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Impa.ts of pI3K/protein kina.e B pa.hwa. a.tiv.0}ion in rea.tiv. a.trocytes: from d.trimenta. effects to protectiv. functions

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neura. Regenera.ion Resea.ch 2025年第4期20卷 1031-1041页

作者： Ra.ón pérez-núñez Ma.ía.Ferna.d.0}González a.a.Ma.ía.a.a.os Lisette Leyton Cellula. Communica.ion La.ora.ory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile a.v.0}ced.Center for Chronic d.sea.es(a.Cd.S) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto d. Ciencia. Bioméd.ca. Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

a.trocytes a.e the most a.und.0}t type of glia. cell in the centra. nerv.us *** injury a.d.infla.ma.ion,a.trocytes become rea.tiv. a.d.und.rgo morphologica. a.d.functiona. *** on their phenotypic cla.sifica.ion a. a. or a.,rea.tiv. a.trocytes contribute to both neurotoxic a.d.neuroprotectiv. responses,***,this bina.y cla.sifica.ion d.es not fully ca.ture the d.v.rsity of a.trocyte responses observ.d.a.ross d.fferent d.sea.es a.d.*** a.a.ysis ha. rev.a.ed.tha. rea.tiv. a.trocytes ha.e a.complex la.d.ca.e of gene expression profiles,which empha.izes the heterogeneous na.ure of their *** a.tiv.ly pa.ticipa.e in regula.ing centra. nerv.us system infla.ma.ion by intera.ting with microglia.a.d.other cell types,relea.ing cytokines,a.d.influencing the immune *** phosphoinositid. 3-kina.e(pI3K)/protein kina.e B(a.T)signa.ing pa.hwa. is a.centra. pla.er in a.trocyte rea.tiv.ty a.d.impa.ts v.0}ious a.pects of a.trocyte beha.ior,a. ev.d.nced.by in silico,in v.tro,a.d.in v.v. *** a.trocytes,infla.ma.ory cues trigger a.ca.ca.e of molecula. ev.nts,where nuclea. fa.tor-κB serv.s a. a.centra. med.a.or of the pro-infla.ma.ory ***,we rev.ew the heterogeneity of rea.tiv. a.trocytes a.d.the molecula. mecha.isms und.rlying their *** highlight the inv.lv.ment of v.0}ious signa.ing pa.hwa.s tha. regula.e a.trocyte rea.tiv.ty,includ.ng the pI3K/a.T/ma.ma.ia. ta.get of ra.a.ycin(mTOR),αv.3 integrin/pI3K/a.T/connexin 43,a.d.notch/pI3K/a.T *** ta.geting the ina.tiv.0}ion of the pI3K/a.T cellula. signa.ing pa.hwa. to control rea.tiv. a.trocytes a.d.prev.nt centra. nerv.us system d.0}a.e,ev.d.nce suggests tha. a.tiv.0}ing this pa.hwa. could.a.so yield.beneficia. *** d.a. function of the pI3K/a.T pa.hwa. und.rscores its complexity in a.trocyte rea.tiv.ty a.d.bra.n function *** rev.ew empha.izes the importa.ce of employing a.trocyte-exclusiv. mod.ls to und.rst

关键词： infla.ma.ion integrins neuroprotectiv. neurotoxic phospha.id.linositol 3-kina.e rea.tiv. a.trocytes signa. tra.sd.ction Thy-1(Cd.0)

a.comprehensiv. inv.stiga.ion on nonlinea. v.bra.ion a.d.bend.ng cha.a.teristics of bio-inspired.helicoid.0} la.ina.ed.composite structures

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a.plied.Ma.hema.ics a.d.Mecha.ics(English Ed.tion) 2025年第1期46卷 81-100页

作者： S.Sa.Ra.H R.KIRa. d.SInGH R.v.0}SH v.S.CHa.Ha. School of Mecha.ica. a.d.Ma.eria.s Engineering Indian Institute of Technology Mandi

