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A De.p Re.n.orce.e.0} Le.rn.n.-Base. Te.hn.que.for Optimal Powe. Allocation.in.Multiple.Acce.s Commun.cation.

In.e.lige.0} Automation.& Soft Computin. 2024年第1期39卷 93-108页

作者： Se.e.r Soltan. e.san.Ghafourian.Re.a Sale.i Die.o Martín.Milad Vahidi De.artme.0} of In.ustrial e.0}in.e.in. College of EngineeringUniversity of HoustonHoustonTX77204USA De.artme.0} of Compute. Scie.0}e Iowa State UniversityAmesIowaUSA e.SI de.Te.e.omun.cación Universidad Politécnica de MadridMadridSpain Faculty of School of Plan. an. e.0}iron.e.0}al Scie.0}e. Virginia Polytechnic Institute and StateUniversityBlacksburgVirginia24060USA

Forman. ye.rs,re.e.rche.s have.e.plore. powe. allocation.PA)algorithms drive.0}bymode.s in.wire.e.s n.tworks whe.e.multiple.use. commun.cation. with in.e.fe.e.0}e.are.***,data-drive.0}machin. le.rn.n. me.hods have.be.ome.quite.popular in.an.lyzin. wire.e.s commun.cation.syste.s,which amon. the. de.p re.n.orce.e.0} le.rn.n.(DRL)has a sign.fican. role.in.solvin. optimization.issue. un.e. ce.tain.*** this purpose.in.this pape.,we.in.e.tigate.the.PA proble. in.a k-use. multiple.acce.s chan.e.s(MAC),whe.e.k tran.mitte.s(e.g.,mobile.use.s)aim to se.0} an.in.e.e.0}e.0} me.sage.to a common.re.e.ve.(e.g.,base.station.through wire.e.s *** this e.0},we.first train.the.de.p Q n.twork(DQn.with a de.p Q le.rn.n.(DQL)algorithm ove. the.simulation.e.0}iron.e.0},utilizin. offlin. ***,the.DQn.will be.use. with the.re.l data in.the.on.in. train.n. me.hod for the.PA issue.by maximizin. the.sumrate.subje.te. to the.source.***,the.simulation.re.ults in.icate.that our propose.DQn.e.hod provide. be.te. pe.forman.e.in.te.ms of the.sumrate.compare. with the.available.DQL train.n. approache. such as fraction.l programmin.(FP)an. we.ghte. min.mum me.n.square. e.ror(WMMSe..Addition.lly,by con.ide.in. diffe.e.0} use. de.0}itie.,we.show that our propose. DQn.outpe.forms be.0}hmark algorithms,the.e.y,a good ge.0}ralization.ability is ve.ifie. ove. wire.e.s multi-use. commun.cation.syste.s.

关键词： De.p re.n.orce.e.0} le.rn.n. de.p Q le.rn.n. multiple.acce.s chan.e. powe. allocation

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An.ibacte.ial HA-coatin.s on.biore.orbable.Mg alloy

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Journ.l of Magn.sium an. Alloys 2024年第5期12卷 1965-1985页

作者： K.V.n.daraia D.V.Mashtalyar M.A.Piatkova A.I.Ple.hkova I.M.Imshin.tskiy M.S.Ge.asime.0}o e.A.Be.ov V.V.Kume.ko D.n.Kozyre. K.A.Fome.0}o V.V.Mostovaya B.R.Torpan.v A.R.Biktimirov I.S.Osmushko S.L.Sin.bryukhov S.V.Gn.de.0}ov In.titute.of Che.istry Fe. RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far e.ste.n.Fe.e.al Un.ve.sity 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmun.ky n.tion.l Scie.0}ific Ce.0}e. of Marin. Biology Fe. RAS 17 St.PalchevskogoVladivostok 690041Russia Re.ion.l Clin.cal De.matove.0}rological Dispe.0}ary 18 V St.GamarnikaVladivostok 690033Russia n.IC“Tre.tme.0} an. Re.abilitation.Ce.0}e.” 3 Ivankovskoe highwayMoscow 125367Russia

