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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

neural regeneration research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza i.Torrado-Tapias iris K.Salgado Jose M.Santiago Samuel E.Ocasio rivera Dina P.Bracho-rincon Luis h.Pagan rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto rico Carolina CampusCarolinaPRUSA institute of neurobiology San JuanPRUSA

in addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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3D tomographic analysis of equatorial plasma bubble using GnSS-TEC data from indonesian GnSS network

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Earth and Planetary Physics 2025年第1期9卷 127-136页

作者： ihsan naufal Muafiry Prayitno Abadi Teguh n.Pratama Dyah r.Martiningrum Sri Ekawati Yuandhika GWismaya Febrylian FChabibi Gatot hPramono research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia indonesian Geospatial information Agency(BiG) JakartaIndonesia Dept.of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Dept.Earth Planet Sci. Hokkaido UniversitySapporoJapan School of Electrical Engineering Telkom UniversityBandungIndonesia

Equatorial Plasma Bubbles(EPBs)are ionospheric irregularities that take place near the magnetic *** most commonly occur after sunset during the equinox months,although they can also be observed during other *** phenomenon significantly disrupts radio wave signals essential to communication and navigation *** national network of Global navigation Satellite System(GnSS)receivers in indonesia(>30°longitudinal range)provides an opportunity for detailed EPB *** explore this,we conducted preliminary 3D tomography of total electron content(TEC)data captured by GnSS receivers following a geomagnetic storm on December 3,2023,when at least four EPB clusters occurred in the Southeast Asian *** and extracted TEC depletion with a 120-minute running average were then used as inputs for a 3D tomography *** 2D spatial distribution consistently captured the four EPB clusters over *** tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources,such as the Global ionospheric Map(GiM)and international reference ionosphere(iri)*** of the results demonstrates the capability of the indonesian GnSS network to measure peak ionospheric *** findings highlight the potential for future three-dimensional research of plasma bubbles in low-latitude regions using existing GnSS networks,with extensive longitudinal coverage.

关键词： EPB indonesian GnSS network 3D tomography

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural regeneration research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.heinzel Antal nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria Ludwig Boltzmann institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). however, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. in this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. in the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期 283-302页

作者： Veeranna MODi Prasad B.rAMPUrE Sunil Kumar ShETTY Madeva nAGArAL Channa Keshava nAiK n Johar MGM Muhammad irsyad ABDULLAh Abdullah i.AL-MAnSOUr Shamshad ALAM KLE College of Engineering and Technology ChikodiVisvesvaraya Technological University nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(random Forest（rF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased nOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20nP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,nOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to rF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

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Leveraging rOTi map derived from indonesian GnSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi ihsan n.Muafiry Teguh n.Pratama Angga Y.Putra Suraina Gatot h.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia indonesian Geospatial information Agency(BiG) JakartaIndonesia research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of indonesia’s GnSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GnSS signals and degrade positioning *** by the indonesian Geospatial information Agency(BiG),the indonesia Continuously Operating reference Station(ina-COrS)network comprises over 300 GnSS receivers spanning equatorial to southern low-latitude ***-COrS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(rOTi)derived from this *** generate rOTi maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the rOTi maps of ina-COrS are ***,the ina-COrS rOTi maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined rOTi maps from ina-COrS and GnSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined rOTi maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing rOTi maps from indonesia and integrating them with regional GnSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GnSS receivers’network indonesia Continuously Operating reference Station(ina-COrS) ionospheric map rate of TEC change index(rOTi)map

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influence of elastic foundations and carbon nanotube reinforcement on the hydrostatic buckling pressure of truncated conical shells

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1011-1026页

作者： A.h.SOFiYEV i.T.PirMAMEDOV n.KUrUOGLU Department of Civil Engineering Suleyman Demirel UniversityIsparta 32260Turkey Department of Mathematics Azerbaijan Technical UniversityBaku 1073Azerbaijan Department of Civil Engineering Gelisim UniversityIstanbul 34310Turkey

in this study,the effects of elastic foundations(EFs)and carbon nanotube(CnT)reinforcement on the hydrostatic buckling pressure(hBP)of truncated conical shells(TCSs)are *** first order shear deformation theory(FOSDT)is generalized to the buckling problem of TCSs reinforced with CnTs resting on the EFs for the first *** material properties of composite TCSs reinforced with CnTs are graded linearly according to the thickness *** Winkler elastic foundation(W-EF)and Pasternak elastic foundation(P-EF)are considered as the *** basic relations and equations of TCSs reinforced with CnTs on the EFs are obtained in the framework of the FOSDT and solved using the Galerkin *** of the innovations in this study is to obtain a closed-form solution for the hBP of TCSs reinforced with CnTs on the ***,the effects of the EFs and various types CnT reinforcements on the hBP are investigated *** obtained results are compared with the results in the literature,and the accuracy of results is confirmed.

