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国际医学放射学杂志 2015年第4期 392-392页

作者： n.furuhashi K.Suzuki Y.Sakurai M.Ikeda Y.Kawai S.naganawa 刘兰 Department of Radiology Nagoya University Graduate School of Medicine

摘要目的评估应用多期相对比增强CT单征象和复合征象鉴别局限型自身免疫性胰腺炎(f-AIP)与胰腺癌(PC)的价值。方法本研究纳入了22例f-AIP及61例PC病人。2名

关键词：胰腺癌 AIP PC 自身免疫性胰腺炎局限型 CT

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Risperidone Versus Yokukansan in the Treatment of Severe Alzheimer’s Disease

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International Journal of Clinical Medicine 2011年第2期2卷 166-170页

作者： Yuko furuhashi Kouichi Shin Medical Care Center Shizuoka University Internal Medicine Asahi Hospital

PURPOSE: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). METHODS: Thirty eight inpatients with AD were investigated. Patients were randomly as-signed to the YKS group (n = 18) or the RIS group (n = 20) and treated for 4 weeks. The primary outcomes were changes in the scores on the neuropsychiatric Inventory (nPI), the Mini-Mental State Examination (MMSE), the Bar-thel Index, and the Cohen-Mansfield Agitation Inventory (CMAI). The frequency of extrapyramidal symptoms (EPS) and other adverse events were recorded at every visit. RESULTS: All participants in both groups completed the trial. The Barthel Index did not significantly change either in the RIS group or the YKS group. The MMSE scores did not change either in the RIS group or the YKS group. Significant improvements in mean total nPI and CMAI scores showed in both groups. Between the YKS and the RIS groups, there were no significant differences in the nPI or the CMAI scores. EPS and other serious adverse effects were not observed in either group. COnCLUSIOnS: In this 4-week trial, YKS treatment significantly improved BPSD in the patients with severe AD. The present study suggests that YKS is as effective as RIS on BPSD with severe AD.

关键词： Alzheimer’s Disease Behavioral and Psychological Symptoms of Dementia Dementia

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Physiological Effects of Salmon Milt nucleoprotein on Movement, Stress Tolerance and Lifespan of <i>C. elegans</i>

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Food and nutrition Sciences 2012年第1期3卷 48-54页

作者： Hiroaki Shintani Tsubasa furuhashi Hiroyuki Hano Masaji Matsunaga Koji Usumi norimasa Shudo Kazuichi Sakamoto 不详

In recent years, various physiological functions of salmon milt extract, which consists of nucleic acid and nucleoprotein, have been reported. The objective of this study is to analyze the physiological function and its mechanism of salmon milt extract (nG) on nematodes (C. elegans). The wild type nematode n2 strain was bred on the plate containing of nG for four days, and its body length increased depending on nG concentration. When nematodes were bred with nG for a longer period, average lifespan was increased, and survival rate was increased by up to 20%. Generally, the movement of nematodes decreases with longer breeding period (i.e. aging). Analysis of movement (both gross thrashing movement and local pumping movement) showed that nG suppressed this decrease f movement with aging. Furthermore, the deease of survival rate by heat stress and oxidative stress was suppressed by nG administration. nile Red staining analysis showed that fat accumulation varied depending on the concentration of nG. RT-PCR analysis revealed that the mRnA expression levels of the stress resistance genes sod-3 and sod-4 were increased. These results indicated that nG administration increased the expression of stress-tolerance-related genes, promoted stress tolerance, increased movement and prolonged lifespan in nematode.

关键词： nematode nucleoprotein Protamine Lifespan Stress Sod

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10年研究期间脂肪肝指数升高与男性和女性新发高血压独立相关

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中华高血压杂志(中英文) 2021年第10期 1027-1027页

作者： Higashiura Y furuhashi M Tanaka M Takahashi S Mori K Miyamori D Koyama M Ohnishi H Moniwa n numata K Hisasue T Hanawa n Miura T 袁源郑武洪

J Am Heart Assoc,2021,10(14):e021430.脂肪肝指数(fatty liver index,FLI)是非酒精性脂肪肝的预测因子,已有报道显示FLI与几种代谢紊乱相关。考虑到FLI水平存在性别差异,本研究假设男性或女性中FLI在很大程度上与高血压发病相关。方...

J Am Heart Assoc,2021,10(14):e021430.脂肪肝指数(fatty liver index,FLI)是非酒精性脂肪肝的预测因子,已有报道显示FLI与几种代谢紊乱相关。考虑到FLI水平存在性别差异,本研究假设男性或女性中FLI在很大程度上与高血压发病相关。方法与结果:本研究在接受每年健康体检的普通人群(n=28 990)中探索10年期间FLI与高血压发病的相关性。排除缺失数据和基线时患有高血压的人群后,

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