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crystal Structure Determination and Hydrogen-Bonding Patterns in 2-Pyridinecarboxamide

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crystal Structure Theory and Applications 2012年第3期1卷 30-34页

作者： Gerzon E. Delgado Asiloé J. Mora Marilia Guillén-Guillén Jeans W. Ramírez Jines E. contreras Laboratorio de cristalografía Departamento de Química Facultad de Ciencias Universidad de Los Andes Mérida Venezuela

The title compound, 2-pyridinecarboxamide, c6H6n2O, crystallize in the monoclinic system with space group P21/n (no14), Z = 4, and unit cell parameters a = 5.2074(1) , b = 7.1004(1) , c = 16.2531(3) , = 100.260(1)o. The crystal structure of the title compound, was reported previously from Weissenberg photographic data with R = 0.127. It has now been redetermined, providing a significant increase in the precision of the derived geometric parameters. The crystal packing is governed by n--HO hydrogen bond-type intermolecular interactions, forming infinite one-dimensional chains with graph-set notation c(4), R22(8) and R24(8).

关键词： Pyridinecarboxamides Picolinamide X-Ray crystal Structure Hydrogen Bonding

Oral administration of the cannabigerol derivative VcE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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Translational neurodegeneration 2019年第1期8卷 111-125页

作者： José Aguareles Juan Paraíso-Luna Belén Palomares Raquel Bajo-Grañeras carmen navarrete Andrea Ruiz-calvo Daniel García-Rincón Elena García-Taboada Manuel Guzmán Eduardo Muñoz Ismael Galve-Roperh Instituto Ramón y cajal de Investigación Sanitaria(IRYcIS) Ctra.Colmenar Viejokm9100 MadridSpain Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación neuroquímica Universidad ComplutenseMadridSpain centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas(cIBERnED) MadridSpain Instituto Maimónides de Investigación Biomédica de córdoba(IMIBIc) CórdobaSpain Departamento de Biología celular Fisiología e InmunologíaUniversidad de CórdobaCórdobaSpain Hospital Universitario Reina Sofía CórdobaSpain Emerald Health Pharmaceuticals San DiegoUSA

Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by cB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including cB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VcE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VcE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VcE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like cTIP2-mediated ***:The cannabigerol derivative VcE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.

关键词： cannabinoid Huntingtin neurodegeneration neurogenesis PPAR

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学拳击

Effect of Seasonal Variations and Weather Factors on Population Dynamics of Mango Mealybug (Drosicha mangiferae) in Bangladesh

1989年

作者：（美）布达克（Bodak c.）（美）马尔伯特（Milbert n.）赵乃均胡宗铎译

本书内容包括心理准备、身体训练、其本技术、战略战术等。

ISBN: (纸本)750090391X

本书内容包括心理准备、身体训练、其本技术、战略战术等。

关键词：拳击学科:基本知识

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American Journal of Plant Sciences 2022年第5期13卷 564-575页

作者： n. Akhter M. A. Latif M. Z. Alam Department of Entomology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Entomology Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural University Salna Gazipur Bangladesh

An experiment was conducted in mango orchard of Sher-E Bangla Agricultural University (SAU) campus, Dhaka to determine the effect of seasonal variation round the year and weather on population dynamics of mango mealybug (Drosicha mangiferae) on mango tree. The mango mealybug was first appeared in early December and disappeared in June in a year. Its population started to increase gradually from December and continued up to February when the ambient average temperature was 20.95°c, relative humidity 63% and rainfall was absent. The highest population of the insect (33.33/30 cm branch) was recorded in February and the lowest (3.75/30cm branch) in May. Adult insects appeared in February on the ground under the selected mango tree showing the population of 6.67 males and 123.33 females per 81 m2. Population of males (32.5/81m2) and that of females (352.75/81m2) reached to the peak when the ambient temperature was 28.19°c, relative humidity 61% and the rainfall was 0.00 mm. When relative humidity was high and rainfall started adult females enter into the soil and disappeared. correlation between population of mealybug and temperature was positive. Its population was negatively correlated with relative humidity and rainfall.

关键词： Seasonal Variations Mango Mealybug Weather Factors

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绕正方形排列的顺排的四个圆柱的流动研究

工程热物理学报 2004年第1期25卷 59-62页

作者：李景银 K Lam K T chan R M c So 西安交通大学能源与动力工程学院陕西西安710049 香港理工大学机械系

本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡... 详细信息

本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散n-S方程计算该流场与实验结果完全不符合,原因尚不清楚。

关键词：流体诱发振动圆柱绕流激光诱导荧光 PIV实验

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人有人的用处:控制论和社会

Streamlining the preparation of “endotoxin-free” clearcoli cell extract with autoinduction media for cell-free protein synthesis of the therapeutic protein crisantaspase

丛书名：汉译世界学术名著丛书

1978年

作者： (美) 维纳(Wiener n.)

本书介绍了控制论发展的历史，阐述了控制论涉及各方面的内容，特别是阐述了控制论与社会的关系。

ISBN: (纸本)9787301173695

本书介绍了控制论发展的历史，阐述了控制论涉及各方面的内容，特别是阐述了控制论与社会的关系。

关键词：控制论应用哲学

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Synthetic and Systems Biotechnology 2019年第4期4卷 220-224页

作者： J.Porter Hunt Emily Long Zhao Mehran Soltani Madison Frei J.Andrew D.nelson Bradley c.Bundy Department of chemical Engineering Brigham Young UniversityProvoUTUSA Department of chemical Engineering Brigham Young University330N Engineering BuildingProvoUT84602USA

An“endotoxin-free”***-based cell-free protein synthesis system has been reported to produce therapeutic proteins rapidly and ***,preparation of the most complex cFPS reagent–the cell extract–remains time-consuming and labor-intensive because of the relatively slow growth kinetics of the endotoxin-free clearcoliTMBL21(DE3)*** we report a streamlined procedure for preparing *** cell extract from clearcoli™using auto-induction *** this work,the term auto-induction describes cell culture media which eliminates the need for manual induction of protein *** clearcoli™cells in autoinduction media significantly reduces the hands-on time required during extract preparation,and the resulting“endotoxinfree”cell extract maintained the same cell-free protein synthesis capability as extract produced with traditional induction as demonstrated by the high-yield expression of crisantaspase,an FDA approved leukemia *** is anticipated that this work will lower the barrier for researchers to enter the field and use this technology as the method to produce endotoxin-free ***-based extract for cFPS.

关键词： Auto-induction Autoinduction cell-free protein synthesis cFPS Endotoxin-free crisantaspase clearcoli