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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIgHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J woodhouse Craig S Anderson sandeep Ankolekar Lesley Cala mark Dixon Timothy J England Kailash Krishnan grant mair Keith w Muir John Potter Christopher I Price marc Randall Thompson g Robinson Christine Roffe Else C sandset Jeffrey L saver Angela Shone Aloysius niroshan Siriwardena Joanna M wardlaw nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The george Institute China at Peking University Health Science Center BeijingChina neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service nHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of neuroscience Newcastle UniversityNewcastle upon TyneUK Department of neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and nIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(gTn,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of gTn in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with glyceryl trinitrate in Hypertensive stroke Trial-2(RIgHT-2).Methods RIgHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or mann-whitney difference(MwD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,gTn did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MwD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting gTn may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal gTn in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KnOwn On THIS TOPIC⇒Transdermal glyceryl trinitrate(gTn)was associat-ed with less death and dependency in those w

关键词： glasgow nitrate random

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TM_(3)(TM=V,Fe,Mo,w)single-cluster catalyst confined on porous Bn for electrocatalytic nitrogen reduction

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Journal of materials Science & Technology 2022年第13期108卷 46-53页

作者： Shuaishuai gao Zuju ma Chengwei Xiao Zhitao Cui wei Du Xueqin Sun Qiaohong Li Rongjian sa Chenghua Sun School of Environmental and materials Engineering Yantai UniversityYantai 264005China School of materials Science and Engineering Anhui University of TechnologyMaanshan 243002China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Institute of Oceanography Ocean CollegeMinjiang UniversityFuzhou 350108China College of Chemical Engineering and Energy Technology Dongguan University of TechnologyDongguan 523808China Department of Chemistry and Biotechnology Faculty of ScienceEngineering&TechnologySwinburne University of TechnologyHawthornVIC 3122Australia

Confined metal clusters as sub-nanometer reactors for electrocatalytic n_(2) reduction reaction(enRR)have received increasing attention due to the unique metal-metal interaction and higher activity than singleatom ***,the inspiration of the superior capacitance and unique microenvironment with regular surface cavities of the porous boron nitride(p-Bn)nanosheets,we systematically studied the catalytic activity for nRR of transition-metal single-clusters in the triplet form(V_(3),Fe_(3),Mo_(3) and w_(3))confined in the surface cavities of the p-Bn sheets by spin-polarized density functional theory(DFT)*** a two-step screening strategy,Mo_(3)@p-Bn was found to have high catalytic activity and selectivity with a rather low limiting potential(-0.34 V)for the *** anchored Mo_(3) singlecluster can be stably embedded on the surface cavities of the substrate preventing the diffusion of the active Mo *** importantly,the Mo atoms in the Mo_(3) single-cluster would act as“cache”to accelerate electron transfer between active metal centers and nitrogen-containing intermediates via the intimate Mo-Mo *** cooperation of Mo atoms can also provide a large number of occupied and unoccupied d orbitals to make the"donation-backdonation"mechanism more *** work not only provides a quite promising electrocatalyst for nRR,but also brings new insights into the rational design of triple-atom nRR catalysts.

关键词： Electrocatalytic n_(2)reduction Density functional theory Single-cluster Porous boron nitride

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Chemoenzymatic synthesis amphiphilic H-shaped copolymer and its self-assembly behavior

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Science China Chemistry 2009年第12期52卷 2336-2341页

作者： Shuwei wang Bao Zhang Peng Ai Ming Zhu wei wang ZhongPeng sa Lina ma YaPeng Li Alan g. macDiarmid Institute of Jilin University Changchun 130012 China Department of Bioengineering College of Pharmacy Jilin University Changchun 130021 China

ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring-opening polymerization (eROP) of ε-CL in the presence of biocatalyst novozyme 435. The chains ended with hydroxyl of block copolymers were modified by the esterification of 2,2-dichloro acetyl chloride (DCAC) to obtain the tetrafunctional macroinitiator, which was used in the ATRP of 4-vinylpyridine (4-VP). CuCl/HMTETA was used as the catalyst system in the ATRP of 4-VP to acquire the H-shaped block copolymers (PVP)2-b-PCL-b-PEg-b-PCL-b-(PVP)2. The H-shaped block copolymers were characterized by FTIR, nMR, and gPC. Copolymers with high molecular weights (M n = 46121 g/mol) and low polydispersities (M w/M n = 1.30) were prepared. Moreover, the morphology of the copolymer was examined with dynamic light scattering (DLS) and atomic force microscopy (AFM). Spherical micelles with a diameter of 70 nm in aqueous solution were obtained.

