检索结果-南通市图书馆

Erlotin.b combin.tion.with a mitochon.ria-targeted ubiquin.n. effectively suppresses pan.reatic can.er cell survival

引用

World Journ.l of Gastroen.erology 2024年第7期30卷 714-726页

作者： Pui-Yin.Leun. Wen.in. Chen.An.ssa n.Sari Poojitha Sitaram Pui-kei Wu Susan.Tsai Jon.-In.Park Departmen. of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Departmen. of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUn. Pan.reatic can.er is a leadin. cause of can.er-related *** activity of the epidermal growth factor receptor(EGFR)is often.observed in.pan.reatic can.er,an. the small molecule EGFR in.ibitor erlotin.b has been.approved for pan.reatic can.er therapy by the food an. drug ***,erlotin.b alon. is in.ffective an. should be combin.d with other drugs to improve therapeutic *** previously showed that certain.receptor tyrosin. kin.se in.ibitors can.in.rease mitochon.rial membran. poten.ial(Δψm),facilitate tumor cell uptake ofΔψm-sen.itive agen.s,disrupt mitochon.rial homeostasis,an. subsequen.ly trigger tumor cell *** has n.t been.tested for this *** To determin. whether erlotin.b can.elevateΔψm an. in.rease tumor cell uptake ofΔψm-sen.itive agen.s,subsequen.ly triggerin. tumor cell ***Δψm-sen.itive fluorescen. dye was used to determin. how erlotin.b affectsΔψm in.pan.reatic aden.carcin.ma(PDAC)cell *** viability of con.en.ion.l an. patien.-derived primary PDAC cell lin.s in.2D-an. 3D cultures was measured after treatin. cells sequen.ially with erlotin.b an. mitochon.ria-targeted ubiquin.n.(MitoQ),aΔψm-sen.itive *** syn.rgy between.erlotin.b an. MitoQ was then.an.lyzed usin. Syn.rgyFin.er *** preclin.cal efficacy of the twodrug combin.tion.was determin.d usin. immun.-compromised n.de mice bearin. PDAC cell lin. *** Erlotin.b elevatedΔψm in.PDAC cells,facilitatin. tumor cell uptake an. mitochon.rial en.ichmen. ofΔψm-sen.itive *** triggered caspase-depen.en. apoptosis in.PDAC cells in.culture if used at high doses,while erlotin.b pretreatmen. poten.iated low doses of *** suggested that these drugs syn.rgistically in.uced tumor cell *** with in.vitro data,erlotin.b an. MitoQ combin.tion.suppressed human.PDAC cell lin. xen.grafts in.mice more effectively than.sin.le treatmen.s of each *** Our fin.in.s suggest tha

关键词： Pan.reatic can.er Erlotin.b Mitochon.ria-targeted ubiquin.n. Mitochon.ria Combin.tion.therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

低温下C4F7n.CO_(2)混合气体的绝缘特性与参数配置

引用

高电压技术 2024年第2期50卷 832-841页

作者：陶子林郑宇高克利朱太云刘伟周文俊武汉大学电气与自动化学院武汉430072 国网安徽省电力有限公司电力科学研究院合肥230000 中国电力科学研究院有限公司北京100192

为提出低温下满足液化温度和绝缘要求的C4F7n.CO_(2)混合气体的参数配置,研究了C4F7n.CO_(2)混合气体在低温下的绝缘特性。首先采用实验和计算得到了不同气压和混合体积比例下C4F7n.CO_(2)混合气体的液化温度,结果表明计算得到的液化温... 详细信息

为提出低温下满足液化温度和绝缘要求的C4F7n.CO_(2)混合气体的参数配置,研究了C4F7n.CO_(2)混合气体在低温下的绝缘特性。首先采用实验和计算得到了不同气压和混合体积比例下C4F7n.CO_(2)混合气体的液化温度,结果表明计算得到的液化温度与实验数据较为相符。其次开展不同温度下C4F7n.CO_(2)混合气体的工频击穿试验,获得了C4F7n.CO_(2)混合气体的击穿电压随温度的变化。结果表明:气体在液化阶段的击穿电压标准差为液化后的2~7倍,且液化后混合气体的绝缘性能出现显著下降。此时击穿电压只与温度有关,基本不受混合体积比例的影响。考虑混合气体设备的应用需求,分别以–25℃和–30℃为最低使用温度,提出了满足要求的C4F7n.CO_(2)混合气体参数配置方案,可为低温下C4F7n.CO_(2)混合气体的应用提供参考。

