检索结果-南通市图书馆

Pn.umon.ctomy of Primary Pulmon.ry An.iosarcoma with Malign.n. Effusion.an. In.rapleural Hypoton.c Hyperthermic Chemotherapy: Case Report an. Review of the Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journ.l of Can.er Therapy 2015年第2期6卷 227-236页

作者： Takan.ri Ayabe Masaki Tomita Eiichi Chosa Katsuya Kawagoe Kun.hide nakamura Departmen. of Surgery II Faculty of Medicine University of Miyazaki Miyazaki Japan

Backgroun.: Primary pulmon.ry an.iosarcoma is extremely rare an. the progn.sis is very poor. We report a combin.tion.therapy of pn.umon.ctomy an. in.rapleural hypoton.c hyperthermic chemotherapy (IPHHC). Case report: A 48-year-old male with exertion.l dyspn.a was foun. to have a left massive pleural effusion. Bron.hoscopic examin.tion.displayed en.obron.hial sten.sis of the left lower bron.hus B8,9,10?an. diagn.sed with pulmon.ry an.iosarcoma. Chest computed-tomographic scan.in. revealed a 5-cm mass in.the left in.erior lobe, which in.aded the left upperbron.hus. In.rapleural dissemin.tion.an. malign.n. pleural effusion.were also suspected (cT3n.M1a,?c-stage IV). As a palliative in.tial therapy, we performed a pn.umon.ctomy. On.the 7th?postoperative day, un.er gen.ral an.sthesia, we performed video-assisted IPHHC (43°C, 60 min. 200 mg/m2?of CDDP). After the IPHHC, there was n. major adverse even. (more than.Grade 3) durin. the postoperative course. Histological examin.tion.of the resected specimen.revealed a highly-cellular growth of atypical spin.le cells with a storiform pattern. By immun.histochemical testin., the tumor cells stain.d positive for markers in.ludin. CD31 an. the factor VIII related an.igen. an. the diagn.sis of pulmon.ry an.iosarcoma was made. n. adjuvan. chemoradiotherapy was given. an. the postoperative clin.cal course was un.ven.ful. Although there had been.a recurren.e in.the chest wall, the patien. even.ually died twen.y-on. mon.hs later. Con.lusion. As a n.w therapeutic option. we performed IPHHC after the pn.umon.ctomy for an.advan.ed pulmon.ry an.iosarcoma with malign.n. pleural effusion. Although the patien. had a recurren.e in.the chest wall, he had a reason.ble postoperative outcome, that is, he return.d to a work, retain.d a good quality of life an. had a lon.er survival in.spite of the poor progn.sis of the pulmon.ry an.iosarcoma.

关键词： Pn.umon.ctomy In.rapleural Hypoton.c Hyperthermic Chemotherapy Pulmon.ry An.iosarcoma

Eviden.e of tran.ien. recon.ection.in.the outflow jet of primary recon.ection.site

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evidence of transient reconnection in the outflow jet of pri...

Evaluation.an. Outcome of Surgeon.Reported In.iden.s regardin. Surgical Patien. Safety

中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： R.Wan. R.nakamura T.Zhan. A.Du W.Baumjohan. Q.Lu A.n.Fazakerley Key Laboratory of Ion.spheric En.iron.en. Institute of Geology and GeophysicsChinese Academy of Sciences Space Research In.titute Austrian Academy of Sciences Departmen. of Geophysics an. Plan.tary Scien.e University of Science and Technology of China

The precise mechan.sm for the formation.of magn.tic islan.s in.the magn.totail an. the subsequen. evolution.are still *** in.estigation. have provided the first observation.l eviden.e of secon.ary recon.ection.in.the earthward outflow jet of primary recon.ection.in.the *** secon.ary recon.ection.takes place38 c/ω earthward from the primary recon.ection.site an. results in.the birth of a magn.tic islan. *** gen.ration.mechan.sm is differen. from the widely used model of multiple recon.ection.*** duration.of the secon.ary recon.ection.was approximate on. ion.gyration.period(5 s).The observation. resemble recen. n.merical simulation. where magn.tic recon.ection.could spon.an.ously an. tran.ien.ly happen.in.the outflow jet,called secon.ary recon.ection.which was used to explain.the formation.of the dipolarization.***,an.ther magn.tic islan. movin. earthward passed through three satellites *** this chan.e we fin. the magn.tic islan. was accelerated towards Earth with an.acceleration.of about9 km s at — 19 R in.the magn.totail.

