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Effects of K and n nutrition on Function and Production of Ranunculus asiaticus

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Pedosphere 2011年第3期21卷 288-301页

作者： n.bernstein M.IOFFE G.LURIA M.BRUnER Y.nISHRI S.PHILOSOPH-HADAS S.SALIM I.DORI E.MATAn Institute of Soil Water and Environmental Science AROThe Volcani CenterPOB 6 Extension Service Ministry of Agriculture Department of Postharvest Science of Fresh Produce AROThe Volcani Center Havat Habsor R&D SouthMP Negev 4

Potassium （K） affects a range of physiological processes in the plant and is a key factor controlling crop productivity and yield quality. Little information is available concerning effects of K nutrition on function of cut flower plants. The present study was carried out to investigate the interaction between K and n nutrition, on flower quantity and quality of Ranunculus asiaticus L. The plants were supplied with three levels of K fertigation （60, 120, or 180 mg K L-1） under 50 mg n L-1 application, and at the intermediate level of 120 mg K L-1, to three levels of n applications （50, 100, or 150 mg n L-l）. The two lowest K treatments and the lowest n treatment excelled in flower production due to the lower incidence of stem-toppling, a disorder associated with localized Ca deficiencies in rapidly expanding tissues of the flower stem. Detrimental effects in terms of yield quality were apparent already under supply of 180 mg K L-1 and 50 mg n L-1, and were not associated with changes in osmotic potential, relative water content or membrane stability of the plant tissue, or with changes in mineral contents of the leaves other than reduced Ca under high n application. Our results suggest a low nutritional requirement of R. asiaticus L. for K and n, a lack of involvement of tissue water relations in the reduced flower quality under the application of high concentrations of K and n, and an induction of stem toppling under high application of n and K by reduced availability of Ca to the expanding tissue of the flower stem.

关键词： calcium cut-flower plant nutrition stem-topple

2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南

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胃肠病学 2010年第9期15卷 548-558页

作者： Charles n.bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌杨川华钱本余

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和... 详细信息

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。

关键词：炎症性肠病克罗恩病溃疡性结肠炎实践指南级联

Impact of intrarectal chromofungin treatment on dendritic cellsrelated markers in different immune compartments in colonic inflammatory conditions

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World Journal of Gastroenterology 2021年第47期27卷 8138-8155页

作者： Kunal Kapoor nour Eissa Diane Tshikudi Charles n.bernstein Jean-Eric Ghia Department of Immunology University of ManitobaWinnipeg R3E0T5MBCanada Children's Hospital Research Institute of Manitoba University of ManitobaWinnipeg R3E0T5MBCanada Section of Gastroenterology Department of Internal MedicineRady Faculty of Health SciencesUniversity of ManitobaWinnipeg R3E0T5MBCanada University of Manitoba IBD Clinical and Research Centre University of ManitobaWinnipeg R3E0T5MBCanada

BACKGROUnD Chromofungin(CHR:chromogranin-A 47-66)is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial *** colitis(UC)is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c+*** To investigate the association between CHR treatment and dendritic cells(DCs)-related markers in different immune compartments in *** A model of acute UC-like colitis using dextran sulphate sodium(DSS)was used in addition to biopsies collected from UC *** Intrarectal CHR treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the expression of CD11c,CD40,CD80,CD86 and interleukin(IL)-12p40 in the inflamed colonic mucosa and CD11c,CD80,CD86 IL-6 and IL-12p40 within the mesenteric lymph nodes and the ***,CHR treatment decreased CD80 and CD86 expression markers of splenic CD11c+cells and decreased nF-κB expression in the colon and of splenic CD11c+*** vitro,CHR decreased CD40,CD80,CD86 IL-6 and IL-12p40 expression in naïve bone marrow-derived CD11c+DCs stimulated with *** studies demonstrated an impact of CHR on the nF-κB *** patients with active UC,CHR level was reduced and showed a negative linear relationship with CD11c and *** CHR has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+*** could be a potential therapy of UC.

