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神经精神药理学治疗药物监测共识指南:2017版

实用药物与临床 2022年第1期25卷 1-20页

作者： C.Hiemke n.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen u.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.J.Müller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.uhr S.ulrich S.unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(主译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(审校) 王传跃(审校) 王刚(审校) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of MainzMainzGermany Kitzberg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Servizio Psichiatrico del Comprensorio Sanitario di Bolzano BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany Medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological Medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum München-Ost Psychiatric HospitalMunich-HaarGermany Department of

治疗药物监测(Therapeutic Drug Monitoring,TDM)通过定量测定和解释血药浓度以优化药物治疗。TDM着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDM的主要患者群体包括少年儿童... 详细信息

治疗药物监测(Therapeutic Drug Monitoring,TDM)通过定量测定和解释血药浓度以优化药物治疗。TDM着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDM的主要患者群体包括少年儿童、孕妇、老年患者、智障患者、药物滥用者、涉法精神病患者、已知或怀疑药代动力学异常的患者以及合并躯体疾病影响药代动力学的患者。常规剂量下治疗无效,用药依从性难以判断,药物耐受性不佳,以及可能存在药代动力学方面的药物-药物相互作用等情况都是治疗药物监测的典型指征。然而,只有将TDM充分整合到临床治疗过程中,才能发挥其优化药物治疗的潜在优势。为了向临床医生和实验室提供有效的TDM信息,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für neuropsychopharmakologie und Pharmakopsychiatrie,AGnP)的TDM专家组在2004年发表了第一版《精神科治疗药物监测指南》。2011年进行了更新之后,现在再次更新。遵循新版指南,可能会改善神经精神药物治疗的效果,加快很多患者的康复,并降低医疗费用。

关键词：抗凝药物妊娠期静脉血栓栓塞疾病抗抑郁药抗癫痫药抗帕金森病药抗精神病药血药浓度共识指南药物分析基因型分析神经药物遗传药理学药代动力学表型分析血浆药物浓度精神药物参考范围血清药物浓度治疗药物监测治疗窗

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神经精神药理学治疗药物监测共识指南:2017版

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实用药物与临床 2022年第2期25卷 97-118页

作者： C.Hiemke n.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts M.Gerlach C.Greiner G.Gründer E.Haen u.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.Messer R.M ssner M.JMüller M.Paulzen B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis M.Schwarz M.Silva Gracia B.Stegmann W.Steimer J.C.Stingl M.uhr S.ulrich S.unterecker R.Waschgler G.Zernig G.Zurek P.Baumann 李文标(译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(译) 王传跃(译) 王刚(译) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of MainzMainzGermany Kitzberg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Servizio Psichiatrico del Comprensorio Sanitario di Bolzano BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany Medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological Medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum München-Ost Psychiatric HospitalMunich-HaarGermany Department of

2.2剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的... 详细信息

2.2剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的药物浓度与理论预期药物浓度范围。参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群(“正常”患者),在日维持剂量(Daily maintenance dose,D m)、给药间隔(Dosing interval,d i)、总清除率(Total clearance,CL)和生物利用度(Bioavailability,F)已知情况下,某种药物在某个“正常”患者体内的预期平均稳态浓度(Average steady-state concentration,C av)可通过下面的公式计算。

关键词：治疗药物监测药效动力学给药间隔维持剂量生物利用度药物浓度药代动力学合并用药

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Measurement of integrated luminosity and center-of-mass energy of data taken by BESⅢ at s^(1/2)=2.125 GeV

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Chinese Physics C 2017年第11期41卷 1-9页

