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RBC aggregation.deformation.an. adhesion.to en.othelium:Role of n.tric oxide derived from L-Argin.n. an. sodium n.troprusside

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Journ.l of In.ovative Optical Health Scien.es 2024年第5期17卷 53-65页

作者： M.K.Maksimov P.B.Ermolin.kiy O.n.Scheglovitova n.n.Sklyan.in. A.V.Muravyov A.E.Lugovtsov A.V.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya n.tion.l Research Cen.er for Epidemiology an. Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushin.ky Yaroslavl State Pedagogical Un.versity 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abun.an. human.blood *** aggregation.an. deformation.stron.ly determin. blood viscosity which impacts hemorheology an. *** turn.RBC properties depen. on.di®eren. en.ogen.us an. exogen.us *** such factor is n.tric oxide(n.),which is main.y produced by en.othelial cells(EC)from L-argin.n. amin. acid in.the circulatory *** the mechan.sms of the RBC-en.othelium in.erplay are n.t clear up to date an. con.iderin. its possible clin.cal importan.e,the aims of this study are to in.estigate in.vitro:(1)The e®ect of L-argin.n. in.uced n. on.RBC aggregation.an. adhesion.to en.othelium;(2)the n. e®ect on.RBC aggregation.an. deformation.in.uced by L-argin.n. an. sodium n.troprusside without the presen.e of en.othelium in.the *** RBC aggregation.an. adhesion.to a mon.layer of EC were studied usin. optical tweezers(OT).The RBC deformability an. aggregation.without en.othelium in.the samples were studied usin. the°ow chamber method an. Myren.e *** con.rmed that n. in.reases deformability an. decreases aggregation.of *** showed that the soluble guan.late cyclase pathway appears to be the on.y n. sign.lin. pathway *** the samples with the en.othelium,the\bell-shaped"depen.en.e of RBC aggregation.force on.L-argin.n. con.en.ration.was observed,which improves our kn.wledge about the process of n. production.by ***,data related to L-argin.n. accumulation.by en.othelium were obtain.d:n.cessity of the presen.e of extracellular L-argin.n. stated by other authors was put un.er *** our study,n. decreased the RBC-en.othelium adhesion.however,the ten.en.y appeared to be weak an. was n.t con.rmed in.an.ther set of *** our kn.wledge,this is the¯rst attempt to measure the forces of RBC adhesion.to en.othelium mon.layer with OT.

关键词： Red blood cells aggregation L-argin.n. en.othelium optical tweezers Myren.e flow chamber

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A FLEXIBLE OBJECTIVE-COn.TRAIn. APPROACH An. A n.W ALGORITHM FOR COn.TRUCTIn. THE PARETO FROn. OF MULTIOBJECTIVE OPTIMIZATIOn.PROBLEMS

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Acta Mathematica Scien.ia 2024年第2期44卷 702-720页

作者： n.HOSEIn.OOR M.GHAZn.VI Faculty of Mathematical Scien.es Shahrood University of TechnologyShahroodIran

In.this article, a n.vel scalarization.techn.que, called the improved objective-con.train. approach, is in.roduced to fin. efficien. solution. of a given.multiobjective programmin. problem. The presen.ed scalarized problem exten.s the objective-con.train. problem. It is demon.trated that how addin. variables to the scalarized problem, can.lead to fin. con.ition. for (weakly, properly) Pareto optimal solution.. Applyin. the obtain.d n.cessary an. sufficien. con.ition., two algorithms for gen.ratin. the Pareto fron. approximation.of bi-objective an. three-objective programmin. problems are design.d. These algorithms are easy to implemen. an. can.achieve an.even.approximation.of (weakly, properly) Pareto optimal solution.. These algorithms can.be gen.ralized for optimization.problems with more than.three criterion.fun.tion., too. The effectiven.ss an. capability of the algorithms are demon.trated in.test problems.

关键词： multiobjective optimization Pareto fron. scalarization objective-con.train. approach proper efficien. solution

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Proximity to corridors ben.fits bird commun.ties in.vegetated in.errow vin.yards in.Men.oza, Argen.in.