关键词： C4F7n.CO_(2)混合气体绝缘特性约化电场液化温度参数配置

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Defin.n. min.mal in.asive surgical therapy for ben.gn.prostatic obstruction.surgery: Perspectives from a global kn.wledge, attitude, an. practice survey

引用

Asian.Journ.l of Urology 2024年第1期11卷 55-64页

作者： Bryan.Kwun.Chun. Chen. Steffi Kar-kei Yuen.Dan.ele Castellan. Marcelo Lan.er Wroclawski Hon.da Zhao Mallikarjun. Chiruvella Wei-Jin.Chua Ho-Yee Tion. Yiloren.Tan.dir Jean.de la Rosette En.ique Rijo Vin.en. Misrai Amy Krambeck Dean.S.Elterman.Bhaskar K.Soman. Jeremy Yuen.Chun.Teoh Vin.et Gauhar Departmen. of Surgery United Christian HospitalHong KongChina S.H.Ho Urology Cen.re Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Departmen. of Urology University Hospital“Ospedali Riuniti”and Polytechnic University of Marche RegionAnconaItaly Hospital Israelita Albert Ein.tein Sao PauloSPBrazil BP—A Ben.ficen.ia Portuguesa de Sao Paulo Sao PauloSPBrazil Faculdade de Medicin. do ABC Santo AndreSPBrazil Departmen. of Urology Asian Institute of Nephrology and UrologyHyderabadTGIndia Departmen. of Urology National University HospitalSingapore Departmen. of Urology Marmara University School of MedicineIstanbulTurkey Departmen. of Urology Medipol Mega University HospitalIstanbul Medipol UniversityIstanbulTurkey Departmen. of Urology Hospital Quiron BarcelonaBarcelonaSpain Departmen. of Urology Clinique PasteurToulouseFrance Departmen. of Urology Indiana University School of MedicineIndianapolisINUSA Division.of Urology Department of SurgeryUniversity Health NetworkUniversity of TorontoTorontoCanada Departmen. of Urology University Hospital Southampton NHS TrustSouthamptonUK Departmen. of Urology Ng Teng Fong General HospitalNUHSSingapore

Objective:To scrutin.ze the defin.tion. of min.mal in.asive surgical therapy(MIST)an. to in.estigate urologists’kn.wledge,attitudes,an. practices for ben.gn.prostatic obstruction.***:A 36-item survey was developed with a Delphi *** on.defin.tion. of MIST an. attitudes an. practices of ben.gn.prostatic obstruction.surgeries were *** were in.ited globally to complete the on.in. *** was achieved when.more than.or equal to 70%respon.es were“agree or stron.ly agree”an. less than.or equal to 15%respon.es were“disagree or stron.ly disagree”(con.en.us agree),or when.more than.or equal to 70%respon.es were“disagree or stron.ly disagree”an. less than.or equal to 15%respon.es were“agree or stron.ly agree”(con.en.us disagree).Results:The top three qualities for defin.n. MIST were min.mal blood loss(n.466,80.3%),fast post-operative recovery(n.431,74.3%),an. short hospital stay(n.425,73.3%).The top three surgeries that were regarded as MIST were Urolift®(n.361,62.2%),Rezum®(n.351,60.5%),an. en.oscopic en.cleation.of the prostate(EEP)(n.332,57.2%).Con.en.us in.the kn.wledge section.was achieved for the superiority of Urolift®,Rezum®,an. iTIn.®over tran.urethral resection.of the prostate with regard to blood loss,recovery,day surgery feasibility,an. post-operative *** in.the attitudes section.was achieved for the superiority of Urolift®,Rezum®,an. iTIn.®over tran.urethral resection.of the prostate with regard to blood loss,recovery,an. day surgery *** on.both section. was achieved for EEP as the option.with the better symptoms an. flow improvemen.,lower retreatmen. rate,an. better suitable for prostate more than.80 ***:Min.mal blood loss,fast post-operative recovery,an. short hospital stay were the most importan. qualities for defin.n. ***®,Rezum®,an. EEP were regarded as MIST by most urologists.

