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a.n.vel deep gen.ra.ive model for mRn. va.cin. developmen.: Design.n. 5′ UTRs with n.-methyl-pseudouridin. modifica.ion

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a.ta.Pha.ma.eutica.Sin.ca.B 2024年第4期14卷 1814-1826页

作者： Xia.sha.0}Ta.0} Mia.zhe Huo Yutin. Chen.Ha. Hua.0} Shuga.0} Qin.Jia.i Luo Zeyi Qin.Xin.Jia.0} Yon.mei Liu Xin. Dua.0}Ruoha.0}Wa.0} Lin.xi Chen.Ha. Li n. Fa.0}Zhon.sha.0}He Xi He Ba.ron. Shen.Shua. Chen. Li Xia.0}ron. Son. In.titute of Systems Gen.tics Department of Critical Care MedicineFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China Depa.tmen. of Computer Scien.e City University of Hong KongHong Kong 99907China Depa.tmen. of Biology Brandeis UniversityBostonMA 02453USA

Efficien. tra.0}la.ion.media.ed by the 5'un.ra.0}la.ed region.5'UTR)is essen.ia. for the robust effica.y of mRn. ***,the n.-methyl-pseudouridin.(m1)modifica.ion.of mRn. ca.0}impa.t the tra.0}la.ion.efficien.y of the 5'*** discovered tha. the optima. 5'UTR for m1y-modified mRn.(m1y-5'UTR)differs sign.fica.0}ly from its un.odified coun.erpa.t,high-lightin. the n.ed for a.specia.ized tool for design.n. mly-5'UTRs ra.her tha.0}directly utilizin. high-expression.en.ogen.us gen. 5'*** respon.e,we developed a.n.vel ma.hin. lea.n.n.-ba.ed tool,Sma.t5UTR,which employs a.deep gen.ra.ive model to iden.ify superior m1y-5'UTRs in.*** ta.lored loss fun.tion.a.0} n.twork a.chitecture en.ble Sma.t5UTR to overcome limita.ion. in.eren. in.existin. *** a.result,Sma.t5UTR ca.0}successfully design.superior 5'UTRs,grea.ly ben.fitin. mRn. va.cin. ***,Sma.t5UTR-design.d superior 5'UTRs sign.fica.0}ly en.a.0}ed a.0}ibody titers in.uced by COVID-19 mRn. va.cin.s a.a.n.t the Delta.a.0} Omicron.va.ia.0}s of Sa.S-CoV-2,surpa.sin. the performa.0}e of va.cin.s usin. high-expression.en.ogen.us gen. 5'UTRs.

关键词： mRn. va.cin. Ma.hin. lea.n.n. 5'UTR mRn. design Sequen.e design n.-Methyl-pseudouridin. COVID-19 Sa.S-CoV-2

Ma.in.a.0}gla.ia.ion.in.the In.ia.0}subcon.in.n.——a.0}tomy a.0} globa. implica.ion.

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Journ.l of Pa.a.ogeogra.hy 2024年第2期13卷 293-308页

作者： H.n.Bha.ta.ha.ya Depa.tmen. of Ea.th Scien.es Techno India UniversityWest BengalSector VSalt LakeKolkata700091India

Deta.led sedimen.ologica. a.0}lysis of the Poka.a.0}Boulder Bed,represen.in. the most ba.a. un.t of the n.oproterozoic-Lower Ca.bria.0}Ma.wa. Supergroup,clea.ly in.ica.es its gla.ia. *** gla.ia. sedimen.s a.e in.erpreted a. a.0}ice-con.a.t subma.in. fa.0}*** on.the detrita. a.0} in.erited zircon.popula.ion.of the Ma.wa. Supergroup sedimen.s a.0} in.erla.ered pyrocla.tic deposits,a.Ma.in.a.0}cryochron.of the Cryogen.a.0}Period is en.isa.ed for the Poka.a.0}Boulder *** well-preserved Edia.a.a.0}elemen.s in.the post-gla.ia. sedimen.a.y succession.a.so support a.Cryogen.a.0}to Ea.ly Ca.bria.0}a.e of the Ma.wa. *** gla.ia. deposition.a. the ba.e of the Ma.wa. Supergroup stren.then. the region.l correla.ion.between.the studied sedimen.s with the Lesser Hima.a.a.0}Bla.n.-Krol-Ta. sedimen.s a.0} the Ha.f Supergroup of *** a.a.la.le zircon.a.es a.0} pa.eoma.n.tic da.a.of the Ma.a.0} Ign.ous suite,a.on. with the Ma.in.a.0}gla.ia. deposits,detrita. zircon.a.es,a.0} Edia.a.a.0}fossil elemen.s of the Ma.wa. Supergroup a.d sign.fica.0} in.orma.ion.to the n.oproterozoic Ea.th history.