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Avian.Research 2024年第2期15卷 147-155页

作者： An.rea Paula Goijman.Agustín.Zarco EEA La Con.ulta Instituto Nacional de Tecnología Agropecuaria(INTA)San CarlosMendozaArgentina In.tituto Argen.in. de In.estigacion.en.las Zon.s Aridas(IADIZA)COn.CET 5500MendozaArgentina

Man.gemen. un.er ecological schemes an. in.reasin. habitat heterogen.ity,are essen.ial for en.an.in. biodiversity in.*** provide several con.ribution. to agriculture,for example pest con.rol,recreation.an. en.an.in. human.men.al health,an. have in.rin.ic *** are also ideal model organ.sms because they are easy to survey,an. species respon. differen.ly to agricultural lan. use at differen. *** borders of crops are key for man. species of birds,an. distan.e to the border have been.foun. to be an.importan. factor in.vin.yard-domin.ted *** evaluate if there are differen.es in.the bird assemblage,between.the in.erior compared to borders within.vin.yards,usin. a hierarchical commun.ty occupan.y *** hypoth-esized that occupan.y of birds is greater in.en.iron.en.s with greater heterogen.ity,which in.this study was con.idered to be con.ributed by the proximity to vegetated *** expected that vin.yard borders close to corridors will have higher bird occupan.y than.the cen.er of the *** research was con.ucted in.three vin.yards with biodiversity-frien.ly man.gemen. practices,in.Gualtallary,Men.oza,*** surveys were con.ucted over three breedin. season. from 2018 to *** an. richn.ss of the bird commun.ty was more closely associated with the borders adjacen. to the corridors than.with the in.erior of the vin.yards,as we in.tially predicted,although the assemblage of birds did n.t differ *** than.75%of the registered species con.ume exclusively or partially ***-frien.ly man.gemen. an. ecological schemes,together with vegetated corridors provide multiple ben.fits for biodiversity *** ap-proaches n.t on.y min.mize the use of agrochemicals but also prioritize soil cover with spon.an.ous vegetation.which supports a diverse commun.ty of in.ectivorous bird species,poten.ially con.ributin. to pest con.rol.

关键词： Avian Bayesian.an.lysis Field scale agroecosystem Man.gemen. Multi-species occupan.y model n.ture’s con.ribution. to people

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Clin.cal profile an. outcomes in.very elderly patien.s with atrial fibrillation.an.icoagulated with rivaroxaban. data from the EMIR study

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Journ.l of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Fran.isco Marín.Man.el An.uita Sán.hez Iñaki Lekuon. Marcelo San.artín.Fern.n.dez Viven.io Barrios Carlos Perez Muñoz Juan.Cosín.Sales Alejan.ro IPérez Cabeza Van.sa Roldán.Schillin. Carles Rafols Priu Esteban.Oren.s-Piñero María Asun.ión.Es-teve-Pastor Departmen. of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Departmen. of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usan.olo BizkaiaSpain Departmen. of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Departmen. of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Cen.er La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Departmen. of Cardiology Hospital Arnau de VilanovaValenciaSpain Departmen. of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Departmen. of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Departmen. of Medical Affairs Bayer HispaniaBarcelonaSpain Departmen. of Biochemistry an. Molecular Biology-A University of MurciaMurciaSpain

Objectives To an.lyze the clin.cal profile,adequacy of treatmen. with rivaroxaban.an. outcomes in.octogen.rian. with atrial fibrillation.AF),takin. rivaroxaban.in.clin.cal *** Observation.l an. n.n.in.erven.ion.l study that in.luded AF adults recruited from 79 Span.sh cen.ers,an.icoagulated with rivaroxaban.≥ 6 mon.hs before bein. *** were an.lyzed accordin. to age(≥ 80 vs.n.s,453(31.6%) were octogen.rian. at *** to youn.er patien.s,octogen.rian. had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P n. HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P n.was adequately prescribed in.83.4% of patien.s,but more frequen.ly in.the youn.er population.71.1% vs.89.1%;P = 0.039).After a mean.follow-up of 2.2 ± 0.6 years,an.ual rates of stroke + systemic embolism + tran.ien. ischemic attack,MACE,cardiovascular death an. major bleedin. were 1.03%,1.24%,1.03% an. 1.75%,respectively,in.octogen.rian.*** for progressive heart failure death an. major bleedin.,rates of outcomes in.octogen.rian. were similar compared to youn.er *** octogen.rian.,the con.omitan. use of an.iplatelet agen.s an. n.n.severe demen.ia were in.epen.en.ly associated with the developmen. of ischemic stroke,whereas previous coron.ry revascularization.an. heart failure with MACE,an. higher HAS-BLED score with major *** In.clin.cal practice,aroun. on. third of patien.s takin. rivaroxaban.are *** patien.s have man. comorbidities an. a high thromboembolic *** that,rates of adverse even.s remain.*** is adequately prescribed in.the majority of octogen.rian..

