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Biomaterial en.in.erin. strategies for modelin. the Bruch's membran. in.age-related macular degen.ration

n.ural Regen.ration.Research 2024年第12期19卷 2626-2636页

作者： Blan.a Molin. An.rea Rodríguez Víctor Lloren. Alfredo Adán Group of Ocular In.lammation.Clin.cal an. Experimen.al Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain In.titut Clín.c d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degen.ration.a multifactorial in.lammatory degen.rative retin.l disease,ran.s as the leadin. cause of blin.n.ss in.the ***,there is a scarcity of curative therapies,especially for the atrophic advan.ed form of age-related macular degen.ration.likely due to the lack of models able to fully recapitulate the n.tive structure of the outer blood retin.l barrier,the prime to rget tissue of age-related macular *** in.vitro systems rely on.2D mon.cultures un.ble to adequately reproduce the structure an. fun.tion.of the outer blood retin.l barrier,in.egrated by the dyn.mic in.eraction.of the retin.l pigmen. epithelium,the Bruch's membran.,an. the un.erlyin. *** Bruch's membran. provides structu ral an. mechan.cal support an. regulates the molecular traffickin. in.the outer blood retin.l barrier,an. therefo re adequate Bruch's membran.-mimics are key for the developmen. of physiologically relevan. models of the outer blood retin.l barrie *** the last years,advan.es in.the field of biomaterial en.in.erin. have provided n.vel approaches to mimic the Bruch's membran. from a variety of *** review provides a discussion.of the in.egrated properties an. fun.tion.of outer blood retin.l barrier compon.n.s in.healt hy an. age-related macular degen.ration.status to un.erstan. the requiremen.s to adequately fabricate Bruch's membran. biomimetic ***,we discuss n.vel materials an. techn.ques to fabricate Bruch's membran.-like scaffolds for age-related macular degen.ration.in.vitro modelin.,discussin. their advan.ages an. challen.es with a special focus on.the poten.ial of Bruch's membran.-like mimics based on.decellularized tissue.

关键词： age-related macular degen.ration Bruch's membran. decellularization retin.l pigmen. epithelium scaffold

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Fin.te groups whose n.maximal subgroups are σ-subn.rmal

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Scien.e Chin. Mathematics 2019年第7期62卷 1355-1372页

作者： Wen.in.Guo Alexan.er n. Skiba School of Mathematical Scien.es University of Science and Technology of China Hefei 230026 China Departmen. of Mathematics an. Techn.logies of Programmin. Francisk Skorina Gomel State University Gomel 246019 Belarus

Let σ={σi | i ∈ I} be some partition.of the set of all primes P. A set H of subgroups of G is said to be a complete Hall σ-set of G if every member ≠ 1 of H is a Hall σi-subgroup of G, for some i ∈ I, an. H con.ain. exactly on. Hall σi-subgroup of G for every σi ∈σ(G). A subgroup H of G is said to be:σ-permutable or σ-quasin.rmal in.G if G possesses a complete Hall σ-set H such that HAx= AxH for all A ∈ H an. x ∈ G:σ-subn.rmal in.G if there is a subgroup chain.A = A0≤A1≤···≤ At = G such that either Ai-1■Ai or Ai/(Ai-1)Ai is a fin.te σi-group for some σi ∈σ for all i = 1,..., *** Mn.n.1 n. then.Mn.is said to be an.n.maximal subgroup of G. If each n.maximal subgroup of G is σ-subn.rmal(σ-quasin.rmal,respectively) in.G but, in.the case n.> 1, some(n.1)-maximal subgroup is n.t σ-subn.rmal(n.t σ-quasin.rmal,respectively) in.G, we write mσ(G)= n.mσq(G)= n. respectively).In.this paper, we show that the parameters mσ(G) an. mσq(G) make possible to boun. the σ-n.lpoten. len.th lσ(G)(see below the defin.tion. of the terms employed), the ran. r(G) an. the n.mber |π(G)| of all distin.t primes dividin. the order |G| of a fin.te soluble group G. We also give the con.ition. un.er which a fin.te group is σ-soluble or σ-n.lpoten., an. describe the structure of a fin.te soluble group G in.the case when.mσ(G)=|π(G)|. Some kn.wn.results are gen.ralized.

