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神经精神药理学治疗药物监测共识指南:2017版

实用药物与临床 2022年第1期25卷 1-20页

作者： C.Hiemke n.bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.J.Müller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.Uhr S.Ulrich S.Unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(主译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(审校) 王传跃(审校) 王刚(审校) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of MainzMainzGermany Kitzberg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Servizio Psichiatrico del Comprensorio Sanitario di Bolzano BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany Medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological Medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry Unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum München-Ost Psychiatric HospitalMunich-HaarGermany Department of

治疗药物监测(Therapeutic Drug Monitoring,TDM)通过定量测定和解释血药浓度以优化药物治疗。TDM着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDM的主要患者群体包括少年儿童... 详细信息

治疗药物监测(Therapeutic Drug Monitoring,TDM)通过定量测定和解释血药浓度以优化药物治疗。TDM着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDM的主要患者群体包括少年儿童、孕妇、老年患者、智障患者、药物滥用者、涉法精神病患者、已知或怀疑药代动力学异常的患者以及合并躯体疾病影响药代动力学的患者。常规剂量下治疗无效,用药依从性难以判断,药物耐受性不佳,以及可能存在药代动力学方面的药物-药物相互作用等情况都是治疗药物监测的典型指征。然而,只有将TDM充分整合到临床治疗过程中,才能发挥其优化药物治疗的潜在优势。为了向临床医生和实验室提供有效的TDM信息,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für neuropsychopharmakologie und Pharmakopsychiatrie,AGnP)的TDM专家组在2004年发表了第一版《精神科治疗药物监测指南》。2011年进行了更新之后,现在再次更新。遵循新版指南,可能会改善神经精神药物治疗的效果,加快很多患者的康复,并降低医疗费用。

关键词：抗凝药物妊娠期静脉血栓栓塞疾病抗抑郁药抗癫痫药抗帕金森病药抗精神病药血药浓度共识指南药物分析基因型分析神经药物遗传药理学药代动力学表型分析血浆药物浓度精神药物参考范围血清药物浓度治疗药物监测治疗窗

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神经精神药理学治疗药物监测共识指南:2017版

引用

实用药物与临床 2022年第2期25卷 97-118页

作者： C.Hiemke n.bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.JMüller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.Uhr S.Ulrich S.Unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(译) 王传跃(译) 王刚(译) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of MainzMainzGermany Kitzberg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Servizio Psichiatrico del Comprensorio Sanitario di Bolzano BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany Medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological Medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry Unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum München-Ost Psychiatric HospitalMunich-HaarGermany Department of

2.2剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的... 详细信息

2.2剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的药物浓度与理论预期药物浓度范围。参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群(“正常”患者),在日维持剂量(Daily maintenance dose,D m)、给药间隔(Dosing interval,d i)、总清除率(Total clearance,CL)和生物利用度(Bioavailability,F)已知情况下,某种药物在某个“正常”患者体内的预期平均稳态浓度(Average steady-state concentration,C av)可通过下面的公式计算。

关键词：治疗药物监测药效动力学给药间隔维持剂量生物利用度药物浓度药代动力学合并用药

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A new mutually destabilized reactive hydride system:LiBH4–Mg2niH4

引用

Journal of Energy Chemistry 2019年第7期28卷 240-254页

作者： nils bergemann Claudio Pistidda Maike Uptmoor Chiara Milanese Antonio Santoru Thomas Emmler Julián Puszkiel Martin Dornheim Thomas Klassen Department of nanotechnology Institute of Materials ResearchHelmholtz-Zentrum Geesthacht21502GeesthachtGermany Pavia Hydrogen Lab C.S.G.I.and Chemistry DepartmentPhysical Chemistry SectionUniversity of Pavia27100 PaviaItaly Institute of Materials Technology Helmut-Schmidt-University22043 HamburgGermany

In this work,the hydrogen sorption properties of the LiBH4-Mg2niH4 composite system with the molar ratio 2:2.5 were thoroughly investigated as a function of the applied temperature and hydrogen *** the best of our knowledge,it has been possible to prove experimentally the mutual destabilization between LiBH4 and Mg2niH4.A detailed account of the kinetic and thermodynamic features of the dehydrogenation process is reported here.

