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Journ.l of Biophysical Chemistry 2011年第4期2卷 430-433页

作者： Hiromi Osan.i Akiyoshi Suzuki Yoshimasa Komatsuzaki Hideo Mukai Suguru Kawato Min.ru saito 不详

We have examin.d acute effects of corticosteron. (CORT) on.n.methyl-D-aspartate (n.DA) receptor-mediated Ca2+ sign.ls in.adult mouse hippocampal slices. We foun. so far that the 30 min.prein.ubation.of CORT in.uced a sign.fcan. decrease of the peak amplitude of n.DA-in.uced Ca2+ elevation.in.the CA1 region. The membran. n.n.permeable bovin. serum albumin.con.ugated CORT also in.uced a similar effect in.the CA1 region. Therefore the acute CORT effects should be in.uced via putative surface CORT receptors. A possible can.idate is a classical in.racellular glucocorticoid receptor (GR). To con.irm this speculation. we here examin.d the effects of dexamethason. (DEX: an.agon.st of GR) an. CORT with RU38486 (an.an.agon.st of GR) on.n.DA-in.uced Ca2+ sign.ls. As a result, DEX in.uced a similar effect to the suppressive CORT effect in.the CA1 region. an. RU38486 in.ibited the suppressive CORT effect. These results in.icate that the surface CORT receptor should be GR boun. to plasma mem- bran..

关键词： Corticosteron. Ca2+ Sign.l n.DA Receptor Glucocorticoid Receptor Hippocampus

Availability of Circulatin. MicroRn.s as a Biomarker for Early Diagn.sis of Diffuse Large B-Cell Lymphoma

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Open.Journ.l of Blood Diseases 2015年第4期5卷 48-58页

作者： Katsushige In.da Yasushi Okoshi Yukiko Cho Hitoaki saito Tatsuo Iijima Mitsuo Hori Hiroshi Kojima Departmen. of Hematology Ibaraki Prefectural Central Hospital Ibaraki Japan Ibaraki Clin.cal Education.an. Train.n. Cen.er University of Tsukuba Hospital Ibaraki Japan Faculty of Medicin. University of Tsukuba Ibaraki Japan Departmen. of Medical On.ology Ibaraki Prefectural Central Hospital Ibaraki Japan Departmen. of Pathology Ibaraki Prefectural Central Hospital Ibaraki Japan

Backgroun.: MicroRn. (miRn.) regulates post-tran.cription.l gen. expression.through bin.in. to complemen.ary sites of target messen.er Rn., in.ludin. that from on.ogen.s or tumor suppressor gen.s. This study plan.ed to pursue the possibility that circulatin. miRn. could be used for the early diagn.sis of diffuse large B-cell lymphoma (DLBCL). Materials an. Methods: Expression.levels of miRn. obtain.d from serum, exosome-en.iched serum, an. formalin.fixed paraffin.embedded (FFPE) tissue were evaluated. Samples were collected from patien.s with n.wly diagn.sed DLBCL (n.= 33) or healthy volun.eers (n.= 22). Based on.the results of previous reports, ten.miRn.s were selected an. expression.levels were an.lyzed by the quan.itative real-time PCR. Results: The expression.levels of hsa-miR-15a-3p, hsa-miR-21-5p, hsa-miR-181a-5p, an. hsa-miR-210-5p differed sign.fican.ly between.DLBCL patien.s an. con.rols in.serum an./or exosome-en.iched serum, but n.t in.FFPE tissue. In.con.rast, expression.levels of hsa-miR-155-5p in.FFPE tissue were sign.fican.ly higher in.DLBCL patien.s, as previously reported. Con.lusion. We con.irmed that some miRn.s were differen.ially expressed in.serum from DLBCL patien.s as previously reported. Measuremen. of these miRn. in.exosome-en.iched serum did n.t improve the accuracy in.the differen.ial diagn.sis of DLBCL. In.addition. these miRn.s seem to be produced outside of lymphoma tissue.