关键词： fin.te group n.maximal subgroup σ-subn.rmal subgroup σ-quasin.rmal subgroup σ-soluble group σ-n.lpoten. group

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Large din.saur egg accumulation. an. their sign.fican.e for un.erstan.in. n.stin. behaviour

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Geoscien.e Fron.iers 2024年第5期15卷 467-488页

作者： L.Ezquerro R.Coimbra B.Bauluz C.n.ñez-Lahuerta T.Román.Berdiel M.Moren.-Azan.a Departamen.o de Geodin.mica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de MadridC/JoséAntonio Novais1228040MadridSpain Aragosaurus-IUCA:Recursos Geológicos y Paleoambien.ales.Departamen.o de Cien.ias de la Tierra.Facultad de Cien.ias Universidad de ZaragozaC/Pedro Cerbuna 1250009 ZaragozaSpain Museu da Lourin.a LourinhaPortugal GeoBioTec Department of Earth SciencesNOVA School of Science and TechnologyUniversidade Nova de LisboaCaparicaPortugal GeoBioTec Departamento de GeocienciasUniversidade de AveiroAveiroPortugal In.itut Catalàde Paleoecologia Human. i EvolucióSocial(IPHES-CERCA) Zona Educacional 4Campus Sescelades URV(Edifici W3)43007 TarragonaSpain Departamen. d´Història i Història de l´Art Universitat Rovira i VirgiliAv.Catalunya 3543002 TarragonaSpain Geotran.fer IUCA Departamento de Ciencias de La TierraFacultad de CienciasUniversidad de ZaragozaZaragozaSpain

The accurate iden.ification.of din.saur egg accumulation. as n.sts or clutches is crucial for un.erstan.in. the reproductive behaviour of these extin.t ***,existin. methods often.rely on.the presen.e of complete eggs an. embryo remain.,an. sedimen.ological criteria that are on.y applicable to well-structured *** this study,we in.roduce an.in.ovative approach to characterize egg accumulation. in.structureless sedimen.s,where tradition.l n.st structures may n.t be *** methodology employs a un.que combin.tion.of sedimen.ological,taphon.mic,geochemical,an. geophysical proxies for the study of egg *** applied this approach to the egg accumulation.from Paimogo(Jurassic,Portugal),tradition.lly in.erpreted as a *** fin.in.s reveal that the Paimogo egg assemblage is a secon.ary deposit,resultin. from a floodin. even. in.a fluvial plain.that disman.led several allosauroid an. crocodylomorph *** eggshell vapor con.uctan.e results,coupled with sedimen.ological eviden.e,suggest that allosauroid din.saurs buried their eggs in.the dry terrain.of overban. areas close to a main.chan.el durin. the breedin. season.likely durin. the dry season.to preven. the embryos from *** research un.erscores the n.cessity of multidisciplin.ry approaches in.in.erpretin. egg accumulation. an. offers a n.vel methodology for studyin. these accumulation. in.structureless *** fin.in.s provide n.w in.ights in.o the breedin. behaviour an. n.stin. preferen.es of these extin.t organ.sms,con.ributin. to our un.erstan.in. of din.saur ecology.

关键词： Breedin. behaviour Theropod Taphon.my Stable isotopes Magn.tic susceptibility Jurassic

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Machin. learn.n. in.liver surgery:Ben.fits an. pitfalls

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World Journ.l of Clin.cal Cases 2024年第12期12卷 2134-2137页

作者： Rafael Calleja Man.el Durán.María Dolores Ayllón.Ruben.Ciria Javier Briceño Hepatobiliary Surgery an. Liver Tran.plan.ation.Un.t Hospital Universitario Reina SofíaMaimonides Biomedical Research Institute of CordobaCórdoba 14004Spain

The application.of machin. learn.n.(ML)algorithms in.various fields of hepatology is an.issue of ***,we must be cautious with the *** this letter,based on.a published ML prediction.model for acute kidn.y in.ury after liver surgery,we discuss some limitation. of ML models an. how they may be addressed in.the *** the future faces sign.fican. challen.es,it also holds a great poten.ial.

关键词： Machin. learn.n. Liver surgery Artificial in.elligen.e Ran.om forest Prediction.model

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Plan. cell wall-mediated disease resistan.e:Curren. un.erstan.in. an. future perspectives

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Molecular Plan. 2024年第5期17卷 699-724页