关键词： truncated conical shell(TCS) carbon nanotube(CnT) Winkler elastic foundation(W-EF) Pasternak elastic foundation(P-EF) hydrostatic pressure buckling

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Synthesis and characterization of CnT/Ce-TiO_2 nanocomposite for phenol degradation

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Journal of rare Earths 2012年第7期30卷 651-658页

作者： Shaari n Tan S h Mohamed A r School of Chemical Engineering Engineering Campus University Sains Malaysia

An innovative photocatalyst, Carbon nanotube （CnT） supported Ce-TiO2 nanocomposite was successfully synthesized via modi-fied sol gel method and investigated in a batch reactor for abolition of phenol under UV light spectrum. Characterization of catalyst micro-structure and internal properties were done by means of X-ray diffraction （XrD）, Brunauer-Emmett-Teller （BET）, scanning electron micros-copy （SEM）, transmission electron microscopy （TEM） and UV-vis diffuse reflectance spectra （DrS）. Ce doping can inhibit phase transfor-mation from anatase to rutile and eliminate the recombination of electron-hole pairs in the catalyst. The presence of CnT in TiO2 composite can both increase the photoactivity under UV and change surface properties to achieve sensitivity to visible light. The optimum mass ratio of CnT support and cerium （Ce） dopant in TiO2 was the prominent factor to harvest CnT/Ce-TiO2 photocatalyst nanocomposite. The results demonstrated that optimum mass ratio of CnT：TiO2：Ce was 0.02：1.0：0.06, which resulted in the great performance of the photocatalyst to de-grade about 94% of phenol in a 50 mg/L solution in only 3 h. in this paper, dissimilar role of CnT support and Ce dopant in the TiO2 photo-catalysis of phenol was also discussed.

关键词： carbon nanotube (CnT) cerium TiO2 nanocomposite photocatalyst phenol rare earths

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numerical investigation of transonic flow over deformable airfoil with plunging motion

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Applied Mathematics and Mechanics(English Edition) 2016年第1期37卷 75-96页

作者： n.nEKOUBin M.r.h.nOBAri Department of Mechanical Engineering Amirkabir University of Technology

in this article, the transonic inviscid flow over a deformable airfoil with plunging motion is studied numerically. A finite volume method based on the roe scheme developed in a generalized coordinate is used along with an arbitrary Lagrangian-Eulerian method and a dynamic mesh algorithm to track the instantaneous position of the airfoil. The effects of different governing parameters such as the phase angle, the deformation amplitude, the initial angle of attack, the flapping frequency, and the Mach number on the unsteady flow field and aerodynamic coefficients are investigated in detail. The results show that maneuverability of the airfoil under various flow conditions is improved by the deformation. in addition, as the oscillation frequency of the airfoil increases, its aerodynamic performance is significantly improved.

关键词： transonic flow inviscid flow fluid-solid interaction deformable airfoil,plunge motion roe scheme

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Magnetic properties of La2CuMnO6 double perovskite ceramic investigated by Monte Carlo simulations

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Chinese Physics B 2020年第5期29卷 387-391页

作者： S Mtougui i EL housni n EL Mekkaoui S Ziti S idrissi h Labrim r Khalladi L Bahmad Laboratoire de la Matière Condensée et des Sciences interdisciplinaires (LaMCSci) Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco intelligent Processing and Security Systems Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco USM/DErS/Centre national de l’Energie des Sciences et des Techniques Nucl´eaires(CNESTEN)RabatMorocco

We present a theoretical study of the magnetic properties of the lanthanum copper manganate double perovskite La2CuMnO6 ceramic,using Monte Carlo *** analyze and discuss the ground state phase diagrams in different planes to show the effect of every physical *** on the Monte Carlo simulations,which combine Metropolis algorithm and ising model,we explore the thermal behavior of the total magnetization and *** also present and discuss the influence of physical parameters such as the external magnetic field,the exchange coupling interactions between magnetic atoms,and the exchange magnetic field on the magnetization of the ***,the critical temperature of the system is about Tc=70 K,in agreement with the experimental ***,the hysteresis loops of La2CuMnO6 are discussed.

关键词： double perovskite La2CuMnO6 Monte Carlo simulations ising model hysteresis loops Metropolis algorithm critical temperature

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A Gaussian Model for Anisotropic Strange Quark Stars

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Chinese Physics Letters 2016年第7期33卷 50-54页

作者： h.Panahi r.Monadi i.Eghdami Department of Physics University of Guilan

For studying the anisotropie strange quark stars, we assume that the radial pressure inside an anisotropic star can be obtained simply by isotropie pressure plus an additional Gaussian term with three free parameters （A, μ and X）. According to recent observations, a pulsar in a mass range of 1.97±0.04M has been measured. hence, we take this opportunity to set the free parameters of our model. We fix X by applying boundary and stability conditions and then search the A - μ parameter space For a maximum mass range of 1.9M 〈 Mmax 〈 2.1M. Our results indicate that anisotropy increases the maximum mass M and also its corresponding radius r for a typical strange quark star. Furthermore, our model shows magnetic field and electric charge increase the anisotropy factor △. in fact, △ has a maximum on the surface and this maximum goes up in the presence of magnetic field and electric charge. Finally, we show that anisotropy can be more effective than either magnetic field or electric charge in raising maximum mass of strange quark stars.

关键词： in is on as of A Gaussian Model for Anisotropic Strange Quark Stars for been that

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