关键词： Hydrogen storage Metal hydrides Borohydrides Reactive Hydride Composites(RHC) Mutual destabilization Ternary borides

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Copper as an alternative antimicrobial coating for implants-An in vitro study

引用

World Journal of Transplantation 2017年第3期7卷 193-202页

作者： Claudia bergemann Sarah Zaatreh Katharina Wegner Kathleen Arndt Andreas Podbielski Rainer Bader Cornelia Prinz Ulrich Lembke J Barbara nebe Department of Cell Biology University Medical Center Rostock Biomechanics and Implant Technology Research Laboratory University Medical Center Rostock Institute of Medical Microbiology Virology and HygieneUniversity Medical Center Rostock DOT GmbH

AIM To investigate osteoconductive and antimicrobial properties of a titanium-copper-nitride(TiC un) film and an additional BOnIT~? coating on titanium *** For micro-structuring, the surface of titanium test samples was modified by titanium plasma spray(TPS). On the TPS-coated samples, the Ti Cu n layer was deposited by physical vapor deposition. The BOnIT~? layer was coated electrochemically. The concentration of copper ions released from TiC un films was measured by atomic absorption spectrometry. MG-63 osteoblasts on Ti Cu n and BOnIT~? were analyzed for cell adhesion, viability and spreading. In parallel, Staphylococcus epidermidis(S. epidermidis) were cultivated on the samples and planktonic and biofilm-bound bacteria were quantified bycounting of the colony-forming units. RESULTS Field emission scanning electron microscopy(FESEM) revealed rough surfaces for TPS and TiC un and a special crystalline surface structure on TiC un + BOnIT~?. TiC un released high amounts of copper quickly within 24 h. These release dynamics were accompanied by complete growth inhibition of bacteria and after 2 d, no planktonic or adherent S. epidermidis were found on these samples. On the other hand viability of MG-63 cells was impaired during direct cultivation on the samples within 24 h. However, high cell colonization could be found after a 24 h pre-incubation step in cell culture medium simulating the in vivo dynamics closer. On pre-incubated TiC un, the osteoblasts span the ridges and demonstrate a flattened, well-spread phenotype. The additional BOnIT~?-coating reduced the copper release of the TiC un layer significantly and showed a positive effect on the initial cell *** The Ti Cu n-coating inhibits the formation of bacterial biofilms on orthopedic implants by influencing the "race for the surface" to the advantage of osteoblasts.

关键词： Implant-coating Antimicrobial effect Titanium plasma spray Titanium-copper-nitride BOnIT^(®) Osteoconductivity

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AGnP精神科治疗药物监测共识指南：2011

引用

实用药物与临床 2016年第10期19卷 1193-1218页

作者： Hiemke C Baumann P bergemann n Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) Department of Psychiatry and Psychotherapy University MedicalCenter of MainzGermany Department of Psychiatry University of LausannePrilly-LausanneSwitzerland Psychiatric Hospital Bad ArolsenGermany Psychiatric Hospital BolzanoItaly Psychiatrc Hospital WeinsbergGermany Department Child and Adolescent Psychiatry University Hospital of WurzburgGermany Kliniken des Bezirks Oberbayern(kbo)Salzach-Inn-Klinikum Was-serburg a.InnGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry and Psychotherapy University of AachenGermany Clinical Pharmacology Department of Psychiatry and Psychoso-maticsUniversity of RegensburgGermany Department of Psychiatry and Psychosomatics University of GotingenGermany Psychiatric Hospital KonigsfeldenBruggAargauSwitzerland Medical Laboratory Bremen Germany Department of Psychiatry and Psychotherapy University of TubingenGermany Psychiatric Hospital PfaffenhofenGermany Psychiatric Hospital Marburg and GieβenGermany Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WurzburgGermany Center of Epilepsy BielefeldGermany Psychiatric Hospital HaarGermany Department of Pharmacology of natural Products and ClinicalPharmacology University of UlmGermany Max Planck Institute of Psychiatry MunichGermany Aristo Pharma GmbH BerlinGermany Psychiatric Hospital FeldkirchAustria Experimental Psychiatry Unit Department of Psychiatry and PsychotherapyMedical University of InnsbruckAustria 首都医科大学附属北京安定医院北京 Emory University School of Medicine AtlantaUSA

治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代... 详细信息

治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für neuropsychopharmakologie und Pharmakopsychiatrie,AGnP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从"强烈推荐"到"可能有用"的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的"治疗参考浓度范围"和"剂量相关参考浓度范围"呈现给大家。本共识指南引入了"实验室警戒浓度"的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。

关键词：共识指南药物分析药代动力学精神药物治疗参考浓度范围治疗药物监测治疗窗

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