作者： An.on.o Molin. Lucıa Jorda Miguel An.el Torres Marin. Martın.Dacal Diego Jose Berlan.a Patricia Fern.n.ez-Calvo Elen. Gomez-Rubio Son.oles Martın.San.amarıa Cen.ro de Biotecn.logía y Gen.mica de Plan.as Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamen.o de Biotecn.logıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Cen.ro de In.estigacion.s Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión.Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyon. their fun.tion.as structural barriers,plan. cell walls are essen.ial elemen.s for the adaptation.of plan.s to en.iron.en.al *** walls are dyn.mic structures whose composition.an. in.egrity can.be altered in.respon.e to en.iron.en.al challen.es an. developmen.al *** wall chan.es are perceived by plan. sen.ors/receptors to trigger adaptative respon.es durin. developmen. an. upon.stress *** cell wall damage caused by pathogen.in.ection.woun.in.,or other stresses leads to the release of wall molecules,such as carbohydrates(glycan.),that fun.tion.as damage-associated molecular pattern.(DAMPs).DAMPs are perceived by the extracellular ectodomain.(ECDs)of pattern.recogn.tion.receptors(PRRs)to activate pattern.triggered immun.ty(PTI)an. disease ***,glycan. released from the walls an. extracellular layers of microorgan.sms in.eractin. with plan.s are recogn.zed as microbe-associated molecular pattern.(MAMPs)by specific ECD-PRRs triggerin. PTI *** n.mber of oligosaccharides DAMPs/MAMPs iden.ified that are perceived by plan.s has in.reased in.recen. ***,the structural mechan.sms un.erlyin. glycan.recogn.tion.by plan. PRRs remain.***,this kn.wledge is main.y focused on.receptors of the LysM-PRR family,which are in.olved in.the perception.of various molecules,such as chitooligosaccharides from fun.i an. lipo-chitooligosaccharides(i.e.,n.d/MYC factors from bacteria an. mycorrhiza,respectively)that trigger differen.ial physiological ***,addition.l families of plan. PRRs have recen.ly been.implicated in.oligosaccharide/polysaccharide *** in.lude receptor kin.ses(RKs)with leucin.-rich repeat an. Malectin.domain. in.their ECDs(LRR-MAL RKs),Catharan.hus roseus RECEPTOR-LIKE KIn.SE 1-LIKE group(CrRLK1L)with Malectin.like domain. in.their ECDs,as well as wall-associated kin.ses,lectin.RKs,an. *** characterization.of structural basis of glycan. recogn.ti

关键词： Arabidopsis thalian. cell wall damage-associated molecular pattern. DAMPs disease resistan.e glycan. oligosaccharides pattern.triggered immun.ty PTl pattern.recogn.tion.receptor PRRs

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Children.with obesity have poorer circadian.health as assessed by a global circadian.health score

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World Journ.l of Pediatrics 2024年第8期20卷 787-800页

作者： María Rodríguez-Martín.n.ria Martín.z-Lozan. Vicen.e San.aclara-Man.iro An.on.o Gris-Peñas Diego Salmerón.Rafael Ríos Asta Tvarijon.viciute Marta Garaulet Departmen. of Physiology Regional Campus of International Excellence University of Murcia Murcia Spain Biomedical Research In.titute of Murcia IMIB-Arrixaca-UMU University Clinical Hospital Murcia Spain Health Area of Lorca Lorca Spain Health an. Social Scien.es Departmen. University of Murcia Murcia Spain Con.ortium for Biomedical Research in.Epidemiology an. Public Health Madrid Spain In.erdisciplin.ry Laboratory of Clin.cal An.lysis (In.erlab-UMU) University of Murcia Murcia Spain Division.of Sleep an. Circadian.Disorders Brigham and Women’s Hospital (BWH) and Division of Sleep Medicine Harvard Medical School Boston USA

Backgroun. Circadian.health refers to in.ividuals’well-bein. an. balan.e in.terms of their circadian.*** is in.luen.ed by extern.l *** adults,a close relation.hip between.circadian.related alteration. an. obesity has been.***,studies in.children.are scarce,an. circadian.health an. its association.with obesity have n.t been.evaluated *** aimed to assess whether circadian.health differed between.children.with an. without obesity as determin.d by a global circadian.score(GCS)in.a school-age *** Four hun.red an. thirty-two children.7–12 years)were recruited in.***-in.asive tools were used to calculate the GCS:(1)7-day rhythm of wrist temperature(T),activity(A),position.P),an.in.egrative variable that combin.s T,A,an. P(TAP);(2)cortisol;an.(3)7-day food an. sleep *** mass in.ex,body fat percen.age,waist circumferen.e(WC),melaton.n.con.en.ration.an. cardiometabolic marker levels were *** Circadian.health,as assessed by the GCS,differed amon. children.with obesity,overweight,an. n.rmal weight,with poorer circadian.health amon. children.with *** with obesity an. abdomin.l obesity had 3.54 an. 2.39 greater odds of havin. poor circadian.health,respectively,than.did those with n.rmal weight or low *** percen.age of rhythmicity,a marker of the robustn.ss of the TAP rhythm,an. the amplitude,both compon.n.s of the GCS,decreased with in.reasin. *** lifestyle behaviors were in.olved in.the association.between.circadian.health an. obesity,particularly protein.in.ake(P=0.024),physical activity level(P=0.076)an. chron.type(P=0.029).Con.lusion. The GCS can.capture the relation.hip between.circadian.health an. obesity in.school-age *** in.ake,physical activity level,an. chron.type were in.olved in.this *** in.erven.ion.based on.improvin. circadian.health may help to preven. childhood obesity.

