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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： Hasan m Isa Fatema A Alkharsi Jawad K Khamis Sawsan A Hasan Zainab A naser Zainab n mohamed Afaf m mohamed Shaikha A Altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BAcKGROUnD Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and medical Departments of Salmaniya medical complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis c

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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks maría F mascardi Adrián Gadano Sebastián marciano Instituto de medicina Traslacional e Ingeniería Biomédica-consejo nacional de Investigaciones científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina consejo nacional de Investigaciones científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(mASLD)risk *** ability to identify patients with mASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of mASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in mASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving mASLD biomarker research.

关键词： metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan n Vinayakumar Ravi V Sowmya center for computational Engineering and networking(cEn) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(cAn)is used as a standard communication method because of its efficient and reliable ***,cAn is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy c-means(Fcm).The proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the mL35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WnS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDcup with accuracy 60.63%,UnSW_nB15 with accuracy 73.62%and Information Security center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor cAn traffic in vehicles and proactively alert during attacks.

关键词： controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy c-means

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Long-term monitoring reveals the effect of precipitation and silviculture on nothofagus regeneration in northern Patagonia mixed forests

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Ecological Processes 2024年第02期13卷 103-117页

作者： Georgina Sola camila mateo Alejandro Dezzotti Paula marchelli Hernán Attis Beltrán Renato Sbrancia Luis chauchard marcelo González Pe?alba martín Lara Verónica El mujtar consejo nacional de Investigaciones científicas y Técnicas (cOnIcET ) Asentamiento Universitario San martín de los Andes (AUSmA-Unco) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB) Instituto Nacional de Tecnología Agropecuaria (INTA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Departamento de conservación y manejo Parque Nacional Lanín- Administración de Parques Nacionales (PNL-APN)

Background Tree regeneration is a key component of resilience because it promotes post-disturbance recovery of forests. northwestern Patagonia from Argentina is occupied by nothofagus alpina（na）, n. obliqua（no）, and n. dombeyi（nd） forests that grow along an intense precipitation gradient, managed throughout shelterwood silvicultural system by technicians of the Lanin natural Reserve. The objective of this study was to evaluate the influence of seeding cuttings over the dynamics of nothofagus mixed forests across landscape（precipitation gradient） based mainly on the composition and abundance of tree regeneration, permanent sampling plots and generalized linear mixed models. In particular, we analysed:（i） the structure of sexual and asexual regeneration during nd > 20 years after harvest（the dynamics of managed forests）, and（ii） the structure of sexual regeneration in primary and managed forests after > 20 years of harvest（the effect of silviculture）.Results nd was the most abundant species in the regeneration of managed forests during all periods in both sites despite its lower contribution to the adult cohort. During the 10–20 years period after harvest, the humid site exhibited higher regeneration density than the mesic site(120,000 and 6000 ind ha-1, respectively), and it decreased afterwards. The number of established regeneration（> 2 m height） was lower for na in the mesic site and for no in the humid site(0 and 57 ind ha-1, respectively). However, in comparison to no, na showed a higher number of sprouted stumps and sprouts per stump, and a higher sprout height in the mesic site. no exhibited higher sprout mortality in the humid site. Finally, the regeneration of primary forests showed lower density and height, and a more balanced composition than that of managed *** The silvicultural effects on the mixed forest regeneration dynamics was strongly influenced by the condition of sites. Therefore, management prescriptions should be adj

关键词： nothofagus alpina nothofagus obliqua nothofagus dombeyi Basal sprouting Shelterwood silvicultural system Ecological resilience

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Polyelectrolyte complexes between Hyperbranched and Linear Polysaccharides: Fucoidan/chitosan

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chinese Journal of Polymer Science 2024年第4期42卷 468-479页