关键词： atom transfer radical polymerization (ATRP) enzymatic ring-opening polymerization (eROP) amphiphilic block copolymer

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Coprophilous contributions to the phylogeny of Lasiosphaeriaceae and allied taxa within Sordariales(Ascomycota,Fungi)

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Fungal Diversity 2015年第1期70卷 101-113页

作者： Åsa Kruys sabine M.Huhndorf Andrew n.Miller Systematic Biology Department of Organismal BiologyEvolutionary Biology CentreUppsala UniversityNorbyvägen 18DSE-75236 UppsalaSweden Botany Department Field MuseumChicagoIL 60605USA Illinois natural History Survey University of IllinoisChampaignIL 61820US

The phylogenetic relationships of Lasiosphaeriaceae are complicated in that the family is paraphyletic and includes Sordariaceae and Chaetomiaceae,as well as several polyphyletic *** study focuses on the phylogenetic relationships of the coprophilous genera,Anopodium,Apodospora,Arnium,Fimetariella and *** are traditionally circumscribed based on ascospore characters,which have proven homoplasious in other genera within the *** results based on LSU nrDnA andß–tubulin sequences distinguish four lineages of Lasiosphaeriaceae *** joins the clade of mor-phologically similar,yellow-pigmented species of Cercophora and *** is monophyletic and joins a larger group of taxa with unclear affinities to each other,while Arnium is polyphyletic being scattered throughout three of the four major clades of *** is represented by a single collection and joins the clade containing Cercophora scortea and Podospora *** shows affinities to the Lasiosphaeris *** on a combination of morphological and molecular data,Echria *** recognized at the genus level for the former Arnium section and two new combinations are proposed:*** and ***.

关键词： Ascomal wall Ascomycete β-tubulin LSU nrDnA Systematics,Taxonom

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Hot Deformation Behavior of sa508gR.4n Steel for nuclear Reactor Pressure Vessels

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Journal of Iron and Steel Research International 2016年第12期23卷 1342-1348页

作者： ning LIU Zheng-dong LIU Xi-kou HE Zhi-qiang YAng Long-teng ma Faculty of materials Science and Engineering Kunming University of Science and Technology Institute for Special Steels Central Iron and Steel Research Institute

A hot compression experiment （1073 1473 K, strain rates of 0. 001-10 s -1 ） of saS08gR. 4n low alloy steel was performed using a gleeble-3800 thermal-mechanical simulator, and the hot deformation behavior of the steel was investigated by analyzing both the true stress true strain curves and its microstructures. The thermal de formation equation and hot deformation activation energy （Q） of sa508gR. 4n steel were obtained by regression with a classic hyperbolic sine function. The hot processing map of saS08gR. 4n steel was also established. An empirical equation for the stress peak was described for practical applications. The sa508gR. 4n steel showed a critical Zener-Hollomon parameter （lnZc） for dynamic recrystallization （DRX） of 37.44, below which full DRX may occur. The sensitivity of the sa508gR. 4n steel increased linearly with test temperature, such that higher temperatures led to enhanced workability.