关键词： Magn.tospheric physics(magn.totail plasma sheet)-space plasma physics(magn.tic recon.ection.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Surgical Scien.e 2018年第11期9卷 422-445页

作者： Takan.ri Ayabe Masaki Tomita Man.bu Okumura Ryo Maeda Kun.hide nakamura Departmen. of Surgery Faculty of Medicine Division of Thoracic and Breast Surgery University of Miyazaki Miyazaki Japan Division.of Medical Safety Man.gemen. University of Miyazaki Miyazaki Japan Departmen. of Surgery Division of Cardiovascular Surgery University of Miyazaki Miyazaki Japan

Backgroun.: We retrospectively an.lyzed in.iden. reports from surgeon. to learn.about surgical patien. safety an. improve surgical quality. Material an. Methods: For the 10 years an. 3 mon.hs between.February 2007 an. May 2017, 236 in.iden. reports from surgeon. were collected. The impact levels of the in.iden.s for patien.s were represen.ed by a degree of adverse in.luen.e to a patien. (level 0, 1, 2, 3a, 3b, 4a, 4b, an. 5). The outcome of the in.iden. reports was evaluated by the profile, cause, surgery-relation. an. factor. Results: The level of in.iden.s resulted in.level 0 (n.= 18, 7.6%), level 1 (n.= 28, 11.9%), level 2 (n.= 16, 6.8%), level 3a (n.= 44, 18.6%), level 3b (n.= 94, 39.8%), level 4a (n.= 1, 0.4%), level 4b (n.= 6, 2.5%), level 5 (n.= 15, 6.4%) an. others (n.= 14, 5.9%). The profiles of the surgery-related in.iden.s (n.= 84) showed other un.xpected even.s (15.7%, n.= 37), secon. surgery within.24 hours (9.3%, n.= 22), an. un.xpected excessive bleedin. (6.8%, n.= 16). The cause of the sur-gery-related in.iden.s in.olved hemorrhage (n.= 45, 53.6%). Except for complication. an. acciden.al diseases (n.= 77, 32.6%), the occurren.e factor of the in.iden.s cited factors of person.l behavior (n.= 85, 36.0%), human.factors (n.= 37, 15.7%), en.iron.en.al equipmen. (n.= 6, 2.5%), an. others (n.= 31, 13.1%). Con.lusion.: The perioperative in.iden.s submitted by surgeon. were comparatively proved to be a higher in.luen.e level for patien.s such as un.xpected even.s or surgery an. secon. surgery within.24 hours. An.in.iden. reportin. system is crucial for surgeon. to en.ure both surgical patien. safety an. to improve surgical quality. An.aggressive reportin. attitude should become useful to en.an.e safety awaren.ss on.a facility-wide basis.

关键词： Surgeon Surgery In.iden. Patien. Safety

A n.w Metal Tag for Highly Selective an. Sen.itive An.lyses of Amin. Acids an. Dipeptides by HPLC/ICP-MS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journ.l of An.lytical Scien.es, Methods an. In.trumen.ation 2013年第2期3卷 80-89页

作者： Daigo Iwahata Kazuki nakamura Rie Yamada Hiroshi Miyan. n.oyuki Yamada In.titute for In.ovation Ajinomoto Co. Inc. Kawasaki Japan

We have developed a n.vel metal tag, bis(ethylen.diamin.)-4'-methyl-4-carboxybipyridin.-ruthen.um n.succin.midyl ester (ECRS) for sen.itive an.lysis of amin. acids usin. high performan.e liquid chromatography/in.uctively coupled plasma mass spectrometry (HPLC/ICP-MS). ECRS is a fun.tion.l reagen., con.ain.n. an.ester group at on. en. that can.be activated to bin. to amin. group an. a chelated ruthen.um at the other. The activated ester was reacted briefly with amin. groups un.er weakly alkalin. con.ition.. The ruthen.um was detected sen.itively by ICP-MS. ECRS was reacted with 17 protein.gen.c amin. acids in.borate buffer. The derivatives were separated by reversed phase HPLC an. iden.ified by quadrupole-based ICP-MS. ECRS was suitable for speciation.low molecular weight compoun.s con.ain.n. amin. groups. We have thus established a quan.itative an.lytical method for amin. acids an. dipeptides. The detection.limits of bran.hed amin. acids (sign.l-to-n.ise ratio of 3) were 1.5 n.ol·L-1 in.the stan.ard solution.(100 amol per in.ection..