关键词： patien.s atrial bleedin.

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Astrophysical S-factor an. reaction.rate for 15n.p,γ)16O within.the modified poten.ial cluster model

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Chin.se Physics C 2024年第4期48卷 130-145页

作者： S.B.Dubovichen.o A.S.Tkachen.o R.Ya.Kezerashvili n.A.Burkova B.M.Yeleusheva Fesen.ov Astrophysical In.titute 050020 AlmatyKazakhstan n.w York City College of Techn.logy City University of New YorkBrooklyn11201 New YorkUSA Graduate School an. Un.versity Cen.er City University of New York10016 New YorkUSA al-Farabi Kazakh n.tion.l Un.versity 050040 AlmatyKazakhstan

We study radiative p^(15)n.capture on.the groun. state of ^(16)O at stellar en.rgies within.the framework of a modified poten.ial cluster model(MPCM)with forbidden.states,in.ludin. low-lyin. *** in.estigation.of the ^(15)n.p,γ0)^(16)O reaction.in.ludes the con.ideration.of ^(3)S_(1) reson.n.es due to E1 tran.ition. an. the con.ribution.of the ^(3)P_(1) scatterin. wave in.the p+^(15)n.chan.el due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-en.rgy S-factor,an. the extrapolated S(0)turn.d out to be within.34.7−40.4 keV·*** importan. role of the asymptotic con.tan.(AC)for the ^(15)n.p,γ0)16O process with in.erferin. ^(3)S_(1)(312)an. ^(3)S_(1)(962)reson.n.es is elucidated.A comparison.of our calculation.for the S-factor with existin. experimen.al an. theoretical data is addressed,an. a reason.ble agreemen. is *** reaction.rate is calculated an. compared with the existin. *** has n.gligible depen.en.e on.the variation.of AC but shows a stron. impact of the in.erferen.e of ^(3)S_(1)(312)an. ^(3)S_(1)(962)reson.n.es in.referen.e to the Cn. Gamow win.ows,especially at low *** estimate the con.ribution.of cascade tran.ition. to the reaction.rate based on.the exclusive experimen.al data from ***.C.85,065810(2012).The reaction.rate en.an.emen. due to the cascade tran.ition. is observed from T_(9)>0.3 an. reaches the maximum factor~1.3 at T_(9)=*** presen. the Gamow en.rgy win.ow an. a comparison.of rates for radiative proton.capture reaction. ^(12)n.p,γ)^(13)O,^(13)n.p,γ)^(14)O,^(14)n.p,γ)^(15)O,an. ^(15)n.p,γ)^(16)O obtain.d in.the framework of the MPCM an. provide the temperature win.ows,prevalen.e,an. sign.fican.e of each process.

关键词： low an. astrophysical en.rgies p^(15)n.system thermon.clear reaction.rate poten.ial cluster model Cn.-cycle

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Omics-based biomarkers as useful tools in.metabolic dysfun.tion.ssociated steatotic liver disease clin.cal practice:How far are we?

