检索结果-南通市图书馆

Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy

Cellular & Molecular Immunology 2021年第6期18卷 1353-1374页

作者： M.J.Mansilla S.Presas-Rodríguez A.Teniente-Serra I.González-Larreategui B.Quirant-Sánchez F.Fondelli n.djedovic D.Iwaszkiewicz-Grześ K.Chwojnicki D.Miljković PTrzonkowski C.Ramo-Tello E.M.Martínez-Cáceres Division of Immunology LCMNGermans Trias i Pujol University Hospital and Research InstituteBarcelonaSpain Department of Cellular Biology Physiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Multiple Sclerosis Unit Department of NeurosciencesGermans Trias i Pujol University HospitalBarcelonaSpain Department of Medicine Universitat Autònoma de BarcelonaBellaterraSpain View author publications Department of Immunology Institute for Biological Research“Siniša Stanković”-National Institute of Republic of SerbiaUniversity of BelgradeBelgradeSerbia Department of Medical Immunology Medical University of GdańskGdańskPoland Poltreg S.A. GdańskPoland Department of Anaesthesiology&Intensive Care Medical University of GdańskGdańskPoland

Multiple sclerosis(MS)is a leading cause of chronic neurological disability in young to middle-aged adults,affecting~2.5 million people ***,most therapeutics for MS are systemic immunosuppressive or immunomodulatory drugs,but these drugs are unable to halt or reverse the disease and have the potential to cause serious adverse ***,there is an urgent need for the development of next-generation treatments that,alone or in combination,stop the undesired autoimmune response and contribute to the restoration of *** review analyzes current MS treatments as well as different cell-based therapies that have been proposed to restore homeostasis in MS patients(tolerogenic dendritic cells,regulatory T cells,mesenchymal stem cells,and vaccination with T cells).Data collected from preclinical studies performed in the experimental autoimmune encephalomyelitis(EAE)model of MS in animals,in vitro cultures of cells from MS patients and the initial results of phase I/II clinical trials are analyzed to better understand which parameters are relevant for obtaining an efficient cell-based therapy for MS.

关键词： multiple sclerosis cell-based therapy tolerance neuroprotection autoimmunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：