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银屑病患者中链球菌M蛋白引发的外周血单核细胞增生及Th1/Th2细胞因子产物

世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 32-33页

作者： Pérez-lorenzo R. núez-oreza l.a. Garma-Quen P.M. 潘敏 Centro de Investigaciones en Enfermedades Tropicales Universidad Autó noma de Campeche Ciudad Universitaria s/n 24030 Campeche Mexico

Background: Psoriasis is a chronic skin disease that is probably a T cell-mediated autoimmune condition which is strongly associated with streptococcal throat infections. Although some groups have associated the involved response with different streptococcal.a.tigens, M protein has been described as the major virulence factor of Streptococcus pyogenes. Thus, it is necessary to describe some features of the cellular responses to this streptococcal.a.tigen. Methods: Proliferation and Th1/Th2 cytokine production of peripheral blood mononucl.a. cells (PBMC) in response to total soluble extracts from type M5 S. pyogenes with (TSE37Sp) and without (M-TSESp) M protein were analyzed in 10 psoriatic patients and 10 healthy controls. Results: PBMC from both patients and controls proliferated to both extracts. Responses to M-TSESp were significantly lower than those to TSE37Sp (P l- 2 and Υ IFn production after TSE37Sp stimulus was much higher than after M-TSESp antigenic stimulation in both groups (P nwhile, Il- 4 production was quite low in both groups and in response to both extracts. We found a differential production of Il- 10 between groups. PBMC from healthy controls responded to TSE37Sp with a much higher production of this cytokine as compared to the responses showed to M-TSESp while the cells from psoriatic patients responded without differences in the production of Il- 10. Conclusion: Results obtained suggest an important Th1 response to M protein in psoriatic patients which could be associated with the cellular responses involved in psoriasis, while healthy subjects respond in a probably non-Th2 Il- 10 producing regulatory T cells fashion.

关键词：细胞因子产物 Th1/Th2 外周血单核细胞单核细胞增生链球菌M蛋白银屑病患者化脓性链球菌链球菌抗原反应特征慢性皮肤病

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