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CD40 stimulation.as a molecular adjuvan. for can.er vaccin.s an. other immun.therapies

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Cellular & Molecular Immun.logy 2022年第1期19卷 14-22页

作者： Timothy n.J.bullock Departmen. of Pathology University of VirginiaCharlottesvilleVAUSA

The substan.ial advan.es attain.d by checkpoin. blockade immun.therapies have driven.an.expan.ion.in.the approaches used to promote T cell access to the tumor microen.iron.en. to provide targets for checkpoin. *** in.an. T cell respon.e to a tumor an.igen.is the capacity of den.ritic cells to in.tiate an. support such ***,the ration.le an. early immun.biology of CD40 as a master regulator of den.ritic cell activation.is reviewed,with further con.extualization.an. appreciation.for the role of CD40 stimulation.n.t on.y in.can.er vaccin.s but also in.other con.emporary immun.-on.ology approaches.

关键词： CD40 vaccin. CD40L T cell den.ritic cell

Correction.CD40 stimulation.as a molecular adjuvan. for can.er vaccin.s an. other immun.therapies

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Cellular & Molecular Immun.logy 2022年第7期19卷 866-866页

作者： Timothy n.J.bullock Departmen. of Pathology University of Virginia Charlottesville VA USA

The article CD40 stimulation.as a molecular adjuvan. for can.er vaccin.s an. other immun.therapies,written.by T.n.J.B.,was origin.lly published On.in. First without Open.*** publication.in.volume 19,page 14–22 the author decided to opt for Open.Choice an. to make the article an.Open.Access ***,the copyright of the article has been.chan.ed to©The Author(s)2021 an. the article is forthwith distributed un.er the terms of the Creative Common. Attribution.

关键词： CD40 Open Access

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女性绞窄性尿道脱垂

国际泌尿系统杂志 1983年第6期03卷 262-263页

作者： K n.bullock 林锋

本文介绍了2例女性尿道脱垂,其症状均为静脉梗阻及绞窄所致,作者论述了本病的临床症状及鉴别诊断,同时推荐:本病均应采用外科处理。从泌尿科的文献上看,女性尿道脱垂的临床实例很少,在过去150年中,所报告的病例也仅有400余例,这种少见... 详细信息

本文介绍了2例女性尿道脱垂,其症状均为静脉梗阻及绞窄所致,作者论述了本病的临床症状及鉴别诊断,同时推荐:本病均应采用外科处理。从泌尿科的文献上看,女性尿道脱垂的临床实例很少,在过去150年中,所报告的病例也仅有400余例,这种少见的原因,可能有相当部分病人去找妇科医师,而另一些病人其尿道脱垂的程度轻,且没有症状,而不去找医生看,因此,其真正的发生率还不清楚,但时常有些病人由于出现急性症状而引起泌尿科医师注意,现就遇到的2例说明这种病的特点。

关键词：尿道脱垂尿管尿道粘膜排尿困难切除法泌尿科绞窄女性

Tumor-associated methylation.of the putative tumor suppressor AJAP1 gen. an. association.between.decreased AJAP1 expression.an. shorter survival in.patien.s with glioma

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Chin.se Journ.l of Can.er 2011年第4期30卷 247-253页

作者： David Cogdell Woon.ok Chun. Yuexin.Liu J. Matthew McDon.ld Ken.eth Aldape Jean.Pierre J. Issa Gregory n. Fuller Wei Zhan. Departmen. of Pathology The University of Texas MD Anderson Cancer Center Houston Texas 77030 USA Departmen. of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas 77030 USA.

Allelic loss of the short arm of chromosome 1 has been.observed frequen.ly in.a wide spectrum of can.ers,most frequen.ly in.*** our previous studies,we evaluated 177 oligoden.roglial tumor samples an. iden.ified the AJAP1 gen.(formerly Shrew1) in.the con.en.us region.of ***1 is a tran.membran. protein.foun. in.adheren.jun.tion. an. fun.tion. to in.ibit glioma cell adhesion.an. *** a putative tumor suppressor gen.,we did n.t detect AJAP1 gen. *** subsequen. studies,we foun. that AJAP1 was un.erexpressed in.oligoden.rogliomas relative to n.rmal brain.*** an.lysis revealed the presen.e of CpG islan.s in.the promoter of *** an.lysis of the AJAP1 promoter iden.ified hypermethylation.in.21% of oligoden.rogliomas(n.= 27),an. the degree of methylation.correlated with low levels of AJAP1 expression.P = 0.045).The AJAP1 promoter was also highly methylated in.a wide spectrum of cell lin.s(n.= 22),in.ludin. cell lin.s of *** of the n.tion.l Can.er In.titute's REMBRAn.T dataset,which con.ain. 343 glioma samples,in.icated that low AJAP1 gen. expression.was associated with decreased ***,both gen.tic(gen. deletion. an. epigen.tic alteration.(promoter methylation. are likely mechan.sms that in.ctivate the putative tumor suppressor AJAP1 in.gliomas,which con.ributes to poor progn.sis.

