors of EGD. In the multivariate analysis transplant Meld-na score (P=0.025,OR:1.175)and pretransplant platelet count(P=0.043,OR:0.956)were independently associated with EGD. COnCLUSIOn:EGD can be identified preoperatively and is associated with increased morbidity after LRLT. A prompt recognition of EGD can trigger a timely treatment.

关键词： Small-for-size graft dysfunction Livingrelated liver transplantation Graft-to-recipient bodyweight ratio Partial liver transplantation Allograftdysfunction

颗粒物对紫外线灭活二级出水中粪大肠菌的影响

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环境科学 2009年第4期30卷 1095-1098页

作者：孙文俊刘文君 Brian.petri Bill Cairns 清华大学环境科学与工程系北京100084 Trojan Technology London N5VT4U7Canada

用低压紫外线照射具有相同颗粒物粒径分布的一系列水样,把实验结果带入二重动力学模型进行计算,评价自然状态下颗粒物对粪大肠菌的保护作用.结果表明,二级出水中的大部分粪大肠菌都与颗粒物交连在一起;在颗粒物***-1时,这种影响不明显.... 详细信息

用低压紫外线照射具有相同颗粒物粒径分布的一系列水样,把实验结果带入二重动力学模型进行计算,评价自然状态下颗粒物对粪大肠菌的保护作用.结果表明,二级出水中的大部分粪大肠菌都与颗粒物交连在一起;在颗粒物***-1时,这种影响不明显.从二重动力学模型的计算结果来看,对于不同颗粒物浓度的水样,难灭活的微生物所占的比重很小且比较稳定,大多数与颗粒物结合的粪大肠菌都较易被紫外线灭活.

关键词：紫外线颗粒物粪大肠菌二重动力学