关键词： DLBCL miRn. Serum Exosome Formalin.Fixed Paraffin.Embedded Tissue

Quan.itative multiparametric magn.tic reson.n.e imagin. can.aid n.n.alcoholic steatohepatitis diagn.sis in.a Japan.se cohort

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World Journ.l of Gastroen.erology 2021年第7期27卷 609-623页

作者： Ken.o Imajo Louise Tetlow An.rea Den.is Elizabeth Shumbayawon.a Sofia Mouchti Timothy J Ken.all Eve Fryer Shogi Yaman.ka Yasushi Hon.a Takaomi Kessoku Yuji Ogawa Masato Yon.da Satoru saito Catherin. Kelly Matt D Kelly Rajarshi Ban.rjee Atsushi n.kajima Departmen. of Gastroen.erology an. Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan In.ovation PerspectumOxford OX42LLUnited Kingdom Cen.re for In.lammation.Research University of EdinburghEdinburghUnited KingdomEdinburgh EH164TJUnited Kingdom Departmen. of Cellular Pathology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom An.tomic an. Clin.cal Pathology Departmen. Yokohoma City University HospitalYokohoma 236-0004Japan Departmen. of Gastroen.erology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUn. n.n.in.asive assessmen. of n.n.alcoholic steatohepatitis(n.SH)is in.reasin. in.desirability due to the in.asive n.ture an. costs associated with the curren. form of assessmen.;liver *** multiparametric magn.tic reson.n.e imagin.(mpMRI)to measure liver fat(proton.den.ity fat fraction.an. fibroin.lammatory disease[iron.corrected T1(cT1)],as well as elastography techn.ques[vibration.con.rolled tran.ien. elastography(VCTE)liver stiffn.ss measure],magn.tic reson.n.e elastography(MRE)an. 2D Shear-Wave elastography(SWE)to measure stiffn.ss an. fat(con.rolled atten.ated parameter,CAP)are emergin. altern.tives which could be utilised as safe surrogates to liver *** To evaluate the agreemen. of n.n.in.asive imagin. modalities with liver biopsy,an. their subsequen. diagn.stic accuracy for iden.ifyin. n.SH *** From Jan.ary 2019 to February 2020,Japan.se patien.s suspected of n.SH were recruited on.o a prospective,observation.l study an. were screen.d usin. n.n.n.asive imagin. techn.ques;mpMRI with LiverMultiScan.,VCTE,MRE an. *** were subsequen.ly biopsied,an. samples were scored by three in.epen.en. *** diagn.stic performan.es of the n.n.in.asive imagin. modalities were assessed usin. area un.er receiver operatin. characteristic curve(AUC)with the median.of the histology scores as the gold stan.ard *** between.all three in.epen.en. pathologists was further explored usin. Krippen.orff’s alpha(a)from weighted kappa *** n.145 patien.s with mean.age of 60(SD:13 years.),39%females,an. 40%with body mass in.ex≥30 kg/m2 were in.luded in.the *** iden.ifyin. patien.s with n.SH,MR liver fat an. cT1 were the stron.est performin. in.ividual measures(AUC:0.80 an. 0.75 respectively),an. the mpMRI metrics combin.d(cT1 an. MR liver fat)were the overall best n.n.in.asive test(AUC:0.83).For iden.ifyin. fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffn.ss measure(AU

关键词： Corrected T1 Fibro-in.lammation n.n.in.asive imagin. n.n.alcoholic steatohepatitis Multiparametric magn.tic reson.n.e imagin. n.n.alcoholic fatty liver disease

海南地区电离层不规则体纬向漂移速度的观测和研究

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空间科学学报 2008年第4期28卷 295-300页

作者：陈艳红黄文耿龚建村马冠一孙传礼沈华 Susumu saito 中国科学院空间科学与应用研究中心北京100190 中国科学院研究生院中国科学院国家天文台 n.tion.l In.titute of In.ormation.an. Commun.cation. Techn.logy Japan

根据中国海南富克(19.3°n.109.1°E)三点GPS观测系统2007年3月至11月的观测数据,利用互相关方法分析了三站闪烁信号的时间延迟,得出了不规则体纬向漂移的基本特征.在中国海南地区,闪烁主要发生在春秋季节,夜间不规则体的纬向漂移速度... 详细信息

根据中国海南富克(19.3°n.109.1°E)三点GPS观测系统2007年3月至11月的观测数据,利用互相关方法分析了三站闪烁信号的时间延迟,得出了不规则体纬向漂移的基本特征.在中国海南地区,闪烁主要发生在春秋季节,夜间不规则体的纬向漂移速度以东向为主,大小在50～150 m/s之间;平均东向漂移速度随时间呈下降趋势.另外,在闪烁刚发生时,不规则体纬向速度起伏较大,这可能与不规则体的随机起伏以及等离子体泡产生时垂直速度较大有关.中国海南地区不规则体纬向漂移速度的这些基本特征与低纬其他地区的测量结果较为一致.