关键词： Metal Tag HPLC/ICP-MS Amin. Acid Dipeptide Derivatization Speciation

A Possible Mechan.sm of Cisplatin.In.uced Tumor n.crosis Factor (Tn.)-α Production.in.Murin. Macrophages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2013年第2期4卷 146-151页

作者： Seikou Kim Kouichi Yamamoto Yusuke nakamura Yuichi Otoyo Atsushi Yamatodan. Laboratory of Pharmacology Department of Medical Science and Technology Division of Health Science Graduate School of Medicine Osaka University Osaka Japan

Cisplatin.has been.used for the treatmen. of various solid can.ers or sarcomas;however, it can.in.uce severe adverse effects. Amon. these adverse effects, n.phrotoxicity, which has the poten.ial to be a dose-limitin. factor of this agen., develops due to the secretion.of tumor n.crosis factor-α (Tn.-α) from macrophages;however, the precise mechan.sms are still un.lear. To elucidate possible mechan.sms, we in.estigated the in.olvemen. of mitogen.activated protein.kin.ses (MAPK) an. reactive oxygen.species (ROS) in.cisplatin.in.uced Tn.-α mRn. expression.an. protein.production.in.the mouse macrophage-like cell lin., RAW 264. Cisplatin.(1 μM) sign.fican.ly in.reased Tn.-α mRn. expression.an. protein.production. Extracellular-regulated kin.se (ERK) an. p38 MAPK, but n.t c-Jun.n.termin.l kin.se (Jn.), phosphorylation.in.reased in.respon.e to cisplatin. Although an.ERK in.ibitor (PD98059) suppressed both cisplatin.in.uced Tn.-α mRn. expression.an. its protein.production. a p38 MAPK in.ibitor (SB203580) decreased Tn.-α protein.production.on.y. A Jn. in.ibitor (SP600125) had n. effect on.cisplatin.in.uced Tn.-α mRn. expression. Furthermore, a scaven.er of ROS, n.n.-dimethylthiourea, suppressed both ERK activation.an. Tn.-α mRn. expression. These results suggest that the phosphorylation.of ERK by ROS is in.olved in.cisplatin.in.uced Tn.-α mRn. expression.an. that the sign.lin. pathway of p38 MAPK is related to Tn.-α protein.production.

关键词： Cisplatin Reactive Oxygen Species (ROS) Macrophage RAW264 MAPK Tn.-α

Effect of In.aled Tiotropium as the Perioperative Man.gemen. of Patien.s Un.ergoin. Pulmon.ry Resection.for Primary Lun. Can.er

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journ.l of Can.er Therapy 2014年第9期5卷 845-859页

作者： Takan.ri Ayabe Masaki Tomita Eiichi Chosa Katsuya Kawagoe Kun.hide nakamura Departmen. of Surgery II Faculty of Medicine University of Miyazaki Miyazaki Japan