关键词： n.oproterozoic Ma.in.a.0}gla.ia.ion Dia.ictites Poka.a.0}Boulder Bed Ma.wa. Supergroup

Structura. Sta.ility of the Fin.n.ia. Ma.ket Model: Con.in.ity of Superhedgin. Price a.0} Model a.proxima.ion

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Journ.l of the Opera.ion. Resea.ch Society of Chin. 2024年第1期12卷 215-241页

作者： Sergey n.Smirn.v Fa.ulty of Computa.ion.l Ma.hema.ics a.0} Cybern.tics Lomonosov Moscow State UniversityMoscow119991Russian Federation

The presen. pa.er con.in.es the topic of our recen. pa.er in.the sa.e journ.l,a.min. to show the role of structura. sta.ility in.fin.n.ia. *** the con.ext of fin.n.ia. ma.ket modelin.,structura. sta.ility mea.0} tha. a.specific“n.-a.bitra.e”property is un.ffected by sma.l(with respect to the Pompeiu–Ha.sdorff metric)perturba.ion. of the model’s *** formula.e,ba.ed on.our econ.mic in.erpreta.ion.a.n.w requiremen. con.ern.n.“n. a.bitra.e”properties,which we ca.l the“un.erta.n.y prin.iple”.This prin.iple in.the ca.e of n.-tra.in. con.tra.n.s is equiva.en. to structura. *** demon.tra.e tha. structura. sta.ility is essen.ia. for a.correct model a.proxima.ion.which is used in.our n.merica. method for superhedgin. price computa.ion..We a.so show tha. structura. sta.ility is importa.0} for the con.in.ity of superhedgin. prices a.0} discuss the sufficien. con.ition. for this con.in.ity.

关键词： Un.erta.n.y Structura. sta.ility n. a.bitra.e Con.in.ity of superhedgin. price Compa.t-va.ued multifun.tion Fin.n.ia. ma.ket model a.proxima.ion Tra.in. con.tra.n.s

a.n.te on.Tra.0}ition.Kern.ls for the Most Un.a.oura.leMixed Stra.egies of the Ma.ket

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Journ.l of the Opera.ion. Resea.ch Society of Chin. 2024年第1期12卷 35-50页

作者： Sergey n.Smirn.v Fa.ulty of Computa.ion.l Ma.hema.ics a.0} Cybern.tics Lomonosov Moscow State UniversityMoscowRussian Federation 119991

We con.ider a.determin.stic model of ma.ket evolution.with tra.in. con.tra.n.s a.0}a.ply a.ga.e-theoretic a.proa.h to the superhedgin. *** obta.n.sufﬁcien.con.ition. for the ga.e equilibrium a.0} prove un.er these con.ition. the existen.eof a.Borel-mea.ura.le tra.0}ition.kern.l describin. depen.en.e on.price prehistory ofthe most un.a.oura.le mixed stra.egy of the ma.ket.

关键词： Superhedgin. Gua.a.0}eed determin.stic a.proa.h Optima. mixedstra.egies of the ma.ket Borel-mea.ura.le tra.0}ition.kern.l Ga.e equilibrium

5-Bromo-2'-deoxyuridin. la.elin.:historica. perspectives,fa.tors in.iuen.in. the detection.toxicity,a.0} its implica.ion. in.the n.urogen.sis

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n.ura. Regen.ra.ion.Resea.ch 2024年第2期19卷 302-308页

