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Anemia and insomnia: a cross-sectional study and meta-analysis

Chinese Medical Journal 2021年第6期134卷 675-681页

作者： Samantha n.neumann Jun-Juan Li Xiao-Dong Yuan Shuo-Hua Chen Chao-Ran Ma Laura E.Murray-Kolb Yun Shen Shou-Ling Wu Xiang Gao Eberly College of Science The Pennsylvania State UniversityUniversity ParkPAUnited States West Virginia School of Osteopathic Medicine LewisburgVWUnited States Department of nephrology Kailuan General HospitalTangshanHebei 063000China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Department of nutritional Sciences The Pennsylvania State UniversityUniversity ParkPAUnited States Department ot neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China

Background: Several recent genome-wide association studies suggested insomnia and anemia may share some common genetic components. We thus examined whether adults with anemia had higher odds of having insomnia relative to those without anemia in a cross-sectional study and a ***: Included in this cross-sectional study were 12,614 Chinese adults who participated in an ongoing cohort, the Kailuan Study. Anemia was defined as hemoglobin levels below 12.0 g/dL in women and 13.0 g/dL in men. Insomnia was assessed using the Chinese version of the Athens Insomnia Scale (AIS). A total AIS score ≥6 was considered insomnia. The association between anemia and insomnia was assessed using a logistic regression model, adjusting for potential confounders such as age, sex, chronic disease status, and plasma C-reactive protein concentrations. A meta-analysis was conducted using the fixed effects model to pool results from our study and three previously published cross-sectional studies on this topic in adult ***: Individuals with anemia had greater odds of having insomnia (adjusted odds ratio [OR]: 1.32;95% confidence interval [CI]: 1.03-1.70) compared with individuals without anemia. A significant association persisted after we excluded individuals with chronic inflammation, as suggested by C-reactive protein levels >1 mg/L (adjusted OR: 1.68;95% CI: 1.22-2.32). The meta-analysis results, including 22,134 participants, also identified a positive association between anemia and insomnia (pooled OR: 1.39;95% CI: 1.22-1.57).Conclusions: The presence of anemia was significantly associated with a higher likelihood of having insomnia in adults. Due to the nature of the cross-sectional study design, results should be interpreted with caution.

关键词： Anemia Insomnia C-reactive protein Inflammation Cohort

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Reflection of intense laser light from microstructured targets as a potential diagnostic of laser focus and plasma temperature

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High Power Laser Science and Engineering 2019年第1期7卷 10-16页

作者： J.Jarrett M.King R.J.Gray n.neumann L.Dhl C.D.Baird T.Ebert M.Hesse A.Tebartz D.R.Rusby n.C.Woolsey D.neely M.Roth P.McKenna Department of Physics SUPA University of Strathclyde Institut f¨ur Kernphysik Technische Universit?t Darmstadt York Plasma Institute University of York STFC-Rutherford Appleton Laboratory Institut fur Kernphysik Technische Universit?t Darmstadt

The spatial-intensity profile of light reflected during the interaction of an intense laser pulse with a microstructured target is investigated experimentally and the potential to apply this as a diagnostic of the interaction physics is explored numerically. Diffraction and speckle patterns are measured in the specularly reflected light in the cases of targets with regular groove and needle-like structures, respectively, highlighting the potential to use this as a diagnostic of the evolving plasma surface. It is shown, via ray-tracing and numerical modelling, that for a laser focal spot diameter smaller than the periodicity of the target structure, the reflected light patterns can potentially be used to diagnose the degree of plasma expansion, and by extension the local plasma temperature, at the focus of the intense laser light. The reflected patterns could also be used to diagnose the size of the laser focal spot during a high-intensity interaction when using a regular structure with known spacing.

