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国际医学放射学杂志 2017年第2期 236-237页

作者： K.Sano T.Ichikawa U.Motosugi S.Ichikawa H.Morisaka n.enomoto 徐滢莹 Department of Radiology University of Yamanashi

摘要目的评估肝硬化病人肝细胞特异期钆酸摄取阳性(高信号)的乏血供肝内结节发展为富血供肝细胞肝癌(HCC)的纵向风险。方法在69例病人中连续随访评估633

关键词：肝硬化内结节供肝病人阳性

Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract

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World Journal of Clinical Cases 2019年第1期7卷 10-18页

作者： Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato nobuyuki enomoto First Department of Internal Medicine Faculty of Medicine University of Yamanashi Yamanashi 409-3898 Japan Department of Health Sciences Interdisciplinary Graduate School and Engineering University of Yamanashi Yamanashi 409-3898 Japan

BACKGROUnD Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected *** To identify ERCP-related risk factors for perforation in patients with surgically altered *** The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or *** All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).COnCLUSIOn Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billro

关键词： Surgically altered anatomy Billroth-Ⅱ Endoscopic retrograde cholangiopancreatography Perforation

初级纵向集成电路的制造工艺、应用和未来(一)

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微电子学与计算机 1991年第2期8卷 41-43页

作者： Tadayoshi enomoto 石广元白古山

为实现高集成密度、高产量和短制造周期,发展了一种新的双层迭式LSI 制造工艺.称作初级纵向集成电路(ELVIC)技术工艺是把两个用常规方法制造的LSI 芯片面对面放置并热压在一起.此工艺还包括上下两层LSI 纵向互连(VI)的形成、上下两层表... 详细信息

为实现高集成密度、高产量和短制造周期,发展了一种新的双层迭式LSI 制造工艺.称作初级纵向集成电路(ELVIC)技术工艺是把两个用常规方法制造的LSI 芯片面对面放置并热压在一起.此工艺还包括上下两层LSI 纵向互连(VI)的形成、上下两层表面的平整化和使用热压方法的中间层连接.本实验中,在5×5mm^2的芯片上,约有52000个10×10μm^2的金-钛纵向互连.测量得知,每对VI 点的拉伸强度为4mg 力.已制造出由上层p 沟和下层n 沟MOSFET 组成的两层31级体硅CMOS 环形振荡器.在电源电压为5V 时,每级的传输延迟时间为1.86ns.

关键词：初级纵向集成电路制造工艺 LSI 大规模集成电路集成密度

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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

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World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang nobuhiro Ohkohchi Yoshitaka enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro narita Hideyuki Yamaya Atsushi nakamura Satoshi Sekiguchi naoki Kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM： To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs. METHODS： The right lateral lobe of pigs, i.e. the 25% of the liver, was transplanted orthotopically. The pigs were divided into two groups： graft without portocaval shunt （n = 11） and graft with portocaval shunt （n = 11）. Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated. RESULTS： In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h afcer transplantation. In the group with portocaval shunt, eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 ml./min/100 g liver tissue, respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 ml./ min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively （P〈0.01）. As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed afl：er reperfusion, but these findings were not recognized in the group with portocaval shunt. COnCLUSIOn： These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词： Hyperperfusion syndrome Liver regeneration Portocaval shunt Postoperative liver dysfunction Sinusoidal microcirculatory injury Small-for-size liver transplantation

慢性丙型肝炎治疗中利巴韦林诱发突变效应和干扰素联用利巴韦林疗法的应答

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 55-56页

作者： Asahina Y. Izumi n. enomoto n. 纪泛扑 Division of Gastroenterology and Hepatology Musashino Red Cross Hospital 1- 26- 1 Kyonan-cho Musashino-shi Tokyo 180- 8610 Japan

Background/Aims: To elucidate whether ribavirin acts as a mutagen in the clinical setting and to clarify the relationship between ribavirin-induced mutations and virological response to combined therapy. Methods: Thirty-four patients with hepatitis C virus (HCV) genotype 1b received ribavirin monotherapy for 4 weeks, followed by a 24-week course of IFn/ribavirin therapy. HCV mutations during a non-treatment observation period and during subsequent ribavirin monotherapy were determined, and the relationship between mutations and response to subsequent IFn/ribavirin therapy was evaluated. Results: Serum HCV significantly decreased from 6.90 to 6.56 log10copy/ml in response to ribavirin monotherapy (P nucleotide mutations in the nS5A and nS5B regions occurred during ribavirin monotherapy at a rate of 2.9× 10- 2/site/year and 1.3× 10- 2/site/year, respectively, a significantly higher rate than the mutation rates during the prior non-treatment observation period (0.60× 10- 2/site/year and 0.24× 10- 2/site/year, P = 0.02, respectively). Mutation rates in the nS5A region were significantly higher in sustained viral responders (SVRs, n = 10) than in non-responders (8.8× 10- 2/site/year vs. 0.38× 10- 2/site/year, P = 0.0005, respectively). In the nS5A region, non-synonymous mutations only occurred in SVRs. Conclusions: Ribavirin may act as a mutagen, and mutations occurring during ribavirin therapy correlate with the virological response to subsequent IFn/ribavirin combination therapy.