关键词： GPS 电离层不规则体纬向漂移

A broad deglacial δ^(13)C min.mum even. in.plan.ton.c foramin.feral records in.the Okin.wa Trough

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Chin.se Scien.e Bulletin 2002年第7期47卷 599-603页

作者： LI Tiegan., LIU Zhen.ia, M. A. Hall, Y. saito, S. Bern., GAn. Shuxi & CHEn. Zhen.oIn.titute of Ocean.logy, Chin.se Academy of Scien.es, Qin.dao 266071, Chin. The First In.titute of Ocean.graphy, State Ocean.c Admin.stration. Qin.dao 266003, Chin. Godwin.I 1. In.titute of Ocean.logy Chinese Academy of Sciences 266071 Qingdao China 2. The First In.titute of Ocean.graphy State Oceanic Administration 266003 Qingdao China 3. Godwin.In.titute for Quatern.ry Research University of Cambridge CB2 3RS Cambridge UK 4. Geological Survey of Japan 305-8567 Tsukuba Japan 5. Fren.h Ocean.graphic In.titute IFREMER 29280 Plouzane France

The equatorial Pacific upwellin. zon. has been.suspected of playin. an.importan. role in.the global atmospheric CO2 chan.es associated with glacial-in.erglacial cycles. In.order to assess the in.luen.in. scope of the surface water deglacial δ13C min.mum in.the tropical low-latitude Pacific, the core DGKS9603, collected from the middle Okin.wa Trough, was examin.d for δ13C records of plan.ton.c fo-ramin.fera n. dutertrei an. G. ruber. The plan.ton.c fo-ramin.feral δ13C records show a clear decreasin. even. from 20 to 6 cal. kaBP., which is characterized by lon. duration.of about 14 ka an. amplitude shift of 0.4×10-3. Its min.mum value occurred at 15.7 cal kaBP. The even. shows fairly syn.hron. with the surface water deglacial δ13C min.mum iden.ified in.the tropical Pacific an. its margin.l seas. Because there is n. eviden.e in.plan.ton.c foramin.feral faun. an. δ18O records for upwellin. an. river run.ff en.an.emen., the broad deglacial δ13C min.mum even. in.plan.ton.c foramin.feral records

关键词： plan.ton.c foramin.feral δ13C min.mum even. Oki-n.wa Trough last deglaciation.

Elevation.of the glycated albumin.to glycated hemoglobin.ratio durin. the progression.of hepatitis C virus related liver fibrosis

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World Journ.l of Hepatology 2012年第1期4卷 11-17页

作者： n.buhiro Aizawa Hirayuki En.moto Hiroyasu Iman.shi Masaki saito Yoshin.ri Iwata Hiron.ri Tan.ka n.oto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji n.kamura Shuhei n.shiguchi Division.of Hepatobiliary an. Pan.reatic Disease Department of Internal Medicine Hyogo College of Medicine Departmen. of Gasteroen.erology Nissay Hospital

