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肾素-血管紧张素系统或钙通道阻断剂对高血压患者心率变异性的昼夜变化、血压和循环儿茶酚胺的影响

世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 61-62页

作者： Karas M. Lacourcière Y. leblanc A.-R. J. De Champlain 代喆 IRCM 110 av. des Pins ouest Montréal Que. H2W 1R7 Canada Dr.

Objective: To determine the effects of 8 weeks of therapy with amlodipine, ramipril or telmisartan on the autonomic system over 24 h in hypertensives. Methods: After a placebo run-in, 57 patients were included in a prospective randomized open-label design protocol for therapy with amlodipine(5 mg for 4 weeks followed by 10 mg for 4 weeks, n=22), or ramipril(2.5 mg for 1 week, 5.0 mg for 3 weeks and 10 mg for 4 weeks, n=17) or telmisartan(80 mg for 8 weeks, n=18). Autonomic functions were assessed by norepinephrine(nE) and epinephrine(E), as well as by the spectral analysis of heart rate variability(HRV). Results: The 24-h ambulatory blood pressure, plasma nE and HRV demonstrated the characteristic day-night circadian rhythm in hypertensives. Higher values for SBP and DBP and for nE levels, as well as for spectral analysis components-low frequency band(LF) and low frequency/high frequency(LF/HF) ratio-were found during the day, whereas the HF was higher during the night. In patients treated with amlodipine, the HF decreased significantly during the night, while the LF and the LF/HF ratio increased during the day in association with the rise in nE. The therapy with telmisartan did increase the HF during the night and the day, while ramipril did not influence all HRV components during the night but significantly increased the HF, and decreased the LF/HF ratio during the day. no changes were observed in plasma nE with telmisartan or ramipril, but a 50%increase in nE levels throughout the 24-h period was found in amlodipine-treated patients. Conclusion: These data suggest a sympathetic activation during the day and a decrease in parasympathetic activity during the night after therapy with amlodipine, correlated with increases in plasma nE. In contrast, the therapy with telmisartan significantly increased parasympathetic activity without changes in nE during the night and day. The therapy with ramipril increased the parasympathetic activity only during the day.

关键词：率变异性钙通道阻断剂昼夜变化替米沙坦雷米普利儿茶酚交感神经活性动态血压昼夜节律自主神经系统

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抑郁症的非药物治疗：系统性综述与证据图

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英国医学杂志中文版 2017年第11期20卷 660-667页

作者： Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang noor Asi Craig n Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie leblanc Evidence-Based Przctiee Center Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester Minnesota USA Knowledge and Evaluation Research Unit Mayo Clinic Rochester Minnesota USA Division of Preventive. Occupational and Aerospace Medicine Mayo Clinic Rochester Minnesota USA Integrated Behavioral Health Departmenl of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA Mayo GraduateSchool Mayo ClinicRochesterMinnesota USA Center for PharmacyInnovation and Outcomes Geislnger Health System Forty Fort PennsylvaniaUSA Department of Emergency Medicine Mayo ClinicRochesterMinnesota USA Mayo Clinic

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，... 详细信息

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT，纳入了约2000名患者，进行了11种治疗，导出17项独立的头对头比较。通过标准化的量表评估，发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而，这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高，导致证据的质量只是低到中等，限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状，在轻度到重度抑郁症患者中，应当合并抗抑郁药物治疗，一同进行。对于非药物治疗的选择，应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。

关键词：抑郁症非药物治疗系统性综述证据图

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Characterization and performance of the Apollon short-focal-area facility following its commissioning at 1 PW level

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Matter and Radiation at Extremes 2021年第6期6卷 12-25页