作者：麦迪娜 M.n.Achasov S.Ahmed 艾小聪 O.Albayrak M.Albrecht D.J.Ambrose A.Amoroso 安芬芬安琪白景芝 R.Baldini Ferroli 班勇 D.W.Bennett J.V.Bennett n.Berger M.Bertani D.Bettoni 边渐鸣 F.Blanchi E.Boger I.Boyko R.A.Briere 蔡浩蔡啸 O.Cakir A.Calcaterra 曹国富 S.A.Cetin J.Chai 常劲帆 G.Chelkov 陈刚陈和生陈江川陈玛丽陈实陈申见堪炫陈旭荣陈元柏程和平褚新坤 G.Cibinetto 代洪亮代建平 A.Dbeyssi D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.DEMori 丁勇董超董静董燎原董明义豆正磊杜书先段鹏飞范荆州方建房双世方馨方易 R.Farinelli L.Fava O.Fedorov F.Feldbauer G.Felici 封常青 E.Fiorauanti M.Fritsch 傅成栋高清高鑫磊高原宁高榛 I.Garzia K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭如盼郭玥郭玉萍 Z.Haddadi A.Hafner 韩爽郝喜庆 F.A.Harris 何康林 F.H.Heinsius T.Held 衡月昆 T.Holtmann 侯治龙胡琛胡海明胡继峰胡涛胡誉黄光顺黄金书黄性涛黄晓忠黄勇黄智玲 T.Hussain 纪全姬清平季晓斌季筱璐姜鲁文江晓山蒋兴雨焦健斌焦铮金大鹏金山 T.Johansson A.Julin n.Kalantar-nayestanaki 康晓琳康晓坤 M.Kavatsyuk 柯百谦 P.Kiese R.Kliemt B.Kloss O.B.Kolcu B.Kopf M.Kornicer A.Kupsc W.Kühn J.S.Lange M.Lara P.Larin H.Leithoff C.Leng 李翠李澄李德民李飞李峰云李刚李海波李惠静李家才李瑾李康李科李蕾李培荣李启云李腾李卫东李卫国李晓玲李小男李学潜李郁博李志兵梁昊梁勇飞梁羽铁廖广睿林德旭刘冰刘北江刘春秀刘栋刘福虎刘芳刘峰刘宏邦刘汇慧刘欢欢刘怀民刘杰刘建北刘觉平刘晶译刘凯刘魁勇刘兰雕刘佩莲刘倩刘树彬刘翔刘玉斌刘媛媛刘振安刘智青 H.Loehner 龙云飞娄辛丑吕海江吕军光卢宇卢云鹏罗成林罗民兴 T.Luo 罗小兰吕晓睿马凤才马海龙马连良马明明马秋梅马天马旭宁马骁妍马玉明 F.E.Maas M.Maggiora Q.A.Malik 冒亚军毛泽普 S.Marcello J.G.Messchendorp G.Mezzadri 闵建闵天觉 R.E.Mitchell 莫晓虎莫玉俊 C.Morales Morales n.Yu.Muchnoi H.Muramatsu P.Musiol Y.nefedov F.nerling I.B.nikolaev 宁哲 S.nisar 牛顺利牛讯伊马鹏欧阳群 S.Pacetti 潘越 P.Patteri M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 R.Poling V.Prasad 漆红荣祁鸣钱森乔从丰秦丽清覃拈秦小帅秦中华邱进发 K.H.Rashid C.F.Redmer M.Ripka 荣刚 Ch.Rosner 阮向东 A.Sarantsev M.Savrié C.Schnier K.Schoenning S.Schumann 邵明沈成平沈培迅沈肖雁盛华义施萌宋维民宋欣颖 S.Sosio S.Spataro 孙功星孙俊峰孙胜森孙新华孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 I.Tapan E.H.Thorndike M.Tieinens I.uman G.S.Varner 王斌王滨龙王东王大勇王科王亮亮王灵淑王萌王平王佩良王炜王维平王雄飞王越王雅迪王贻芳王亚乾王铮王志刚王志宏王至勇王宗源 T.Weber 魏代会 P.Weidenkaff 文硕频 u.Wiedner M.Wolke 伍灵慧吴连近吴智夏磊夏力钢夏宇肖栋肖浩肖振军谢宇广修青磊许国发徐静静徐雷徐庆君徐庆年徐新平严亮鄢文标闫文成颜永红杨海军杨洪勋杨柳杨永栩叶梅叶铭汉殷俊昊尤郑昀 Institute of High Energy Physics G.I.Budker Institute of nuclear Physics SB RAS (BInP) the novosibirsk State university Helmholtz Institute Mainz Carnegie Mellon university Bochum Ruhr-university university of Rochester university of Turin InFn university of Science and Technology of China State Key Laboratory of Particle Detection and Electronics InFn Laboratori nazionali di Frascati Peking university Indiana university Johannes Gutenberg university of Mainz InFn Sezione di Ferrara university of Minnesota Joint Institute for nuclear Research the Moscow Institute of Physics and Technology Wuhan university Ankara university Istanbul Bilgi university the Functional Electronics Laboratory Tomsk State University university of Chinese Academy of Sciences nanjing university Lanzhou university Huangshan College Shanghai Jiao Tong university Liaoning university nankai university Zhengzhou university Tsinghua university university of Ferrara university of Eastern Piedmont GSI Helmholtzcentre for Heavy Ion Research GmbH Guangxi university nanjing normal university KVI-CART University of Groningen Henan normal university university of Hawaii Shandong university university of the Punjab uppsala university Istanbul Arel university Justus-Liebig-universitaet Giessen Ⅱ.Physikalisches Institut Seoul national university Hangzhou normal university Beijing Institute of Petrochemical Technology Beihang university Sun Yat-Sen university Sichuan university Guangxi normal university Shanxi university Central China normal university Henan university of Science and Technology university of Texas at Dallas Zhejiang university university of Hawaii Honolulu university of Minnesota Minneapolis COMSATS Institute of Information Technology InFn and university of Perugia Goethe university Frankfurt the nRC "Kurchatov Institute" PNPI uludag university near East university Soochow university Hunan university university of South China China Center of Advanced Science and Technology Bogazici university university of Science and Technology Liaoning