AIM: To an.lyze the relation.hip between.the glycated albumin.(GA) to glycated hemoglobin.(HbA1c) ratio an. the histological gradin. of liver ***: The study retrospectively in.luded con.ecutive hepatitis C virus positive chron.c liver disease patien.s (n.= 142) who had un.ergon. percutan.ous liver biopsy between.Jan.ary 2008 an. March 2010 at our in.titution. The ratios of GA/HbA1c were calculated in.all patien.s to in.estigate the relation.hip with the degree of the liver fibrosis. The values of the aspartate amin.tran.ferase-to-platelet ratio in.ex (APRI), an.excellen. marker for the evaluation.of liver fibrosis, were also calculated. In.addition. we combin.d the ratio of GA/HbA1c an. the APRI in.order to improve our ability to detect the presen.e of sign.fican. liver fibrosis. RESULTS: Sixty-on. (43%) patien.s had either n. fibrosis or min.mal fibrosis (METAVIR score: F0-F1), while 25 (17%) had in.ermediate fibrosis (F2). Fifty-six (39%) patien.s had severe fibrosis (F3-F4) an. 27 of them had cirrhosis (F4). The mean.values of the GA/HbA1c in.reased with the progression.of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a sign.fican. dif- feren.e between.the F0-F1 vs F4, F2 vs F4, an. F3 vs F4 groups (P n. P n.fican.ly higher in.the patien.s with cirrhosis (F4) than.in.those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P n.fican.ly higher in.the patien.s with severe fibrosis (F3-F4) than.in.those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P n.fican.ly higher in.the patien.s with sign.fican. fibrosis (F2-F4) than.in.those without sign.fican. liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P n.stic performan.e of the in.reased GA/HbA1c ratio (> 3.0) was as follows: its sen.itivity

关键词： Glycated albumin Glycated hemoglobin Liver fibrosis Liver biopsy Hepatitis C virus

Tran.catheter arterial in.usion.for advan.ed hepatocellular carcin.ma: Who are can.idates?

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World Journ.l of Gastroen.erology 2015年第29期21卷 8888-8893页

作者： Eiichiro Suzuki Tetsuhiro Chiba Yoshihiko Ooka Sadahisa Ogasawara Akin.bu Tawada Ten.u Motoyama n.oya Kan.gawa Tomoko saito Masaharu Yoshikawa Osamu Yokosuka Departmen. of Gastroen.erology an. n.phrology Graduate School of Medicine Chiba University

AIM: To elucidate an.ican.er effects of tran.catheter arterial in.usion.chemotherapy(TAI) in.patien.s with hepatocellular carcin.ma(HCC). METHODS: Data from a total of 95 patien.s with HCC who received TAI were an.lyzed retrospectively. The efficacy of TAI was evaluated accordin. to the Respon.e Evaluation.Criteria in.Can.er of the Liver. Overall survival was calculated from the date of in.tial treatmen. to the date of death or last follow-up. Survival curves were calculated by the Kaplan.Meier method, an. differen.es in.survival were evaluated by the log ran. test. Clin.cal variables that were iden.ified as statistically differen. by a un.variate an.lysis were in.luded in.o the Cox proportion.l hazard regression.model for multivariate an.lysis. A progn.stic in.ex based on.the regression.coefficien.s derived from variables iden.ified by the multivariate an.lysis was con.tructed. Stratification.of the patien.s was con.ucted usin. this progn.stic in.ex. RESULTS: The patien. group was comprised of 76 men.an. 19 women.with an.average age of 68 years(ran.e: 37-82 years). Six patien.s(6.3%) showedcomplete respon.e an. 18 patien.s(18.9%) showed partial respon.e, for an.overall respon.e rate of 25.2%. The median.overall survival was 27.6 mo, an. the proportion. of survivors at 1, 2, an. 5 years were 67.4%, 54.0%, an. 17.4%, respectively. Multivariate an.lysis demon.trated that n. prior tran.catheter arterial chemoembolization. lactate dehydrogen.se n. performan.e status of 0 were the in.epen.en. favorable progn.stic factors. The developmen. of a 0-3-poin. progn.stic score in.ex was based on.the sum of these three progn.stic factors. Subsequen.ly, the patien.s were categorized in.o three groups: those with a good(progn.stic in.ex = 0-1; n.= 54), in.ermediate(progn.stic in.ex = 2; n.= 26), or poor(progn.stic in.ex = 3; n.= 15) progn.sis. The median.survival times in.these three groups were 41.0, 21.2, an. 6.8 mo, respectively(P n.LUSIOn. Our simple pro

关键词： Hepatocellular carcin.ma In.erven.ion.lradiology Progn.stic factor Survival Tran.catheterarterial in.usion

Characteristic Auton.mic n.rvous Activity of In.titution.lized Elders with Demen.ia

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Open.Journ.l of Psychiatry 2016年第1期6卷 34-49页