关键词： Chromofungin Chromogranin-A Colitis Cytokines Dendritic cells Gut hormones

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World Journal of Gastrointestinal Oncology 2014年第7期6卷 225-243页

作者： Anil R Prasad Shilpa Prasad Huy nguyen Alexaner Facista Cristy Lewis Beryl Zaitlin Harris bernstein Carol bernstein Department of Pathology Northwest Medical Center Tucson AZ 85741 United States Department of Pathology College of Medicine University of Arizona Tucson AZ 85724 United States College of Arts and Sciences Boston University Boston MA 2215 United States Department of Cellular and Molecular Medicine College of Medicine University of Arizona Tucson AZ 85724 United States Matrix Solutions Inc. Alberta T2R 0V2 Canada

AIM:To investigate the close parallels between our novel diet-related mouse model of colon cancer and human colon ***:Twenty-two wild-type female mice(ages 6-8 wk)were fed the standard control diet(AIn-93G)and an additional 22 female mice(ages 6-8 wk)were fed the control diet supplemented with 0.2%deoxycho-lic acid[diet+deoxycholic acid(DOC)]for 10 ***-mors occurred in the colons of mice fed diet+DOC and showed progression to colon cancer[adenocarcinoma(AC)].This progression is through the stages of tubular adenoma(TA),TA with high grade dysplasia or ad-enoma with sessile serrated morphology,intramucosal AC,AC stage T1,and AC stage *** mouse tumors were compared to human tumors at the same stages by histopathological *** of the small and large intestines of mice and humans were evaluated for glandular architecture,cellular and nuclear morphology including cellular orientation,cellular and nuclear atyp-ia,pleomorphism,mitotic activity,frequency of goblet cells,crypt architecture,ulceration,penetration of crypts through the muscularis mucosa and presence of malignant crypts in the muscularis *** addition,preserved colonic tissues from genetically similar male mice,obtained from a prior experiment,were analyzed by *** male mice had been fed the control diet or diet+*** molecular markers were evaluated:8-OH-dG,DnA repair protein ERCC1,autophagy protein beclin-1 and the nuclear location of beta-catenin in the stem cell region of ***,male mice fed diet+DOC plus 0.007%chlorogenic acid(diet+DOC+CGA)were evaluated for ERCC1,beclin-1 and nuclear location of ***:Humans with high levels of diet-relatedDOC in their colons are at a substantially increased riskof developing colon *** mice fed diet+DOChad levels of DOC in their colons comparable to that ofhumans on a high fat *** 22 mice without addedDOC in their diet had no colonic tumors while 20 ofthe 22 mice(91%)fed diet+DOC deve

关键词： Diet Deoxycholate Mouse model Colon cancer Histology Chlorogenic acid 8-OH-dG Beclin 1 Beta-catenin

De novo exploration and self-guided learning of potentialenergy surfaces

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npj Computational Materials 2019年第1期5卷 262-270页

作者： noam bernstein Gábor Csányi Volker L.Deringer Center for Materials Physics and Technology U.S.Naval Research LaboratoryWashingtonDC 20375USA Department of Engineering University of CambridgeCambridge CB21PZUK Department of Chemistry University of OxfordOxford OX13QRUK

Interatomic potential models based on machine learning(ML)are rapidly developing as tools for material ***,because of their flexibility,they require large fitting databases that are normally created with substantial manual selection and tuning of reference ***,we show that ML potentials can be built in a largely automated fashion,exploring and fitting potential-energy surfaces from the beginning(de novo)within one and the same *** key enabling step is the use of a configuration-averaged kernel metric that allows one to select the few most relevant and diverse structures at each *** resulting potentials are accurate and robust for the wide range of configurations that occur during structure searching,despite only requiring a relatively small number of single-point DFT calculations on small unit *** apply the method to materials with diverse chemical nature and coordination environments,marking an important step toward the more routine application of ML potentials in physics,chemistry,and materials science.

关键词： apply routine searching

Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey

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World Journal of Gastroenterology 2019年第30期25卷 4246-4260页

作者： Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna naftali Rami Eliakim Ofer Ben-Bassat Charles n.bernstein Eran Israeli Institute of Gastroenterology and Liver Diseases Hadassah-Hebrew University Medical CenterJerusalem 91120Israel Department of Gastroenterology Galilee Medical CenterFaculty of Medicine in the GalileeBar-Ilan UniversityNahariya 22100Israel IBD Clinical and Research Centre University of ManitobaWinnipegMB R3E3P4Canada Research Branch IDF Medical CorpsTel-HashomerRamat Gan 52630Israel Institute of Gastroenterology Meir Medical CenterKfar-saba 4428164Israel Sackler School of Medicine Tel-Aviv UniversityTel-Aviv 6997801Israel Institute of Gastroenterology Sheba Medical CenterRamat-Gan 52630Israel Institute of Gastroenterology Rabin Medical CenterPetach-Tikva 49100Israel

BACKGROUnD Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on *** informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their *** large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and *** hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the *** To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information *** We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current *** performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study *** Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six *** responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P nts w

关键词： Inflammatory bowel diseases Information needs Patient education Knowledge resources Patient profiles

Abomasal infusion of branched-chain amino acids or branched-chain keto-acids alter lactation performance and liver triglycerides in fresh cows