关键词： high power laser laser-solid interactions plasma temperature diagnosis

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日粮中添加蝇蛆粉对尼罗罗非鱼鱼苗生长性能、血浆葡萄糖和皮质醇浓度及血液特性的影响

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饲料与畜牧（新饲料） 2008年第9期 57-57页

作者：霍艳军 J.O.Ogunji W.Kloas M.Wirth n.neumann C.Pietsch

通过56d的饲养试验研究日粮中添加蝇蛆粉对尼罗罗非鱼鱼苗生长性能、血浆葡萄糖、皮质醇浓度及血液特性的影响。配制蛋白含量为36％、总能为（DM为基础）20kJ／g的日粮共7种，用蝇蛆粉代替鱼粉。每个试验池饲养15条鱼苗（平均初体重2．0... 详细信息

通过56d的饲养试验研究日粮中添加蝇蛆粉对尼罗罗非鱼鱼苗生长性能、血浆葡萄糖、皮质醇浓度及血液特性的影响。配制蛋白含量为36％、总能为（DM为基础）20kJ／g的日粮共7种，用蝇蛆粉代替鱼粉。每个试验池饲养15条鱼苗（平均初体重2．0±0．1g），饲喂量为鱼体重5％的3倍，每天饲喂两次。结果表明鱼苗的生长和饲料转化率较高，但各处理组之间差异不显著。

关键词：尼罗罗非鱼生长性能蝇蛆粉醇浓度葡萄糖鱼苗日粮特性

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Polarity,intramolecular charge transfer,and hydrogen bond comediated solvent effects on the optical properties of graphene quantum dots

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nano Research 2023年第1期16卷 45-52页

作者： Yalei Hu Christof neumann Lena Scholtz Andrey Turchanin Ute Resch-Genger Siegfried Eigler Institute of Chemistry and Biochemistry Freie Universität BerlinTakustraße 314195 BerlinGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich Schiller University JenaLessingstraße 1007743 JenaGermany Federal Institute for Materials Research and Testing(BAM) Division BiophotonicsRichard Willstätter Straße 1112489 BerlinGermany

Graphene quantum dots(GQDs)have attracted increasing attention due to their favorable optical properties and have been widely used,e.g.,in the biomedical ***,the properties related to the chemical structure of GQDs,resulting in solventdependent optical properties,still remain ***,we present the synthesis of long-wavelength emitting GQDs with a size of about 3.6 nm via a solvothermal method using oxo-functionalized graphene(oxo-G)and p-phenylenediamine as precursors and their structural and surface chemical analysis by transmission electron and atomic force microscopy(TEM;AFM)as well as Fourier-transform infrared,Raman,and X-ray photoelectron spectroscopy(FTIR;Raman;XPS).Subsequently,the influence of solvent polarity and proticity on the optical properties of the as-prepared GQDs bearing–OH,–nH_(2),–COOH and pyridine surface groups was *** on the results of the absorption and fluorescence(FL)studies,a possible luminescence mechanism is *** observed solvent-induced changes in the spectral position of the FL maximum,FL quantum yield,and FL decay kinetics in protic and aprotic solvents of low and high polarity are ascribed to a combination of polarity effects,intramolecular charge transfer(ICT)processes,and hydrogen ***,the potential of GQDs for the optical sensing of trace amount of water was *** results of our systematic spectroscopic study will promote the rational design of GQDs and shed more light on the FL mechanism of carbon-based fluorescent nanomaterials.

关键词： graphene quantum dots(GQDs) polarity intramolecular charge transfer(ICT) hydrogen bond optical properties

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Multiple mating by both sexes in an invasive insect species,Aethina tumida(Coleoptera:nitidulidae)

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Insect Science 2023年第2期30卷 517-529页

作者： Anna Papach Alexis Beaurepaire Orlando Yanez Meret Huwiler Geoffrey R.Williams Peter neumann Institute of Bee Health Vetsuisse FacultyUniversity of BernBernSwitzerland Agroscope Swiss Bee Research CentreBernSwitzerland Department of Entomology&Plant Pathology Auburn UniversityAuburnAlabamaUSA