关键词：慢性丙型肝炎病毒学应答诱发突变诱变剂核苷酸突变持续病毒应答突变率应答者突变情况非同

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Ultrasonogram of hepatocellular carcinoma is associated with outcome after radiofrequency ablation

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World Journal of Hepatology 2012年第12期4卷 374-381页

作者： Kosaku Moribata Hideyuki Tamai naoki Shingaki Yoshiyuki Mori Tatsuya Shiraki Shotaro enomoto Hisanobu Deguchi Kazuki Ueda Izumi Inoue Takao Maekita Mikitaka Iguchi Masao Ichinose Second Department of Internal Medicine Wakayama Medical University

AIM: To investigate the association between B-mode ultrasound classification of small hepatocellular carcinoma (HCC) and outcome after radiofrequency ablation (RFA).

关键词： B-mode ultrasound Hepatocellular carcinoma Radiofrequency ablation Recurrence Prognosis

用地理信息系统研究1993年钏路近海地震破坏和地震烈度分布的评估方法

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世界地震译丛 1996年第6期27卷 58-63页

作者： K.Amakuni K.Masunaga T.Mochizuki T.enomoto H.Kagami n.Okada 王永才河北省地震局

引言 1993年1月15日钏路近海地震是震级为7.8的强震,震源深度约为30 km,震中位于北海道钏路近海,北海道至关东地区有感,由于接近震源,钏路市烈度鉴定为日本烈度表的6度。震后4天本文诸作者开始在现场调查,包括破坏调查和场地信息的搜集... 详细信息

引言 1993年1月15日钏路近海地震是震级为7.8的强震,震源深度约为30 km,震中位于北海道钏路近海,北海道至关东地区有感,由于接近震源,钏路市烈度鉴定为日本烈度表的6度。震后4天本文诸作者开始在现场调查,包括破坏调查和场地信息的搜集,然后用约2～3个月的时间,

关键词： GIS 地震烈度震源深度钏路近海

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Intervertebral disc development and disease-related genetic polymorphisms

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Genes & Diseases 2016年第3期3卷 171-177页

作者： Jason W.Ashley Motomi enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaUSA Department of Surgery Division of Orthopaedic SurgeryChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA School of Biomedical Sciences The University of Hong KongHong Kong Department of Orthopedic Surgery University of ChicagoChicagoILUSA Corporal Michael J.Crescenz Veterans Affairs Medical Center PhiladelphiaPAUSA Department of Medicine Perelman School of MedicineUniversity of PennsylvaniaUSA Department of Orthopedic Surgery Rush University Medical CenterChicagoILUSA Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaUSA

The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;nP)and concentric rings(annulus fibrosus;AF).The nP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic *** vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until ***,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical *** its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and *** pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue *** factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the *** summary,the spinal column is a landmark development in *** directing the development of the IVD may also contribute to its maintenance,degeneration,and ***,structural genes as well as genes responsible for maintenance of the structure are related to IVD ***,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context.

关键词： Back pain Development Intervertebral disc(IVD) notochord Regeneration

Efficacy and Tolerability of Second-Line Metronidazole Triple Therapy Using Vonoprazan for Helicobacter pylori Eradication in Japan—Comparative Study: Vonoprazan vs. Proton Pump Inhibitors

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Open Journal of Gastroenterology 2018年第1期8卷 27-38页

作者： Masahiko Ohtaka Mika Miura Mitsuhiko Hanawa Yuichi Hirose Atsuko Kitahashi naoki Imamura Ikko Watanabe Kazuhiko Takaso naoki Shimura Yoshioki Yoda Ichiro Takayama Mitsuharu Fukasawa nobuyuki enomoto Yamanashi Koseiren Health Care Center Yamanashi Japan First Department of Internal Medicine Graduate School of Medical and Engineering Science University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan

Aim: To investigate the efficacy and tolerability of second-line metronidazole triple therapy with vonoprazan (VPZ) for Helicobacter pylori (H. pylori). Methods: We retrospectively reviewed medical records of patients who experienced clarithromycin triple therapy failure and were treated with second-line (20 mg VPZ (n = 274)/30 mg lansoprazole (n = 323) or 10 mg rabeprazole (n = 141) twice daily, 750 mg amoxicillin twice daily, 250 mg metronidazole twice daily for 7 days) eradication therapies. Successful eradication rates were compared between two groups: those receiving VPZ and those receiving a proton pump inhibitor (PPI). Adverse events were also investigated. Results: Successful second-line eradication rates according to ITT analysis and PP analysis, respectively, were 79.9% and 92.4% for VPZ therapy and 83.6% and 93.3% for PPI therapy. There were no significant differences between treatment groups. The eradication rates in those who had received first-line VPZ therapy previously according to ITT and PP analysis were 75.2% and 88.1%, respectively;in contrast, values were 82.5% and 95.4%, respectively, for those who had received first-line PPI therapy previously. In second-line therapy, the overall adverse event rate for VPZ therapy was the same as for PPI therapy. Conclusions: The efficacy and tolerability of metronidazole-containing second-line triple therapy with VPZ or a PPI were equivalent.

关键词： Vonoprazan Metronidazole Proton Pump Inhibitor Second-Line Eradication Helicobacter pylori

乳酸菌制剂LFK抑制变态反应炎症的实验研究

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乳酸菌制剂LFK抑制变态反应炎症的实验研究