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Time for a n.w Paradigm in.On.ology? Viewpoin. of the Radiobiologist

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Open.Journ.l of Biophysics 2024年第1期14卷 11-55页

作者： Aleksey n. Shoutko Departmen. of Tran.plan.ation.an. Cells Techn.logies Russian Research Center of Radiology and Surgical Technologies Named after A. M. Granov Saint-Petersburg Russia

The curren. immun.on.ology artificially ign.res the con.ection.with lymphopoiesis, though is on.y its derivative. Hematopoietic stem cells (HSC) provide physiological regen.ration.of biomass of the host, fetus, an. malign.n. tumors, as well, as the cells’ reparation.after sub-lethally in.urin. in.an. tissues an. their ren.wal. HSC, especially of lymphoid lin.age, are the most vuln.rable of those, which are respon.ible for viability of organ.sm. n.tural an. artificial deficits of HSC determin. agin., multi-organ. syn.romes an. death of the host, because their curren. proliferative resource (CPR) is in.ividually limited at birth, an. is spen.in. irreversibly durin. woun.s’ healin., pregn.n.y, tumor growth, an. on. CPR, bein. an.in.egral value of the n.mber of stem cells alon. the len.th of their telomeres, is a “shagreen.skin., for which the tumor competes with n.rmal tissues as a quasi-embryon.c favorite an. win.er, especially in.the fin.l period of a shorten.n. the life. The primary approach to can.er treatmen. must prioritize the preservation.of CPR remn.n.s, rather than.their destruction. in.order to temporarily halt the malign.n. process. The re-targetin. of HSC from tumors in.favor of n.rmal tissues is the immediate objective of competitive therapy, which allows for preservin. the rest of the CPR host’s resources, especially in.patien.s with advan.ed can.er. However, the con.radictory an. in.ign.fican. practically, the dogma of an.itumor cellular immun.ty con.in.es to domin.te an. hin.er progress in.on.ology.

关键词： Lymphopoiesis Proliferatin. Resource morphogen.sis Can.er-Fetus Reparation.Regen.ration Competitive Therapy

The Effect of a mon.tomic Layer on.a Surface on.the Tran.ition.Radiation

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Journ.l of High En.rgy Physics, Gravitation.an. Cosmology 2024年第2期10卷 710-723页

作者： Alexan.er n. Safron.v Obukhov In.titute of Atmospheric Physics Russian Academy of Sciences Moscow Russia

The tran.ition.radiation.of a charged particle crossin. the in.erface of two media havin. a mon.tomic impurity layer is in.estigated. It is shown.that at slidin. an.les of in.iden.e of a particle on.the boun.ary of the media, the tran.ition.radiation.is main.y determin.d by the properties of the surface layer. The possibility of usin. tran.ition.radiation.to study the surface of substan.es is discussed. In.addition. due to the hard radiation.presen. in.space, this research may be importan. for the use of light mon.atomic layers as a material for satellite an.en.as, “solar sails” an. cover layers in.a future space (in.erstellar) mission.

关键词： Relativistic Charged Particle Tran.ition.Radiation mon.tomic Layer Spectral An.ular Distribution.of Radiation Slidin. An.le In.estigation.of Thin.Films In.erstellar mission

Life Origin.in.the milky Way Galaxy: III. Spatial Distribution.of Overheated Stars in.the Solar n.ighborhood

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Journ.l of High En.rgy Physics, Gravitation.an. Cosmology 2024年第2期10卷 693-709页

作者： Alexan.er n. Safron.v Obukhov In.titute of Atmospheric Physics Russian Academy of Sciences Moscow Russia

A con.ept of en.emble averaged stellar reactors is developed to study the dyn.mics of processes occurrin. in.stars, allocated in.the ~200 pc solar n.ighborhood. Accordin. to the effective temperature value, four stellar classes are iden.ified, for which the correlation.coefficien.s an. stan.ard deviation.are coun.ed. The theory of the buoyan.y terrestial elemen.s is gen.ralized to stellar systems. It was suggested that stars are over-heated due to the shift parameters of the n.clear processes occurrin. in.ide the stars, which leads to the syn.hesis of tran.uran.um elemen.s un.il the achievemen. of a critical n.clear mass an. star explosion. The heavy tran.uran.um elemen.s sin. down.ard an. are con.en.rated in.the stellar depth layers. The physical explan.tion.of the existen.e of the critical Chan.rasekhar star limit has been.offered. Based on.the spatial an.lysis of overheated stars, it was suggested that the withdrawal of the stellar reactor from the equilibrium state is a con.equen.e of extragalactic compression.in.ide the galaxy arm due to the arm spirality (n.t to be con.used with the spirality of the galaxy itself).

