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Effects of Propolis on Peripheral White Cells, Antioxidative Activity and Tumor Growth in Irradiated mice

Journal of Traditional Chinese Medicine 2006年第4期26卷 299-305页

作者： Takashi Nakamura Yuka Itokawa Kwang-Ho Cho Jung-sook choi Ikukatsu Suzuki Toshihoro Miura Torao Ishida Yeunhwa Gu Graduate School of Health Science Suzuka University of Medical Science Japan Gyeongdo provincial college Kyoungbook korea Department of Radiological Science Catholic University of Deagu College of Health Science Deagu Korea Hi-tech Research Center Suzuka University of Medical Science Japan

The effect of continuous water-soluble propolis administration on radioactivity-induced reduction of hemocytes, and the antioxidant and antitumor effects were investigated. Following a 1-week adjustment period, water-soluble propolis was administered intraperitoneally to male ICR mice at a dose of 100 mg/kg every other day for 2 weeks. Following administration, 2 Gy whole-body irradiation was performed and the counts of leukocytes, lymphocytes, and granulocytes and monocytes in the peripheral blood were determined 1, 3, 7, 15 and 30 days after irradiation. In the second experiment, water-soluble propolis was similarly administered to the mice for 2 weeks after a 1-week adjustment period, and 2 Gy whole-body irradiation was performed. The antioxidant effects in hemocytes were then investigated using 2,2＇-azobis（2-amidinopropane） dihydrochloride （AAPH）, a radical generator. In the third experiment, 1×10^6 Sarcoma-180 cells were inoculated into the right thigh of mice, which were divided into four groups： control, water-soluble propolis-treated, 6 Gy irradiated and water-soluble propolis-treated ＋ 6 Gy irradiated groups, and changes in tumor size were measured for 20 days. Results show that administration of water-soluble propolis inhibits the reduction of hemocytes caused by whole-bodv irradiation, enhances antioxidant effects against radioactivity, and inhibits tumor growth.

关键词： Propolis Antioxidant effects radioprotective effects Anti-tumor T lymphocyte

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Radioprotective Effect of Lyophyllum Decastes and the Effect on Immunological Functions in Irradiated Mice

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Journal of Traditional Chinese Medicine 2007年第1期27卷 70-75页

作者： Takashi Nakamura Yuka Itokawa Masayuki Tajima Yuuichi Ukawa Kwang-Ho Cho Jung-sook choi Torao Ishida Yeunhwa Gu Graduate School of Health Science Suzuka University of Medical Science Oji Forest & Product Co. Ltd Department of Radiological Science Catholic University of Deagu College of Heallth Science Gyeongdo Provincial College Hi-tech Research Center Suzuka University of Medical Science

In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing （LDS）, a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells （lymphocytes, monocyte, and granulocytes） one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of ieukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary irffections associated with irradiation.

关键词： Lyophyllum Decastes (LD) Radiation Lymphocytes NK LAK

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Does a Professor＇s Somatotype Influence Perceptions of Their Intelligence from Exercise Science Students？

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Journal of Sports Science 2013年第1期1卷 46-51页

作者： Danielle Hemingson Andrew Shim Hee-sook choi The School of Education The University of South Dakota Vermillion 57069 SD USA

The purpose of this study was to evaluate if Exercise Science students perceived their professors having high intelligence, based on a certain somatotype. A survey was conducted on 107 Exercise Science students at a Midwestern public university. Each student was shown pictures （male and female） of Sheldon＇s three somatotypes （ectomorph, endomorph, and mesomorph） and asked one question about their impression from each photo. A Wilks＇ Lambda distribution concluded at least two of the means for each somatotype group were significantly different. A pairwise comparison analysis was conducted which indicated that all of the group means were different from each other. Upon further examination of the data, a statistical significance was found using a multinomial logistic regression. The researchers＇ hypothesis was confirmed in that there was a difference in opinion regarding students＇ perception on Exercise Science professors＇. In conclusion, this study demonstrates that overweight people are also often perceived as less intelligent, unpopular, and unsuccessful than people of average weight. The findings in this study do support the outcomes of the research from previous investigations.

关键词： Perception intelligence somatotype.

