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Selective Separation.of Au（lll） by the Column.of Algin.te Xerogel Microcapsules En.losin. TOA Extractan.

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Journ.l of Chemistry an. Chemical En.in.erin. 2012年第5期6卷 462-469页

作者： Ran. Syed Masud Hitoshi mimura Yuichi n.ibori Departmen. of Quan.um Scien.e ＆ En.rgy En.in.erin. Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Relation.hip between.Social Capital an. Cogn.tive Fun.tion. amon. Commun.ty-Based Elderly

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Advan.es in.Alzheimer's Disease 2017年第2期6卷 45-51页

作者： Sayuri Takechi Kimio Yoshimura Yuko Oguma Yoshin.bu Saito Masaru mimura Departmen. of n.uropsychiatry Keio University School of Medicine Tokyo Japan Departmen. of Health Policy an. Man.gemen. Keio University School of Medicine Tokyo Japan Graduate School of Health Man.gemen. Keio University Fujisawa Japan Sports Medicin. Research Cen.er Keio University Yokohama Japan

The con.ept of social capital en.ompasses all relation.hips an. n.tworks amon. people in.a local commun.ty or society as a whole. It has been.foun. to be associated with the health an. daily livin. status of people. Furthermore, an.association.between.social capital an. cogn.tive fun.tion. amon. the elderly has been.suggested in.recen. years. However, the n.mber of such reports is very few. Hen.e, the presen. study aims to evaluate the relation.hip between.social capital an. cogn.tive fun.tion. amon. the elderly livin. in.a local commun.ty in.Japan. A question.aire survey was admin.stered to 192 elderly in.ividuals belon.in. to 10 n.ighborhood elderly groups. A regression.an.lysis was con.ucted to determin. the relation.hip between.cogn.tive fun.tion. an. the level of en.agemen. with the local commun.ty, after adjustin. for age, gen.er, an. symptoms of depression. Valid respon.es were collected from 145 participan.s (mean.age: 75.3 years). An.an.lysis of the data con.ern.n. the level of en.agemen. with the local commun.ty revealed a sign.fican. differen.e in.the cogn.tive fun.tion.scores between.the group of people who in.icated that they had someon. they could con.ult (n.= 69) an. the group that in.icated they had n. on. to con.ult (n.= 76) (regression.coefficien.: -0.61, p = 0.0038, 95% con.iden.e in.erval: -1.02 to -0.20). This result in.icates the existen.e of a sign.fican. correlation.between.social capital an. cogn.tive fun.tion. of the elderly livin. in.a local commun.ty. In.future studies, we n.ed to in.estigate the same with a larger n.mber of participan.s from a wider geographical area, an. by in.orporatin. more in.icators for a comprehen.ive evaluation.of social capital.

关键词： Social Capital Cogn.tive Fun.tion. Elderly Commun.ty

Application.of Magn.tic Particle Imagin. to Pulmon.ry Imagin. Usin. n.bulized Magn.tic n.n.particles

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Open.Journ.l of Medical Imagin. 2015年第2期5卷 49-55页

作者： Kohei n.shimoto Atsushi mimura Marin. Aoki n.tsuo Ban.ra Ken.a Murase Departmen. of Medical Physics an. En.in.erin. Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: To in.estigate the feasibility of applyin. magn.tic particle imagin. (MPI) to pulmon.ry imagin. usin. n.bulized magn.tic n.n.particles (Mn.s) an. to quan.ify the mucociliary clearan.e in.the lun., usin. small an.mal experimen.s. Materials an. Methods: In.rapulmon.ry admin.stration.of Mn.s was performed in.seven.week-old male ICR (In.titute of Can.er Research) mice (n.= 8) usin. a n.bulized microsprayer con.ected to a high-pressure syrin.e con.ain.n. 50 μL of Mn.s (500 mM Resovist®). We imaged the lun.s usin. our MPI scan.er 2.5 hours, 1 day, 3 days, an. 7 days after the in.rapulmon.ry admin.stration.of Mn.s. The average MPI value was calculated by drawin. a region.of in.erest (ROI) on.the lun.s by takin. the threshold value for extractin. the con.our as 20% of the maximum MPI value within.the ROI. The MPI value was defin.d as the pixel value of the tran.verse image recon.tructed from the third-harmon.c sign.ls. Mice were sacrificed immediately after the last MPI an. X-ray CT studies on.day 7, an. 5 lobes of the lun. in.each mouse were extracted to con.irm the accumulation.of iron.usin. Berlin.blue stain.n.. Results: We could visualize the distribution.of Mn.s in.the lun.s as positive con.rast usin. MPI with use of n.bulized Mn.s. The presen.e of iron.in.the lun. was con.irmed by Berlin.blue stain.n.. The average MPI value decreased with time an. ten.ed to saturate. The clearan.e rate was calculated to be 0.505 day&min.s;1 from the time course of the average MPI value in.the lun.s. Con.lusion. Our prelimin.ry results suggest that MPI can.be applied to pulmon.ry imagin. by n.bulizin. Mn.s an. can.be useful for quan.ifyin. the mucociliary clearan.e in.the lun..

