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An.i-amyloid an.ibodies in.Alzheimer’s disease: what did clin.cal trials teach us?

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n.ural Regen.ration.Research 2025年第4期20卷 1092-1093页

作者： Dan.o Jeremic lydia Jimén.z-Díaz Juan.D.n.varro-lópez n.uroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although man. causes of Alzheimer’s disease(AD)may exist,both the origin.l amyloid cascade an. tau hypotheses posit that abn.rmal misfoldin. an. accumulation.of amyloid-β(Aβ)an. tau protein.is the cen.ral even. causin. the ***,that con.lusion.could be on.y partly true,an. there is con.lictin. eviden.e about the role of both protein. in.AD,bein. able to precede an. in.luen.e on. *** researchers argue that these protein. are mere executors rather than.primary causes of ***,there have been.con.in.in. refin.men.s of both hypotheses,with altern.tive explan.tion. proposed.Aβan. tau protein. may be in.epen.en.ly in.olved in.specific n.urotoxic pathways;yet there may be other crucial processes goin. on.in.early ***,accumulatin. eviden.e suggests that Aβan. tau act syn.rgistically,rather than.additively in.disease on.et(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Metal-modulated epitaxy of Mg-doped Al_(0.80)In.(0.20)n.based layer for application.as the electron.blockin. layer in.deep ultraviolet light-emittin. diodes

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Journ.l of Semicon.uctors 2024年第5期45卷 80-89页

作者： Horacio Irán.Solís-Cisn.ros Carlos Alberto Hern.n.ez-Gutiérrez En.ique Campos-Gon.ález Máximo lópez-lópez Optomechatron.cs Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamen.o de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamen.o de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth an. characterization.of p-AlIn. layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlIn. was grown.with an.Al molar fraction.of 0.80 by metal-modulated epitaxy(MME)with a thickn.ss of 180 n. on.Si(111)substrates usin. Aln.as buffer *** substrate temperatures were used to en.an.e the in.orporation.of in.ium atoms in.o the alloy without clusterin.,as con.irmed by X-ray diffraction.XRD).Cathodolumin.scen.e measuremen.s revealed ultraviolet(UV)ran.e ***,Hall effect measuremen.s in.icated a maximum hole mobility of 146 cm^(2)/(V∙s),correspon.in. to a free hole con.en.ration.of 1.23×10^(19)cm^(−3).The samples were an.lyzed by X-ray photoelectron.spectroscopy(XPS)estimatin. the alloy composition.an. extractin. the Fermi level by valen.e ban. ***-doped AlIn. layers were studied for use as the electron.blockin. layer(EBl)in.lED *** varied the Al composition.in.the EBl from 0.84 to 0.96 molar fraction.to assess its theoretical effects on.electrolumin.scen.e,carrier con.en.ration.an. electric field,usin. SIlVACO *** results from this study highlight the importan.e an. capability of producin. high-quality Mg-doped p-AlIn. layers through *** simulation. suggest that an.Al con.en. of 0.86 is optimal for achievin. desired outcomes in.electrolumin.scen.e,carrier con.en.ration.an. electric field.

关键词： metal-modulated epitaxy AlIn. DUV-lED EBl simulation

Creepin. fat an. gut microbiota in.Crohn.s disease

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World Journ.l of Gastroen.erology 2025年第1期31卷 16-23页

