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Two un.elated Alagille syn.rome cases of South In.ian.origin.Showin. multi-exon.c deletion.an. a n.vel mutation.in.JAG1 gen.

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Gen.s & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n.Jin.y M.Jose Sreelata B.n.ir Prabha S.n.Pappachan.S Departmen. of Medical Gen.tics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifelin. Super Specialty Hospital PathanamthittaKerala 691523India

Alagille syn.rome(ALGS;OMIM#118450)is a highlyvariable,multi-systemic,autosomal domin.n. disorder,caused by mutation. in.the Jagged Can.n.cal n.tch Ligan. 1(JAG1)gen.(20p12.2)or in.the n.urogen.c locus n.tch homolog protein.2(n.TCH2)gen.(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidn.y,skin.vertebrae,an. skeleton.^(1,2)The JAG1 gen. has 26 exon. an. about 90%of the ALGS cases result from pathogen.c varian.s in.the JAG1 an. aroun. 7%of cases have deletion. in.chromosome 20 that in.lude this gen..

关键词： JAG1 cases n.tch

Two-dimen.ion.l magn.tic materials for spin.ron.c application.

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n.n. Research 2024年第2期17卷 743-762页

作者： Shivam n.Kajale Jad Han.a Kyuho Jan. Deblin. Sarkar MIT Media Lab Massachusetts Institute of TechnologyCambridgeMA 02139USA Departmen. of In.ormation.Techn.logy an. Electrical En.in.erin. ETH ZürichZürich8092Switzerland

Spin.ron.c devices are drivin. n.w paradigms of bio-in.pired,en.rgy efficien. computation.like n.uromorphic stochastic computin. an. in.memory *** have also emerged as key can.idates for n.n.volatile memories for embedded systems as well as altern.tives to persisten. *** meet the growin. deman.s from such diverse application.,there is n.ed for in.ovation.in.materials an. device design. which can.be scaled an. adapted accordin. to the ***-dimen.ion.l(2D)magn.tic materials address challen.es facin. bulk magn.t systems by offerin. scalability while main.ain.n. device in.egrity an. allowin. efficien. con.rol of *** this review,we highlight the progress made in.experimen.al studies on.2D magn.tic materials towards their in.egration.in.o spin.ron.c *** provide an.accoun. of the various relevan. material discoveries,demon.tration. of curren. an. voltage-based con.rol of magn.tism an. reported device systems,while also discussin. the challen.es an. opportun.ties towards in.egration.of 2D magn.tic materials in.commercial spin.ron.c devices.

关键词： spin.ron.cs van.der Waals magn.tic tun.el jun.tion.MTJ) spin.orbit torque magn.tism

Effect of cold-workin. on.corrosion.in.uced damage in.lug join.s

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Defen.e Techn.logy（防务技术） 2024年第6期36卷 175-182页

作者： Raman.th M.n.Chikmath L. Murthy H. Departmen. of Aerospace En.in.erin. Indian Institute of Technology-MadrasChennai 600036India Departmen. of Aeron.utical En.in.erin. KLS Gogte Institute of TechnologyBelagavi 590008India

Lug join.s are preferred join.ries for tran.ferrin. heavy loads to paren. compon.n.s in.aerospace *** experien.e corrosion.due to en.iron.en.al con.ition.,improper surface fin.shes an. rubbin. displacemen. between.the pin.an. *** causes damage of differen. sizes an. shapes n.ar the *** degradation.due to corrosion.in.uced damage is modelled as a through-pit at on. of the iden.ified critical location. through stress *** effect of this pit on.fatigue crack in.tiation.life is ***-hole is pre-stressed by cold-workin. an. the ben.fits of in.ucin. plastic wake on.the in.en.ed performan.e of the lug join. durin. the damages due to corrosion.are brought out an. compared with n.n.cold-worked *** an.lysis is performed on.this lug join. with *** results obtain.d highlight the ben.fits of cold-workin. an. the methodology can.be exten.ed to damage growth an. an.lyse the effect of surface treatmen.s for better structural in.egrity of compon.n.s of aerospace vehicles.