关键词： Ben.gn.rostate hyperplasia Min.malin.asive surgical therapy Surgery Bladderoutlet obstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ran.-On. Cross Commutators on.Backward Shift In.arian. Subspaces on.the Bidisk

引用

Acta Mathematica Sin.ca,En.lish Series 2009年第5期25卷 693-714页

作者： kei Ji IZUCHI Kou Hei IZUCHI Departmen. of Mathematics Niigata University Graduate School of Scien.e an. Techn.logy Niigata University Departmen. of Mathematics Graduate School of ScienceHokkaido University

For a backward shift in.arian. subspace n.in.H^2（Г^2）, the operators Sz an. Sw on.n.are defin.d by Sz = Pn.z｜n.an. Sw, = Pn.w｜n. where Pn.is the orthogon.l projection.from L^2（Г^2） on.o n. We give a characteri... 详细信息

关键词： backward shift in.arian. subspace in.arian. subspace Hardy space cross commutator ran.-on. operator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Con.rol of Distributed Gen.ration.Usin. n.n.Sin.soidal Pulse Width Modulation

引用

Computers, Materials & Con.in.a 2023年第2期74卷 4149-4164页

作者： Mehrdad Ahmadi Kamarposhti Phatiphat Thoun.hon. Ilhami Colak kei Eguchi Departmen. of Electrical En.in.erin. Jouybar BranchIslamic Azad UniversityJouybar***Iran Ren.wable En.rgy Research Cen.re(RERC) Department of Teacher Training in Electrical EngineeringFaculty of Technical EducationKing Mongkut’s University of Technology North Bangkok1518Pracharat 1 RoadBangsueBangkok10800Thailand Departmen. of Electrical an. Electron.cs En.in.erin. Faculty of Engineering and ArchitecturesNisantasi UniversityIstanbul34398Turkey Departmen. of In.ormation.Electron.cs Fukuoka Institute of TechnologyFukuoka811-0295Japan

The islan.ed mode is on. of the con.ection.modes of the grid distributed gen.ration.*** this study,a distributed gen.ration.resource is con.ected to lin.ar an. n.n.in.ar loads via a three-phase in.erter where a con.rol method n.edin. n. curren. sen.ors or compen.ator elemen.s is applied to the distribute gen.ration.system in.the islan.ed *** con.rol method has two main.loops in.each *** first loop con.rols the voltage con.rol loops that adjust the three-phase poin. of common.couplin.,the amplitude of the n.n.sin.soidal referen.e waveform an. the n.ar-state pulse width modulation.n.PWM)*** n.xt loop compen.ates the harmon.c compen.ator loop that calculates the voltage harmon.cs of the poin. of common.couplin. in.each phase,an. in.ects them to compen.ate the n.n.sin.soidal referen.e waveforms of each *** simulation.results in.MATLAB/SIMULIn. show that this method can.gen.rate balan.ed threephase sin.soidal voltage with an.acceptable total harmon.c distortion.THD)at the join. con.ection.poin..

关键词： Islan.ed mode distributed gen.ration.resource the poin. of common.couplin. voltage total harmon.c distortion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelin. an. Simulation.of DVR an. D-STATCOM in.Presen.e of Win. En.rgy System

引用

Computers, Materials & Con.in.a 2023年第2期74卷 4547-4570页

作者： Mehrdad Ahmadi Kamarposhti Ilhami Colak Phatiphat Thoun.hon. kei Eguchi Departmen. of Electrical En.in.erin. Jouybar BranchIslamic Azad UniversityJouybarIran Departmen. of Electrical an. Electron.cs En.in.erin. Faculty of Engineering and ArchitecturesNisantasi UniversityIstanbulTurkey Ren.wable En.rgy Research Cen.re(RERC) Department of Teacher Training in Electrical EngineeringFaculty of Technical EducationKing Mongkut’s University of Technology North Bangkok1518Pracharat 1 RoadBangsueBangkok10800Thailand Departmen. of In.ormation.Electron.cs Fukuoka Institute of TechnologyFukuokaJapan

The presen. study suggests that series voltage in.ection.is more effective than.parallel curren. in.ection.to improve voltage quality on.the load *** lin. voltage can.be accurately symmetrized at the con.ection.poin. by creatin. an. con.rollin. a series voltage compon.n. in.each *** is more reliable an. effective than.parallel curren. in.ection.A dyn.mic voltage restorer(DVR)an. a distribution.static syn.hron.us compen.ator(DSTATCOM)were utilized to provide the required *** DVR is an.effective an.modern.device utilized in.parallel within.the grid an. can.protect sen.itive loads from voltage problems in.the grid by in.ectin. *** DVR an. D-STATCOM were used to improve voltage stability in.faults.A stan.ard 13-bus system was studied in.the presen.e of a win. *** simulation.results demon.trated that sin.le an. three-phase overloads dramatically altered the voltage of the system,makin. it n.cessary to use compen.ators to improve voltage *** DVR an. D-STATCOM showed similar performan.e un.er n.rmal con.ition. an. somewhat improved grid voltage ***,the DVR outperformed D-STATCOM un.er asymmetric faults con.ition. an. led to lower voltage variation..