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Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease

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World Journal of Gastroenterology 2010年第20期16卷 2496-2503页

作者： Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin choi In Suh Park Jee Young Han Young Chae Chu Kye sook Kwon Eun Joo Kim Department of Pathology College of Medicine Inha University7-206 Shin-heung-Dong 3 GaJoong-GuIncheon 400-711South Korea Gastroenterology College of Medicine Inha University7-206 Shinheung-Dong 3 GaJoong-GuIncheon 400-711South Korea Department of Nano and Bio Research Daegu Gyeongbuk Institute of Science and TechnologyDeocksan-dong 110Daegu 700-742South Korea

AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and ***: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic *** features of ITB and CD were reviewed,and eight pathologic parameters were *** cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,*** assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy ***: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with *** sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,*** PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy *** the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combi

关键词： Intestine Tuberculosis Crohn’s disease Histopathology Polymerase chain reaction Kit IS6110 MPB64

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Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1203-1211页

作者： Seong-Jae Kim Min-Jun Kim Mee- Young Ckoi Yoon-sook Kim Ji-Myong Yoo Eun-Kyung Hong Sunmi Ju Wan-Sung choi Department of Ophthalmology School of MedicineGyeongsang National University Jinju 52727 Korea Department of Anatomy and Convergence Medical Science School of Medicine Gyeongsang National University Jinju52727 Korea Institute of Health Science Gyeongsang National UniversityJinju 52727 Korea Medvill Co. Ltd. Seoul 08511 Korea Division of Pulmonology and Allergy Department ofInternal Medicine School of Medicine Gyeongsang NationalUniversity Jinju 52727 Korea

AIM： To investigate the role of O-GIcNAcylation of nuclear factor-kappa B （NF-KB） in retinal ganglion cell （RGC） death and analysedthe effect of Aralia elata （AE） on neurodegen- eration in diabetic mice. METHODS： C57BL/6mice with streptozotocin-induced diabetes were fed daily with AE extract or control （CTL） diet at the onset of diabetes mellitus （DM）. Two months af- tar injection of streptozotocin or saline, the degree of cell death and the expression of O-GIcNAc transferase （OGT）, N-acetyl-b-D-glucosaminidase （OGA）, O-GIcNAcylated pro- teins, and O-GIcNAcylation of NF-KB were examined. RESULTS： AE did not affect the metabolic status of diabetic mice. The decrease in the inner retinal thickness （P〈0.001 vs CTL, P〈0.01 vs DM） and increases in RGCs with terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling （P〈0.001 vs CTL, P〈0.0001 vs DM）, glial activation, and active caspase-3 （P〈0.0001 vs CTL, P〈0.0001 vs DM） were blocked in diabetic retinas of AE extract-fed mice. Expression levels of protein O-GIcNAcylation and OGT were increased in diabetic retinas （P〈0.0001 vs CTL）, and the level of O-GIcNAcylation of the NF-KB p65 subunit was higher in diabetic retinas than in controls （P〈0.0001 vs CTL）. AE extract downregulated O-GIcNAcylation of NF-KB and prevented neurodegeneration induced by hyperglycemia （P〈0.0001 vs DM）. CONCLUSION： O-GIcNAcylation of NF-KB is concerned in neuronal degeneration and that AE prevents diabetes-in- duced RGC apoptosis via downregulation of NF-KB O-GI- cNAcylation. Hence, O-GIcNAcylation may be a new object for the treatment of DR, and AE may have therapeutic pos- sibility to prevent diabetes-induced neurodegeneration.

关键词： Aralia elata diabetic retinopathy neurode- generation nuclear factor-kappa B O-GlcNAc O-GlcNAc transferase mice

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Hepatocellular carcinoma,decompensation,and mortality based on hepatitis C treatment:A prospective cohort study

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World Journal of Gastroenterology 2022年第30期28卷 4182-4200页

作者： Gwang Hyeon choi Eun Sun Jang Young Seok Kim Youn Jae Lee In Hee Kim Sung Bum Cho Han Chu Lee Jeong Won Jang Moran Ki Hwa Young choi Dahye Baik sook-Hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907JeonbukSouth Korea Department of Internal Medicine Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea Cancer Control and Population Health Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408South Korea