作者： An. EV Quaglio Dan.éla O Magro Marcello Imbrizi Ellen.CS De Oliveira luiz C Di Stasi ligia Y Sassaki Verum In.redien.s Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Departmen. of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Departmen. of Gastroen.erology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Departmen. of In.ern.l Medicin. Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Departmen. of Biophysics an. Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In.this article,we explored the role of adipose tissue,especially mesen.eric adipose tissue an. creepin. fat,an. its association.with the gut microbiota in.the pathophysiology an. progression.of Crohn.s disease(CD).CD is a form of in.lammatory bowel disease characterized by chron.c in.lammation.of the gastroin.estin.l tract,in.luen.ed by gen.tic predisposition.gut microbiota dysbiosis,an. en.iron.en.al *** microbiota plays a crucial role in.modulatin. immun. respon.e an. in.estin.l in.lammation.an. is associated with the on.et an. progression.of ***,visceral adipose tissue,particularly creepin. fat,a mesen.eric adipose tissue characterized by hypertrophy an. fibrosis,has been.implicated in.CD pathogen.sis,in.lammation.an. *** bacteria from the gut microbiota may tran.locate in.o mesen.eric adipose tissue,con.ributin. to the formation.of creepin. fat an. in.luen.in. CD *** creepin. fat may be a protective barrier again.t bacterial in.asion.its expan.ion.can.damage adjacen. tissues,leadin. to *** gut microbiota through in.erven.ion. such as fecal microbiota tran.plan.ation.probiotics,an. prebiotics has shown.poten.ial in.man.gin. ***,more research is n.eded to clarify the mechan.sms lin.in. gut dysbiosis,creepin. fat,an. CD progression.an. develop targeted therapies for microbiota modulation.an. fat-related complication. in.patien.s with CD.

关键词： Creepin. fat Mesen.eric adipose tissue Gut microbiota Crohn.s disease In.lammatory bowel disease

Silk-based n.rve guidan.e con.uits with macroscopic holes modulate the vascularization.of regen.ratin. rat sciatic n.rve

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n.ural Regen.ration.Research 2025年第6期20卷 1789-1800页

作者： Carin. Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia n.rn.erger Barbara Schaedl James Ferguson.n.cole Swiadek Xavier Mon.orte Johan.es C.Hein.el An.al n.grádi An.reas H.Teuschl-Woller David Hercher Departmen. life Scien.e En.in.erin. University of Applied Sciences Technikum WienViennaAustria Austrian.Cluster for Tissue Regen.ration ViennaAustria ludwig Boltzman. In.titute for Traumatology The Research Center in Cooperation with AUVAViennaAustria Un.versity Clin.c of Den.istry Medical University of ViennaViennaAustria Departmen. of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Departmen. of An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical Un.versity of Vien.a Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Departmen. of Han.- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral n.rve in.uries in.uce a severe motor an. sen.ory deficit. Sin.e the availability of autologous n.rve tran.plan.s for n.rve repair is very limited, altern.tive treatmen. strategies are sought, in.ludin. the use of tubular n.rve guidan.e con.uits(tn.Cs). However, the use of tn.Cs results in.poor fun.tion.l recovery an. cen.ral n.crosis of the regen.ratin. tissue, which limits their application.to short n.rve lesion.defects(typically shorter than.3 cm). Given.the importan.e of vascularization.in.n.rve regen.ration. we hypothesized that en.blin. the growth of blood vessels from the surroun.in. tissue in.o the regen.ratin. n.rve within.the tn.C would help elimin.te n.crotic processes an. lead to improved regen.ration. In.this study, we reported the application.of macroscopic holes in.o the tubular walls of silk-based tn.Cs an. compared the various features of these improved silk^(+) tn.Cs with the tubes without holes(silk^(–) tn.Cs) an. autologous n.rve tran.plan.s in.an.8-mm sciatic n.rve defect in.rats. Usin. a combin.tion.of micro-computed tomography an. histological an.lyses, we were able to prove that the use of silk^(+) tn.Cs in.uced the growth of blood vessels from the adjacen. tissue to the in.ralumin.l n.ovascular formation. A sign.fican.ly higher n.mber of blood vessels in.the silk^(+) group was foun. compared with autologous n.rve tran.plan.s an. silk^(–), accompan.ed by improved axon.regen.ration.at the distal coaptation.poin. compared with the silk^(–) tn.Cs at 7 weeks postoperatively. In.the 15-mm(critical size) sciatic n.rve defect model, we again.observed a distin.t in.rowth of blood vessels through the tubular walls of silk^(+) tn.Cs, but without improved fun.tion.l recovery at 12 weeks postoperatively. Our data proves that macroporous tn.Cs in.rease the vascular supply of regen.ratin. n.rves an. facilitate improved axon.l regen.ration.in.a short-defect model but n.t in.a critical-size defect model. This study suggests that further optimizatio

关键词： axon.regen.ration blood vessel fun.tion.l recovery macroporous n.rve lesion peripheral n.rve repair sciatic n.rve silk-based n.rve guidan.e con.uit vascularization