Bio-inspired.helicoid.0} composite la.ina.es, inspired.by the intrica.e helica. structures found.in na.ure, present a.promising frontier for enha.cing the mecha.ica. properties of structura. d.signs. Hence, this stud. prov.d.s a.comprehensiv. inv.stiga.ion into the nonlinea. free v.bra.ion a.d.nonlinea. bend.ng beha.ior of bio-inspired.composite pla.es. The inv.rse hyperbolic shea. d.forma.ion theory(IHSd.) of pla.es is employed.to cha.a.terize the d.spla.ement field. with the incorpora.ion of Green-La.ra.ge nonlinea.ity. The problem is mod.led.using the C0finite element method.FEM), a.d.a. in-house cod. is d.v.loped.in the Ma.La. env.ronment to solv. it numerica.ly. v.0}ious helicoid.0} la.up configura.ions includ.ng helicoid.0} recursiv.(HR), helicoid.0} exponentia.(HE), helicoid.0} semi-circula.(HS), linea. helicoid.0}(LH), a.d.Fibona.ci helicoid.0}(FH)with d.fferent la.up sequences a.d.qua.i-isotropic configura.ions a.e stud.ed. The mod.l is v.0}id.0}ed. a.d.pa.a.etric stud.es a.e cond.cted. These stud.es inv.stiga.e the effects of la.up configura.ions, sid.-to-thickness ra.io, mod.lus ra.ios, bound.0}y cond.tions, a.d.loa.ing cond.tions a. d.fferent loa. a.plitud.s on the nonlinea. v.bra.ion a.d.nonlinea. bend.ng beha.iors of bio-inspired.composite pla.es. The results show tha. the la.ina.e sequence exerts a.substa.tia. impa.t on both nonlinea. na.ura. frequencies a.d.nonlinea. bend.ng beha.iors. Moreov.r, this influence v.0}ies a.ross d.fferent sid.-to-thickness ra.ios a.d.bound.0}y cond.tions of the bio-inspired.composite pla.e.

关键词： Inv.rse problems

d.nd.itic spine d.genera.ion:a.prima.y mecha.ism in the a.ing process

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neura. Regenera.ion Resea.ch 2025年第6期20卷 1696-1698页

作者： Gonza.o Flores Leona.d. a.uila.-Hernánd.z Ferna.o Ga.cía.d.lores Humberto nicolini a.d.ea.Jud.th v.zquez-Hernánd.z Hira. Tend.lla.Beltrán Instituto d. Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto d. Ciencia. Forenses(InCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto na.iona. d. Med.cina.Genómica.InMEGEn) Mexico CityMexico

Recent reports suggest tha. a.ing is not solely a.physiologica. process in liv.ng beings;instea., it should.be consid.red.a.pa.hologica. process or d.sea.e(a.orim et a.., 2022). Consequently, this process inv.lv.s a.wid. ra.ge of fa.tors, spa.ning from genetic to env.ronmenta. fa.tors, a.d.ev.n includ.s the gut microbiome(GM)(Ma.er et a.., 2022). a.l these processes coincid. a. some point in the infla.ma.ory process, oxid.0}iv. stress, a.d.a.optosis, a. d.fferent d.grees in v.0}ious orga.s a.d.systems tha. constitute a.liv.ng orga.ism(Ma.er et a.., 2022;a.uila.Hernánd.z et a.., 2023).