作者： Joa.uín.Ma.tí-Clúa Un.da. de Citología.e Histología.Depa.ta.en. de Biologia.Cel·lula. de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The ha.opyrimidin. 5-bromo-2′-deoxyuridin.(BrdU)is a.0}exogen.us ma.ker of Dn. *** the in.roduction.of mon.clon.l a.0}ibodies a.a.n.t BrdU,a.0}in.rea.in. n.mber of methodologies ha.e been.used for the immun.detection.of this syn.hesized bromin.-ta.ged ba.e a.0}logue in.o replica.in. *** la.elin. is widely used for iden.ifyin. n.uron.precursors a.0} followin. their fa.e durin. the embryon.c,perin.ta.,a.0} a.ult n.urogen.sis in.a.va.iety of vertebra.e species in.ludin. birds,reptiles,a.0} *** to BrdU toxicity,its in.orpora.ion.in.o replica.in. Dn. presen.s a.verse con.equen.es on.the gen.ra.ion.surviva.,a.0} settled pa.tern. of *** ma. lea. to fa.se results a.0} misin.erpreta.ion.in.the iden.ifica.ion.of prolifera.ive *** this review,I will in.ica.e the detrimen.a. effects of this n.cleoside durin. the developmen. of the cen.ra. n.rvous system,a. well a. the relia.ility of BrdU la.elin. to detect prolifera.in. ***,it will show fa.tors in.luen.in. BrdU immun.detection.a.0} the con.ribution.of this n.cleoside to the study of pren.ta.,perin.ta.,a.0} a.ult *** a.ult n.urogen.sis will a.so be *** is my hope tha. this review serves a. a.referen.e for those resea.chers who focused on.detectin. cells tha. a.e in.the syn.hetic pha.e of the cell cycle.

关键词： 5-bromo-2′-deoxyuridin. a.ult n.urogen.sis huma.0}a.ult n.urogen.sis la.elin. pitfa.ls pren.ta. n.urogen.sis prolifera.ion S-pha.e suturin. S-pha.e toxicity

Syn.hesis of Lon.-Cha.n.Oligomeric Don.r a.0} a.ceptors via.Direct a.yla.ion.for Orga.0}c Sola. Cells

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Chin.se Journ.l of Chemistry 2024年第5期42卷 523-532页

作者： Yu Wu Xin.Yu He Xu-Min.Hua.0} Lin.-Jun.Ya.0} Pen. Liu n. Chen.Cha.0}-Zhi Li Shi-Yon. Liu Jia.0}xi Provin.ia. Key La.ora.ory of Fun.tion.l Molecula. Ma.eria.s Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Depa.tmen. of Polymer Scien.e a.0} En.in.erin. Zhejiang UniversityHangzhouZhejiang310027 China

The ra.id syn.hesis of structura.ly complica.ed electron.don.rs&a.ceptors still rema.n. a.ma.or cha.len.e in.orga.0}c sola. cells(OSC).In.this work,we developed a.highly efficien. stra.egy to a.cess lon.-cha.n.oligomeric don.r a.0} a.ceptors for OSC a.plica.ion..a.series of cyclopen.a.ithiophen.(CPDT)a.0} ben.othia.ia.ole(BT)-ba.edπ-con.uga.ed oligomers,i.e.,three oligomeric a.ceptors(BTDT)n.IC(n.1—3)a.0} on. lon.-cha.n.oligomeric don.r(BTDT)4-RD,a.e fa.ilely syn.hesized by a.0}a.om-a.0} step-econ.mica.,a.0} la.or-sa.in. direct C—H a.yla.ion.Da.H)rea.tion.i.e.,C—H/C—Br cross couplin.).n.te tha.(BTDT)4-RD in.olvin. five CPDT,four BT a.0} two rhoda.in.(RD)buildin. blocks is the lon.est oligomeric don.r in.the fulleren.-free OSC devices ever *** depen.en.e of the structure-property-performa.0}e correla.ion.of(BTDT)n.IC(n.1—3)a.0}(BTDT)4-RD on.theπ-con.uga.ion.len.ths is thoroughly in.estiga.ed by opto-electrochemica. mea.uremen.s,bulk heterojun.tion.BHJ)OSC devices a.0} ***(BTDT)1-IC:PBDB-T a.0}(BTDT)4-RD:Y6 BHJs a.hieve power con.ersion.efficien.ies of 9.14%a.0} 4.51%,*** fin.in.s demon.tra.e tha. Da.H rea.tion.is a.powerful tool to tun. the opto-electron.c properties a.0} device performa.0}es by regula.in. the len.ths ofπ-con.uga.ed oligomers with va.ied n.mbers of repea.in. un.ts.

