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Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

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World Journal of Gastroenterology 2005年第28期11卷 4375-4381页

作者： n pallotta P Pezzotti E Calabrese F Baccini E Corazziari Dpt Scienze Cliniche Università degli Studi di Roma "La Sapienza" Reparto AIDS e Malattie Sessualmente Trasmesse Istituto Superiore di Sanità Rome Italy Dpt Scienze Cliniche

AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains *** study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional ***: In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultrasonography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression ***: Delayed gastric emptying was detected in 39.8% of the patients. Postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%.COnCLUSIOn: In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying,and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying.

关键词：胃肠疾病临床表现功能性消化不良病理机制

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High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease

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World Journal of Gastroenterology 2012年第41期18卷 5918-5924页

作者： Edith Lahner Gianluca Esposito Angelo Zullo Cesare Hassan Claudio Cannaviello Maria Carla Di Paolo Lorella pallotta nicoletta Garbagna Enzo Grossi Bruno Annibale Department of Digestive and Liver Disease University SapienzaRome 2nd Medical SchoolSant'Andrea Hospital00189 RomeItaly Ospedale nuovo Regina Margherita 00189 RomeItaly Gastroenterology Unit Ospedale Israelitico00148 RomeItaly Gastroenterology Unit Ospedale San Giovanni00184 RomeItaly Medical Department Bracco Spa 20134 MilanItaly

AIM:To investigate in symptomatic uncomplicated diverticular disease the efficacy of symbiotics associated with a high-fibre diet on abdominal ***:This study was a multicentre,6-mo randomized,controlled,parallel-group intervention with a preceding 4-wk washout *** outpatients with symptomatic uncomplicated diverticular disease,aged 40-80 years,evaluated in 4 Gastroenter-ology Units,were *** uncomplicated diverticular disease patients were randomized to two treatment arms A or *** A(n = 24 patients) received 1 symbiotic sachet Flortec(Lactobacillus paracasei B21060) once daily plus high-fibre diet for 6 *** B(n = 21 patients) received high-fibre diet alone for 6 *** primary endpoint was regression of abdominal symptoms and change of symptom severity after 3 and 6 mo of ***:In group A,the proportion of patients with abdominal pain ne to 35% and 25% after 3 and 6 mo,respectively(P n group B the proportion of patients with this symptom decreased from 90.5% at baseline to 61.9% and 38.1% after 3 and 6 mo,respectively(P = 0.001).Symptom improvement became statistically significant at 3 and 6 mo in group A and B,*** proportion of patients with abdominal pain >24 h decreased from 60% to 20% then 5% after 3 and 6 mo,respectively in group A(P nd from 33.3% to 9.5% at both 3 and 6 mo in group B(P = 0.03).In group A the proportion of patients with abdominal bloating significantly decreased from 95% to 60% after 3 mo,and remained stable(65%) at 6-mo follow-up(P = 0.005) while in group B,no significant changes in abdominal bloating was observed(P = 0.11).After 6 mo of treatment,the mean visual analogic scale(VAS) values of both short-lasting abdominal pain(VAS,mean ± SD,group A:4.6 ± 2.1 vs 2.2 ± 0.8,P = 0.02;group B:4.6 ± 2.9 vs 2.0 ± 1.9,P = 0.03) and abdominal bloating(VAS,mean ± SD,group A:5.3 ± 2.2 vs 3.0 ± 1.7,P = 0.005;group B:

关键词：饮食治疗疾病症状干酪乳杆菌高纤维并发症 VAS 胃肠病学随机分配

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