作者： Ekaterina R.Gasilova Daria n.Poshina Aleksandra O.Sitnikova natalia n.Saprykina Yury A.Skorik Institute of macromolecular compounds of the Russian Academy of Sciences Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PEcs)of hyperbranched(HB)and linear polysaccharides are promising as more effective encapsulation agents compared to PEcs formed by linear *** investigated the PEcs between the HB anionic polysaccharide fucoidan(FUc)and the cationic linear polysaccharide chitosan(cS).The FUc had a molecular weight(mW)of 30×*** PEcs were prepared in three solvents(water,0.01 and 0.1 mol/L acetic acid)with cS of mW of 15,110 and 170 kDa,and deacetylation degrees(DDA)of 70%and 97%.The structures of the PEcs and the initial FUc were investigated by multi-angle static and dynamic light *** the FUc contained 18 wt%of—OSO3 groups and 5 wt%of uronic acid units,it was a“strong-weak”copolyanion,so the HB macromolecules of the FUc formed nanogel particles in 0.1 mol/L AcOH and open branched structures in water,as confirmed by the Kratky *** mixing the solutions of original components,the PEc structures underwent an equilibration period,the duration of which increased with the mW of *** the charge stoichiometry was approached,the PEcs shrank;the fractal dimension approached unity,indicating the side-by-side packing of adjacent FUc branches with the help of *** aggregation in the vicinity of the charge compensation was hardly observed,as it occurred in a very narrow *** PEc content at theζ-potential inversion depended on solvents’pH and the DDA of *** the extreme case of core-shell PEcs in 0.1 mol/L AcOH,obtained by mixing FUc nanogels with the solutions of high mW cS of 97%DDA,the protruding tails of cS formed a positively charged shell in the whole range of FUc content(10 wt%ccanning electron microscopy and atomic force microscopy images of dried samples were discussed in relation to the light scattering results.

关键词： Polyelectrolyte complexes chitosan Hyperbranched fucoidan Light scattering

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magnetic resonance imaging-guided focused ultrasound thalamotomy launch with remote telemedicine international proctorship

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chronic Diseases and Translational medicine 2024年第1期10卷 40-50页

作者： Igor V.Buzaev Rezida m.Galimova Dinara I.nabiullina Sergey n.Illarioshkin naufal Sh.Zagidullin Shamil m.Safin Department of Surgery Bashkir State Medical UniversityUfaRussia Intelligent neurosurgery clinic Ltd.International Medical Center V.S.Buzaev memorialUfaRussia Directorate Research Center of NeurologyVolokolamskoye ShosseMoscowRussia

Background: cOVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the *** share our first experience of magnetic resonance imaging(mRI)-guided focused ultrasound(mRgFUS)treatment with an international remote online proctorship,and develop and evaluate the methodology of remote mRgFUS ***: This single-center,nonrandomized controlled prospective study included 94 patients:27 with essential tremor(ET)and 67 with tremor-dominant Parkinson's disease(PD).The coming of proctors was impossible,so we arranged for the remote participation of proctors from the United Kingdom,Spain,and Israel.A total of 38 patients(40.4%)received telemedicine-proctored treatment(proctor group)and 56 received their treatment independently(solo group).We used the clinical Rating Scale for Tremor(cRST)for ET patients and the Unified Parkinson's Disease Rating Scale(UPDRS)Part III for PD ***: In patients with ET,success rates were 81.8%(proctor group)and 100%(solo group)(p=0.22).cRST reduction on the treated side was 71.43%[65.83%;80.56%](proctor group)versus 60.87%[53.99;79.58](solo group)(p=0.19).none of the patients showed worsening of tremors within 1 *** patients with PD,the success rates were 92.6%(proctor group)and 100%(solo group)(p=0.08).The UPDRS Part III improvement was 30.1%(proctor group)versus 39.9%(solo group)(p=0.003).The 1-year recurrence rate was 40%(proctor group)and 17.5%(solo group)(p=0.04).no complications were observed at 6 ***: We developed a feasible and safe methodology for telemedicine remote online-proctored mRgFUS *** significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate,effect,and long-term results;however,UPDRS Part III improvement was better in the PD solo *** study demonstrated that the mRgFUS international proctorship can be performed successfully remotely.

关键词： essential tremor mRgFUS Parkinson's disease proctor telemedicine

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Effects of synthesis parameters on the performance of crosslinked co-polymers with clays for conformance control

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Petroleum Research 2024年第1期9卷 98-108页

作者： A.A.Roslan n.A.A.Aziz n.F.A.Deraman I.Dzulkarnain Petroleum Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia chemical Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

conformance control or water shut-off is a technique used to improve oil *** conformance control,polymers block high permeability water areas and redistribute water drive toward unswept oil *** this study,co-polymers(denoted ATP-PGV/Am-co-AmPS)were synthesized using acrylamide(Am)and 2-acrylamide-2-methylpropane sulfonic acid(AmPS)as the monomers,polyethylene glycol(PEG)-200 and methylenebisacrylamide(mBA)as the crosslinkers,attapulgite(ATP)and bentonite(PGV)as the clay types,and ammonium persulfate(APS)as the initiator,in addition to paraffin oil and *** were synthesized using inverse emulsion polymerization with different concentrations of monomers,crosslinkers,and clays,and they were characterized using Fourier-transform infrared(FTIR)spectroscopy and scanning electron microscopy(SEm)with energy dispersive X-ray spectroscopy(EDX).FTIR spectra of the samples confirmed the existence of sulfonate and hydroxyl groups,which are important for polymer ***-EDX images indicated that the morphology and elemental composition were different before and after swelling,confirming the occurrence of ***,samples were placed in sodium chloride solution(20,000 ppm)for 7 days to evaluate swelling at both room temperature and 90°*** analysis(TGA)and differential scanning calorimetry(DSc)were used to determine the thermal characteristics of the ***,rheological measurements were used to assess the deformation and rheological behavior of the *** results showed that after 1 day,good swelling without loss of mechanical strength was achieved with the composite synthesized using 10%Am,15%AmPS,6%PGV,and 10%ATP.