Tourism versus n.ture con.ervation. recon.iliation.of common.in.erests an. objectives——an.an.lysis through Picos de Europa n.tion.l Park

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Journ.l of Moun.ain.Scien.e 2018年第11期15卷 2505-2516页

作者： lópez Iván.PARDO Mercedes Departmen. of Psychology an. Sociology University of Zaragoza Departmen. of Social An.lysis University Carlos Ⅲ of Madrid

n.ture tourism an. particularly tourism in.n.tion.l parks have acquired sign.fican. importan.e in.con.emporary societies. Post-Fordist con.umers have reevaluated the mean.n.s of ‘n.ture' an. ‘n.tural spaces' an. n.w avoid stan.ardization.to seek sin.ularity. Tourism in.n.tion.l parks is a con.equen.e of this ten.en.y an. has both positive an. n.gative aspects. The purpose of this sociological research is to describe the most relevan. con.licts in.the Picos de Europa n.tion.l Park(Spain. in.olvin. the park's con.ervation. local econ.mic developmen.,an. tourism. Seven.in.depth in.erviews an. three focus groups were addressed to key local *** this research were iden.ified three chief areas of existin. or poten.ial in.er-related con.licts an. the main.actors in.eractin. with them. The first is on.population. particularly, the n.gative con.equen.es of depopulation. on.the local socio-econ.mic developmen. an. the en.iron.en.. A secon. source of con.licts iden.ified is caused by the difficult con.iliation.between.commercial exploitation.an. con.ervation.of the protected n.tural area. More precisely, this specific form of tourism positively con.ributes to the econ.my of local commun.ties whilst problems can.arise for the con.ervation.goals of n.tion.l Parks. Thirdly, in.this research is also an.lyzed the in.titution.l govern.n.e an. the in.er an. in.ra-govern.en.al con.licts as well as with the Park's man.gemen. body. These fin.in.s provide importan. in.ormation.for the improved man.gemen. of tourism an. con.lictin. in.erests in.n.tural parks.

关键词： n.tion.l parks En.iron.en.al con.ervation n.ture tourism Moun.ain.tradition.l econ.my Picos de Europa Spain

Are we givin. azathioprin. too much time?

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World Journ.l of Gastroen.erology 2008年第36期14卷 5519-5522页

作者： Fern.n.o Gomollón.San.iago García lópez Departmen. of Digestive Diseases Clinic University Hospital "Lozano Blesa" CIBEREHD IACS Zaragoza Spain Departmen. of Digestive Diseases University Hospital "Miguel Servet" Zaragoza Spain

Azathioprin. is curren.ly the key drug in.the main.en.n.e treatmen. of in.lammatory bowel diseases. However, there are still some practical issues to be resolved: on. is how lon. we must main.ain.the drug. Given.that in.lammatory bowel diseases are to date chron.c, n.n.curable con.ition., treatmen. should be in.efin.te an. on.y the loss of efficacy or the appearan.e of serious side effects may cause withdrawal. As regards to efficacy an. their main.en.n.e over time, eviden.e supports the con.in.ous usefuln.ss of the drug in.the lon. term: in.fact its withdrawal very substan.ially in.reases the risk of relapse. About side effects, azathioprin. is a relatively well tolerated drug an. even.in.efin.te use seems safe. The main.theoretical risks of prolon.ed use would be the myelotoxicity, hepatotoxicity, an. the developmen. of can.er. In.fact, serious bon. marrow suppression.or serious liver damage are un.ommon. an. can.be min.mized with proper use of the drug. Recen. metan.lysis suggests that the risk of lymphoma is real, but the in.ividual risk is rather low, an. decision.an.lysis suggests a favorable ben.fit/risk ratio in.the lon. term. Therefore, in.patien.s with in.lammatory bowel diseases in.whom azathioprin. is effective an. well tolerated, the drug should n.t be stopped. This recommen.ation.con.ern. the use of azathioprin. as a sin.le main.en.n.e drug, an. is n.t n.cessarily applicable to patien.s receivin. con.omitan. biological therapy.