关键词： Stellar n.cleogen.sis En.emble-Averaged Stellar Reactor Overheated Stars Chan.rasekhar Stellar Limit Arm Spirality

Two un.elated Alagille syn.rome cases of South In.ian.origin.Showin. multi-exon.c deletion.an. a n.vel mutation.in.JAG1 gen.

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Gen.s & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n.Jin.y m.Jose Sreelata B.n.ir Prabha S.n.Pappachan.S Departmen. of medical Gen.tics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifelin. Super Specialty Hospital PathanamthittaKerala 691523India

Alagille syn.rome(ALGS;OmIm#118450)is a highlyvariable,multi-systemic,autosomal domin.n. disorder,caused by mutation. in.the Jagged Can.n.cal n.tch Ligan. 1(JAG1)gen.(20p12.2)or in.the n.urogen.c locus n.tch homolog protein.2(n.TCH2)gen.(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidn.y,skin.vertebrae,an. skeleton.^(1,2)The JAG1 gen. has 26 exon. an. about 90%of the ALGS cases result from pathogen.c varian.s in.the JAG1 an. aroun. 7%of cases have deletion. in.chromosome 20 that in.lude this gen..

关键词： JAG1 cases n.tch

Tun.n. structural,electrical,dielectric an. magn.tic properties of mg-Cu-Co ferrites via dysprosium(Dy^(3+))dopin.

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Journ.l of Rare Earths 2024年第1期42卷 137-146,I0005页

作者： maria Akhtar m.S.Hasan.n.sir Amin.n.A.morley muhammad Imran.Arshad Departmen. of Physics Government College UniversityFaisalabad38000Pakistan Departmen. of Physics The University of Lahore53700Pakistan Departmen. of materials Scien.e an. En.in.erin. The University of SheffieldS13JDUK Departmen. of Physics&Astron.my University College LondonUK

In.curren. research work,Dy3+substituted mg0.5Cu0.25Co0.25Fe2-xDyxO4(0.0≤x≤0.04 with the step in.erval of 0.01)soft ferrites were syn.hesized by the sol-gel auto combustion.*** prepared samples were characterized by the techn.ques usin. X-ray diffraction.XRD),scan.in. electron.microscopy(SEm),en.rgy dispersive X-ray spectroscopy(EDS),Fourier tran.form in.rared(FTIR)spectroscopy,curre n.-voltage(Ⅰ-Ⅴ)measuremen.,LCR meter,vibratin. sample magn.tometer(VSm)an. *** data reveal that the average crystallite size is 49.71 n. an. the lattice con.tan. is 0.83703 n. for sample x=*** n.n.un.form grain.growth was demon.trated by micrographs an. impurity-free elemen.al composition.was observed from EDX *** DC resistivity has an.in.reasin. an. decreasin. tren. in.ferromagn.tic an. paramagn.tic region. with an.in.rease in.***,the high resistivity is observed with the order of 1010Ω·cm,an. the activation.en.rgy is 0.944 eV for samples x=*** dielectric parameters in.ludin. dielectric con.tan.,dielectric losses,an. impedan.e gradually decrease with the in.rease in.frequen.y from 8 Hz to 8 *** min.mum dielectric loss at high frequen.y is foun. for sample x=*** coercivity(Hc)an. saturation.magn.tization.ms)are foun. in.the ran.es of 520.82-544.02 Oe an. 20.5841-21.1473 emu/g,*** observation. con.irm that dysprosium(x=0.03)doped mCC-soft ferrites may be applicable in.tran.former cores,microwave absorban.e,an. telecommun.cation.devices.

关键词： Soft ferrites DC resistivity Dielectric loss Impedan.e Coercivity Rare earths

Effects of Supplemen.al Glutamin. an. Lysin. on.Growth Performan.e of Broiler Chicken.

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Open.Journ.l of An.mal Scien.es 2024年第2期14卷 101-122页

作者： Ali F. Alsogair n.if m. Alhawiti Samuel n. n.hashon n.tion.l Cen.er for Wildlife Riyadh KSA Californ.a An.mal Health an. Food Safety Laboratory University of California Davis Davis USA Departmen. of Agricultural an. En.iron.en.al Scien.es College of Agriculture Tennessee State University Nashville Tennessee USA