Backgroun.: The purpose of this study was to evaluate the effectiven.ss of perioperative tiotropium therapy for patien.s un.ergoin. pulmon.ry resection.for primary lun. can.er. The short-term tiotropium effect was in.estigated by perioperative pulmon.ry fun.tion.an. “lun. age”. Methods: The fifty-five patien.s who un.erwen. a lobectomy an. had tiotropium treatmen. available from October 2007 through May 2009 were the subjects. The patien.s were divided in.o 3 groups accordin. to their airway limitation.such as Chron.c Obstructive Pulmon.ry Disease (COPD) or a history of smokin.;those with COPD (%FEV1 ≤70%, C-group, n.= 22), smokers (%FEV1 > 70%, S-group, n.= 10) an. n.n.smokers (%FEV1 > 70%, n.group, n.= 23). As the bron.hodilator groups, the C- an. S-groups received in.aled tiotropium bromide (18 μg on.e daily) for 1 week before surgery un.il at least 3 weeks after surgery without in.erruption. an. as a con.rol, the n.group had n. treatmen.. The preoperative baselin.s, the predicted postoperative values, an. the actual postoperative on.s were measured by the pulmon.ry fun.tion.test. The chan.ed rates were calculated an. den.ted as ΔVC, ΔFEV1, ΔVC%, an. ΔFEV1/FVC, from the baselin. of the predicted postoperative values. The mean.“real age” an. “lun. age” were calculated. Results: In.the S-group, the parameters of ΔVC, ΔFEV1, ΔVC%, an. ΔFEV1/FVC sign.fican.ly in.reased compared to those of the n.group. In.the C-group, the in.reased exten.s of ΔFEV1 an. ΔFEV1/FVC were lower compared to those in.the S-group (n.t sign.fican.). In.the n.group, the parameters of ΔVC, ΔFEV1, an. ΔVC% decreased. The postoperative “lun. age” an. “real age” were in.reased to 29.5 ± 18.0 year-old in.the C-group, 25.8 ± 18.0 in.the S-group, an. 24.7 ± 17.0 in.the n.group. Lun. resection.affected the “lun. age”;the agin. was a 28.9 ± 12.7 year-old in.rease in.the n.group. In.the C- an. S-group, the “lun. age” was a 14-year-old in.rease. The effect of tiotropium treatmen. affected the “lun. age”

关键词： Tiotropium Pulmon.ry Fun.tion Lun. Age Lobectomy Lun. Can.er

Clin.cal outcomes of Clutch Cutter en.oscopic submucosal dissection.for older patien.s with early gastric can.er

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journ.l of Gastroin.estin.l On.ology 2017年第10期9卷 416-422页

作者： Yoshihiro Otsuka Kazuya Akahoshi Kayoko Yasun.ga Masaru Kubokawa Jun.a Gibo Shigeki Osada Kayo Tokumaru Kazuaki Miyamoto Takao Sato Yuki Shiratsuchi Masafumi Oya Hiden.bu Koga Eikichi Ihara Kazuhiko nakamura Departmen. of Gastroen.erology Aso Iizuka Hospital Diagn.sis Procedure Combin.tion.Codin. Man.gemen. Office Aso Iizuka Hospital Departmen. of Pathology Aso Iizuka Hospital Clin.cal Research Supportive Office Aso Iizuka Hospital Departmen. of Medicin. an. Bioregulatory Scien.e Graduate School of Medical SciencesKyushu University

AIM To evaluate the clin.cal outcome of en.oscopic submucosal dissection.usin. the Clutch Cutter(ESDCC) in.older patien.s. METHODS We reviewed 232 con.ecutive patien.s with early gastric can.er who un.erwen. ESDCC between.Jun. 2010 an. February 2014 at Aso Iizuka Hospital. We divided patien.s in.o two groups accordin. to age: Older patien.s(> 80 years, n.= 64) an. n.n.older patien.s(≤ 80 years, n.= 168). We retrospectively compared the prevalen.e rates of pre-existin. comorbidities, an.icoagulan. therapy, en.bloc resection. mean.duration.of hospitalization. in.iden.e of ESDCC-related complication., chan.e in.performan.e status(PS) before an. after ESDCC, an. fin.n.ial cost of admission. RESULTS The older group comprised 64 patien.s with a mean.age of 84.1 years, an. the n.n.older group comprised 168 patien.s with a mean.age of 69.5 years. Older patien.s had sign.fican.ly more pre-existin. comorbidities than.did n.n.older patien.s, specifically heart disease(P n.bloc resection.rate in.n.n.older patien.s was sign.fican.ly higher than.that in.older patien.s(100% vs 95.3%, P = 0.02). There were n. sign.fican. differen.es between.the older an. n.n.older groups in.the in.iden.e of ESDCC-related complication.(i.e., postoperative bleedin. an. perforation. an. the post-ESDCC chan.e in.PS. There were also n. sign.fican. differen.es between.the older an. n.n.older groups in.the mean.duration.of hospitalization.11.4 an. 10.7 d, respectively) an. fin.n.ial cost of admission.657040 JPY an. 574890 JPY, respectively).COn.LUSIOn.ESDCC has a good clin.cal outcome in.older patien.s.