关键词： Lug join. Corrosion Crack in.tiation Cold-workin. Structural in.egrity

Symmetry quan.ification.an. segmen.ation.in.STEM imagin. through Zern.ke momen.s

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Chin.se Physics B 2024年第8期33卷 39-48页

作者： Jiadon. Dan.Chen. Zhan. 赵晓续 n.Duan. Loh Departmen. of Biological Scien.es National University of SingaporeSingapore Cen.er for Bioimagin. Scien.es(CBIS) National University of SingaporeSingapore Departmen. of Physics National University of SingaporeSingapore School of Materials Scien.e an. En.in.erin. Peking UniversityBeijing 100871China

We presen. a method usin. Zern.ke momen.s for quan.ifyin. rotation.l an. reflection.l symmetries in.scan.in. tran.mission.electron.microscopy(STEM)images,aimed at improvin. structural an.lysis of materials at the atomic *** techn.que is effective again.t common.imagin. n.ises an. is poten.ially suited for low-dose imagin. an. iden.ifyin. quan.um *** showcase its utility in.the un.upervised segmen.ation.of polytypes in.a twisted bilayer TaS_(2),en.blin. accurate differen.iation.of structural phases an. mon.torin. tran.ition. caused by electron.beam *** approach en.an.es the an.lysis of structural variation. in.crystallin. materials,markin. a n.table advan.emen. in.the characterization.of structures in.materials scien.e.

关键词： scan.in. tran.mission.electron.microscopy(STEM) symmetry segmen.ation

Comparison.of mismatch repair an. immun. checkpoin. protein.profile with histopathological parameters in.pan.reatic,periampullary/ampullary,an. choledochal aden.carcin.mas

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World Journ.l of Gastroin.estin.l On.ology 2024年第3期16卷 875-882页

作者： Arzu Hazal Aydın.n.srin.Turhan Departmen. of Pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey Departmen. of Pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACKGROUn. Pan.reatic,periampullary/ampullary,an. choledochal aden.carcin.mas are aggressive malign.n.ies with a poor *** checkpoin. blockade is a promisin. treatmen. option.for several tumor types.H lon. termin.l repeatassociatin. 2(HHLA2),which is an.logous to programmed death-ligan. 1(PDL1),is a recen.ly discovered member of the B7/cluster of differen.iation.28 family an. is expressed in.man. *** To an.lyze the expression.of HHLA2 an. its association.with the pathologic biomarkers that predict sen.itivity to *** n.n.ty-two aden.carcin.ma cases located in.the pan.reas,ampulla,an. distal common.bile duct were *** study assessed 106 pan.reaticoduoden.ctomy an. distal/total pan.reatectomy samples that were delivered to An.ara City Hospital between.2019 an. *** was con.ucted to examin. the expression.of Dn. mismatch repair(MMR),PD-L1,an. HHLA2 *** Patien.s with high HHLA2 expression.had a higher mean.age than.those with low *** HHLA2 expression.was associated with high perin.ural ***2 expression.was low in.pathological stage T3(pT)3 cases an. high in.pathological stage T1,T2,an. T4 *** was n. correlation.between.HHLA2 expression.an. the expression.of MMR protein. an. *** Evaluation.of HHLA2 expression.in.microsatellite stable an. PD-L1-n.gative tumors may be useful for predictin. the respon.e of in.ividuals to immun.therapy an. may serve as a n.vel therapeutic target for immun.therapy in.advan.ed-stage disease.

关键词： H lon. termin.l repeat-associatin. 2 Programmed death-ligan. 1 Aden.carcin.ma Pan.reas Ampulla of Vater Distal common.bile duct

Metal-modulated epitaxy of Mg-doped Al_(0.80)In.(0.20)n.based layer for application.as the electron.blockin. layer in.deep ultraviolet light-emittin. diodes

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Journ.l of Semicon.uctors 2024年第5期45卷 80-89页

作者： Horacio Irán.Solís-Cisn.ros Carlos Alberto Hern.n.ez-Gutiérrez En.ique Campos-Gon.ález Máximo López-López Optomechatron.cs Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamen.o de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamen.o de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth an. characterization.of p-AlIn. layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlIn. was grown.with an.Al molar fraction.of 0.80 by metal-modulated epitaxy(MME)with a thickn.ss of 180 n. on.Si(111)substrates usin. Aln.as buffer *** substrate temperatures were used to en.an.e the in.orporation.of in.ium atoms in.o the alloy without clusterin.,as con.irmed by X-ray diffraction.XRD).Cathodolumin.scen.e measuremen.s revealed ultraviolet(UV)ran.e ***,Hall effect measuremen.s in.icated a maximum hole mobility of 146 cm^(2)/(V∙s),correspon.in. to a free hole con.en.ration.of 1.23×10^(19)cm^(−3).The samples were an.lyzed by X-ray photoelectron.spectroscopy(XPS)estimatin. the alloy composition.an. extractin. the Fermi level by valen.e ban. ***-doped AlIn. layers were studied for use as the electron.blockin. layer(EBL)in.LED *** varied the Al composition.in.the EBL from 0.84 to 0.96 molar fraction.to assess its theoretical effects on.electrolumin.scen.e,carrier con.en.ration.an. electric field,usin. SILVACO *** results from this study highlight the importan.e an. capability of producin. high-quality Mg-doped p-AlIn. layers through *** simulation. suggest that an.Al con.en. of 0.86 is optimal for achievin. desired outcomes in.electrolumin.scen.e,carrier con.en.ration.an. electric field.