关键词： Magn.tic Particle Imagin. Pulmon.ry Imagin. n.bulized Magn.tic n.n.particles An.mal Experimen.s

Magn.tic Particle Imagin. for Magn.tic Hyperthermia Treatmen.: Visualization.an. Quan.ification.of the In.ratumoral Distribution.an. Temporal Chan.e of Magn.tic n.n.particles in.Vivo

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Open.Journ.l of Medical Imagin. 2016年第1期6卷 1-15页

作者： Tomomi Kuboyabu Isamu Yabata Marin. Aoki n.tsuo Ban.ra Kohei n.shimoto Atsushi mimura Ken.a Murase Departmen. of Medical Physics an. En.in.erin. Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: Magn.tic hyperthermia treatmen. (MHT) is a strategy for can.er therapy usin. the tem-perature rise of magn.tic n.n.particles (Mn.s) un.er an.altern.tin. magn.tic field (AMF). Re-cen.ly, a n.w imagin. method called magn.tic particle imagin. (MPI) has been.in.roduced. MPI allows imagin. of the spatial distribution.of Mn.s. The purpose of this study was to in.estigate the feasibility of visualizin. an. quan.ifyin. the in.ratumoral distribution.an. temporal chan.e of Mn.s an. predictin. the therapeutic effect of MHT usin. MPI. Materials an. Methods: Colon.26 cells (1 × 106 cells) were implan.ed in.o the backs of eight-week-old male BALB/c mice. When.the tumor volume reached approximately 100 mm3, mice were divided in.o un.reated (n.= 10) an. treated groups (n.= 27). The tumors in.the treated group were directly in.ected with Mn.s (Resovist?) with iron.con.en.ration. of 500 mM (A, n.= 9), 400 mM (B, n.= 8), an. 250 mM (C, n.= 10), respectively, an. MHT was performed usin. an.AMF with a frequen.y of 600 kHz an. a peak amplitude of 3.5 kA/m. The mice in.the treated group were scan.ed usin. our MPI scan.er immediately before, immediately after, 7 days, an. 14 days after MHT. We drew a region.of in.erest (ROI) on.the tumor in.the MPI image an. calculated the average, maximum, an. total MPI values an. the n.mber of pixels by takin. the threshold value for extractin. the con.our as 40% of the maximum MPI value (pixel value) within.the ROI. These parameters in.the un.reated group were taken.as zero. We also measured the relative tumor volume growth (RTVG) defin.d by (V-V0)/V0, where V0 an. V are the tumor volumes immediately before an. after MHT, respectively. Results: The average, maximum, an. total MPI values decreased up to 7 days after MHT an. remain.d almost con.tan. thereafter in.all groups, whereas the n.mber of pixels ten.ed to in.rease with time. The RTVG values in.Groups A an. B were sign.fican.ly lower than.those in.the con.rol group 3 days or more an. 5 day

关键词： Magn.tic Particle Imagin. Magn.tic Hyperthermia Treatmen. Magn.tic n.n.particles In.ratumoral Distribution Temporal Chan.e

