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International Journal of Digital Earth 2008年第4期1卷 347-366页

作者： n.m.saadi E.Aboud H.Saibi K.Watanabe Laboratory of Economic Geology Faculty of EngineeringKyushu University744 MotookaFukuoka 819-0395Japan national Research Institute of Astronomy and Geophysics CairoEgypt Laboratory of Geothermics Faculty of EngineeringKyushu University744 MotookaNishi-kuFukuoka 819-0395Japan

The present work deals with the integration of remote-sensing,surface-geology and gravity-survey data to improve the structural knowledge of the Tarhunah area,northwest *** information and remote-sensing data provided information about the surface structure.A gravity survey was conducted to decipher the subsurface *** results revealed that a basin having a width of 39 to 48 km trends nE.A two-dimensional(2-D)schematic model shows that the basin gradually deepens toward the *** determined from a horizontal gradient,tilt derivative,and Euler deconvolution show a depth range of 2.5 to 7.5 *** integration and interpretation of the results indicate that volcanic activity was related to the tectonic activity of an anticlinal structure called the Jabal Uplift.

关键词： Libya Tarhunah area remote sensing gravity integration

neurocircuit regeneration by extracellular matrix reprogramming

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Effective point kinetic parameters calculation in Tehran research reactor using deterministic and probabilistic methods

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nuclear Science and Techniques 2017年第12期28卷 182-192页

作者： m.Kheradmand saadi A.Abbaspour Department of nuclear Engineering Science and Research Branch Islamic Azad University Department of Electrical Engineering Sharif University of Technology

The exact calculation of point kinetic parameters is very important in nuclear reactor safety assessment, and most sophisticated safety codes such as RELAP5, PARCS,DYn3D, and PARET are using these parameters in their dynamic models. These parameters include effective delayed neutron fractions as well as mean generation *** parameters are adjoint-weighted, and adjoint flux is employed as a weighting function in their *** flux calculation is an easy task for most of deterministic codes, but its evaluation is cumbersome for monte Carlo codes. However, in recent years, some sophisticated techniques have been proposed for monte Carlo-based point kinetic parameters calculation without any need of adjoint flux. The most straightforward scheme is known as the ‘‘prompt method'' and has been used widely in literature. The main objective of this article is dedicated to point kinetic parameters calculation in Tehran research reactor(TRR) using deterministic as well as probabilistic techniques. WImS-D5B and CITATIOn codes have been used in deterministic calculation of forward and adjoint fluxes in the TRR core. On the other hand, the mCnP monte Carlo code has been employed in the ‘‘prompt method''scheme for effective delayed neutron fraction *** results have been cross-checked with probabilistic ones and validated with SAR and experimental data. In comparison with experimental results, the relativedifferences of deterministic as well as probabilistic methods are 7.6 and 3.2%, respectively. These quantities are10.7 and 6.4%, respectively, in comparison with SAR report.

关键词： Point kinetic parameters Tehran research reactor Adjoint flux Prompt method Deterministic method Probabilistic method

Influence of Auxiliary Equation on Wave Functions for Time-Dependent Pauli Equation in Presence of Aharonov-Bohm Effect

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Communications in Theoretical Physics 2009年第5期51卷 803-810页

作者： m.maamache C.Lahoulou Y.saadi Laboratoire

Invariant operator method for discrete or continuous spectrum eigenvalue and unitary transformation approach are employed to study the two-dimensional time-dependent Pauli equation in presence of the Aharonov-Bohm effect （AB） and external scalar potential. For the spin particles the problem with the magnetic field is that it introduces a singularity into wave equation at the origin. A physical motivation is to replace the zero radius flux tube by one of radius R, with the additional condition that the magnetic field be confined to the surface of the tube, and then taking the limit R → 0 at the end of the computations. We point that the invariant operator must contain the step function θ（r - R）. Consequently, the problem becomes more complicated. In order to avoid this dimculty, we replace the radius R by ρ（t）R, where ρ（t） is a positive time-dependent function. Then at the end of calculations we take the limit R →0. The qualitative properties for the invariant operator spectrum are described separately for the different values of the parameter C appearing in the nonlinear auxiliary equation satisfied by p（t）, i.e., C 〉 0, C = 0, and C 〈0. Following the C＇s values the spectrum of quantum states is discrete （C 〉 0） or continuous （C ≤ 0）.