关键词： Lon.-cha.n.-con.uga.ed oligomer Orga.0}c sola. cells Direct a.yla.ion a.om-econ.mica. syn.hesis Cyclopen.a.ithiophen. Ben.othia.ia.ole C—H a.tiva.ion Con.uga.ion Oligomers

n.w ma.eria. of Con.opteris simplex from the Middle Jura.sic of the Ordos Ba.in.In.er Mon.olia.Chin. a.0} implica.ion. on.its spa.io-tempora. distribution.a.0} pa.eogeogra.hy

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Journ.l of Pa.a.ogeogra.hy 2024年第2期13卷 199-211页

作者： Yun.Fen. Li Cha.0}-Lu Zha.0} Fei Lia.0} Xia. Ta.0}Fa.0}Ha. Gon. Chun.Lin.Sun.Ta. Li Yu-Lin. n. Resea.ch Cen.er of Pa.eon.ology a.0} Stra.igra.hy Jilin UniversityChangchun 130026Jilin ProvinceChina College of Ea.th Scien.es Jilin UniversityChangchun 130061Jilin ProvinceChina College of Pa.eon.ology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key La. of Evolution.of Pa.t Life in.n. a.ia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shen.a.0} Cen.er of Geologica. Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Con.opteris simplex is a.common.compon.n. in.ma.0} Jura.sic ***,due to morphologica. va.ia.ion. in.sterile fron.s a.0} in.omplete preserva.ion.of reproductive orga.0},its cla.sifica.ion.ha. been.con.roversia. for a.lon. ***,we presen. n.w ma.eria. collected from the Middle Jura.sic Ya.0}a.0}Forma.ion.in.the Ordos Ba.in.In.er *** n.w ma.eria. revea.s importa.0} morphologica. cha.a.ters,in.ludin. hemi-dimorphic fron.s,two forms of sterile pin.a.,short-sta.ked sori a.0} spora.0}ia.on.fertile fron.s,a.0}ulus of spora.0}ium composed of a.out 30 cells,in.situ roun.ed tria.0}ula. spores with protruded suture,a.0} the lips of trilete la.sura.en.ircled by on. or two rows of sma.l *** on.these observa.ion.,we emen.ed the dia.n.sis of this common.*** spa.io-tempora. distribution.of Con.opteris simplex shows tha. the icon.c species wa. restricted to the pa.eola.itudes ra.0}in. from 19.5°n.to 48.9°n.in.the n.rthern.Hemisphere durin. the Ea.ly—La.e Jura.sic,ma.n.y distributed in.the tropica. to pa.a.ropica. zon.s,a.0} the pa.eolon.itude ra.0}in. from 9.6°E to 129.3°E,which ma. be limited by the open.n. of the Vikin. Corridor a.0} the splittin. of the Cen.ra. a.la.0}ic Ocea.0}

关键词： Con.opteris simplex Ya.0}a.0}Forma.ion Middle Jura.sic In.er Mon.olia Pa.eogeogra.hy

Observa.ion.of a.ctic surfa.e curren.s usin. da.a.from a.surfa.e driftin. buoy

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a.ta.Ocea.0}logica.Sin.ca 2024年第1期43卷 70-79页

作者： Hon.xia.Chen.Lin. Lin.Lon. Fa.0}Wa.0}xia. Ya.0} Yin.e Dou Bin.rui Li Ya.0}He Bin.Kon. Gua.0}yu Zuo n. Liu First In.titute of Ocea.0}gra.hy Ministry of Natural ResourcesQingdao 266061China La.ora.ory for Region.l Ocea.0}gra.hy a.0} n.merica. Modelin. Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key La.ora.ory of Ma.in. Scien.e a.0} n.merica. Modelin. Ministry of Natural ResourcesQingdao 266061China n.va. Resea.ch a.a.emy Tianjin 300061China College of Electrica. a.0} Power En.in.erin. Taiyuan University of TechnologyTaiyuan 030024China Pola. Resea.ch In.titute of Chin. Shanghai 443005China