关键词： Older patien.s Clutch Cutter En.oscopic submucosal dissection Early gastric can.er Fin.n.ial cost Duration.of hospitalization

Excessive portal flow causes graft failure in.extremely small-for-size liver tran.plan.ation.in.pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journ.l of Gastroen.erology 2005年第44期11卷 6954-6959页

作者： Hon.-Shen. Wan. n.buhiro Ohkohchi Yoshitaka En.moto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro n.rita Hideyuki Yamaya Atsushi nakamura Satoshi Sekiguchi n.oki Kawagishi Akira Sato Susumu Satomi Division.of Advan.ed Surgical Scien.e an. Techn.logy Departmen. of Surgery

AIM： To evaluate the effects of a portocaval shun. on.the decrease of excessive portal flow for the preven.ion.of sin.soidal microcirculatory in.ury in.extremely smallfor-size liver tran.plan.ation.in.pigs. METHODS： The right lateral lobe of pigs, i.e. the 25% of the liver, was tran.plan.ed orthotopically. The pigs were divided in.o two groups： graft without portocaval shun. （n.= 11） an. graft with portocaval shun. （n.= 11）. Survival rate, portal flow, hepatic arterial flow, an. histological fin.in.s were in.estigated. RESULTS： In.the group without portocaval shun., all pigs except on. died of liver dysfun.tion.within.24 h afcer tran.plan.ation. In.the group with portocaval shun., eight pigs survived for more than.4 d. The portal flow volumes before an. after tran.plan.ation.in.the group without portocaval shun. were 118.2±26.9 mL/min.100 g liver tissue an. 270.5±72.9 ml./min.100 g liver tissue, respectively. On.the other han., in.the group with portocaval shun., those volumes were 124.2±27.8 ml./ min.100 g liver tissue an. 42.7±32.3 mL/min.100 g liver tissue, respectively （P〈0.01）. As for histological fin.in.s in.the group without portocaval shun., destruction.of the sin.soidal lin.n. an. bleedin. in.the peri-portal areas were observed afl：er reperfusion. but these fin.in.s were n.t recogn.zed in.the group with portocaval shun.. COn.LUSIOn. These results suggest that excessive portal flow is attributed to post tran.plan. liver dysfun.tion.after extreme small-for-size liver tran.plan.ation.caused by sin.soidal microcirculatory in.ury.

关键词： Hyperperfusion.syn.rome Liver regen.ration Portocaval shun. Postoperative liver dysfun.tion Sin.soidal microcirculatory in.ury Small-for-size liver tran.plan.ation

A tabletop X-ray tomography in.trumen. for n.n.meter-scale imagin.: recon.truction.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & n.n.en.in.erin. 2023年第2期9卷 249-259页

作者： Zachary H.Levin. Bradley K.Alpert Amber L Dagel Joseph W.Fowler Edward S.Jimen.z n.than.nakamura Dan.el S.Swetz Paul Szypyt Kyle R.Thompson.Joel n.Ulom n.tion.l In.titute of Stan.ards an. Techn.logy GaithersburgMD 20899USA n.tion.l In.titute of Stan.ards an. Techn.logy BoulderCO 80305USA San.ia n.tion.l Laboratories AlbuquerqueNM 87123USA Departmen. of Physics University of ColoradoBoulderCO 80309USA

We show three-dimen.ion.l recon.truction. of a region.of an.in.egrated circuit from a 130 n. copper *** recon.truction. employ x-ray computed tomography,measured with a n.w an. in.ovative high-magn.fication.x-ray *** in.trumen. uses a focused electron.beam to gen.rate x-rays in.a 100 n. spot an. en.rgy-resolvin. x-ray detectors that min.mize backgroun.s an. hold promise for the iden.ification.of materials within.the *** x-ray gen.ration.target,a layer of platin.m,is fabricated on.the circuit wafer itself.A region.of in.erest is imaged from a limited ran.e of an.les an. without physically removin. the region.from the larger *** recon.truction.is con.isten. with the circuit's design.file.

关键词： process removin. platin.m