To study the nature of the state Y（2175）,a dedicated data set of e ＋ e-collision data was collected at the center-of-mass energy of 2.125 GeV with the BESⅢ detector at the BEPCⅡ *** analyzing large-angle Bhabha scattering events,the integrated luminosity of this data set is determined to be 108.49±0.02±0.85 pb-1,where the first uncertainty is statistical and the second one is *** addition,the center-of-mass energy of the data set is determined with radiative dimuon events to be 2126.55±0.03±0.85 MeV,where the first uncertainty is statistical and the second one is systematic.

关键词： Bhabha scattering luminosity radiative dimuon events center-of-mass energy

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Energy calibration of HPGe detector using the high-energy characteristic γ rays in 13C formed in 6Li + 12C reaction

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nuclear Science and Techniques 2020年第5期31卷 57-63页

作者： Jia-Tai Li Xue-Dou Su Gao-Long Zhang Guang-Xin Zhang Shi-Peng Hu Jing-Bin Lu Yi-Feng Lv Hui-Bin Sun Huan-Qiao Zhang D.Testov P.R.John J.J.Valiente-Dobon A.Goasduff M.Siciliano F.Galtarossa F.Recchia D.Mengoni D.Bazzacco School of Physics Beihang UniversityBeijing 100191China Shenyuan Honors College Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine and EngineeringBeihang University and Key Laboratory of Big Data-Based Precision Medicine(Beihang University)Ministry of Industry and Information TechnologyBeihang UniversityBeijing 100191China Dipartimento di Fisica Astronomia dell’Universit'a di PadovaPaduaItaly Istituto nazionale di Fisica nucleare Sezione di PadovaPaduaItaly College of Physics Science and Technology Shenzhen UniversityShenzhen 518060China College of Physics Jilin UniversityChangChun 130012China China Institute of Atomic Energy Beijing 102413China Laboratori nazionali di Legnaro INFNLegnaroPaduaItaly Irfu/CEA Universit de Paris-SaclayGif-sur-YvetteFrance