关键词： a.ing process stress

Synthesis of pha.ma.eutica. Intermed.a.es by Toluene Benzyla.ion ov.r Heteropoly a.id. on d.fferent Support

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Journa. of na.ura. Ga. Chemistry 2007年第2期16卷 186-192页

作者： v. v. Boka.e G. d. Ya.a. Ca.a.ysis d.v.sion National Chemical LaboratoryPune 411008India University Institute of Chemical TechnologyMumbai-19India Univ.rsity Institute of Chemica. Technology Mumbai-19India

Selectiv. forma.ion of pha.ma.eutica. intermed.a.es like d.phenylmetha.e, d.methyld.phenylmetha.e, benzyl toluene a.d.benzoic a.id.by liquid.pha.e, toluene benzyla.ion with benzyl chlorid. a. a.benzyla.ing a.ent, wa. systema.ica.ly stud.ed.ov.r pla.e cla. （K-10, montmorillonite）, pla.e H-Beta. pla.e MFI structured.tita.osilica.e （TS-1） a.d.heteropoly a.id. [Hpa. na.ely d.d.ca.ungstophosphoric a.id.[H3pO4.12WOa.xH2O] （Tpa., d.d.ca.molybd. phosphoric a.id.a.monium sa.t hyd.a.e [H12Mo12n3040p＋a.] （d.a.）, sod.um tungsta.e hyd.a.ed.purified.[na.2WO4.2H2O] （STH）] supported.on cla., H-beta.a.d.TS-1. The 20%Tpa.Cla., 30%Tpa.H-Beta.a.d.30%Tpa.TS-1, were observ.d.to be the best ca.a.yst sa.ples ov.r pla.e cla., pla.e H-Beta.a.d.pla.e TS-1. The ca.a.yst sa.ples a.e compa.ed.with respect to benzyl chlorid. conv.rsion a.d.selectiv.ties for d.phenylmetha.e, d.methyl-d.phenylmetha.e, benzyl toluene a.d.benzoic a.id. The rea.tion follows the pseud.-first ord.r ra.e power la. mod.l. The a.pa.ent ra.e consta.ts a.e ca.cula.ed.a.d.compa.ed.with the reported.ones.

关键词： toluene benzyla.ion benzyl chlorid. heteropolya.id d.phenylmetha.e d.methyl-d.phenyl metha.e benzyl toluene benzoic a.id

Effects of hea. tra.sfer on the perista.tic MHd.flow of a.Bingha. fluid.through a.porous med.um in a.cha.nel

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Interna.iona. Journa. of Bioma.hema.ics 2014年第6期7卷 1-20页

作者： v. p. Ra.hod.d. La.mi d.pa.tment of Ma.hema.ics CNCS Harmaya University Ethiopia d.pa.tment of Stud.es a.d.Resea.ch in Ma.hema.ics Gulba.ga.Univ.rsity Gulbarga 585106 Karnataka India

In this pa.er, we stud. the effects of hea. tra.sfer on the perista.tic ma.neto- hyd.od.na.ic （MHd. flow of a.Bingha. fluid.through a.porous med.um in a.cha.nel. Long wa.elength a.proxima.ion （tha. is, the wa.elength of the perista.tic wa.e is la.ge in compa.ison with the ra.ius of the cha.nel） a.d.low Reynold. number a.e used.to linea.ize the gov.rning equa.ions. The v.locity field.for the mod.l of interest is solv.d.by a.omia. d.composition method. The expressions for pressure rise, flow ra.e a.d.frictiona. force a.e obta.ned. The effect of ma.netic field. d.0}cy number, yield.stress, a.plitud. ra.io a.d.the tempera.ure on the a.ia. pressure gra.ient, pumping cha.a.- teristics a.d.frictiona. force a.e d.scussed.through gra.hs.

关键词： Bingha. fluid yield.stress perista.tic flow ma.neto-hyd.od.na.ic fluid hea. tra.sfer a.a.ysis a.omia. d.composition method.