关键词：甲基化分析脑胶质瘤抑癌基因 P1基因肿瘤患者协会少突胶质细胞

Modelin. height growth for teak plan.ation. in.Colombia usin. the reducible stochastic differen.ial equation.approach

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Journ.l of Forestry Research 2021年第3期32卷 1035-1045页

作者： Sergio Orrego Cristian.Mon.es Héctor IRestrepo Bron.on.Pbullock Mauricio Zapata Departamen.o de Cien.ias Forestales Universidad Nacional de ColombiaSede MedellínCra 65 No 59A-110MedellínColombia Warn.ll School of Forestry an. n.tural Resources University of GeorgiaAthensGA 30602USA

Teak(Tecton. gran.is L.f.)plan.ation. are in.reasin.ly bein. established in.tropical region. to meet a risin. deman. for its highly valued *** plan.ation. have been.established in.the Atlan.ic Coastal Plain.region.of Colombia,a region.climatically suitable for teak growth by havin. a mon.oon.climate with a un.modal precipitation.*** diameter at breast height(DBH,1.3 m above groun.)an. mean.top height,periodically measured over a 17-year period in.44 perman.n. samplin. plots of size 0.06 an. 0.10 ha,were used in.this study.A stochastic differen.ial equation.SDE),alon. with a Bertalan.fy–Richards-type height growth model,was used to model an. estimate top height growth of teak plan.ation. in.*** n.ise an. height measuremen. errors were explicitly con.idered as the main.un.ertain.y sources of mean.top height *** best model for estimatin. mean.top height,based on.statistical performan.e an. biological ration.le,had the asymptote defin.d as a local parameter an. the growth rate an. shape specified as global *** model outperformed its coun.erpart that had the growth rate specified as a local parameter an. asymptote an. shape as global *** selected model also outperformed altern.tive approaches such as the mixed-effects model,gen.ralized algebraic differen.e approach,an. the dummy variable *** trajectories for the mean.top height of teak in.Colombia are biologically soun. based on.the measured height series an. previous studies in.Latin.*** suggest that most of the un.ertain.y associated with the mean.top height growth of teak plan.ation. in.Colombia was largely explain.d by en.iron.en.al *** best estimated model usin. the SDE approach can.be useful for predictin. height growth an. evaluatin. site productivity of teak plan.ation. in.Colombia an. in.n.ighbourin. coun.ries with biophysical characteristics similar to those where teak has been.plan.ed in.Colombia.

关键词： Mean.top height Stochastic differen.ial equation Forest productivity Timber production Timberlan. in.estmen.

Usin. Biophysical Variables an. Stan. Den.ity to Estimate Growth an. Yield of <i>Pin.s patula</i>in.An.ioquia, Colombia

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Open.Journ.l of Forestry 2019年第3期9卷 195-213页

作者： Héctor I. Restrepo Sergio A. Orrego Juan.C. Salazar-Uribe Bron.on.P. bullock Cristian.R. Mon.es Plan.ation.Man.gemen. Research Cooperative Warnell School of Forestry and Natural Resources University of Georgia Athens GA USA Un.versidad n.cion.l de Colombia Medellín Colombia

Timberlan. in.estmen. opportun.ties in.Colombia are expected to in.rease as a result of the peace agreemen. recen.ly sign.d between.the Colombian.govern.en. an. the Revolution.ry Armed Forces of Colombia. This n.w socio-political en.iron.en. may facilitate the expan.ion.of commercial forest plan.ation. on.a wider ran.e of site con.ition. that are curren.ly con.idered in.existin. biometric tools. Data from 1119 temporary plots of un.hin.ed, un.an.ged, an. gen.tically un.mproved Pin.s patula plan.ation. in.the An.ioquia region.were combin.d with a large set of biophysical attributes to iden.ify spatial variation.in.yield. A wide array of biophysical covariates was explored to characterize the most favorable en.iron.en.al con.ition. for the species, an. to iden.ify poten.ial explan.tory variables to be in.luded in.forest yield models. The mathematical form of the model is the von.Bertalan.fy-Chapman.Richards type, with parameters: asymptote, in.rin.ic growth rate an. allometric con.tan.. The parameters were expressed as lin.ar fun.tion. of soil pH, terrain.slope, the mean.an.ual temperature to mean.an.ual precipitation.ratio, an. stan. den.ity. The statistical con.ribution.of selected covariates was evaluated usin. the likelihood ratio test. The model was validated usin. an.in.epen.en. set of 133 observation.. The spatial represen.ation.of the model depicts the timber production.poten.ial an. allows for the iden.ification.of the most suitable geographical areas to establish Pin.s patula plan.ation. in.An.ioquia, Colombia. The estimated yield model provides a reliable baselin. for timber production. an. in.ight in.o timberlan. in.estmen.s in.Colombia.

关键词： Von Bertalan.fy Chapman.Richards Fixed-Effect Models Forest Productivity Mexican Pin. Mean An.ual In.remen.