关键词： Power quality distribution.system DVR D-STATCOM win. turbin.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Age-depen.en. chan.es in.the association.between.sleep duration.an. impaired glucose metabolism

引用

World Journ.l of Diabetes 2017年第8期8卷 397-406页

作者： kei n.kajima Kan.me Suwa Ken.i Toyama School of n.trition.an. Dietetics Faculty of Health and Social Services Kanagawa University of Human Services Yokosuka Departmen. of En.ocrin.logy an. Diabetes Saitama Medical Center Saitama Medical University Saitama Health Promotion.Corporation

AIM To in.estigate whether the association.between.sleep duration.an. impaired glucose metabolism varies amon. youn.er an. older *** We reviewed data of self-reported habitual sleep duration.per n.ght, HbA1c levels, an. clin.cally relevan. factors in.a cross-section.l checkup database of 75472 Japan.se from the gen.ral population.aged 20-79 years(51695 men.an. 23777 women.. Association. of prediabetes(HbA1c ≥ 5.7% an./or diabetic pharmacotherapy) or diabetes(HbA1c ≥ 6.5% an./or diabetic pharmacotherapy) with short an. lon. sleep duration. compared with a referen.e sleep duration.7 h) were in.estigated by multivariate logistic regression.an.lysis. We con.rolled for poten.ial relevan. con.oun.ers, in.ludin. age, sex, an. work duration.per day accordin. to youn.er an. older *** As age advan.ed, sleep duration.became lon.er an. this in.rease in.the 40 s an. 50 s was two times greater in.men.than.in.women. This fin.in. was accompan.ed by a deterioration.in.HbA1c levels. In.subjects aged youn.erthan.40 years(n.= 32929), HbA1c levels were in.ersely an. lin.arly correlated with sleep duration.in.both sexes. However, in.subjects aged 40 years or older(n.= 42543), HbA1c levels showed a n.n.lin.ar relation.hip again.t sleep duration.with a n.dir at 7 h. Multivariate logistic regression.an.lysis showed that in.youn.er subjects, short duration. of sleep(≤ 5 h an. 6 h) were positively associated with prediabetes(both P n. duration.of sleep(≥ 8 h) was in.ersely associated with prediabetes(P n. remain.d sign.fican. after adjustmen. for relevan. con.oun.ers, in.ludin. age, sex, an. work duration.per day(ORs = 1.20, 95%CI: 1.05-1.37, P n. ORs = 0.84, 95%CI: 0.72-0.99, P n.con.rast, in.older subjects, besides an.association.of prediabetes with a short duration.of sleep(≤ 5 h)(ORs = 1.12, 95%CI: 1.03-1.21, P n.fican.

关键词： Sleep Prediabetes Diabetes HbA1c Agin.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chan.e in.arterial tumor perfusion.is an.early biomarker of len.atin.b efficacy in.patien.s with un.esectable hepatocellular carcin.ma

引用

World Journ.l of Gastroen.erology 2019年第19期25卷 2365-2372页

作者： Hidekatsu Kuorda Tamami Abe Yudai Fujiwara Takuya Okamoto Miki Yon.zawa Hiroki Sato kei En.o Takayoshi Oikawa kei Sawara Yasuhiro Takikawa Division.of Hepatology Department of Internal Medicine Iwate Medical University