BACKGROUND Prospective studies of the long-term outcomes of patients with hepatitis C virus(HCV)infection after treatment with interferon-based therapy(IBT)or directacting antivirals(DAA)are limited in many Asian *** To elucidate the incidences of hepatocellular carcinoma(HCC)and death/transplantation based on treatment with IBT or DAA,to compare the outcomes of the sustained virologic response(SVR)to IBT and DAA,and to investigate outcome-determining factors after *** This cohort included 2054 viremic patients(mean age,57 years;46.5%male;27.4%with cirrhosis)prospectively enrolled at seven hospitals between 2007 and *** were classified as the untreated group(n=619),IBT group(n=578),and DAA group(n=857).Outcomes included the incidences of HCC and death/*** incidences of the outcomes for each group according to treatment were calculated using an exact method based on the Poisson distribution.A multivariate Cox regression analysis was performed to determine the factors associated with HCC or death/transplantation,followed by propensity score matching to confirm the *** During a median of 4.1 years of follow-up,HCC and death/transplantation occurred in 113 and 206 patients,respectively,in the entire *** with the untreated group,the incidences of HCC and death/transplantation were significantly lower in the IBT group[adjusted hazard ratio(aHR)0.47,95%CI:0.28-0.80 and aHR 0.28,95%CI:0.18-0.43,respectively]and the DAA group(aHR 0.58,95%CI:0.35-0.96,and aHR 0.19,95%CI:0.20-0.68,respectively).Among 1268 patients who attained SVR with IBT(n=451)or DAA(n=816),the multivariable-adjusted analysis showed no differences in the risks of HCC(HR 2.03;95%CI:0.76-5.43)and death/transplantation(HR 1.38;95%CI:0.55-3.49)between the two *** was confirmed by a propensity score-matching *** factors for HCC after SVR were age,genotype 1,and the presence of *** Treatment and achieving SVR

关键词： Hepatitis C virus Direct-acting antiviral Sustained virologic response Hepatocellular carcinoma Mortality

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Effects of K. Lysolecithin on Blood Levels of Monoamines in Mice

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Journal of Traditional Chinese Medicine 2007年第3期27卷 212-219页

作者： Yuka Itokwa Aki Kozu Takashi Nakamura Takashi Masubuchi Masami Oshima Kwang-Ho Cho Jung-sook choi Toshihiro Miura Torao Ishida Yeunhwa Gu Suzuka Univercity of Medical Science Graduate School of Health Science Society of Preventive and Alternative Medicine Department of Radiological Science Catholic University of Deagu College of Health Science Gyeongdo Provincial College

In this research, Lysolecithin-a substance made with 100% natural ingredients - was given to ICR mice as medication to measure its periodic effect on the noradrenalin (NA), dopamine (DA), and serotonin (5-HT) levels of the brain. Both ICR and SAM mice were separated into two groups - control group and Lysolecithin (K. Lysolecithin: hydrolytic lysolecithin) medicated group, and given 1-week preparation period. The K. Lysolecithin group was given 500mg/kg of K. Lysolecithin at 0.2mL per dosage for 4 weeks, and the control group was given the same amount of dosage of water during the same period. NA, DA and 5-HT concentrations were measured from the blood before medication and 8 weeks / 12 weeks / 16 weeks after the first medication. For the SAM mice, 8 weeks after they were medicated with K .Lysolecithin, Morris Water Maze Test was conducted for 7 consecutive days and then the concentrations were measured by drawing blood from the heart. The K. Lysolecithin medicated group showed a tendency to have a statistically significant higher concentrations of 5-HT and NA in the blood. Also, periodic examination showed that the monoamine levels were highest in the 12th week and declined thereafter.