Multiple mating by both sexes is common among sexually reproducing *** hive beetles(SHB),Aethina tumida,are parasites of bee nests endemic to sub-Saharan Africa and have become a widespread invasive *** the considerable economic damages they can cause,their basic biology remains poorly *** we show that male and female small hive beetles can mate multiple times,suggesting that costs for mating are low in this *** an invasive *** population in the United States,a combination of laboratory experiments for males and paternity analysis with eight polymorphic DnA microsatellite markers for field-caught females were used to estimate the number of mating by both *** data show that females and males can mate multiple times—females mated with up to eight males,whereas males mated with at least seven *** results also showed that *** displayed a skewed paternity,although this was not consistent among the tested ***,first or last male advantage seem to be unlikely in *** observations that individuals of both sexes of *** can mate multiple times opens new research avenues for examining drivers of multiple mating and determining the role it may play in promoting biological invasions.

关键词： evolution of sex invasive species multiple partners polygynandry reproductive biology

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Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 506-511页

作者： Tom Florian Ulmer Anne Weiland Georg Lurje Christian Klink Anne Andert Hamid Alizai Christoph Heidenhain Ulf neumann Department of General Visceral and Transplantation Surgery RWTH Aachen University Hospital Aachen Germany Department of Urology Helios Hospital Berlin-Buch Germany

BACKGROUnD: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and ***: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically ***: neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of live

关键词： liver regeneration liver failure terlipressin splenectomy hepatectomy

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Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss

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Bone Research 2021年第4期9卷 549-556页

作者： Martina Rauner Marta Murray Sylvia Thiele Deepika Watts Drorit neumann Yankel Gabet Lorenz C.Hofbauer Ben Wielockx Department of Medicine III&Center for Healthy Aging Technische Universitat DresdenDresdenGermany lnstitute for Clinical Chemistry and Laboratory Medicine Technische Universitat DresdenDresdenGermany Department of Cell and Developmental Biology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Anatomy&Anthropology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

High erythropoietin(Epo)levels are detrimental to bone health in adult *** mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone *** humans,high serum Epo levels are linked to fractures in elderly *** earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still ***,we created mice lacking EpoR in osteoprogenitor cells to specifically address this *** of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female *** was associated with low bone ***(osteoblast number,bone formation rate)and serum(P1nP,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and TRAP serum *** of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and Col1a1 on day 21,whereas the mineralization capacity was ***,the RAnKL70PG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control ***,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO *** data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RAnKI70PG ***,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss.

关键词： progenitor homeostasis doses

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Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 617-623页

作者： Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai Christoph Heidenhain Ulf neumann Maximilian Schmeding Department of General Visceral and Transplant SurgeryUniklinik RWTH Aachen AachenGermany Department of Internal Medicine Uniklinik RWTH Aachen AachenGermany Department of Anaesthesiology Uniklinik RWTH Aachen AachenGermany Department of General and Visceral Surgery Sana Hospital Düsseldorf-Gerresheim Germany

BACKGROUnD:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver ***:ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS n=27), MiS 30%-60%(n=41) and MiS >60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PnF). RESULTS:The incidences of EAD and PnF did not differ significantly between the groups. We observed 5 cases of PnF,one occurred in the MiS nd 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS n the MiS 30%-60% group and 90.9% in the MiS >60% ***:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation.