An 6 Li+89Y experiment was conducted at the Laboratori nazinali di Legnaro,InFn,*** 550μg/cm^2 thick^89Y target was backed on a 340μg/cm^2 thick 12C *** severalγrays in the experiment with energies higher than 3000 keV can most likely be ascribed to the transitions in the 13C nuclei,which can be formed through various interactions between the 6 Li beam and the 12C *** high-energy properties ofγrays in 13C are employed for energy calibrating HPGe detectors,especially for the>3000 keV region,which is impossible to reach by common standard sources(152Eu,133Ba,etc.).Furthermore,γ-γand particle-γcoincidence measurements were performed to investigate the formation of 13C.

关键词： Energy calibration Coincidence measurement Weakly bound nuclei Reaction mechanism

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质子数Z分别位于Ru之上和之下的A～(100～126)丰中子原子核三轴形变在原子核形状变迁和共存中的重要作用(英文)

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原子核物理评论 2015年第1期32卷 1-23页

作者：罗亦孝 J.H.Hamilton J.O.Rasmussen A.V.Ramayya S.Frauendorf 王恩宏 J.K.Hwang 王建国李红洁杨韵颐朱胜江刘艳鑫焦长峰梁午阳石跃许甫荣孙扬刘少华 n.T.Brewer I.Y.Lee G.M.Ter-Akopian A.V.Daniel Yu.Oganessian M.A.Stoyer R.Donangelo 马文超 Physics Department Vanderbilt University Lawrence Berkeley national Laboratory Department of Chemistry U.C.Berkeley Department of Physics University of Notre Dame Institut für Strahlenphysik FZD-Rossendorf Department of Physics Tsinghua University School of Science Huzhou Teachers College School of Physics Peking University Department of Physics and Astronomy Shanghai Jiao Tong University Institute of Modern Physics Chinese Academy of Sciences Chemistry Department University of Kentucky Physics Division Oak Ridge National Laboratory Flerov Laboratory for nuclear Reactions JINR Lawrence Livermore national Laboratory Instituto de Fisica Facultad de Ingenieria Physics Department Mississippi State University