BACKGROUn. Len.atin.b is on. of the first-lin. tyrosin. kin.se in.ibitors used for un.esectable hepatocellular carcin.ma(HCC). In.the presen. study, we evaluated the poten.ial of early chan.es in.the time-in.en.ity curve(TIC) of arterial phase on.con.rasten.an.ed ultrasoun.(CEUS) as early imagin. biomarkers of len.atin.b *** To evaluate the poten.ial of the early chan.es in.the TIC of CEUS as early imagin. biomarkers of len.atin.b efficacy in.patien.s with un.esectable *** We an.lyzed 20 con.ecutive patien.s with un.esectable HCC treated with len.atin.b from March to n.vember 2018. Tumor respon.e at 8 wk was assessed by computed tomography usin. the modified Respon.e Evaluation.Criteria in.Solid Tumors(m RECIST). CEUS was performed at baselin. before treatmen.(Day 0) an. on.day 7(Day 7), an. the images were an.lyzed in.the arterial phase for 20 secon.s after the con.rast agen. arrived at the target tumor. Three perfusion.parameters were extracted from the TICs: the slope of wash-in.Slope),time to peak(TTP) in.en.ity, an. the total area un.er the curve(AUC) durin. wash-in. The rate of chan.e in.the TIC parameters between.Day 0 an. Day 7 was compared between.treatmen. respon.ers an. n.n.respon.ers based on.m *** The rate of chan.e for all TIC parameters showed sign.fican. differen.es between.the respon.ers(n.= 9) an. n.n.respon.ers(n.= 11)(Slope, P = 0.025; TTP, P =0.004; an. AUC, P = 0.0003). The area un.er the receiver operatin. curve values for slope, TTP, an. AUC for the prediction.of respon.ers were 0.805, 0.869, an.0.939, *** CEUS may be useful for the early prediction.of tumor respon.e to len.atin.b therapy in.patien.s with un.esectable HCC.

关键词： Hepatocellular carcin.ma Len.atin.b Con.rast-en.an.ed ultrasoun. Timein.en.ity curve

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

沙库巴曲缬沙坦联合酒石酸美托洛尔治疗高血压伴心力衰竭患者的效果

引用

中国民康医学 2024年第16期36卷 20-23页

作者：孟席君冯克丽孟平平商丘市第四人民医院心内科河南商丘476000

目的:观察沙库巴曲缬沙坦联合酒石酸美托洛尔治疗高血压伴心力衰竭患者的效果。方法:选取2021年1月至2023年1月该院收治的80例高血压伴心力衰竭患者进行前瞻性研究,按照随机数字表法分为对照组与观察组各40例。对照组采用酒石酸美托洛... 详细信息

目的:观察沙库巴曲缬沙坦联合酒石酸美托洛尔治疗高血压伴心力衰竭患者的效果。方法:选取2021年1月至2023年1月该院收治的80例高血压伴心力衰竭患者进行前瞻性研究,按照随机数字表法分为对照组与观察组各40例。对照组采用酒石酸美托洛尔片治疗,观察组在对照组基础上联合沙库巴曲缬沙坦钠片治疗。比较两组临床疗效,治疗前后血压、心功能指标[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、心排血量(CO)]、心肌损伤标志物[n.末端脑钠肽前体(n.-proBn.)、肌钙蛋白I(cTn.)、脑钠肽(Bn.)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的77.50%(31/40),差异有统计学意义(Pn.-proBn.、cTn.、Bn.水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P0.05)。结论:沙库巴曲缬沙坦联合酒石酸美托洛尔治疗高血压伴心力衰竭患者可提高临床疗效,改善心功能指标水平,降低血压和心肌损伤标志物水平,其效果优于单纯酒石酸美托洛尔治疗。

关键词：高血压心力衰竭沙库巴曲缬沙坦酒石酸美托洛尔心功能心肌损伤标志物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用于Friedel-Craft甲苯苯甲酰化反应的铟催化剂的多相化(英文)

引用

催化学报 2012年第11期33卷 1802-1808页

作者： Farook ADAM kei Lin.SEK School of Chemical Scien.es Universiti Sains MalaysiaPenang 11800Malaysia

In.ium in.orporated silica samples with differen. in.ium con.en.s were syn.hesized usin. a template free sol-gel *** silica used was extracted from rice husk(RH) an. the resultin. catalyst was labeled as RH-xIn.x = 5%,10%,15%,an. 20%).From the n. adsorption.an.lysis the presen.e of type IV isotherm in.RH-blan. an. RH-xIn.in.icated the mesoporous n.ture of the *** the XRD pattern.a broad ban. at ca.2θ = 25° was observed for all the catalysts which showed them to be *** micrographs revealed that the material is composed of ***-Craft ben.oylation.of toluen. was carried out usin. the RH-xIn.*** optimum con.ition. for the ben.oylation.of toluen. were determin.d an. at 373 K,100% con.ersion.an. 89% selectivity for the para-product(i.e.4-methylben.ophen.n.) were obtain.d.

关键词： LFCO XRD 化学化学动力学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：