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Eolian versus fluvial supply to the northern Arabian Sea during the Holocene based on nd isotope and geochemical records

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Geoscience Frontiers 2023年第5期14卷 280-294页

作者： Waliur Rahaman n.lathika Priyesh Prabhat Mohd.Tarique K.S.Arya Ravi Mishra Meloth Thamban national Centre for Polar and Ocean Research Ministry of Earth SciencesGoa 403802India Kerala University of Fisheries and Ocean Studies Cochin 682506KeralaIndia

The north-eastern Arabian Sea(nE-AS)comes under a strong influence of land–ocean–climate interactions and regulates biogeochemical processes through the supply of huge amounts of dissolved and particulate materials and nutrients via eolian and fluvial *** processes underwent dramatic changes in the coastal regions due to sea-level rise and climate change during the Holocene;however,their relative roles remain *** nE-AS receives large amounts of dissolved and particulate fluxes,and therefore,reconstruction of the past surface water nd isotope composition(end)and tracing the provenance of sediment using detrital end and geochemical records would enable us to assess the role of various processes controlling these fluxes to the northern Arabian *** this study,we have generated authigenic and detrital end records and geochemical records in a sediment core from the coastal region of the nE-AS,offshore *** found that the authigenic end profile closely followed the Holocene sea-level records;early Holocene less radiogenic values(-8)were sharply shifted to more radiogenic values(-5.5)during the mid-Holocene(6–7 ka)and thereafter remained stable,close to the modern surface water end *** detrital end record broadly followed the authigenic end record,however,they differ in *** geochemical records based on major and trace elemental abundances show a similar trend to the authigenic end record and concomitant changes with the Holocene *** investigation reveals that lower sea-level stand combined with a stronger monsoon during the early Holocene resulted in enhanced fluvial weathering fluxes from the west-flowing rivers and contributed to less radiogenic *** situation changed dramatically during the mid-Holocene due to the weakening of the south-west monsoon and rapid sea level rise,which caused enhanced influence of open ocean water characterised by more radiogenic end(-6)derived from the dissolution of dust from Arabia a

关键词： nd isotopes Circulation Arabian Sea Sea-level Holocene

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A Meta-Analysis of the Genome-Wide Association Studies on Two Genetically Correlated Phenotypes Suggests Four new Risk Loci for Headaches

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Phenomics 2023年第1期3卷 64-76页

作者： Weihua Meng Parminder S.Reel Charvi nangia Aravind lathika Rajendrakumar Harry L.Hebert Qian Guo Mark J.Adams Hua Zheng Zen Haut Lu Me Research Team Debashree Ray Lesley A.Colvin Colin n.A.Palmer Andrew M.McIntosh Blair H.Smith nottingham ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100China Division of Population Health and Genomics Ninewells Hospital and Medical SchoolUniversity of DundeeDundee DD24BFUK Division of Psychiatry Edinburgh Medical SchoolUniversity of EdinburghEdinburgh EH105HFUK Department of Anaesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China PAPRSB Institute of Health Sciences Universiti Brunei DarussalamBandar Seri Begawan BE1410Brunei Darussalam andMe Inc.SunnyvaleCA 94086USA Department of Epidemiology Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA Department of Biostatistics Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA

Headache is one of the commonest complaints that doctors need to address in clinical *** genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically *** this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(n=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly *** LDL receptor related protein 1(LRP1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of *** One Cut homeobox 2(OnECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of *** study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for *** study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.

关键词： Headache Migraine Unified Score-based Association Test Correlated phenotypes Meta-analysis Genome-wide association study

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