关键词： Polymer clay Water shut-off conformance Swelling

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conducting Polymer-Based e-Refinery for Sustainable Hydrogen Peroxide Production

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Energy & Environmental materials 2024年第2期7卷 334-342页

作者： Zhixing Wu Penghui Ding Viktor Gueskine Robert Boyd Eric Daniel G■owacki magnus Odén Xaνier crispin magnus Berggren Emma m.Björk mikhail Vagin nanostructured materials Department of PhysicsChemistry and Biology(IFM)Linköping UniversitySE 58183LinköpingSweden Laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversitySE 60174NorrköpingSweden

Electrocatalysis enables the industrial transition to sustainable production of chemicals using abundant precursors and electricity from renewable ***-centralized production of hydrogen peroxide(H_(2)O_(2))from water and oxygen of air is highly desirable for daily life and *** report an effective electrochemical refinery(e-refinery)for H_(2)O_(2)by means of electrocatalysis-controlled comproportionation reaction(2_(H)O+o→2HO),feeding pure water and oxygen *** nickel(Ⅱ)oxide(niO)was used as electrocatalyst for oxygen evolution reaction(OER),producing oxygen at the *** polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)drove the oxygen reduction reaction(ORR),forming H_(2)O_(2)on the *** reactions were evaluated in both half-cell and device *** performance of the H_(2)O_(2)e-refinery,assembled on anion-exchange solid electrolyte and fed with pure water,was limited by the unbalanced ionic *** of the operation conditions allowed a conversion efficiency of 80%.

关键词： conducting polymer hydrogen peroxide nickel(Ⅱ)oxide oxygen evolution reaction oxygen reduction reaction

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Psychological consequences of a diagnosis of infertility in men:a systematic analysis

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Asian Journal of Andrology 2024年第1期26卷 10-19页

作者： Sarah n Biggs Jane Halliday Karin Hammarberg Reproductive Epidemiology Murdoch Children's Research InstituteMelbourne 3052Australia Department of Paediatrics University of MelbourneMelbourne 3052Australia Public Health and Preventative medicine Monash UniversityMelbourne 3004Australia Victorian Assisted Reproductive Treatment Authority Melbourne 3000Australia

Almost half of infertility cases involve male *** the consequence of a diagnosis of male infertility,as a sole or partial contributor to the couples'infertility,to the mental health of men is required to ensure clinical care meets their psychological *** aim of this systematic analysis was to synthesize the evidence regarding whether men diagnosed with male factor infertility experience greater psychological distress than(1)men described as fertile and(2)men in couples with other infertility *** databases were searched using a combination of medical Subject Headings(meSH)headings and keywords relating to male infertility and psychological *** search yielded 1016 unique publications,of which 23 were included:8 case-control,14 prospective cohort,and 1 data linkage *** aspects of psychological distress were identified depression,anxiety,self-esteem,quality of life,fertility-related stress,general psychological stress or well-being,and psychiatric ***-control studies reported that men with male factor infertility have more symptoms of depression,anxiety and general psychological distress,worse quality of some aspects of life,and lower self-esteem than *** men with male factor infertility were compared to men in couples with other causes of infertility,there were few differences in the assessed aspects of psychological *** methodological limitations within the studies,this systematic analysis suggests that the experience of infertility,irrespective of its cause,negatively affects men's mental health and demonstrates the need for assisted reproduction technology(ART)providers to consider men undergoing assisted reproduction as individuals with their own unique support needs.

关键词： anxiety depression infertility male mental health quality of life

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Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

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World Journal of clinical cases 2024年第8期12卷 1517-1522页

作者： Işın Kaya medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BAcKGROUnD nonallelic homologous recombination(nAHR)of segmental duplications or low copy repeats(LcRs)result in DnA gain/loss and play an important role in the origin of genomic *** SUmmARY A 3-year-old boy was referred for genetic *** genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal *** Genomic imbalances caused by nAHR in LcRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements case report

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