关键词： K. Lysolecithin Serotonin Noradrenalin Dopamine Alzheimer's Syndrome

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Serial evaluation of myocardial function using the myocardial performance index in Kawasaki disease

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World Journal of Pediatrics 2018年第3期14卷 259-268页

作者： Eun Song Song Somy Yoon Joo Hyun Cho Eun Mi Yang Hwa Jin Cho Young Youn choi Jae sook Ma Gwang Hyeon Eom Young Kuk Cho Department of Pediatrics Chonnam National University HospitalChonnam National University Medical School42 Jebong-roDong-guGwangju 501-757South Korea Department of Pharmacology and Medical Research Center for Gene Regulation Chonnam National University Medical School160 Baekseo-roDong-guGwangju 61469South Korea Department of Pediatrics KS HospitalGwangjuSouth Korea

Background Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myo-carditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. Methods We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012. We assessed the presence of coronary artery lesions (CALs) and the LV ejection fraction, PD-MPI, and TDI-MPI at diagnosis, and 2, 14, and 56 days after intravenous immunoglobulin (IVIG) treatment. We enrolled 70 healthy children as a control group. Results The ejection fraction in patients with KD at diagnosis (67.3 ± 0.9%) was lower than that in the control group (69.8 ± 0.8%,P = 0.035), and the LV TDI-MPIs for patients with KD at diagnosis (0.49 ± 0.01) and 2 days after IVIG treatment (0.48 ± 0.01) were higher than those in the control group (0.45 ± 0.01,P = 0.002,P = 0.033, respectively). No signifi cant diff erences were found in the LV dysfunction between the patients with complete and incomplete KD. Septal TDI-MPIs in patients with KD with CAL at diagnosis (0.52 ± 0.02) were higher than those in patients with KD without CAL (0.47 ± 0.01,P = 0.019). Conclusions Transient LV dysfunction occurred in patients with complete and incomplete KD in the acute stage. In patients with KD with CAL at diagnosis, the LV dysfunction was more prominent. The PD-MPI and TDI-MPI are useful parameters for assessing LV function in patients with KD.

关键词： Kawasaki disease Myocardial function Myocardial performance index Tissue Doppler imaging

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Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 262-269页

作者： Su-Hyeon Cho Tae-Hyung Kwon Hoibin Jeong Jin sook Kim Song-Rae Kim Myeong Seon Jeong SeonJu Park Miri choi Jung-Hee Woo Juhee Ahn Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea Department of Research and Development Chuncheon Bio-industry FoundationChuncheonRepublic of Korea Marine Industry Research Institute for East se rim Uljin-gunGyeongsangbuk-doRepublic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 ***:Murine macrophage RAW 264.7 cells were subjected to dieckol treatment,followed by treatment with receptor activator of nuclear factor kappa-B ligand(RANKL)to induce ***-resistant acid phosphatase(TRAP)activity was examined using a TRAP activity *** blotting analysis was conducted to examine the level of osteoclast-related factors,including TRAP and calcitonin receptor(CTR),transcriptional factors,including c-Fos,c-Jun,and nuclear factor of activated T cells cytoplasmic 1(NFATc1),nuclear factor kappa-B(NF-κB),extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase(JNK).Immunofluorescence staining was conducted to examine the expression of c-Fos,c-Jun,and ***:Among the four phlorotannin compounds present in Eisenia bicyclis,dieckol significantly hindered osteoclast differentiation and expression of RANKL-induced TRAP and *** addition,dieckol downregulated the expression levels of c-Fos,c-Jun,NFATc1,ERK,and JNK,and suppressed NF-κB ***:Dieckol can suppress RANKL-induced ***,it has therapeutic potential in treating osteoclastogenesis-associated diseases.

关键词： Eisenia bicyclis Dieckol Osteoclasts ERK JNK NF-κB RANKL TRAP Calcitonin receptor NFATc1 RAW 264.7 cell

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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World Journal of Gastroenterology 2016年第42期22卷 9427-9436页

作者： Junhyeon Cho Sang Soo Lee Yun Suk choi Yejoo Jeon Jung Wha Chung Joo Yeong Baeg Won Keun Si Eun Sun Jang Jin-Wook Kim sook-Hyang Jeong Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University College of Medicine

AIM To clarify the prevalence of occult hepatitis B virus(HBV) infection(OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma(HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus(HCV) infection. METHODS This prospective cohort study enrolled 174 patients with chronic HCV infection(chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or moredifferent viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome. RESULTS The overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively(P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response(SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development. CONCLUSION The prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

关键词： Hepatitis B virus Hepatitis C virus Disease control Oncogenesis

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