关键词： time-dependent systems invariant theory Aharonov-Bohm effect Pauli equation

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Lipschitz Continuity and Explicit Form of Solution in a Class of Free Boundary Problem with neumann Boundary Condition

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Journal of Partial Differential Equations 2023年第4期36卷 331-348页

作者： saadi Abderachid Department of mathematics University of MsilaAlgeria.Laboratory of Nonlinear Partial Differential Equations and History of MathematicsENSKoubaAlgeria

We consider a class of free boundary problems with neumann boundary *** would like to give certain results with regularity of solutions(mainly the local interior and boundary Lipschitz continuity).We will also show an... 详细信息

关键词： Lipschitz continuity free boundary neumann boundary condition.

Generalized Coherent States of a Particle in a Time-Dependent Linear Potential

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Chinese Physics Letters 2009年第7期26卷 36-39页

作者： L. Krache m. maamache Y. saadi A. Beniaiche Lab PQSD Faculté des Sciences Université Ferhat Abbas de Sétif Sétif 19000 Algeria Lab SPOnL Faculté des Sciences de l'Ingénieur Université Ferhat Abbas de Sétif Sétif 19000 Algeria

We derive, with an invariant operator method and unitary transformation approach, that the Schr6dinger equation with a time-dependent linear potential possesses an infinite string of shape-preseving wave-packet states 1φ,λ （t） having classical motion. The qualitative properties of the invariant eigenvalue spectrum （discrete or continuous） are described separately for the different values of the frequency ω of a harmonic oscillator. It is also shown that, for a discrete eigenvalue spectrum, the states 1φ,λ （t） could be obtained from the coherent state 1φ,λ （t）.

关键词： mathematical physics Quantum information and quantum mechanics

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Application of SALTmED and HYDRUS-1D models for simulations of soil water content and soil salinity in controlled groundwater depth

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Journal of Arid Land 2020年第3期12卷 447-461页

作者： masoud nOSHADI Saghar FAHAnDEJ-saadi Ali R SEPASKHAH Department of Irrigation Shiraz UniversityShiraz 71441-65186Iran

Salinization is a gradual process that should be *** is a suitable alternative technique that saves time and cost for the field *** the performance of the models should be evaluated using the measured ***,the aim of this study was to evaluate and compare the SALTmED and HYDRUS-1D models using the measured soil water content,soil salinity and wheat yield data under different levels of saline irrigation water and groundwater *** field experiment was conducted in 2013 and in this research three controlled groundwater depths,i.e.,60(CD60),80(CD80)and 100(CD100)cm and two salinity levels of irrigation water,i.e.,4(EC4)and 8(EC8)dS/m were used in a complete randomized design with three *** water content and soil salinity were measured in soil profile and compared with the predicted values by the SALTmED and HYDRUS-1D *** of the SALTmED and HYDRUS-1D models were carried out using the measured data under EC4-CD100 treatment and the data of the other treatments were used for *** statistical parameters including normalized root mean square error(nRmSE)and degree of agreement(d)showed that the values for predicting soil water content and soil salinity were more accurate in the HYDRUS-1D model than in the SALTmED *** nRmSE and d values of the HYDRUS-1D model were 9.6%and 0.64 for the predicted soil water content and 6.2%and 0.98 for the predicted soil salinity,*** indices of the SALTmED model were 10.6%and 0.81 for the predicted soil water content and 11.0%and 0.97 for the predicted soil salinity,*** to the nRmSE and d values for the predicted wheat yield(9.8%and 0.91,respectively)and dry matter(2.9%and 0.99,respectively),we concluded that the SALTmED model predicted the wheat yield and dry matter accurately.

关键词： wheat yield dry matter simulation normalized root mean square error