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营养输液和它的生产

氨基酸和生物资源 1982年第4期10卷 45-51页

作者： T.Takami Ya Yugari n.mimura 孙淑卿日本味之素公司沈阳第一制药厂药物研究所

我们日本味之素公司(东京都中央区京桥1街6号)根据日本专利法,申报发明,请求专利权,如愿获得批准,现将专利内容评述如下: 我们发明的是一种静脉营养输液和营养液的生产工艺。这种输液适用于患有慢。

关键词：日本味之素公司肾机能不全中央区克分子比异亮氨酸精氨酸无机阴离子正氮平衡东京都无菌蒸馏水

Usefuln.ss of Magn.tic Particle Imagin. for Predictin. the Therapeutic Effect of Magn.tic Hyperthermia

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Open.Journ.l of Medical Imagin. 2015年第2期5卷 85-99页

作者： Ken.a Murase Marin. Aoki n.tsuo Ban.ra Kohei n.shimoto Atsushi mimura Tomomi Kuboyabu Isamu Yabata Departmen. of Medical Physics an. En.in.erin. Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: To in.estigate the usefuln.ss of magn.tic particle imagin. (MPI) for predictin. the therapeutic effect of magn.tic hyperthermia (MH). Materials an. Methods: First, we performed phan.om experimen.s to in.estigate the relation.hip between.the MPI value an. the temperature rise of magn.tic n.n.particles (Mn.s) un.er an.altern.tin. magn.tic field (AMF). The MPI value was defin.d as the pixel value of the tran.verse image recon.tructed from the third-harmon.c sign.ls. Samples filled with various iron.con.en.ration. of Mn.s (Resovist®) were prepared an. were imaged usin. our MPI scan.er. These samples were also heated usin. the AMF, an. the specific loss power (SLP) an. volume-specific loss power (vSLP) were calculated from the in.tial slope of the time-depen.en. temperature rise. Secon., we performed an.mal experimen.s usin. tumor-bearin. mice, which were divided in.o un.reated (n.= 10) an. treated groups (n.= 20). The tumors in.the treated group were in.ected with Resovist®?at an.iron.con.en.ration.of 250 mM (n.= 10) or 500 mM (n.= 10), an. received MH for 20 min. durin. which the temperatures in.the tumor an. rectum were measured. The relative tumor volume growth (RTVG) was calculated from (V15 -?V0)/V0, where V0 an. V15 represen.ed the tumor volume on.day 0 an. day 15 after MH, respectively. Results: In.phan.om experimen.s, the MPI value had sign.fican. correlation. with the iron.con.en.ration.of Mn.s (r = 0.997), temperature rise (r = 0.981), an. vSLP (r = 0.961). In.an.mal experimen.s, the MPI value had sign.fican. correlation. with the temperature rise in.the tumor (r = 0.731) an. RTVG (r = ﹣0.687). Con.lusion. Our prelimin.ry results suggest that MPI is useful for predictin. the therapeutic effect of MH.

关键词： Magn.tic Particle Imagin. Magn.tic Hyperthermia Magn.tic n.n.particles Phan.om Experimen.s An.mal Experimen.s

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n.硅微尖场发射电子能谱的模拟计算

发光学报 2008年第3期29卷 557-560页

作者：元光曹崇龙宋翠华宋航屿拹秀隆三村秀典中国海洋大学物理系山东青岛266100 中国科学院激发态物理重点实验室吉林长春130033 日本静冈大学电子工学研究所日本滨松

结合金属的场发射电子能谱,模拟计算了场渗透对n.半导体硅微尖的场发射能谱的影响,并与n.硅微尖的场发射能谱实验结果进行了比较,讨论了模拟计算误差的来源。计算结果表明电场渗透现象导致硅的场发射能谱向低能方向偏移,表面电场越高... 详细信息

结合金属的场发射电子能谱,模拟计算了场渗透对n.半导体硅微尖的场发射能谱的影响,并与n.硅微尖的场发射能谱实验结果进行了比较,讨论了模拟计算误差的来源。计算结果表明电场渗透现象导致硅的场发射能谱向低能方向偏移,表面电场越高,能谱的偏移量越大,其偏移程度可超过1eV。导致硅微尖的场发射能谱偏移的主要因素是半导体的场渗透现象。

关键词：场发射电子能谱硅微尖电场渗透