基于Ru(Z=44)丰中子同位素中存在最大三轴形变的理论预言和实验证据,综述了近年来Rh(Z=45),Pd(Z=46),Ag(Z=47),Cd(Z=48)(质子数Z位于Ru,Z=44之上)及Zr(Z=40),nb(Z=41),Mo(Z=42),Tc(Z=43)(质子数Z位于Ru,Z=44之下)的A～(100～126)丰中子同位素中关于三轴形变的形状变迁和形状共存系统性研究的重要进展。252Cf自发裂变瞬发γ射线γ-γ-γ三重符合、特别是新建立的γ-γ-γ-γ四重符合数据的系统观测和研究,在Ru,Pd,Cd和nb丰中子同位素中显著扩展或首次观测到了一系列能带,为这个核区原子核形状的研究提供了新的、重要的实验数据。联系此前报道的有关进展,使用PES,TRS,PSM,CCCSM和SCTAC理论模型计算拟合新的实验数据,在该核区沿同中素和同位素链,并随自旋和激发能变化各自由度,跟踪原子核形状渐进变化,获得了新的系统性研究成果,显著扩展和深化了人们对原子核形状变迁和形状共存的认知。对于Ru及其上的Rh(Z=45),Pd(Z=46),Ag(Z=47)和Cd(Z=48)丰中子同位素的研究表明:Rh丰中子核具有比最大值稍小的三轴形变,γ=-28°,并在103–106Rh同位素链上鉴别出了手征对称破缺;在三轴形变核112Ru和114Pd(n=68)中发现了三轴原子核的摆动运动,该摆动运动也可能在114Ru(n=70)中存在;观察到了从具有最大三轴形变的110,112Ru中手征破缺到稍小三轴形变的112,114,116Pd中扰动的手征破缺的过渡;在较软的Ag核中观察到了丰富的谱学结构,在104,105Ag中鉴别出了可能的手征对称破缺,在较重的115,117Ag中提出了趋于三轴形变的γ软度;具有小形变的Cd核的能级结构被解释为准粒子耦合、准转动和软三轴形变;最近的库伦激发的研究提供了Z=50,n=82满壳附近122,124,126Cd核中出现核集体性的实验和理论证据;上述研究成果展现出从Ru中的最大三轴形变(γ=-30°,三轴形变极小增益为0.67 Me V),经具有大三轴形变的Rh核(γ=-28°),到Pd核中的稍小、但稳定于中等自旋到高自旋区的三轴形变(γ～-41°,三轴形变极小增益为0.32 Me V),再经Ag核中的γ软度,最后到具有很小形变、但仍出现集体性质、包括软三轴形变的Cd核的过渡。对于Pd核转动带交叉系统性的研究揭示了其第一带交叉(νh11/2)2中子转动顺排的上行γ驱动,和第二带交叉(πg9/2)2质子转动顺排的下行γ驱动效应,成功地解释了114Pd中的三轴摆动运动,并给出了110-118Pd同位素链中理论早已预言、而比早期理论预言更为完整准确的形状渐进变迁和形状共存的图像。根据该核区的系统研究,发现最大三轴形变出现在112Ru,而在相邻的偶Z(Pd)同位素链,三轴形变极小的中心在114Pd,两者均为n=68。上述系统性研究沿相邻的Ru和Pd偶Z同位素链,在n=68同中素中鉴别出最大三轴形变,均比理论预言的108Ru和110Pd多4个中子。在Z值位于Ru(Z=44)之下的Zr(Z=40),nb(Z=41),Mo(Z=42)and Tc(Z=43)丰中子同位素中,Y和Zr核具有很强的轴对称四极形变,而在较重的Zr同位素中出现了γ自由度;较重的nb核(A=104～106)基态具有中等程度的软三轴形变和强四极形变,随着自旋和激发能的增加,过渡到接近于轴对称的强四极形变;而较轻的nb核(A 103)基态均接近轴对称形状;在nb同位素链上基态由球形到强四极形变的形状突变发生在100nb(n=59),在100–106nb同位素链中基态的软三轴形变随中子数增加而增加;在nb核中还观察到关于软三轴形变的形状共存;Mo核具有大的三轴形变,观察到了γ振动和手征对称破缺;Tc核具有比最大值稍小的三轴形变,γ=-26°,并观察到了手征对称破缺。质子数Z从41到48的A～(100～126)丰中子同位素,特别是Pd和nb同位素,呈现出关于三轴形变的过渡特征。

关键词：质子数从41到48范围的丰中子核原子核形状变迁和共存长椭球到扁椭球形状变迁三轴形变三轴形变原子核摆动运动原子核手征对称破缺扰动手征态 γ振动能带高自旋态带交叉 γ驱动效应准转动 Z=50和n=82闭壳附近集体性和软三轴形变的出现能级纲图原子核能级自旋/宇称/组态指定位能面(PES) 投影壳模型(PSM) 总Routhian面(TRS) 推转和组态限制壳模型(CCCSM)和壳修正斜轴推转模型(SCTAC)理论计算自发裂变瞬发γ谱学 γ射线三重和四重符合及角关联测量锎-252 Gammasphere多探测器系统

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Improved measurement of the reactor antineutrino flux and spectrum at Daya Bay

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Chinese Physics C 2017年第1期41卷 11-46页