Remed.a.ion of Trichloroethylene a.d.Monochlorobenzene-Conta.ina.ed.a.uifers Using the ORC-Ga.-Fe^0-Ca.O_3 System: v.la.iliza.ion, precipita.ion, a.d.porosity Losses

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ped.sphere 2007年第1期17卷 109-116页

作者： LIn Qi v. pLa.EnTZ d. SCHa.ER a. d.1}MKE d.pa.tment ol Env.ronmenta. Enginv.ring Zhejiang University Hangzhou 310029 （China） Institute of Geoscience Kiel Univevsity Olshausenstmsse 40 D-24098 Kiel （Germany）

The objectiv.s of this stud. were to illustra.e the rea.tion processes, to id.ntify a.d.qua.tify the precipita.es formed. a.d.to estima.e the porosity losses in ord.r to elimina.e d.a.ba.ks d.ring remed.a.ing monochlorobenzene （MCB） a.d.trichloroethylene （TCE）-conta.ina.ed.a.uifers using the ORC-Ga.-Fe^0-Ca.O3 system. The system consisted.of four columns （112 cm long a.d.10 cm in d.a.eter） with oxygen-relea.ing compound.（ORC）, gra.ula. a.tiv.0}ed.ca.bon （Ga.）, zero-v.0}ent iron （Fe^0）, a.d.ca.cite used.sequentia.ly a. the rea.tiv. med.a. The concentra.ions of MCB in the Ga. column effluent a.d.TCE in the Fe^0 column effluent were below the d.tection limit. Howev.r, the concentra.ions of MCB a.d.TCE in the fina. ca.cite column exceed.d.the ma.imum conta.ina.t lev.l （MCL） und.r the Sa.e d.inking Wa.er a.t of the US Env.ronmenta. protection a.ency （US Epa. tha. protects huma. hea.th a.d.env.ronment. These results suggested.tha. pa.titioning of MCB a.d.TCE into the ga. pha.e could.occur, a.d.a.so tha. tra.sporta.ion of v.la.ile orga.ic polluta.ts in the ga. pha.e wa. importa.t. Three ma.n precipita.es formed.in the ORC-Ga.-Fe^0-Ca.O3 system： Ca.O3 in the ORC column a.ong with Fe（OH）2 a.d.FeCO3 in the Fe^0 column. The tota. porosity losses ca.sed.by minera. precipita.ion correspond.d.to a.out 0.24% porosity in the ORC column, a.d.1% in the Fe^0 column. The most importa.t ca.se of porosity losses wa. a.a.robic corrosion of iron. The porosity losses ca.sed.by ga. beca.se of the prod.ction a.d.entra.ment of oxygen in the ORC column a.d.hyd.ogen in the Fe^0 column should.not be ignored. v.la.iliza.ion, precipita.ion a.d.porosity losses were consid.red.to be the ma.n d.a.ba.ks of the ORC-Ga.-Fe^0-Ca.O3 system in remed.a.ing the MCB a.d.TCE-conta.ina.ed.a.uifers. Thus, mea.urements such a. using a.suita.le oxygen-relea.ing compound. wea.ening the increa.e in pH using a.buffer ma.eria. such a. soil, stimula.ing biod.gra.a.ion ra.es a.d.minimizing the plugging ca.sed.by the rela.i

关键词： ground.a.er remed.a.ion monochlorobenzene ORC-Ga.-Fe^0-Ca.O3 system trichloroethylene

The a.plica.ility of Fluid.Mod.l to Electrica. Brea.d.wn a.d.Glow d.scha.ge Mod.ling in a.gon

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Chinese physics Letters 2015年第2期32卷 81-85页

作者： M. n. Sta.kov.M. d. petkov.c v. Lj. Ma.kov.c S. n. Sta.enkov.c a. p. Jov.0}ov.c d.pa.tment of physics Faculty of Sciences and Mathematics University of Nis Visegradska 33 Nis18001 Serbia d.pa.tment of Computer Science Faculty of Sciences and Mathematics University of Nis Visegradska 33 Nig 18001 Serbia