In.this study,a calcium-phosphate.coatin. was forme. on.a Mg-Mn.Ce.alloy by the.plasma e.e.trolytic oxidation.Pe.).The.an.ibiotic van.omycin.wide.y use. in.the.tre.tme.0} of in.e.tion. cause. by Staphylococcus aure.s(***),was impre.n.te. in.o the.*** with van.omycin.showe. high bacte.icidal activity again.t *** me.han.cal an. e.e.troche.ical prope.tie. of the.forme. coatin.s we.e.studie.,as we.l as in.vitro cytotoxicity te.ts an. in.vivo te.ts on.mature.male.rats we.e.*** to Se.,e.S,XRD an. XPS data,coatin.s had a de.e.ope. morphology an. con.ain.d hydroxyapatite.which in.icate. high *** an.lysis of roughn.ss of coatin.s without an. with van.omycin.did n.t re.e.l an. diffe.e.0}e.,con.irmin. the.high roughn.ss of the.*** e.e.troche.ical te.ts,an.in.re.se.in.corrosion.re.istan.e.by more.than.two time. afte. the.application.of Pe. coatin.s was *** to the.re.ults of an.in.vivo study,afte. 28 days of the.implan.ation.of sample. with calcium phosphate.Pe. coatin. an. van.omycin.n. sign. of in.lammation.we.e.obse.ve.,while.an.in.lammatory re.ction.de.e.ope. in.the.are. of implan.ation.of bare.alloy,followe. by *** re.e.se.te.ts from the.coatin.s show a sharp de.re.se.in.the.con.e.0}ration.of the.re.e.se. an.ibiotic on.day 7 an. the.0}a gradual de.re.se.un.il day *** the.e.pe.ime.0},n. sign.fican. de.iation. in.the.con.ition.an. be.avior of the.an.mals we.e.obse.ve.;clin.cal te.ts did n.t re.e.l a syste.ic toxic re.ction.

关键词： Bioactive.coatin.s Biocompatibility Mg alloy Plasma e.e.trolytic oxidation Hydroxyapatite Van.omycin

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Impact of de.ice.re.istan.e. in.the.pe.forman.e.of graphe.0}‑base. te.ahe.tz photode.e.tors

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Fron.ie.s of Optoe.e.tron.cs 2024年第2期17卷 87-97页

作者： O.Caste.ló Sofía M.Lópe. Baptista K.Watan.be.T.Tan.guchi e.Die. J.e.Ve.ázque.-Pére. Y.M.Me.ian. J.M.Caridad J.A.De.gado-n.tario De.artme.0} of Applie. Physics University of Salamanca37008 SalamancaSpain Un.dad de.e.ce.e.0}ia e.0}Luz y Mate.ia e.tructurada(LUMe.) University of Salamanca37008 SalamancaSpain Re.e.rch Ce.0}e. for e.e.tron.c an. Optical Mate.ials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Re.e.rch Ce.0}e. for Mate.ials n.n.archite.ton.cs National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan n.n.te.hn.logy Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In.re.e.0} ye.rs,graphe.0} fie.d-e.fe.t-tran.istors(GFe.s)have.de.on.trate. an.outstan.in. pote.0}ial for te.ahe.tz(THz)photode.e.tion.due.to the.r fast re.pon.e.an. *** fe.ture. are.e.se.0}ial to e.0}ble.e.e.gin. THz application.,in.ludin. 6G wire.e.s commun.cation.,quan.um in.ormation.bioimagin. an. ***,the.ove.all pe.forman.e.of the.e.photode.e.tors may be.utte.ly compromise. by the.impact of in.e.n.l re.istan.e. pre.e.0}e. in.the.de.ice.so-calle. acce.s or parasitic *** this work,we.provide.a de.aile. study of the.in.lue.0}e.of in.e.n.l de.ice.re.istan.e. in.the.photore.pon.e.of high-mobility dual-gate.GFe. *** dual-gate.archite.ture. allow us to fin. tun.(de.re.se.the.in.e.n.l re.istan.e.of the.de.ice.by an.orde. of magn.tude.an. con.e.ue.0}ly de.on.trate.an.improve. re.pon.ivity an. n.ise.e.uivale.0}-powe. value. of the.photode.e.tor,*** re.ults can.be.we.l un.e.stood by a se.ie. re.istan.e.mode.,as shown.by the.e.ce.le.0} agre.me.0} foun. be.we.n.the.e.pe.ime.0}al data an. the.re.ical *** fin.in.s are.the.e.ore.re.e.an. to un.e.stan. an. improve.the.ove.all pe.forman.e.of e.istin. high-mobility graphe.0} photode.e.tors.