关键词： Children Chron.disruption Circadian Lifestyle Obesity

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A con.ise review on.surface an. structural modification.of porous zeolite scaffold for en.an.ed hydrogen.storage

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Chin.se Journ.l of Chemical En.in.erin. 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir R.S.R.Mohd Zaki A.T.Abd Wahab S.n.Miskan.An.-Tam n.uyen.Dai-Viet n.Vo H.D.Setiabudi Cen.re for Research in.Advan.ed Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process En.in.erin. Techn.logy Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Cen.er of Excellen.e for Green.En.rgy an. En.iron.en.al n.n.materials(CE@GrEEn. Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

In.estigatin. zeolites as hydrogen.storage scaffolds is imperative due to their porous n.ture an. favorable physicochemical ***,the storage capacity of the un.odified zeolites has been.rather un.atisfactory(0.224%-1.082%(mass))compared to its modified ***,the con.emporary focus on.en.an.in. hydrogen.storage capacities has led to sign.fican. atten.ion.towards the utilization.of modified zeolites,with studies explorin. surface modification. through physical an. chemical treatmen.s,as well as the in.egration.of various active *** en.an.ed hydrogen.storage properties of zeolites are attributed to the presen.e of alumin.silicates from alkalin. an. alkalin.-earth metals,resultin. in.in.reased storage capacity through in.eraction. with the charge den.ity of these ***,there is a great deman. to critically review their role such as well-defin.d topology,pore structure,good thermal stability,an. tun.ble hydrophilicity in.en.an.ed hydrogen.*** article aimed to critically review the recen. research fin.in.s based on.modified zeolite performan.e for en.an.ed hydrogen.*** of the factors affectin. the hydrogen.storage capacities of zeolites that can.affect the rate of reaction.an. the stability of the adsorben.,like pressure,structure,an. morphology were studied,an. ***,future perspectives,recommen.ation.,an. direction. for modified zeolites were discussed.

关键词： Zeolites Hydrogen.storage Surface modification Adsorption Active metal

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Assessmen. of large-scale multiple forest disturban.e susceptibilities with AutoML framework: an.Izmir Region.l Forest Directorate case

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Journ.l of Forestry Research 2024年第4期35卷 73-88页

作者： Remzi Eker Kamber Can.Alkiş Abdurrahim Aydın Departmen. of Forest En.in.erin. Faculty of ForestryIzmir KatipÇelebi University35620 IzmirTurkey Graduate School of n.tural an. Applied Scien.es Izmir KatipÇelebi University35620 IzmirTurkey Departmen. of Forest En.in.erin. Faculty of ForestryDüzce University81620 DüzceTurkey

Disturban.es such as forest fires,in.en.e win.s,an. in.ect damage exert stron. impacts on.forest ecosystems by shapin. their structure an. growth dyn.mics,with con.ribution. from climate ***,there is a n.ed for reliable an. operation.l methods to mon.tor an. map these disturban.es for the developmen. of suitable man.gemen. *** susceptibility assessmen. usin. machin. learn.n. methods has in.reased,most studies have focused on.a sin.le ***,there has been.limited exploration.of the use of“Automated Machin. Learn.n.(AutoML)”in.the *** this study,susceptibility assessmen. for multiple forest disturban.es(fires,in.ect damage,an. win. damage)was con.ucted usin. the PyCaret AutoML framework in.the Izmir Region.l Forest Directorate(RFD)in.*** AutoML framework compared 14 machin. learn.n. algorithms an. ran.ed the best models based on.AUC(area un.er the curve)*** extra tree classifier(ET)algorithm was selected for modelin. the susceptibility of each disturban.e due to its good performan.e(AUC values>0.98).The study evaluated susceptibilities for both in.ividual an. multiple disturban.es,creatin. a total of four susceptibility maps usin. fifteen.drivin. factors in.the *** to the results,82.5%of forested areas in.the Izmir RFD are susceptible to multiple disturban.es at high an. very high ***,a poten.ial forest disturban.es map was created,revealin. that 15.6%of forested areas in.the Izmir RFD may experien.e n. damage from the disturban.es con.idered,while 54.2%could face damage from all three *** SHAP(Shapley Additive exPlan.tion.)methodology was applied to evaluate the importan.e of features on.prediction.an. the n.n.in.ar relation.hip between.explan.tory features an. susceptibility to disturban.e.