作者：安丰鹏 A.B.Balantekin H.R.Band M.Bishai S.Blyth 曹德文曹国富曹俊岑吴镕陳日朗常劲帆張立楚张昀陈和生陈泉佑陈少敏陈义学陈羽程佳樺程捷程雅苹成兆侃 J.J.Cherwinka 朱明中 A.Chukanov J.P.Cummings J.de Arcos 邓子艳丁雪峰丁雅韵 M.V.Diwan M.Dolgareva J.Dove D.A.Dwyer W.R.Edwards R.Gill M.Gonchar 龚光华宫辉 M.Grassi 顾文强关梦云郭磊郭如盼郭新恒郭子溢 R.W.Hackenburg 韩然 S.Hans 何苗 K.M.Heeger 衡月昆 A.Higuera Y.K.Hor 熊怡胡貝禎胡涛胡维黄恩泉黄翰雄黄性涛 P.Huber 霍文驹 G.Hussain D.E.Jaffe P.Jaffke 任國綸 S.Jetter 季向盼季筱璐焦健斌 R.A.Johnson D.Jones J.Joshi 康丽 S.H.Kettell S.Kohn M.Kramer 關健强郭文伟郭天能 T.J.Langford K.Lau L.Lebanowski J.Lee 李曉菁雷瑞庭 R.Leitner 李超李登杰李飞李高嵩李秋菊黎山峰 S.C.Li 李卫东李小男李玉峰李志兵梁昊林政儒林贵林林盛鑫林士凱林禹丞凌家杰 J.M.Link L.Littenberg B.R.Littlejohn 刘大为刘江来刘金昌 C.W.Loh 陆昌国路浩奇陆稼书陆锦标吕志鹏马秋梅马晓妍马续波马宇倩 Y.Malyshkin D.A.Martinez Caicedo K.T.McDonald R.D.McKeown I.Mitchell M.Mooney Y.nakajima J.napolitano D.naumov E.naumova 倪浩然宁哲 J.P.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.Park S.Patton V.Pec 彭仁杰 L.Pinsky 潘振声齐法制祁鸣钱鑫 n.Raper 任杰 R.Rosero B.Roskovec 阮锡超 H.Steiner 孙功星孙吉良唐炜 D.Taychenachev K.TVeskov K.V.Tsang C.E.Tull n.Viaux B.Viren V.Vorobei 王正祥王萌王乃彦王瑞光王为王玺王贻芳王喆王铮王志民魏瀚宇温良剑 K.Whisnant C.G.White L.Whitehead T.Wise 黄显诺黄振辉 E.Worcester 吳珈豪吴群吴文杰夏冬梅夏经凯邢志忠徐建一徐吉磊徐晔薛涛杨长根杨海波杨雷阳马生杨梦婷叶梅 Z.Ye 叶铭芳杨炳麟于泽源曾珊占亮张超张宏浩张家文张清民张玄同张一鸣张一心张玉美张志坚张智勇张子平赵洁赵庆旺赵豫斌钟玮丽周莉 n.Zhou 庄红林邹佳恒 Institute of Modern Physics East China University of Science and Technology university of Wisconsin Department of Physics Yale University Brookhaven national Laboratory Department of Physics National Taiwan University national united university nanjing university Institute of High Energy Physics Chinese university of Hong Kong Institute of Physics National Chiao-Tung University Shandong university Department of Engineering Physics Tsinghua University north China Electric Power university Shenzhen university Sun Yat-Sen (Zhongshan) university Joint Institute for nuclear Research Siena College Department of Physics Illinois Institute of Technology Department of Physics University of Illinois at Urbana-Champaign Lawrence Berkeley national Laboratory Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Beijing normal university Department of Chemistry and Chemical Technology Bronx Community College Department of Physics University of Houston Center for neutrino Physics Virginia Tech China Institute of Atomic Energy university of Science and Technology of China School of Physics Nankai University Department of Physics University of Cincinnati Department of Physics College of Science and Technology Temple University Dongguan university of Technology Department of Physics University of California Department of Physics The University of Hong Kong Charles university Faculty of Mathematics and Physics Joseph Henry Laboratories Princeton University Department of nuclear Science and Technology School of Energy and Power Engineering Xi’an Jiaotong University Instituto de F'?sica Pontificia Universidad Católica de Chile California Institute of Technology College of William and Mary Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute China General nuclear Power Group College of Electronic Science and Engineering National University of Defense Technology Iowa State university Chongqing university