作者： K.Burdonov A.Fazzini V.Lelasseux J.Albrecht P.Antici Y.Ayoul A.Beluze D.Cavanna T.Ceccotti M.Chabanis A.Chaleil S.n.Chen Z.Chen F.Consoli M.Cuciuc X.Davoine J.P.Delaneau E.d’Humieres J.-L.Dubois C.Evrard E.Filippov A.Freneaux P.Forestier-Colleoni L.Gremillet V.Horny L.Lancia L.Lecherbourg n.Lebas A.leblanc W.Ma L.Martin F.negoita J.-L.Paillard D.Papadopoulos F.Perez S.Pikuz G.Qi F.Quere L.Ranc P.-A.Soderstrom M.Sciscio S.Sun S.Vallieres P.Wang W.Yao F.Mathieu P.Audebert J.Fuchs LULI–CnRS CEASorbonne UniversiteEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Universite Observatoire de ParisUniversite PSLCNRSLERMAF-75005 ParisFrance IAP Russian Academy of Sciences603155 Nizhny NovgorodRussia InRS-EMT 1650Boulevard Lionel-BouletVarennesQuebec J3X 1S2Canada Universite Paris-Saclay CEACNRSLIDYL91191Gif-sur-YvetteFrance Universite Paris-Saclay CEALMCE91680 Bruy`eres-le-ChˆatelFrance “Horia Hulubei”national Institute for Physics and nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania EnEA Fusion and Technologies for Nuclear Safety DepartmentC.R.FrascatiVia E.Fermi 4500044 FrascatiItaly University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance Joint Institute for High Temperatures RAS125412 MoscowRussia Laboratoire d’Optique Appliquee Ecole Polytechnique–ENSTA–CNRS–Institut Polytechnique de ParisPalaiseauFrance State Key Laboratory of nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China Laboratoire Charles Fabry Institut d’Optique Graduate SchoolCNRSUniversite Paris-Saclay91127 Palaiseau CedexFrance

We present the results of the first commissioning phase of the short-focal-length area of the Apollon laser facility(located in Saclay,France),which was performed with the first available laser beam(F2),scaled to a nominal power of 1 *** the conditions that were tested,this beam delivered on-target pulses of 10 J average energy and 24 fs *** diagnostics were fielded to assess the performance of the *** on-target focal spot and its spatial stability,the temporal intensity profile prior to the main pulse,and the resulting density gradient formed at the irradiated side of solid targets have been thoroughly characterized,with the goal of helping users design future *** of energetic electrons,ions,and electromagnetic radiation were recorded,showing good laser-to-target coupling efficiency and an overall performance comparable to that of similar international *** will be followed in 2022 by a further commissioning stage at the multipetawatt level.

关键词： performance beam nominal

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美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准

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国际脑血管病杂志 2007年第1期15卷 4-24页

作者： Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj n.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.leblanc 李焰生（译）俞羚（译）高枚春（译）张静芳（译）熊昕丽（译）邹静（译）林岩（译）潘元美（译）不详上海交通大学医学院附属仁济医院神经内科 200127

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断... 详细信息

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体，尤其是在早期阶段，而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法：美国国立神经疾病和卒中研究所（MInDS）与加拿大卒中网（CSn）召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员，为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果：将这些讨论的结果发表于此。结论：一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者，使不同的研究具有可比性，并且通过整合知识来加速研究进展的步伐。

关键词： Bimwanger病CADASIL 综合征脑梗死脑血管病痴呆遗传学缺血腔隙性梗死白质疏松神经心理学卒中血管性痴呆

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling n.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.n. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama n.n. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.n. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan n. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai n.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.n. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUOn TAGGInG

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糖尿病、血糖水平与心源性猝死的风险

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 52-52页

作者： Jouven X. Lematre R. n. Rea T. D. 张步升 Service de Cardiologie Université Paris-5 Hpital Europé en Georges Pompidou 20 rue Leblanc 75015 Paris France

Aims: The prevalence of diabetes mellitus in industrialized countries is rapidly increasing,and diabetes is suspected to carry a particular high risk for sudden cardiac death(SCD). Methods and results: We conducted a population-based case-control study at Group Health Cooperative. Cases(n=2040) experienced out-of-hospital cardiac arrest due to heart disease between 1980 and 1994. Controls(n=3800) were a stratified random sample of enrollees. Diabetes status was classified into four exclusive groups:(i) no diabetes,(ii) borderline,(iii) diabetes without microvascular disease(retinopathy or proteinuria), and(iv) diabetes with microvascular disease. When compared with no diabetes, we observed progressively higher risk of SCD associated with borderline diabetes[Odds ratio(OR)=1.24(0.98-1.57)], diabetes without microvascular disease[OR=1.73(1.28-2.34)], and diabetes with microvascular disease[OR=2.66(1.84-3.85)], after adjustment for potential confounders(P-value for trendn the absence and in the presence of microvascular disease. However, subjects with microvascular complications but with glucose levelnot at significant increased risk of SCD. Conclusion: These results emphasize the role of diabetes as a strong risk factor for SCD and outline the importance of glucose level at every stage of diabetes severity.

关键词：心源性猝死血糖水平糖尿病代谢病

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