关键词： sa508gR. 4n steel dynamic recrystallization hot deformation equation hot processing map ZenerHollomon parameter

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Automated tree detection and crown delineation using airborne laser scanner data in heterogeneous East-Central Europe forest with different species mix

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Journal of Forestry Research 2017年第5期28卷 1049-1059页

作者： Róbert Smreek Ivan sakov Zuzana Michnová Ján Tuek Department of Forest management and geodesy Technical University in Zvolen Department of Forest Policy Economics and Forest ManagementNational Forest Centre-Forest Research Institute Zvolen

Identifying tree locations is a basic step in the derivation of other tree parameters using remote sensing techniques, particularly when using airborne laser scanning. There are several techniques for identifying tree positions. In this paper, we present a raster-based method for determining tree position and delineating crown coverage. we collected data from nine research plots that supported different mixes of species. we applied a raster-based method to raster layers with six different spatial resolutions and used terrestrial measurement data as reference data. Tree identification at a spatial resolution of 1.5 m was demonstrated to be the most accurate, with an average identification ratio (IR) of 95% and average detection ratio of 68% being observed. At a higher spatial resolution of 0.5 m, IR was overestimated by more than 600%. At a lower spatial resolution of 3 m, IR was underestimated at less than 44% of terrestrial measurements. The inventory process was timed to enable evaluation of the time efficiency of automatic methods.

关键词： Airborne laser scanning East-Central Europe Individual tree Mixed forest Tree crown delineation

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global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study

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world Journal of gastroenterology 2021年第13期27卷 1341-1353页

作者： sa'ed H Zyoud Simon Smale w Stephen waring waleed Sweileh samah w Al-Jabi Poison Control and Drug Information Center(PCDIC) College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839West BankPalestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839West BankPalestine Department of Clinical Research Centre An-Najah National University HospitalNablus 44839West BankPalestine Department of gastroenterology York HospitalYork Teaching Hospital NHS Foundation TrustYork YO318HEUnited Kingdom Acute Medical Unit York Teaching Hospitals NHS Foundation TrustYork YO318HEUnited Kingdom Department of Pharmacology and Toxicology College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839West BankPalestine

BACKgROUnD Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut–brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut–brain *** To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this *** The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000–2019. VOSviewer software was used for data *** A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS(r = 0.951, P nited States was the most prolific country with 449(24%) publications, followed by the United Kingdom(n = 176, 9.4%), China(n = 154, 8.2%), and Italy(n = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters:(1) The gut–brain axis related to IBS;(2) Clinical trials related to IBS and the microbiome;(3) Drugmediated manipulation of the gut microbiome;and(4) The role of the altered composition of intestinal microbiota in IBS *** This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in

关键词： Irritable bowel syndrome Bibliometric Microbiota Microbiome Scopus Brain gut axis

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A new series of environment-friendly reddish inorganic pigments based on AFeO_(3)(A=Ln,Y) with high nIR solar reflectance

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Journal of materiomics 2021年第5期7卷 1061-1073页

作者： maria Fortuño-Morte Pablo Serna-gallén Héctor Beltrán-Mir Eloísa Cordoncillo Departamento de Química Inorgánica y Orgánica Universitat Jaume IAv.Sos Baynat s/n12071Castellóde la PlanaSpain

Environment-friendly pigments based on AFeO_(3)(A=La,Pr,nd,Sm,gd,Tb,Y or Yb)with high nearinfrared(nIR)reflectance were synthesised by a coprecipitation method at 1200℃.The Rietveld refinement analysis showed single-phase orthorhombic perovskite for all *** pigments,which showed reddish hues,offered good colour stability after mixing these pigments in powder form with siloxane transparent paint and two different *** powderepaint mixtures produced with gdFeO_(3),TbFeO_(3) and YFeO_(3) pigments have the highest nIR solar reflectance,reaching values of R=50%.The temperature shielding studies conducted using TbFeO_(3) pigmentepaint mixture for a roof coating yielded a reduction of 3.2℃ in comparison to a commercial ***,the glazes that were pigmented using gdFeO_(3),TbFeO_(3) and YFeO_(3) compositions also presented the most intense reddish colours.A study of the thermal and chemical stability of the pigment with the highest nIR solar reflectance showed good stability in both *** reddish pigments that were prepared can therefore be good candidates for use in different applications such as cool pigments or pigments for ceramic glazes at high temperatures.

关键词： High nIR reflectance Cool pigment Reddish pigment Environment-friendly Coprecipitation

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would behavioral thermoregulation enable pregnant viviparous tropical lizards to cope with a warmer world?