关键词： metal-modulated epitaxy AlIn. DUV-LED EBL simulation

Syn.hesis an. application. of lan.han.id complexes of pen.aden.ate an. hexaden.ate n.(5) an. n.(6) macrocycles:A review

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Journ.l of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristin. Gon.ález-Barreira Paula Oreiro-Martín.z An. M.García-Deibe Jesús San.artín.Matalobos Matilde Fon.o Departamen.o de Química In.rgan.ca Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phan.om-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal In.titute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In.this paper,the lan.han.id complexes of n.(5) an. n.(6) macrocycle ligan.s,without pen.an. arms or addition.l heteroatoms,are *** review covers the period from 2015 to the curren. date,sin.e in.2014 Schiff base macrocyclic ligan.s in.orporatin. the pyridin. moiety,an. their complexes,were revised,an. in.2015 the chemistry of pen.aaza macrocycle ligan.s with rare earth metals was also *** an. phthalocyan.n. ligan.s are n.t in.luded in.this review,which primarily focuses on.complexes with Schiff bases an. amin.s without pen.an. arms or an. addition.l don.r other than.*** syn.hetic methods,structural characterization.based on.sin.le X-ray crystal data,an. properties of the lan.han.id complexes,with special atten.ion.to magn.to-structural correlation.,are presen.ed herein.

关键词： Lan.han.id n.(5),n.(6)macrocycle Coordin.tion.chemistry Chirality Biological activity Molecule magn.t

In.ider Attack Preven.ion.LAPUP—Lightweight Authen.ication.Protocol Usin. PUF

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Journ.l of Commun.cation. an. In.ormation.n.tworks 2024年第2期9卷 192-206页

作者： Siran.eevi Rajaman.ckam Satyan.rayan. Vollala n.Ramasubraman.an Departmen. of Computer En.in.erin. Government Polytechnic CollegeTiruchirappalli 620022India Departmen. of Computer Scien.e an. En.in.erin. Dr.Shyama Prasad Mukherjee International Institute of Information Technology-Naya RaipurChhattisgarh 493661India Departmen. of Computer Scien.e an. En.in.erin. National Institute of TechnologyTiruchirappalli 620015India

The in.redible progress in.techn.logies has drastically in.reased the usage of Web *** share their creden.ials like userid an. password or use their smart cards to get authen.icated by the application.*** cards are han.y to use,but they are susceptible to stolen.smart card attacks an. few other n.table security *** prefer to use Web application. that guaran.ee for security again.t several security attacks,especially in.ider attacks,which is *** of several existin. schemes prove the security pitfalls of the protocols from preven.in. security attacks,specifically in.ider *** paper in.roduces LAPUP:a n.vel lightweight authen.ication.protocol usin. physically un.lon.ble fun.tion.PUF)to preven. security attacks,prin.ipally in.ider *** PUFs are used to gen.rate the security keys,challen.e-respon.e pair(CRP)an. hardware sign.ture for design.n. the *** tran.mitted messages are shared as hash values an. en.rypted by the keys gen.rated by *** messages are devoid of all possible attacks executed by an. attacker,in.ludin. in.ider *** is also free from stolen.verifier attacks,as the databases are secured by usin. the hardware sign.ture gen.rated by *** an.lysis of the protocol exhibits the stren.th of LAPUP in.preven.in. in.ider attacks an. its resistan.e again.t several other security *** evaluation.results of the commun.cation.an. computation.costs of LAPUP clearly shows that it achieves better performan.e than.existin. protocols,despite providin. en.an.ed security.

关键词： physically un.lon.ble fun.tion.PUF) in.iderattacks authen.ication.eyman.gemen.server(AKMS) security

Aberran. adult n.urogen.sis in.in.ractable epilepsy:can.GABAergic progen.tor tran.plan.ation.n.rmalize this process?

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n.ural Regen.ration.Research 2024年第7期19卷 1419-1420页

作者： Muhammad n.Arshad Jan.ce R.n.egele Departmen. of Biology Wesleyan UniversityMiddletownCTUSA Departmen. of n.uroscien.e Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common.type of focal epilepsy characterized by seizure foci within.the temporal *** surgical resection.of the foci is an.established an. effective approach for con.rollin. seizures,both temporal lobes can.ot be removed,due to their promin.n. roles in.learn.n. an. ***,seizures in.uce chan.es to the temporal lobes that con.ribute to hyperexcitability,in.ludin. mossy fiber sproutin.,astrogliosis.

关键词： epilepsy progen.tor seizures