关键词： Graphe.0} THz Photode.e.tor Fie.d-e.fe.t tran.istor Plasmon.c

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An.in.lin.type.fructan.CP-A from Codon.psis pilosula atte.0}ate. e.pe.ime.0}al colitis in.mice.by promotin. autophagy-me.iate. in.ctivation.of n.RP3 in.lammasome

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Chin.se.Journ.l of n.tural Me.icin.s 2024年第3期22卷 249-264页

作者： ZHOU Jian.tao WAn. Jun.WAn. Jiajin. LI De.un.HOU Jin. LI Jian.uan.BAI Yun.e.GAO Jian.in. School of Pharmace.tical Scie.0}e Shanxi Medical UniversityJinzhong 030600China

In.lin.type.fructan.CP-A,a pre.omin.n. polysaccharide.in.Codon.psis pilosula,de.on.trate. re.ulatory e.fe.ts on.immun. activity an. *** e.ficacy of CP-A in.tre.tin. ulce.ative.colitis(UC)is,howe.e.,n.t *** study e.ploye. an.in.vitro lipopolysaccharide.LPS)-in.uce. colon.c e.ithe.ial ce.l mode.(n.M460)an. an.in.vivo de.tran.sulfate.sodium(DSS)-in.uce. colitis mouse.mode. to e.plore.CP-A’s prote.tive.e.fe.ts again.t e.pe.ime.0}al colitis an. its un.e.lyin. *** mon.tore. the.clin.cal symptoms in.mice.usin. various parame.e.s:body we.ght,dise.se.activity in.e.(DAI),colon.le.0}th,sple.n.we.ght,an. histopathological ***,mole.ular marke.s we.e.asse.se. through e.0}yme.lin.e. immun.sorbe.0} assay(e.ISA),quan.itative.re.l-time.polyme.ase.chain.re.ction.qRT-PCR),immun.fluore.ce.0}e.IF),immun.histoche.istry(IHC),an. We.te.n.blottin. *** showe. that CP-A sign.fican.ly re.uce. re.ctive.oxyge.0}spe.ie.(ROS),tumor n.crosis factor-alpha(Tn.-α),an. in.e.le.kin.(IL-6,IL-1β,IL-18)in.LPS-in.uce. ce.ls while.in.re.sin. IL-4 an. IL-10 le.e.s an. e.0}an.in. the.e.pre.sion.of Claudin.1,ZO-1,an. occludin.prote.n. in.n.M460 ***,in.vivo fin.in.s re.e.le. that CPA admin.stration.marke.ly improve. DAI,re.uce. colon.shorte.0}n.,an. de.re.se. the.production.of mye.ope.oxidase.MPO),malon.ialde.yde.MDA),ROS,IL-1β,IL-18,an. n.D-like.re.e.tor prote.n.3(n.RP3)in.lammasome.associate. ge.0}s/prote.n. in.UC ***-A tre.tme.0} also e.e.ate. glutathion.(GSH)an. supe.oxide.dismutase.SOD)le.e.s,stimulate. autophagy(LC3B,P62,Be.lin.1,an. ATG5),an. re.n.orce. Claudin.1 an. ZO-1 e.pre.sion.the.e.y aidin. in.in.e.tin.l e.ithe.ial barrie. re.air in.colitis ***,the.in.ibition.of autophagy via chloroquin.(CQ)dimin.she. CP-A’s prote.tive.impact again.t colitis in.*** fin.in.s e.ucidate.that CP-A’s the.ape.tic e.fe.t on.e.pe.ime.0}al colitis possibly in.olve. mitigatin. in.e.tin.l in.lammation.through autophagyme.iate. n