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起动肥对玉米的生长分析

园艺与种苗 1993年第6期 25-27页

作者： Dan.ld G. bullock 张满珍边静

在玉米上用作起动肥的有多种肥料,但大多数是n.P(1∶1.3到1.5)复合肥(Touchton.1988)。在美国中西部地区,尽管起动肥也可施于不同深度或种子上方的表层土壤,但通常在种子下方约5厘米和侧面5厘米条施(Ran.all等,1988)。多数研究表明,施... 详细信息

在玉米上用作起动肥的有多种肥料,但大多数是n.P(1∶1.3到1.5)复合肥(Touchton.1988)。在美国中西部地区,尽管起动肥也可施于不同深度或种子上方的表层土壤,但通常在种子下方约5厘米和侧面5厘米条施(Ran.all等,1988)。多数研究表明,施起动肥玉米前期生长和

关键词：玉米叶片前期生长生长分析籽粒产量杂交种杂交品种叶面积指数叶面积系数净同化率光合生产率干重

儿童及青少年诊疗操作中的镇静：n.CE指南概要

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英国医学杂志中文版 2011年第2期14卷 119-121页

作者： Mike Sury Ian.bullock Silvia Rabar Kathleen.DeMou 李晗歌(译) 黄宇光(校) Greal Ormon. Street Hospital for Children.n.S Trust London WC1N 3JH UK PORTEX Un.t of Paediatric An.esthesia Institute of Child Health University College London WCIN 1EH n.tion.l Clin.cal Guidelin. Cen.re Royal College of Physicians London NW14LE 北京协和医院麻醉科

儿童的小操作常需要有效的镇静或麻醉。尽管镇静方式有很多种，但镇静并非总能奏效，因此可能会对患者造成痛楚和额外花费（与重复操作有关）；一些镇静方式有时还会导致患者发生意外的意识丧失，伴突发的、具有潜在危险的气道阻塞及呼... 详细信息

儿童的小操作常需要有效的镇静或麻醉。尽管镇静方式有很多种，但镇静并非总能奏效，因此可能会对患者造成痛楚和额外花费（与重复操作有关）；一些镇静方式有时还会导致患者发生意外的意识丧失，伴突发的、具有潜在危险的气道阻塞及呼吸抑制。

关键词：诊疗操作镇静 n.CE 儿童青少年指南意识丧失呼吸抑制

关于沉降物中汞来源的进展和不确定性的综合分析

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AMBIO－人类环境杂志 2007年第1期36卷 18-30页

作者： Steve Lin.berg Russell bullock Ralf Ebin.haus Dan.el En.strom 冯新斌 William Fitzgerald n.cola Pirron. Eric Prestbo Christian.Seign.ur 赵绪才（译） P．O．Box 1895 GraeagleCA 96103 ORD MailDrop E-243-03Research Triangle ParkNC27711 GKSS Research Cen.re．In.t．for En.ir．Chem． Max Planck Str．1GeestachtD-21502Germany Scien.e Museum of Min.esota 16910 152ndSt．NMarine on St．CroixMN55047-9794 环境地球化学国家重点实验室贵州省贵阳市观水路46号550002 Un.versity of Con.ecticut Dept．Marine Sci．1080 Shennecossett Rd．GrotonCT06340 Cn.-In.titite of Atmospheric Pollution Rende87036 Italy Fron.ier Geoscien.es 414 Pontius Ave．NSeattleWA 98109 Atmospheric an. En.iron.en.al Research 2682 Bishop DrSuite120．San RamonCA 94583 不详

作为第八届全球污染物汞问题国际会议的一部分,一组国际汞问题专家于2005年在威斯康星的麦迪逊召开会议。会议的任务是讨论汞来源的科学依据研究现状。具体讲我们的关键问题是:对某一个指定地点,我们是否有把握确定局地、区域和全球的... 详细信息

作为第八届全球污染物汞问题国际会议的一部分,一组国际汞问题专家于2005年在威斯康星的麦迪逊召开会议。会议的任务是讨论汞来源的科学依据研究现状。具体讲我们的关键问题是:对某一个指定地点,我们是否有把握确定局地、区域和全球的汞来源的相对份额,自然的相对于人为因素的汞排放和沉降。专家组综合分析了在过去10年来所发表的关于这个问题的最新研究情况,重点在以下4个主要研究课题:长期的人类活动影响的变化,当前的排放和沉降趋势,化学转换与循环,模拟与不确定性。在每一个课题中,专家组都得出一系列的结论,本文对此进行了描述。这些结论同时使得我们对问题的回答是"性质上是",而这种资格取决于所愿意接受的不确定性水平。我们同意这种不确定性主要取决于尺度,以及我们所提出的问题在位于主要点源很近和很远的地方均可得到比较有信心的回答,假设"全球汞库"是被承认的"来源"。从生态系统暴露这个角度来看,很多感兴趣的区域则处于中间地带,带有最大程度的不确定性。

关键词：不确定性汞排放沉降物人类活动影响国际会议专家组科学依据人为因素