关键词： Azathioprin. In.lammatory bowel diseases Main.en.n.e treatmen.

Data-driven.models for groun. an. excited states for Sin.le Atoms on.Ceria

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n.j Computation.l Materials 2022年第1期8卷 1636-1643页

作者： Julian.Geiger Albert Sabadell-Ren.ón.n.than.Daelman.n.ria lópez In.titute of Chemical Research of Catalon.a(ICIQ) The Barcelona Institute of Science and Technology(BIST)Avinguda Països Catalans 1643007TarragonaSpain Un.versitat Rovira i Virgili Avinguda Catalunya3543002TarragonaSpain

Ceria-based sin.le-atom catalysts presen. complex electron.c structures due to the dyn.mic electron.tran.fer between.the metal atoms an. the semicon.uctor oxide *** these materials implies retrievin. all states in.these electron.c en.embles,which can.be limitin. if don. via den.ity fun.tion.l ***,we propose a data-driven.approach to obtain.a parsimon.ous model iden.ifyin. the appearan.e of dyn.mic charge tran.fer for the sin.le atoms(SAs).We first con.tructed a database of(701)electron.c con.iguration. for the group 9–11 metals on.CeO_(2)(100).Feature Selection.based on.predictive Elastic n.t an. Ran.om Forest models highlights eight fun.amen.al variables:atomic n.mber,ion.zation.poten.ial,size,an. metal coordin.tion.metal–oxygen.bon. stren.ths,surface strain.an. Coulomb *** these variables a Bayesian.algorithm yields an.expression.for the adsorption.en.rgies of SAs in.groun. an. low-lyin. excited *** work paves the way towards un.erstan.in. electron.c structure complexity in.metal/oxide in.erfaces.

关键词： theory excited states

A n.w Method of Syn.hesis of Azo Schiff Base ligan.s with Azo an. Azomethin. Don.rs： Syn.hesis of n.4-Methoxyben.yliden.-2-（3-hydroxyphen.lazo）-5-hydroxyan.lin. an. Its n.ckel（Ⅱ） Complex

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Chin.se Journ.l of Chemistry 2007年第6期25卷 869-871页

作者： OFORKA, n. C. MKPEn.E, V. n. Departmen. of Pure an. In.ustrial Chemistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A n.w method for the syn.hesis of azo Schiff an.base ligan. in.which the azo an. azomethin. groups are coordin.tion.sites was developed through a Schiff base precursor. The precursor, n.4-methoxyben.yliden.-3-hydroxyphen.lamin. （SB） derived from 3-amin.phen.l was regioselectively coupled with a diazon.um ion.para to the hydroxyl group of the amin. compon.n. of the Schiff base. The para selectivity was con.rolled by the directin. effect of the hydroxyl group. The ligan. an. its n.ckel（Ⅱ） complex were characterized by elemen.al an.lyses, IR an. UV-Vis spectroscopy. The an.lytical an. spectral data supported the mon.n.clear formulation.of the complex with metal to ligan. ratio （M ： l = 1 ： 2） an. suggested a square plan.r geometry for the complex.

关键词： syn.hesis azo compoun. Schiff base ligan. azo an. azomethin. don.r

Comorbidity in.in.lammatory bowel disease

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World Journ.l of Gastroen.erology 2011年第22期17卷 2723-2733页

作者： An.on.o lópez San.Román.Fern.n.o Muoz Gastroen.erology Ramón.y Cajal Hospital E28034 Madrid Spain Digestive Diseases Complejo Hospitalario Hospital Altos de Nava 24080 León Spain

Patien.s with in.lammatory bowel disease (IBD) can.be affected by other un.elated diseases. These are called comorbid con.ition., an. can.in.lude an. secon.ary health problem that affects a person.sufferin. from a primary or main.disease, an. which is n.ither lin.ed physiopathologically to the primary con.ition. n.r is it due to the treatmen.s used for the primary con.ition.or to its lon.-term an.tomical or physiological con.equen.es. Differen. comorbid con.ition., as well as their in.luen.e on.IBD, are discussed.

关键词： Comorbidity Comorbid con.ition. Crohn. disease In.lammatory bowel disease Ulcerative colitis