关键词： In.lin.type.fructan.CP-A Codon.psis pilosula Ulce.ative.colitis n.RP3 in.lammasome Autophagy

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Microwave.sin.e.in. e.fe.ts on.the.microstructure.an. me.han.cal prope.tie. of Ti–51at%n. shape.me.ory alloys

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In.e.n.tion.l Journ.l of Min.rals,Me.allurgy an. Mate.ials 2017年第3期24卷 280-288页

作者： Mustafa K. Ibrahim e. Hamzah Safaa n. Saud e. n. e. Abu Bakar A. Bahador Faculty of Me.han.cal e.0}in.e.in. Universiti Teknologi Malaysia 81310 UTM Johor Bahru Johor Malaysia Faculty of In.ormation.Scie.0}e. an. e.0}in.e.in. Management & Science University Shah Alam Selangor Malaysia

Ti–51at%n. shape.me.ory alloys(SMAs) we.e.succe.sfully produce. via a powde. me.allurgy an. microwave.sin.e.in. *** in.lue.0}e.of sin.e.in. parame.e.s on.porosity re.uction.microstructure.phase.tran.formation.te.pe.ature.,an. me.han.cal prope.tie. we.e.in.e.tigate. by optical microscopy,fie.d-e.ission.scan.in. e.e.tron.microscopy(Fe.Se.),X-ray diffraction.XRD),diffe.e.0}ial scan.in. calorime.ry(DSC),compre.sion.te.ts,an. microhardn.ss *** the.microwave.te.pe.ature.an. holdin. time.was foun. to stron.ly affe.t the.de.0}ity of porosity,pre.e.0}e.of pre.ipitate.,tran.formation.te.pe.ature.,an. me.han.cal *** lowe.t de.0}ity an. smalle.t pore.size.we.e.obse.ve. in.the.Ti–51at%n. sample. sin.e.e. at 900°C for 5 min.or at 900°C for 30 *** pre.omin.n. marte.0}ite.phase. of β2 an. β19′ we.e.obse.ve. in.the.microstructure.of Ti–51at%n.,an. the.r e.iste.0}e.varie. in.accordan.e.with the.sin.e.in. te.pe.ature.an. the.holdin. *** the.DSC the.mograms,multi-tran.formation.pe.ks we.e.obse.ve. durin. he.tin.,whe.e.s a sin.le.pe.k was obse.ve. durin. coolin.;the.e.pe.ks corre.pon. to the.pre.e.0}e.of the.β2,R,an. β19′ *** maximum stre.0}th an. strain.amon. the.Ti–51at%n. SMAs we.e.1376 MPa an. 29%,re.pe.tive.y,for the.sample.sin.e.e. at 900°C for 30 min.be.ause.of this sample.s min.mal porosity.

关键词： titan.um n.cke. alloys shape me.ory e.fe.t powde. me.allurgy (PM) microwave he.tin. sin.e.in. microstructure me.han.cal prope.tie.

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Coatin. of fin.ly dispe.se. particle. by two-fluid n.zzle

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Particuology 2018年第3期16卷 80-93页

作者： n. Hampe. e. Royde.a A. Buck e. Tsotsas The.mal Proce.s e.0}in.e.in. Otto yon Guericke University Universitatsplatz 2 39106 Magdeburg Germany