A new measurement of the reactor antineutrino flux and energy spectrum by the Daya Bay reactor neutrino experiment is reported. The antineutrinos were generated by six 2.9 GWth nuclear reactors and detected by eight antineutrino detectors deployed in two near（560 m and 600 m flux-weighted baselines） and one far（1640 m flux-weighted baseline） underground experimental halls. With 621 days of data, more than 1.2 million inverse beta decay（IBD） candidates were detected. The IBD yield in the eight detectors was measured, and the ratio of measured to predicted flux was found to be 0.946±0.020（0.992±0.021） for the Huber＋Mueller（ILL＋Vogel） model. A 2.9σ deviation was found in the measured IBD positron energy spectrum compared to the predictions. In particular, an excess of events in the region of 4–6 MeV was found in the measured spectrum, with a local significance of 4.4σ. A reactor antineutrino spectrum weighted by the IBD cross section is extracted for model-independent predictions.

关键词： antineutrino flux energy spectrum reactor Daya Bay

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Observation of the Y(4230)and a new structure in e^(+)e^(-)→K^(+)K^(-)J/Ψ

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Chinese Physics C 2022年第11期46卷 7-21页

作者： M.Ablikim M.n.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren n.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao n.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov C.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Z.J.Chen W.S.Cheng X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.Ede Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du P.Egorov Y.L.Fan J.Fang S.S.Fang W.X.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng K Fischer M.Fritsch C.Fritzsch C.D.Fu H.Gao Y.n.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco M.H.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold M.Himmelreich T.Holtmann G.Y.Hou Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain n Husken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji Y.Y.Ji Z.K.Jia H.B.Jiang S.S.Jiang X.S.Jiang Y.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing T.Johansson n.Kalantar-nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kuhn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li H.n.Li J.Q.Li J.S.Li J.W.Li Ke Li L.J Li L.K.Li Lei Li M.H.Li P.R.Li S.X.Li S.Y.Li T.Li W.D.Li W.G.Li X.H.Li X.L.Li Xiaoyu Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao J.Libby A.Limphirat C.X.Lin D.X.Lin T.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu G.M.Liu H.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.L Institute of High Energy Physics Beijing 100049China Beihang university Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-university D-44780 BochumGermany Carnegie Mellon university PittsburghPennsylvania 15213USA Central China normal university Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China G.I.Budker Institute of nuclear Physics SB RAS(BInP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi normal university Guilin 541004China Hangzhou normal university Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan normal university Xinxiang 453007China Henan university of Science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA InFn Laboratori nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly InFn Laboratori nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly InFn Laboratori nazionali di Frascati University of PerugiaI-06100PerugiaItaly InFn Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly InFn Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin university Changchun 130012China Johannes Gutenberg university of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

The cross sections of e^(+)e^(-)→K^(+)K^(-)J/Ψat center-of-mass energies from 4.127 to 4.600 GeV are measured based on 15.6 fb-1data collected with the BESⅢ detector operating at the BEPCⅡ storage *** resonant structures are observed in the line shape of the cross *** mass and width of the first structure are measured to be(4225.3±2.3±21.5)MeV and(72.9±6.1±30.8)MeV,*** are consistent with those of the established Y(4230).The second structure is observed for the first time with a statistical significance greater than 8σ,denoted as Y(4500).Its mass and width are determined to be(4484.7±13.3±24.1)MeV and(111.1±30.1±15.2)MeV,*** first presented uncertainties are statistical and the second ones are *** product of the electronic partial width with the decay branching fractionΓ(Y(4230)→e^(+)e^(−))B(Y(4230)→K^(+)K^(−)J/Ψ)is reported.

关键词： Y states charmonium-like states BESⅢ

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Do non-dipole geomagnetic field behaviors persistently exist in the subarctic Pacific Ocean over the past 140 ka?