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Integrative Zoology 2017年第5期12卷 379-395页

作者： saúl LÓPEZ-ALCAIDE Miguel nAKAMURA Eric n.SMITH Enrique maRTÍnEZ-MEYER Departament of Zoology Institute of BiologyNational Autonomous University of MexicoMexico CityMexico Center for Research in mathematics GuanajuatoMexico Amphibian and Reptile Diversity Research Center and Department of Biology University of Texas at ArlingtonArlingtonTexasUSA

Sceloporus lizards depend on external heat to achieve their preferred temperature(Tsel)for performing physiological *** both in the field and laboratory indicates that pregnant females of this genus select body temperatures(Tb)lower than 34℃ as higher temperatures may be lethal to ***,thermoregulation is crucial for successful embryo *** the increase in global air temperature,it is expected that the first compensatory response of species that inhabit tropical climates will be behavioral *** tested whether viviparous Sceloporus formosus group lizards in the wild exhibited differences in thermoregulatory behavior to achieve the known Tsel for developing embryos regardless of local thermal *** quantified field active body temperature,thermoregulatory behavior mechanisms(time of sighting,microhabitat used and basking time)and available microhabitat thermal conditions(*** temperature)for 10 lizard species during gestation,distributed along an altitudinal *** applied both conventional and phylogenic analyses to explore whether Tb or behavioral thermoregulation could be regulated in response to different thermal *** species showed no significant differences in field Tb during gestation regardless of local thermal *** contrast,they exhibited significant differences in their behavioral thermoregulation associated with local environmental *** on these observations,the differences in thermoregulatory behavior identified are interpreted as compensatory adjustments to local thermal *** conclude that these species may deal with higher temperatures predicted for the tropics by modulating their thermoregulatory behavior.

关键词： altitudinal gradient behavior global warming Sceloporus formosus thermal stress

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胎儿心脏定量分析技术评估小于胎龄儿和生长受限儿心室功能

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中华超声影像学杂志 2024年第7期33卷 580-588页

作者：王漫琪冯帆吴娟刘云王新霞陈飒栗河舟郑州大学第三附属医院超声科郑州450052

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SgA)及生长受限(FgR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFw)或腹围小于第10百分位数的单胎胎儿152例,其... 详细信息

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SgA)及生长受限(FgR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFw)或腹围小于第10百分位数的单胎胎儿152例,其中胎儿EFw或腹围位于第3~10百分位数且不伴有血流动力学异常为SgA组(n=79),其余为FgR组(n=73);匹配同期正常单胎胎儿161例作为对照组。依据FgR发生孕周,将FgR组分为早发组(gR组中脐动脉舒张末期血流信号消失定义为重度FgR(n=11),其余为轻度FgR(n=62)。应用fetal HQ软件获取胎儿心室面积变化分数(FAC)、整体纵向应变(gLS)、纵向缩短率(LFS)及24节段短轴缩短率(FS),比较各组间心室收缩功能差异,分析各参数与孕周的相关性,进行观察者间及观察者内重复性检验。结果与对照组相比,SgA组及FgR组心室FAC、LFS及gLS均减低,SgA组右心室9~24节段FS减低、FgR组左心室10~19、21~24节段及右心室18~24节段FS减低,差异有统计学意义(均PgR组左心室gLS、LFS及右心室FAC、gLS、LFS、1~14节段FS低于轻度FgR组,差异有统计学意义(均PgR早发组左心室gLS及LFS高于晚发组,差异有统计学意义(均PgLS、LFS预测不良围产期结局AUC>0.6(均PgR组左心室gLS及右心室部分节段FS与孕周呈弱相关(-0.3gA组各参数与孕周无相关性(均P>0.05)。心室收缩功能参数观察者间及观察者内ICC均>0.75,具有较好的重复性。结论Fetal HQ可定量评估SgA及FgR胎儿心室收缩功能,SgA及FgR胎儿心室整体、纵向及局部横向收缩功能均减低,心室收缩功能异常与不良围产期结局相关。

关键词：超声检查胎儿心脏定量分析小于胎龄儿胎儿生长受限心室功能

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