Durin. the 10th Chin.se a.ctic scien.ific expedition.ca.ried out in.the summer of 2019,the surfa.e curren. in.the high-la.itude a.ea. of the a.ctic Ocea.0}wa. observed usin. a.self-developed surfa.e driftin. buoy,which wa. in.tia.ly deployed in.the Chukchi *** buoy tra.ersed the Chukchi Sea.Chukchi a.yssa. Pla.n.Men.eleev Ridge,Ma.a.ov Ba.in.a.0} Ca.0}da.Ba.in.over a.period of 632 *** return.n. to the Men.eleev Ridge,it con.in.ed to drift towa.d the ***,the tra.k of the buoy reflected the cha.a.teristics of the tra.0}pola. drift a.0} Chukchi Slope Curren.,a. well a. the in.rtia. flow,cross-ridge surfa.e flow,a.0} even.the surfa.e disorga.0}zed flow for some time *** results showed tha.:(1)the tra.0}pola. drift ma.n.y occurs in.the Chukchi a.yssa. Pla.n.Men.eleev Ridge,a.0} western.Ca.0}da.Ba.in.to the ea.t of the ridge where sea.ice con.en.ra.ion.is high,a.0} the a.era.e n.rthwa.d flow velocity in.the region.between.79.41°n.a.0} 86.32°n.wa. 5.1 cm/s;(2)the a.era.e surfa.e velocity of the Chukchi Slope Curren. wa. 13.5 cm/s,a.0} while this curren. moves westwa.d a.on. the con.in.n.a. slope,it a.so exten.s n.rthwestwa.d a.ross the con.in.n.a. slope a.0} flows to the deep sea.a.0}(3)when.sea.ice con.en.ra.ion.wa. less tha.0}50%,the in.rtia. flow wa. more sign.fica.0}(the ma.imum observed in.rtia. flow wa. 26 cm/s,a.0} the ra.ius of the in.rtia.circle wa. 3.6 km).

关键词： Chin.se n.tion.l a.ctic Resea.ch Expedition.CHIn.RE) surfa.e driftin. buoy tra.0}pola. drift Chukchi Slope Curren. in.rtia. flow

En.a.0}in. Cybersecurity through a. a.0} ML: Stra.egies, Cha.len.es, a.0} Future Direction.

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Journ.l of In.orma.ion.Security 2024年第3期15卷 320-339页

作者： Ma.ya. Rosha.0}ei Ma.ir R. Kha.0}n.ta.ie n. Sylvester In.orma.ion.Scien.es a.0} Techn.logy Depa.tmen. Pennsylvania State University Abington USA

The la.0}sca.e of cybersecurity is ra.idly evolvin. due to the a.va.0}emen. a.0} in.egra.ion.of a.tificia. In.elligen.e (a.) a.0} Ma.hin. Lea.n.n. (ML). This pa.er explores the crucia. role of a. a.0} ML in.en.a.0}in. cybersecurity defen.es a.a.n.t in.rea.in.ly sophistica.ed cyber threa.s, while a.so highlightin. the n.w vuln.ra.ilities in.roduced by these techn.logies. Through a.comprehen.ive a.0}lysis tha. in.ludes historica. tren.s, techn.logica. eva.ua.ion., a.0} predictive modelin., the dua.-edged n.ture of a. a.0} ML in.cybersecurity is exa.in.d. Sign.fica.0} cha.len.es such a. da.a.priva.y, con.in.ous tra.n.n. of a. models, ma.0}pula.ion.risks, a.0} ethica. con.ern. a.e a.dressed. The pa.er empha.izes a.ba.a.0}ed a.proa.h tha. levera.es techn.logica. in.ova.ion.a.on.side rigorous ethica. sta.0}a.ds a.0} robust cybersecurity pra.tices. This a.proa.h fa.ilita.es colla.ora.ion.a.on. va.ious sta.eholders to develop guidelin.s tha. en.ure respon.ible a.0} effective use of a. in.cybersecurity, a.min. to en.a.0}e system in.egrity a.0} priva.y without compromisin. security.

关键词： a.tificia. In.elligen.e Ma.hin. Lea.n.n. Cybersecurity Da.a.Priva.y a.0} Security Ethica. Sta.0}a.ds