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World Journ.l of Gastroen.erology 2024年第14期30卷 1982-1989页

作者： Julieta Trin.s María F Mascardi Adrián.Gadan. Sebastián.Marcian. In.tituto de Medicin. Traslacion.l e In.en.ería Biomédica-Con.ejo n.cion.l de In.estigacion.s Cien.íficas y Técn.cas-In.tituto Un.versitario del Hospital Italian.-Hospital Italian. de Buen.s Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Con.ejo n.cion.l de In.estigacion.s Cien.íficas y Técn.cas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Un.t Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Departmen. of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Un.et n.eds exist in.metabolic dysfun.tion.associated steatotic liver disease(MASLD)risk *** ability to iden.ify patien.s with MASLD with advan.ed fibrosis an. at higher risk for adverse outcomes is still *** n.vel biomarkers could represen. a mean.n.ful improvemen. to curren. risk *** this aim,omics techn.logies have revolution.zed the process of MASLD biomarker discovery over the past *** the research in.this field is thrivin.,much of the publication.has been.haphazard,often.usin. sin.le-omics data an. specimen.sets of con.en.en.e,with man. iden.ified can.idate biomarkers but lackin. clin.cal validation.an. *** we in.orporate these biomarkers to direct patien.s’man.gemen.,it should be con.idered that the roadmap for tran.latin. a n.wly discovered omics-based sign.ture to an.actual,an.lytically valid test useful in.MASLD clin.cal practice is rigorous an.,therefore,n.t easily *** article presen.s an.overview of this area’s curren. state,the con.eivable opportun.ties an. challen.es of omics-based laboratory diagn.stics,an. a roadmap for improvin. MASLD biomarker research.

关键词： Metabolic dysfun.tion.associated steatotic liver disease n.n.alcoholic steatohepatitis Biomarker Risk stratification Omics

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Un.upervised in.rusion.detection.system for in.vehicle commun.cation.n.tworks

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Journ.l of Safety Scien.e an. Resilien.e 2024年第2期5卷 119-129页

作者： Kabilan.n.Vin.yakumar Ravi V Sowmya Cen.er for Computation.l En.in.erin. an. n.tworkin.(CEn. Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Cen.er for Artificial In.lligen.e Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In.vehicle commun.cation.has been.optimized day to day to keep updated of the *** area n.twork(CAn.is used as a stan.ard commun.cation.method because of its efficien. an. reliable ***,CAn.is pron. to several n.twork level attacks because of its lack in.security *** methods have been.in.roduced to in.orporate this in.*** proposed an.un.upervised method of in.rusion.detection.for in.vehicle commun.cation.n.tworks by combin.n. the optimal feature extractin. ability of autoen.oders an. more precise clusterin. usin. fuzzy C-mean.(FCM).The proposed method is light weight an. requires less computation.*** performed an.exten.ive experimen. an. achieved an.accuracy of 75.51%with the ML35o in.vehicle in.rusion.*** experimen.al result,the proposed method also works better for other in.rusion.detection.problems like wireless in.rusion.detection.datasets such as Wn.-DS with accuracy of 84.05%an. n.twork in.rusion.detection.datasets such as KDDCup with accuracy 60.63%,Un.W_n.15 with accuracy 73.62%an. In.ormation.Security Cen.er of Excellen.e(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existin. methods an. avoids labeled datasets when.train.n. an.in.vehicle in.rusion.detection.*** results of the experimen. of our proposed method performed on.various in.ru-sion.detection.datasets in.icate that the proposed approach is gen.ralized an. robust in.detectin. in.rusion. an. can.be effectively deployed in.real time to mon.tor CAn.traffic in.vehicles an. proactively alert durin. attacks.

关键词： Con.rolarea n.twork In.rusion.etection Un.upervised learn.n. Autoen.oders Fuzzy C-mean.

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连云港耕地土壤有机碳时空分异及影响因素

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农业环境科学学报 2024年第10期43卷 2363-2374页

作者：苟富刚蔡露明陆徐荣江苏省地质调查研究院自然资源部地裂缝地质灾害重点实验室南京210049

为了揭示连云港耕地土壤有机碳(SOC)的时空分布特征及影响因素,选取连云港市耕地土壤作为研究对象,采取表层(0~20cm)土壤及深层(150~200 cm)土壤样品,进行了SOC、总氮(Tn.及总磷(TP)的测试。结果表明:2004年SOC含量在中等级分布频率最高... 详细信息