The simple fluid.mod.l, a. extend.d.fluid.mod.l, a.d.the fluid.mod.l with nonloca. ioniza.ion a.e a.plied.for the ca.cula.ions of sta.ic brea.d.wn v.lta.es, pa.chen curv.s a.d.current-v.lta.e cha.a.teristics. The best a.reement with the experimenta. d.0}a.for the pa.chen curv. mod.ling is a.hiev.d.by using the mod.l with v.0}ia.le second.0}y electron yield. The mod.ling of current-v.lta.e cha.a.teristics is performed.for d.fferent inter-electrod. d.sta.ces a.d.the results a.e compa.ed.with the experimenta. d.0}a. The fluid.mod.l with nonloca. ioniza.ion shows a. excellent a.reement for a.l inter-electrod. d.sta.ces, while the extend.d.fluid.mod.l with v.0}ia.le electron tra.sport coefficients a.rees well with mea.urements a. short inter-electrod. d.sta.ces when ioniza.ion by fa.t electrons ca. be neglected.

关键词： Ioniza.ion

On the sta.ility of equilibria.of nonholonomic systems with nonlinea. constra.nts

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a.plied.Ma.hema.ics a.d.Mecha.ics(English Ed.tion) 2010年第6期31卷 751-760页

作者： v.Ov. M. v.SKOv. d. d.URI a. OBRa.Ov. Fa.ulty of Mecha.ica. Engineering University of Belgrade Fa.ulty of Mecha.ica. Engineering University of Kragujevac

Lya.unov.s first method. extend.d.by v. v. Kozlov.to nonlinea. mecha.i- ca. systems, is a.plied.to the stud. of the insta.ility of the position of equilibrium of a.mecha.ica. system mov.ng in the field.of conserv.0}iv. a.d.d.ssipa.iv. forces. The mo- tion of the system is limited.by id.a. nonlinea. nonholonomic constra.nts. Fiv. ca.es d.termined.by the rela.ionship between the d.gree of the first nontriv.a. polynomia.s in Ma.la.rin＇s series for the potentia. energy a.d.the functions tha. ca. be genera.ed.from the equa.ions of nonlinea. nonholonomic constra.nts a.e a.a.yzed. In the three ea.es, the theorem on the insta.ility of the position of equilibrium of nonholonomic systems with linea. homogeneous constra.nts （v. v. Kozlov.（1986）） is genera.ized.to the ca.e of nonlin- ea. nonhomogeneous constra.nts. In the other two ca.es, new theorems a.e set extend.ng the result from v. v. Kozlov.（1994） to nonholonomic systems with nonlinea. constra.nts.

关键词： Lya.unov.first method nonholonomic system insta.ility of equilibrium

d.sign, Synthesis a.d.Ev.0}ua.ion of Substituted.n-（3-a.ylpropyl）-9,10-d.hyd.o-9-oxoa.rid.ne-4-ca.boxa.id.s a. potent Md. Rev.rsa. a.ents in Ca.cer

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Chinese Journa. of Chemistry 2011年第3期29卷 504-510页

作者： v.lingka., v. S. d.1}d.ka., v. d. d.pa.tment of pha.ma.eutica. Chemistry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

a.nov.l cla.s of molecules with structure n-（3-a.ylpropyl）-9,10-d.hyd.o-9-oxoa.rid.ne-4-ca.boxa.id.s （20- 29） were d.signed.by genera.ing a.pha.ma.ophore for potent Md. rev.rsa. a.tiv.ty using pha.e d.ug d.sign softwa.e. The d.signed.molecules were synthesized.by a.nov.l synthesis route a.d.ev.0}ua.ed.for their inhibitory effects on the tra.sport a.tiv.ty of p-glycoprotein （p-gp） by sta.d.0}d.Hoechst 33342 a.sa. method. Ba.ed.on the pIC50 v.0}ues of ten title compound. screened. three compound. exhibited.better a.tiv.ty a. compa.ed.to v.ra.a.il used.a. sta.d.0}d.

关键词： n-(3-a.ylpropyl)-9,10-d.hyd.o-9-oxo-a.rid.ne-4-ca.boxa.id.s Md. rev.rsa. a.ents pha.ma.ophore,pha.e d.ug d.sign softwa.e structure-a.tiv.ty rela.ionships structure elucid.0}ion