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Science Bulletin 2020年第18期65卷 1505-1507,M0003页

作者： Yi Zhong Yanguang Liu Xiaoqiang Yang Jian Zhang Jiabo Liu Aleksandr Bosin Sergey A.Gorbarenko Xuefa Shi Ting Chen Yu-Min Chou Wei Liu Haosen Wang Congcong Gai Jianxing Liu Alexander nDerkachev Xiaoke Qiang Qingsong Liu Centre for Marine Magnetism Department of Ocean Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Key Laboratory of Marine Sedimentology and Metallogeny First Institute of OceanographyMinistry of Natural ResoursesQingdao 266061China Laboratory for Marine Geology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266061China Department of Earth Science Sun Yat-sen UniversityGuangzhou 510275China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China V.I.Il'ichev Pacific Oceanological Institute Far East Branch of Russian Academy of ScienceVladivostok 690041Russia State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Research School of Earth Sciences Australian National UniversityCanberra ACT 2601Australia State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China

Paleomagnetic records from globally distributed locations are essential for fully understanding geomagnetic field variations,particularly non-dipole field fluctuations[1].Paleomagnetic studies on historical time scales have demonstrated the existence of persistent geomagnetic flux patches,such as the Canadian(north America)and Siberian(East Asia)flux lobes,which may result from an organizing structure imposed on the geomagnetic field by lower mantle heterogeneity[2].Holocene paleomagnetic secular variations,reconstructed from the Alaskan margin of the Subarctic Pacific Ocean(SPO)[3]and revealed by dynamo modeling[4],further suggest that time-varying flux expulsions on the core-mantle boundary recurrently occur in high-latitude locations(***).

关键词： geomagnetic mantle Holocene

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正己烷在Znni/HZSM-5上微波芳构化

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石油化工高等学校学报 2003年第2期16卷 4-8页

作者：许健张晓彤桂建舟罗有训孙兆林 Rees L V C 辽宁石油化工大学石油化工学院辽宁抚顺113001 School of Chemistry University of Edinburgh

　研究了常规加热和微波辐射两种加热方法对正己烷在Znni/HZSM-5催化剂上的芳构化反应的影响。考察了温度、空速对反应性能的影响,并利用XRD对Znni/HZSM-5催化剂作了表征。结果表明,金属锌和镍高度分散于HZSM-5沸石中,微波辐射对分子筛... 详细信息

　研究了常规加热和微波辐射两种加热方法对正己烷在Znni/HZSM-5催化剂上的芳构化反应的影响。考察了温度、空速对反应性能的影响,并利用XRD对Znni/HZSM-5催化剂作了表征。结果表明,金属锌和镍高度分散于HZSM-5沸石中,微波辐射对分子筛结构的影响很小。与常规加热反应相比,要达到相同的芳烃收率,在微波加热条件下能使反应温度降低约100℃左右。在一定程度上提高反应温度可以获得较高的总芳烃收率和BTX收率,亦能明显地改变BTX中各组分的相对选择性。改变空速能显著影响总芳烃收率和BTX收率,在常规加热和微波加热条件下的最佳空速分别为1.5h-1和1.0h-1。讨论了正己烷在微波辐射下Znni/HZSM-5上的芳构化反应机理。正己烷首先裂解为C03+C=3,一部分烯烃齐聚、环化生成芳烃,另一部分烯烃则经氢转移或加氢生成烷烃,C03和C04在锌和镍活性中心上直接脱氢二聚环化生成芳烃。

关键词：正己烷 Znni/HZSM—5 微波辐射芳构化

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基于TIC5402DSK的频谱分析

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通信技术 2003年第4期36卷 36-38页

作者：乔瑞萍邢征北李振安党胜茂西安交通大学电子与信息工程学院西安710049 西北机器厂设计所西安722405

利用TIC5402DSK完成了音频的输入输出接口,实现了一个语音处理程序。对声音进行采样并对其进行频谱分析。这个程序改编后,可作为MP3实时压缩算法中的一部分。

关键词： MP3 DSK 频谱分析音频接口

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