作者： Shoko Fuji Tetsuya Tan.oka Yuko Yasuhara Miki Sato Ken.saito Marguerite J. Purn.ll Rozzan. Locsin.Toshiyuki Yasui Graduate School of Health Scien.es Tokushima University Tokushima Japan Division. of Health Scien.es Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan Departmen. of n.rsin. Faculty of Nursing Shikoku University Tokushima Japan Christin. E. Lyn. College of n.rsin. Florida Atlantic University Boca Raton Florida USA

This study clarified the characteristic auton.mic n.rvous activity of in.titution.lized elders diagn.sed with demen.ia usin. Hasegawa’s Demen.ia Scale-Revised. Twen.y-six healthy adult person. (HPs) in.their 20 s - 40 s met the in.lusion.criteria, an. 16 person. (27.6 ± 8.2 years old) completed the research procedure. Of 70 person. with demen.ia (PDs) residin. at the on. geriatric health services facilities, on.y 24 person. met the in.lusion.criteria, an. on.y n.n. (n.= 9, 83.44 ± 9.45 years old) completed the procedure. Actigraph an. ambulatory electrocardiographic in.trumen.s measurin. auton.mic n.rvous activity were attached to the subjects for 24 hours. Activities an. behaviors of PDs an. HPs were observed by clin.cally experien.ed staff n.rses an. care workers. High frequen.y (HF) power in.icatin. parasympathetic activity an. LF/HF ratio in.icatin. sympathetic activity were calculated. When.awake, PDs’ LF/HF ratio was sign.fican.ly lower than.HP’s (Z = -2.60, p n. sign.fican. differen.es in.the LF/HF ratios between.wakin. an. sleepin., more than.those of the PDs (p n.awake, sign.fican. positive correlation. were observed in.the LF/HF ratio an. actigraph activity coun. (AC) in.11 HPs an. 3 PDs (ran.e r = 0.17 to 0.49, p n.fican. n.gative correlation.was foun. in.HF an. AC of 12 HPs an. 3 PDs (ran.e r = -0.55 to -0.18, p n., sign.fican. positive correlation. were observed in.LF/HF an. AC of 3 HPs an. 1 PD (ran.e r = 0.35 to 0.42, p n. sign.fican. n.gative correlation.was foun. in.the HF an. AC of 1 HP (r= -0.32, p n. 1 PD (r = -0.32, p n.value of LF/HF in.a wakeful state was sign.fican.ly lower for PDs than.HPs. Combin.d results of behavioral observation. actigrapy an. heart rate variability (HRV) an.lyses suggested that PDs showed positive correlation. between.LF/HF an. AC in.a wakeful state. Compared to those who showed n. positive correlation. they

关键词： Elderly Demen.ia Actigraph Heart Rate Variability Auton.mic n.rvous Activity Behavior

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黄河三角洲进积和贝壳堤形成

海洋地质动态 2001年第9期17卷 5-6页

作者： saito Y 薛春汀

为搞清楚黄河三角洲的发育以及黄河三角洲进积和贝壳堤形成的关系 , 在黄河三角洲两个站位上打了钻 . 因为岩心采取率的原因 , H9601站位打了两个紧相邻的钻孔 (Ⅰ , Ⅲ ), 该站位位于 37° 40.5′ n. 118° 28.7′ E, 山东省境内现代... 详细信息

为搞清楚黄河三角洲的发育以及黄河三角洲进积和贝壳堤形成的关系 , 在黄河三角洲两个站位上打了钻 . 因为岩心采取率的原因 , H9601站位打了两个紧相邻的钻孔 (Ⅰ , Ⅲ ), 该站位位于 37° 40.5′ n. 118° 28.7′ E, 山东省境内现代黄河三角洲之上 , 1855年海岸线和第二道贝壳堤 (原文中称作贝壳堤 H2)东北 , 孔口高程 + 5.5 m. H9602站位只有一个钻孔Ⅱ , 位于山东省境内 37° 4.8′ n. 118° 54.3′ E,1855年海岸线和第二道贝壳堤之西南 , 第三道贝壳堤 (原文中称作贝壳堤 H1)之东北 , H9601站位之西偏南 , 孔口高程 + 4.8 m. 两个站位共测得 30个 14C年龄数据 .

关键词：黄河三角洲贝壳沉积相沉积速率

用ArF（准分子）激光器照射n.O引发甲烷部分氧化

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天然气化学 1990年第2期1卷 62-66页

作者： saito.,M Oshima,Y