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1145-1157页

作者： Kristen Gallagher Isabelle bernstein Cynthia Collings David Main Ghayyoor Ahmad Sarah naughton Jayasimha Daddam Vengai Mavangira Mike Vandehaar Zheng Zhou Department of Animal Science Michigan State UniversityEast Lansing 48824USA Department of Veterinary Diagnostic and Production Animal Medicine Ames 50011USA

Background Dairy cows are at high risk of fatty liver disease in early lactation,but current preventative measures are not always *** with fatty liver have lower circulating branched-chain amino acid(BCAA)concentra-tions whereas cows with high circulating BCAA levels have low liver triglyceride(TG).Our objective was to determine the impact of BCAA and their corresponding ketoacids(branched-chain ketoacids,BCKA)on production performance and liver TG accumulation in Holstein cows in the first 3 weeks *** Thirty-six multiparous Holstein cows were used in a randomized block design *** were abomasally infused for the first 21 d postpartum with solutions of 1)saline(COn,n=12);2)BCA(67 g valine,50 g leu-cine,and 34 g isoleucine,n=12);and 3)BCK(77 g 2-ketovaline calcium salt,57 g 2-ketoleucine calcium salt,and 39 g 2-ketoisoleucine calcium salt,n=12).All cows received the same *** effects were determined using PROC GLIMMIX in *** no differences were detected for body weight,body condition score,or dry matter intake averaged over the first 21 d *** receiving BCK had significantly lower liver TG concentrations compared to COn(6.60%vs.4.77%,standard error of the mean(SEM)0.49)during the first 3 weeks of *** of BCA increased milk yield(39.5 vs.35.3 kg/d,SEM 1.8),milk fat yield(2.10 vs.1.69 kg/d,SEM 0.08),and lactose yield(2.11 vs.1.67 kg/d,SEM 0.07)compared with *** to COn,cows receiving BCA had lower plasma glucose(55.0 vs.59.2 mg/dL,SEM 0.86)but higherβ-hydroxybutyrate(9.17 vs.6.00 mg/dL,SEM 0.80).Conclusions Overall,BCAA supplementation in this study improved milk production,whereas BCKA supplementa-tion reduced TG accumulation in the liver of fresh cows.

关键词： Branched-chain amino acids Branched-chain ketoacids Fatty liver Fresh cow

A Mountain‑Pass Theorem for Asymptotically Conical Self‑Expanders

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Peking Mathematical Journal 2022年第2期5卷 213-278页

作者： Jacob bernstein Lu Wang Department of Mathematics Johns Hopkins University3400 N.Charles StreetBaltimoreMD 21218USA Department of Mathematics California Institute of Technology1200 E.California BoulevardPasadenaCA 91125USA Present Address:Department of Mathematics Yale University10 Hillhouse AvenueNew HavenCT 06511USA

We develop a min–max theory for asymptotically conical self-expanders of mean curvature *** particular,we show that given two distinct strictly stable selfexpanders that are asymptotic to the same cone and bound a do... 详细信息

关键词： Self-expander Mean curvature flow Min-max theory

Machine-learned interatomic potentials for alloys and alloy phase diagrams

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npj Computational Materials 2021年第1期7卷 139-147页

作者： Conrad W.Rosenbrock Konstantin Gubaev Alexander VShapeev Livia B.Pártay noam bernstein Gábor Csányi Gus L.W.Hart Department of Physics and Astronomy Brigham Young UniversityProvoUTUSA84602 Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel Str.3Moscow 143026Russia Department of Chemistry University of ReadingWhiteknightsReading RG66ADUK Department of Chemistry University of WarwickCoventry CV47ALUK US naval Research Laboratory Center for Computational Materials ScienceWashingtonDC 20375USA Department of Engineering University of CambridgeTrumpington StreetCambridge CB21PZUK

We introduce machine-learned potentials for Ag-Pd to describe the energy of alloy configurations over a wide range of *** compare two different *** tensor potentials(MTPs)are polynomial-like functions of interatomic distances and *** Gaussian approximation potential(GAP)framework uses kernel regression,and we use the smooth overlap of atomic position(SOAP)representation of atomic neighborhoods that consist of a complete set of rotational and permutational invariants provided by the power spectrum of the spherical Fourier transform of the neighbor *** types of potentials give excellent accuracy for a wide range of compositions,competitive with the accuracy of cluster expansion,a benchmark for this *** both models are able to describe small deformations away from the lattice positions,SOAP-GAP excels at transferability as shown by sensible transformation paths between configurations,and MTP allows,due to its lower computational cost,the calculation of compositional phase *** the fact that both methods perform nearly as well as cluster expansion but yield off-lattice models,we expect them to open new avenues in computational materials modeling for alloys.

关键词： alloy alloys phase