关键词： liver transplantation liver steatosis microvesicular steatosis early allograft dysfunction

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Improving the Dietary Protein Quality by Amino Acid Fortification with a High Inclusion Level of Micro Algae (Spirulina platensis) or Insect Meal (Hermetia illucens) in Meat Type Chicken Diets

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Open Journal of Animal Sciences 2018年第1期8卷 12-26页

作者： Carmen.neumann Susanne Velten Frank Liebert Department of Animal Sciences Division Animal Nutrition PhysiologyGeorg-August-University of GoettingenGoettingenGermany

The objective of this study was to measure protein quality parameters (PPV, nPU and nPUstd) of chicken diets with complete substitution of soybean meal (SBM) by Spirulina meal (SM) or partly defatted Hermetia meal (HM). n balance experiments were based on the quantitative excreta collection method, divided into starter period (10 - 20 d) and grower period (25 - 35 d). The study utilized 70 all male meat type chicken (Ross 308). Data assessment applied the exponential n utilization model of the “Goettingen approach”. The control diet was based on wheat, corn and SBM. In four experimental diets SBM was completely substituted by SM or HM, but fortified with feed amino acids (AA) both on a basic level of supplementation (Lys and Met added equal to the control diet) and on an extended level (Lys, Met, Thr, Arg, Val, Ile, His added). At a basic level of AA supplementation, complete replacement of SBM by SM or HM in chicken diets depressed dietary protein quality significantly (p 0.05). However, the extended level of AA supplementation improved protein quality parameters of the diets with both of the alternative proteins significantly (p nerally not on par with the control diet. The observed responses were accentuated when the well-known effect of n intake on protein utilization was eliminated through the standardization of n intake by application of the “Goettingen approach”.

关键词： n Balance Growing Chickens n Utilization Model Amino Acids Protein Qual-ity Spirulina platensis Hermetia illucens

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The Graded Inclusion of Algae (Spirulina platensis) or Insect (Hermetia illucens) Meal as a Soybean Meal Substitute in Meat Type Chicken Diets Impacts on Growth, nutrient Deposition and Dietary Protein Quality Depending on the Extent of Amino Acid Supplementation

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Open Journal of Animal Sciences 2018年第2期8卷 163-183页

作者： Carmen.neumann Susanne Velten Frank Liebert Department of Animal Sciences Division Animal Nutrition PhysiologyGeorg-August-University of GoettingenGoettingenGermany

Three consecutive growth experiments were conducted to evaluate growth performance, whole body analyses and protein quality parameters from chicken diets with 50%, 75% and 100% substitution of soybean meal (SBM) by Spirulina meal (SM) or partly defatted Hermetia meal (HM). Each of the experiments was divided into a starter period (1 - 21 d) and a grower period (22 - 34 d). One-day-old male growing chickens (Ross 308) were randomly allotted to 48 floor pens making use of 6 birds/pen (Exp.1) or 7 birds/pen (Exp. 2, 3), and the experiments included a control diet (n = 12) and four experimental diets (n = 9). Experiment 1 examined a 50 % replacement of SBM by the alternative proteins under study, both on a basic and an advanced level of amino acid (AA) fortification to meet the recommended ideal amino acid ratio (IAAR). In experiment 2, 75% (starter diet) and 50% (grower diet) replacement of SBM was investigated. Experiment 3 investigated the effects of complete SBM substitution by SM or HM in starter and grower diets. In the second and third experiment diets with both of the alternative proteins and the control diet were AA supplemented to meet the current IAAR. In a further step, the calculated first limiting AA (LAA) was reduced to 80% of its requirement recommendation to allow for further evaluation of the individual AA efficiency according to the “Goettingen approach”. Different levels (50%, 75%, or 100%) of replacing SBM by HM or SM in chicken diets depressed dietary protein quality (p 0.001) and zoo-technical parameters (p 0.001) with only a basic level of AA supplementation. This effect was much more pronounced in diets with SM. However, with an extended level of dietary AA supplementation zoo-technical parameters (p 0.001), crude protein deposition (p 0.001) and protein quality parameters (p 0.001) were significantly improved. HM diets with an advanced level of AA tended to provide higher dietary protein quality and growth performance as compared to all SBM rep

关键词： Growing Chickens Amino Acids n Utilization Model Growth Performance Body Analyses Alternative Proteins Feed Protein Quality

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