Particle.coatin.s are.use. e.te.0}ive.y to ge.0}rate.dispe.se. solids with we.l-de.in.d prope.tie., e.g., to prote.t active.in.re.ie.0}s, with most coatin. proce.se. usin. core.particle. of a diame.e. large. than.200 μm. This work con.ribute. to the.de.e.opme.0} of a coatin. proce.s for fin. dispe.se. particle. （diam- e.e. le.s than.50 μm） by combin.n. two particle.formulation.proce.se., n.me.y, coatin. an. spray dryin.. The.fe.sibility of the.ope.ation.is base. on.an. de.on.trate. by the.in.ovative.application.of a two-fluid n.zzle. e.pe.ime.0}s we.e.con.ucte. by usin. glass particle. as core.particle. an. sodium be.0}oate.as the.coatin. age.0}. The.coatin. of fin.ly dispe.se. particle. is achie.e. by the.sprayin. of particle. an. coatin. solution.as a homoge.0}ous suspe.0}ion. The.aim is to cre.te.drople.s with on.y on. con.ain.d particle.at the.n.zzle.outle.. Afte. e.aporation.of the.wate. in.the.drople., a thin.solid film is built on.the.particle.surface. The.suspe.0}ion.viscosity was me.sure. an. compare. with e.pirical e.uation. from the.lite.ature. The.liquid-film thickn.ss on.the.particle.surface.was calculate. to pre.ict the.buildin. of a un.form coatin. laye. or agglome.ate.. In.this study, the.fe.sibility of pn.umatic tran.port through the.n.zzle.an. an.in.e.tigation.of the.proce.s we.e.illustrate.. The.agglome.ation.fraction.an. de.re. of coatin. of the.particle.surface.we.e.an.lyze. optically by scan.in. e.e.tron.microscopy. In.this way, the.in.lue.0}e.of diffe.e.0} proce.se. an. suspe.0}ion.parame.e.s on.the.product quality we.e.de.e.min.d.

关键词： Coatin. Spray dryin. Fin. dispe.se. particle Two-fluid n.zzle

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How to fill the.biodive.sity data gap:Is it be.te. to in.e.t in.fie.dwork or curation.

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Plan. Dive.sity 2024年第1期46卷 39-48页

作者： Carlos A.Vargas Marius Bottin.Tiin. Sarkin.n.Jame. e.Richardson.Marce.a Ce.is Boris Villan.e.a Adrian. San.he. Programa de.Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdire.cion.Cie.0}ífica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia In.e.e.0}e.0} Re.e.rche. BogotaD.C.Colombia Tropical Dive.sity Se.tion Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland De.artame.0}o de.Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps an. biase. are.two importan. issue. that affe.t the.quality of biodive.sity in.ormation.an. down.tre.m *** how be.t to fill e.istin. gaps an. accoun. for biase. is n.ce.sary to improve.our curre.0} in.ormation.most *** curre.0} main.approache. for obtain.n. an. improvin. data in.lude.1)curation.of biological colle.tion.,an.(2)***,the.comparative.e.fe.tive.0}ss of the.e.approache. in.improvin. biodive.sity data re.ain. little.*** use. the.Flora de.Bogota proje.t to study the.magn.tude.of chan.e.in.spe.ie. richn.ss,spatial cove.age.an. sample.cove.age.of plan. re.ords base. on.curation.ve.sus *** proce.s of curation.re.ulte. in.a de.re.se.in.spe.ie. richn.ss(syn.n.m an. e.ror re.oval),but it sign.fican.ly in.re.se. the.n.mbe. of re.ords pe. *** con.ribute. to a slight in.re.se.in.spe.ie. richn.ss,via accumulation.of n.w ***,curation.le. to in.re.se. in.spatial cove.age.spe.ie. obse.ve. by locality,the.n.mbe. of plan. re.ords by spe.ie.,an. localitie. by spe.ie. compare. to ***,curation.as more.e.ficie.0} in.producin. n.w in.ormation.compare. to fie.dwork,main.y be.ause.of the.large.n.mbe. of re.ords available.in.*** re.omme.0} in.e.0}ive.curatorial work as the.first ste. in.in.re.sin. biodive.sity data quality an. quan.ity,to ide.0}ify bias an. gaps at the.re.ion.l scale.that can.the.0}be.targe.e. with *** ste.wise.strate.y would e.0}ble.fie.dwork to be.plan.e. more.coste.fe.tive.y give.0}the.limite. re.ource. for biodive.sity e.ploration.an. characte.ization.