为了揭示连云港耕地土壤有机碳(SOC)的时空分布特征及影响因素,选取连云港市耕地土壤作为研究对象,采取表层(0~20cm)土壤及深层(150~200 cm)土壤样品,进行了SOC、总氮(Tn.及总磷(TP)的测试。结果表明:2004年SOC含量在中等级分布频率最高,2019年SOC含量在中、中上、高、极高4个等级上均广泛分布。近15 a(2004-2019年)耕地浅表SOC含量增加了0.57个百分点,有机碳密度增加了1.34 kg·m^(-2),SOC储量增加了1.36 Tg,平均固碳速率为7.26×10~4kg·km^(-2)·a^(-1)。不同类型土壤固碳速率差异较大,平均固碳速率表现为灰潮土>滨海盐土>砂姜黑土>棕潮土>棕壤>粗骨土。不同用地类型土壤的SOC含量差异大,平均固碳速率为水田>旱地>水浇地。近15 a研究区土壤C:n.P(SOC:Tn.TP)稍有提高,说明SOC含量空间异质性稍有提高,研究区土壤C:n.P数值与江西耕地土壤等相比明显偏低,表明土壤微生物对SOC矿化分解速率较快,研究区耕地土壤环境不利于碳的储存。

关键词：有机碳耕地土壤类型用地类型人类活动

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Effects of syn.hesis parameters on.the performan.e of crosslin.ed Co-polymers with clays for con.orman.e con.rol

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Petroleum Research 2024年第1期9卷 98-108页

作者： A.A.Roslan.n.A.A.Aziz n.F.A.Deraman.I.Dzulkarn.in Petroleum En.in.erin. Departmen. Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia Chemical En.in.erin. Departmen. Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Con.orman.e con.rol or water shut-off is a techn.que used to improve oil *** con.orman.e con.rol,polymers block high permeability water areas an. redistribute water drive toward un.wept oil *** this study,co-polymers(den.ted ATP-PGV/AM-co-AMPS)were syn.hesized usin. acrylamide(AM)an. 2-acrylamide-2-methylpropan. sulfon.c acid(AMPS)as the mon.mers,polyethylen. glycol(PEG)-200 an. methylen.bisacrylamide(MBA)as the crosslin.ers,attapulgite(ATP)an. ben.on.te(PGV)as the clay types,an. ammon.um persulfate(APS)as the in.tiator,in.addition.to paraffin.oil an. *** were syn.hesized usin. in.erse emulsion.polymerization.with differen. con.en.ration. of mon.mers,crosslin.ers,an. clays,an. they were characterized usin. Fourier-tran.form in.rared(FTIR)spectroscopy an. scan.in. electron.microscopy(SEM)with en.rgy dispersive X-ray spectroscopy(EDX).FTIR spectra of the samples con.irmed the existen.e of sulfon.te an. hydroxyl groups,which are importan. for polymer ***-EDX images in.icated that the morphology an. elemen.al composition.were differen. before an. after swellin.,con.irmin. the occurren.e of ***,samples were placed in.sodium chloride solution.20,000 ppm)for 7 days to evaluate swellin. at both room temperature an. 90°*** an.lysis(TGA)an. differen.ial scan.in. calorimetry(DSC)were used to determin. the thermal characteristics of the ***,rheological measuremen.s were used to assess the deformation.an. rheological behavior of the *** results showed that after 1 day,good swellin. without loss of mechan.cal stren.th was achieved with the composite syn.hesized usin. 10%AM,15%AMPS,6%PGV,an. 10%ATP.

关键词： Polymer Clay Water shut-off Con.orman.e Swellin.

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Detection.of 4p16.3 deletion.an. 11p15.5p15.4 gain.in.a boy by comparative gen.mic hybridization.array:A case report

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World Journ.l of Clin.cal Cases 2024年第8期12卷 1517-1522页

作者： Işın.Kaya Medical Gen.tics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUn. n.n.llelic homologous recombin.tion.n.HR)of segmen.al duplication. or low copy repeats(LCRs)result in.Dn. gain.loss an. play an.importan. role in.the origin.of gen.mic *** SUMMARY A 3-year-old boy was referred for gen.tic *** gen.mic hybrid-ization.array an.lysis revealed a loss of 3776 kb in.the 4p16.3 chromosomal region.an. a gain.of 3201 kb in.the 11p15.5p15.4 chromosomal *** Gen.mic imbalan.es caused by n.HR in.LCRs result in.deletion.an. duplication.syn.romes.

关键词： Wolf-Hirschhorn.syn.rome Silver-Russell syn.rome Recurren. rearran.emen.s Case report

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