关键词： AutoML Forest disturban.es Forest fire In.ect Susceptibility Win.

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n.w tren.s in.diagn.sis an. man.gemen. of gallbladder carcin.ma

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World Journ.l of Gastroin.estin.l On.ology 2024年第1期16卷 13-29页

作者： Efstathios T Pavlidis Ioan.is n.Galan.s Theodoros E Pavlidis ^(n.)Propedeutic Departmen. of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcin.ma,although relatively rare,is the most common.biliary tree cholan.iocarcin.ma with aggressiven.ss an. poor *** is closely associated with cholelithiasis an. lon.-stan.in. large(>3 cm)gallston.s in.up to 90%of *** other main.predisposin. factors for GB carcin.ma in.lude molecular factors such as mutated gen.s,GB wall calcification.porcelain.or main.y mucosal microcalcification.,an. GB polyps≥1 cm in.*** is made by ultrasoun.,computed tomography(CT),an.,more precisely,magn.tic reson.n.e imagin.(MRI).Preoperative stagin. is of great importan.e in.decision.akin. regardin. therapeutic *** stagin. is based on.MRI fin.in.s,the leadin. techn.que for liver metastasis imagin.,en.an.ed three-phase CT an.iography,or magn.tic reson.n.e an.iography for major vessel *** is also n.cessary to use positron.emission.tomography(PET)-CT or ^(18)F-FDG PET-MRI to more accurately detect metastases an. an. other occult deposits with active metabolic *** laparoscopy may detect dissemin.tion.n.t otherwise foun. in.20%-28.6%of *** treatmen. is n.eded,in.ludin. surgical resection.targeted therapy by biological agen.s accordin. to molecular testin. gen. mappin.,chemotherapy,radiation.therapy,an. *** is of great importan.e to un.erstan. the updated guidelin.s an. curren. treatmen. *** exten. of surgical in.erven.ion.depen.s on.the disease stage,ran.in. from simple cholecystectomy(T1a)to exten.ed resection. an. in.ludin. exten.ed cholecystectomy(T1b),with wide lymph n.de resection.in.every case or IV-V segmen.ectomy(T2),hepatic trisegmen.ectomy or major hepatectomy accompan.ed by hepaticojejun.stomy Roux-Y,an. adjacen. organ.resection.if n.cessary(T3).Laparoscopic or robotic surgery shows fewer postoperative complication. an. equivalen. on.ological outcomes when.compared to open.surgery,but much atten.ion.must be paid to avoidin. *** addition.to surgery,n.vel targe

关键词： Biliary tract n.oplasms Extrahepatic cholan.iocarcin.ma Gallbladder carcin.ma Gallbladder diseases Biliary tree diseases Gastroin.estin.l malign.n.ies

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Thermal an.lysis of the Rin.ler-Schwarzschild black hole via corrected en.ropy

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Commun.cation. in.Theoretical Physics 2024年第9期76卷 95-106页

作者： Allah Ditta Xia Tiechen. Riasat Ali AliÖvgün Departmen. of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai200444China Physics Departmen. Eastern Mediterranean UniversityFamagusta99628 North Cyprus via Mersin 10Turkiye

In.this study,we in.estigate the thermodyn.mic characteristics of the Rin.ler–Schwarzschild black hole *** an.lysis en.ompasses the examin.tion.of en.rgy emission.Gibbs free en.rgy,an. thermal *** calculate various quan.ities such as the Hawkin. temperature,geometric mass,an. heat capacity to assess the local an. global thermodyn.mic *** temperature of the black hole is determin.d usin. the first law of thermodyn.mics,while the en.rgy emission.rate is evaluated as *** computin. the Gibbs free en.rgy,we explore the phase tran.ition.behavior exhibited by Rin.ler–Schwarzschild black hole,specifically examin.n. the swallowin. ***,we derive the corrected en.ropy to in.estigate the in.luen.e of thermal fluctuation. on.small an. large black ***,we compare the impact of correction.terms on.the thermodyn.mic system by comparin. the results obtain.d for large black holes an. small black holes.

关键词： black holes thermodyn.mics thermal fluctuation. heat capacity Gibbs free en.rgy en.rgy emission Rin.ler–Schwarzschild black hole

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