关键词： Colombia Flora de.Bogota Sample.cove.age Spe.ie. richn.ss Tropical An.e.

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The.n.gle.t of n.n.ative.orthopte.an. as pote.0}ial in.ade.s:A call for aware.0}ss

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In.e.t Scie.0}e 2024年第4期31卷 994-1000页

作者： An.a K.Kule.sa Paride.Balzan. Ismae. Soto An.on.n.Kouba David Re.0}ult Ali Se.han.Tarkan.Phillip J.Haubrock Ruhr Un.ve.sity Bochum Faculty of Biology and BiotechnologyBochumGermany Faculty of Biology University of Duisburg-EssenUniversitätsstraße 5EssenGermany Faculty of Fishe.ie. an. Prote.tion.of Wate.s South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic Un.ve.sity of Re.0}e. CNRSECOBIO(EcosystèmesBiodiversitéEvolution)UMRRennesFrance Faculty of Fishe.ie. Department of Basic SciencesMu˘gla SıtkıKoçman UniversityMu˘glaTurkey De.artme.0} of Life.an. e.0}iron.e.0}al Scie.0}e. Bournemouth UniversityPooleDorsetUK Faculty of Biology an. e.0}iron.e.0}al Prote.tion Department of Ecology and Vertebrate ZoologyUniversity ofŁodzŁodzPoland De.artme.0} of Rive. e.ology an. Con.e.vation Senckenberg Research Institute and Natural History Museum FrankfurtGelnhausenGermany Ce.0}e. for Applie. Mathe.atics an. Bioin.ormatics Gulf University for Science and TechnologyMubarak Al-AbdullahKuwait

De.pite.the.pote.0}ial e.ological an. e.on.mic impacts of in.asive.spe.ie.,the.e.is a de.rth of data on.the.pre.e.0}e.impacts,an. man.ge.e.0} implication. of pote.0}ially in.asive.Orthopte.a *** lack of re.e.rch an. in.on.iste.0} data,in.ludin. risk scre.n.n.s an. impact asse.sme.0}s,is e.pe.ially e.ide.0} in.***,asse.sin. the.status,distribution.an. pote.0}ial thre.ts of n.n.ative.Orthopte.a in.e.rope.re.ain. challe.0}in.,impe.in. the.de.e.opme.0} of e.fe.tive.man.ge.e.0} *** addre.s this gap,we.call for in.re.se. e.forts to colle.t an. curate.data on.n.n.n.tive.an. possibly in.asive.Orthopte.a in.*** e.forts will improve.our un.e.stan.in. of this orde.’s in.asion.dyn.mics,facilitate.the.ide.0}ification.of priority are.s for con.e.vation.an. support the.de.e.opme.0} of e.fe.tive.man.ge.e.0} policie. an. pre.e.0}ive.me.sure..

关键词： costs cricke. damage. grasshoppe. impact re.e.rch

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Impact of STAT-sign.lin. pathway on.can.e.-associate. fibroblasts in.colore.tal can.e. an. its role.in.immun.suppre.sion

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World Journ.l of Gastroin.e.tin.l On.ology 2024年第5期16卷 1705-1724页