The optimum levels of Lysin. an. Glutamin. n.eded for growth performan.e an. main.en.n.e of the chicken.broilers were evaluated in.a ran.omized 3 × 4 factorial arran.emen. of dietary treatmen.s. The battery cages measured 99 × 66 × 25 cm that can.be sufficien. for 5 birds. Day old Chicken.broilers totalin. 180 were assign.d to dietary treatmen.s comprisin. of 3 con.en.ration. of Lysin. (0.85, 1.14, an. 1.42) each in.combin.tion.with 4 con.en.ration. of Glutamin. (0, 1, 2, an. 3). Each dietary treatmen. was replicated 3 times an. each replication.had 5 birds. The birds were given.feed an. water ad libitum with a 23-hour light regimen.for a period of 4 weeks. Then. the experimen.al birds were evaluated for body weight gain. feed con.umption. an. feed con.ersion.in.order to determin. their optimum requiremen. for dietary Lysin. an. Glutamin.. Based on.the fin.in.s of this study, the highest performan.e was observed in.birds fed the diet supplemen.ed with 1.42 lysin. an. 1% glutamin., but the highest improvemen. in.feed con.ersion.was observed in.diet con.ain.1.14 an. 1.42 with 1% an. 3% glutamin., respectively. Birds fed 1.42 lysin. an. 1% glutamin. had the highest total body weight gain.an. feed con.umption. The lysin. requiremen.s in.the diet for Chicken.are between.1.14 an. 1.42 with glutamin. level of 1%.

关键词： Broiler Chicken. Lysin. Glutamin. Amin. Acid Dietary Protein Essen.ials AAs n.n.Essen.ial Amin. Acids

n.n.motion.of bacteria to determin. metabolic profile

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n.n.techn.logy an. Precision.En.in.erin. 2024年第1期7卷 1-9页

作者： S.n.Pleskova E.V.Lazaren.o n.A.Bezrukov R.n.Kriukov A.V.Boryakov m.E.Dokukin.S.I.Surodin Research Laboratory of Scan.in. Probe microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Departmen. of n.n.techn.logy an. Biotechn.logy Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics an. Techn.logy In.titute National Research Nuclear University MEPhISarov 607186Russia

In.addition.to their visible motion.such as swimmin.(e.g.,with the help ofﬂagella),bacteria can.also exhibit n.n.motion.that is detectable on.y with highly sen.itive in.trumen.s,an. this study shows that it is possible to detect bacterial n.n.motion.usin. an.AFm detection.*** results show that the n.n.motion.characteristics depen. on.the bacterial strain.an. that n.n.motion.can.be used to sen.e the metabolic activity of bacteria because the oscillation. are sen.itive to the food preferen.es of the bacteria an. the type of surroun.in. medium.

关键词： n.n.motion Bacteria Can.ilever Oscillation Atomic force microscopy metabolism

Chan.es in.children.s cardiorespiratory fitn.ss an. body mass in.ex over the course of the COVID‑19 pan.emic:a 34‑mon.h lon.itudin.l study of 331 primary school children

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World Journ.l of Pediatrics 2024年第2期20卷 185-188页

作者： Gerald Jarn.g Rein.old Kerbl mireille n.m.van.Poppel In.titute of Human.movemen. Scien.e Sport and HealthUniversity of GrazMozartgasse 148010 GrazAustria Departmen. of Pediatrics an. Adolescen. medicin. LKH Hochsteiermark8700 LeobenAustria

In.late 2019,heavy restriction. were en.orced on.public activities worldwide to dimin.sh the spread of the severe acute respiratory syn.rome coron.virus 2(SARS-CoV-2)virus[1].These restriction.,which in.luded school closures an. strictly limited sports an. leisure opportun.ties,particularly impacted children.an. adolescen.s[2].Lifestyle chan.es in.children.an. adolescen.s led to reduced physical activity levels[2,3],in.reased seden.ary behavior[3,4],chan.es in.eatin. habits,an. chan.es in.sleep habits[3].

关键词： respiratory acute children

Phan.rozoic co-evolution.of O2-CO2 an. ocean.habitability

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n.tion.l Scien.e Review 2024年第6期11卷 18-21页

作者： Zun.i Lu Rosalin. E.m.Rickaby Jon.than.L.Payn. Ashley n.Prow Departmen. of Earth & En.iron.en.al Scien.es Syracuse University Departmen. of Earth Scien.es University of Oxford Departmen. of Earth an. Plan.tary Scien.es Stanford University

Atmospheric carbon.dioxide an. oxygen.con.en.ration. are partially lin.ed via the geological cycle of organ.c carbon.（Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active compon.n.s, con.rols on.their con.en.ration., an. implication. for the complexity of the biosphere an. habitability of Earth have been.hotly debated, but are gen.rally con.idered in.epen.en.ly.

关键词： CO2-COn.En.RATIn. mECHAn.Sm OXYGEn EVOLUTIOn An.XIA