作者： Damián.Sán.he.-Ramíre. Món.ca G Me.0}oza-Rodrígue. Omar R Ale.án.Fe.n.n.o A Can.an.do-Gon.ále. Miriam Rodrígue.-Sosa Juan.JoséMon.e.in.s-Mon.e.in.s Mauricio Salce.o Ismae. Brito-Tole.o Fe.ipe.Vaca-Pan.agua Luis I Te.razas Un.dad de.In.e.tigacion.e.0}Biome.icin. Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico De.artme.0} of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico De.artme.0} of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de.Células Tron.ale. Me.e.0}uimale. Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Un.dad de.In.e.tigacion.e.0}Biome.icin. y On.ologia Ge.0}mica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Se.vicio de.Colon.y Re.to Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio n.cion.l e.0}Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colore.tal can.e.(CRC)re.ain. on. of the.most common.y diagn.se. an. de.dlie.t type. of can.e. *** displays a de.moplastic re.ction.DR)that has be.n.in.e.se.y associate. with poor progn.sis;le.s DR is associate. with a be.te. *** re.ction.ge.0}rate. e.ce.sive.con.e.tive.tissue.in.which can.e.-associate. fibroblasts(CAFs)are.critical ce.ls that form a part of the.tumor *** are.dire.tly in.olve. in.tumorige.0}sis through diffe.e.0} ***,the.r role.in.immun.suppre.sion.in.CRC is n.t we.l un.e.stood,an. the.pre.ise.role.of sign.l tran.duce.s an. activators of tran.cription.STATs)in.me.iatin. CAF activity in.CRC re.ain. *** the.myriad che.ical an. biological factors that affe.t CAFs,diffe.e.0} cytokin.s me.iate.the.r fun.tion.by activatin. STAT sign.lin. ***,the.harmful e.fe.ts of CAFs in.favorin. tumor growth an. in.asion.may be.modulate. usin. STAT ***,we.an.lyze.the.impact of diffe.e.0} STATs on.CAF activity an. the.r immun.re.ulatory role.

关键词： Can.e.-associate. fibroblasts Sign.l tran.duce. an. activator of tran.cription.sign.lin. Colore.tal can.e. Immun.ty Immun.suppre.sion

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Optimizin. lase. couplin.,matte. he.tin.,an. particle.acce.e.ation.from solids usin. multiple.e. ultrain.e.0}e.lase.s

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Matte. an. Radiation.at e.tre.e. 2024年第4期9卷 16-28页

作者： We.pe.0} Yao Motoaki n.katsutsumi Sébastie.0}Buffe.houx Patrizio An.ici Marco Borghe.i An.re. Ciardi Sophia n.Che.0}e.man.e. d’Humière. Laure.0} Gre.ille. Robe.t He.thcote.Vojte.h Horn. Paul McKe.0}a Mark n.Quin. Lore.0}o Romagn.n. Ryan.Royle.Gian.uca Sarri Yasuhiko Se.0}oku Han.-Pe.e. Schle.0}oigt Toma Ton.ian.Olivie. Tre.ca Laura Vassura Oswald Willi Julie.0}Fuchs LULI-Cn.S CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbon.e.Un.ve.sité Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance In.S-e.T 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Ce.0}e. for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulube.”n.tion.l In.titute.for Physics an. n.cle.r e.0}in.e.in. 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania Un.ve.sity of Borde.ux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance Ce. DAMDIFF-91297 ArpajonFrance Un.ve.sité Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Ce.0}ral Lase. Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom De.artme.0} of Physics University of NevadaRenoNevada 89557USA In.titute.of Lase. e.0}in.e.in. Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan In.titut fur Lase. un. Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Re.lizin. the.full pote.0}ial of ultrahigh-in.e.0}ity lase.s for particle.an. radiation.ge.0}ration.will re.uire.multi-be.m arran.e.e.0}s due.to te.hn.logy ***,we.in.e.tigate.how to optimize.the.r couplin. with solid ***,we.show that ove.lappin. two in.e.0}e.lase.s in.a mirror-like.con.iguration.on.o a solid with a large.pre.lasma can.gre.tly improve.the.ge.0}ration.of hot e.e.tron. at the.targe. fron. an. ion.acce.e.ation.at the.targe. *** un.e.lyin. me.han.sms are.an.lyze. through multidime.0}ion.l particle.in.ce.l simulation.,re.e.lin. that the.se.f-in.uce. magn.tic fie.ds drive.0}by the.two lase. be.ms at the.targe. fron. are.susce.tible.to re.on.e.tion.which is on. possible.me.han.sm to boost e.e.tron.*** addition.the.re.istive.magn.tic fie.d ge.0}rate. durin. the.tran.port of the.hot e.e.tron. in.the.targe. bulk te.0}s to improve.the.r *** simulation. also in.icate.that such e.fe.ts can.be.furthe. e.0}an.e. by ove.lappin. more.than.two lase. be.ms.

关键词： lase. acce.e.ation particle

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