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Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy

Cellular & Molecular Immunology 2022年第1期19卷 33-45页

作者： Laura A.Huppert Michael D.Green luke Kim Christine Chow Yan Leyfman Adil I.Daud James C.lee Division of Hematology/Oncology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA Department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System Ann ArborMIUSA University of California San Francisco School of MedicineSan FranciscoCAUSA Penn State College of Medicine HersheyPAUSA Parker Institute for Cancer Immunotherapy San FranciscoCAUSA

Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer ***,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic *** insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy *** immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune *** the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy *** improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer *** knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer.

关键词： Tissue Tregs Immunotherapy Organ-specific tolerance Metastasis Cancer

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天然气水合物和游离气饱和度评价方法及其在南海北部的应用

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海洋地质与第四纪地质 2017年第5期37卷 35-47页

作者：王秀娟钱进 lee myung 中国科学院海洋研究所海洋地质与环境重点实验室青岛266071 海洋国家实验室海洋矿产资源评价与探测技术功能实验室青岛266071 美国地质调查局丹佛能源中心丹佛美国80225

饱和度是评价天然气水合物资源量的重要参数之一,不同海域由于水合物微观赋存状态差异,评价方法不同。大量水合物钻探取心显示在珠江口盆地不同海域发现了不同类型的水合物,在东部海域发现了呈脉状、块状、结核状等裂隙内形成肉眼可视... 详细信息

饱和度是评价天然气水合物资源量的重要参数之一,不同海域由于水合物微观赋存状态差异,评价方法不同。大量水合物钻探取心显示在珠江口盆地不同海域发现了不同类型的水合物,在东部海域发现了呈脉状、块状、结核状等裂隙内形成肉眼可视的水合物,而神狐海域发现了呈分散状充填在孔隙空间不同饱和度的水合物,两种不同类型水合物层的测井异常响应特征不同,评价饱和度方法不同。研究表明东部海域基于各向异性电阻率模型估算的水合物饱和度与压力取心吻合,近海底发育的水合物层饱和度相对较低,约为10%,而基于各向同性模型估算水合物饱和度高达60%,远大于压力取心饱和度。在碳酸盐岩层,基于未固结地层各向同性与各向异性估算水合物饱和度大于氯离子异常估算水合物饱和度,而利用胶结模式估算水合物饱和度与氯离子吻合。利用地震资料,以测井为约束利用稀疏脉冲反演地层的速度或波阻抗,结合不同岩石物理模型分析,再通过线性拟合或循环迭代方法可以估算水合物饱和度体,研究水合物的空间分布。通过沿稳定带底界提取水合物饱和度属性,发现神狐海域水合物呈不均匀分布,在局部峡谷脊部呈条带状特征。

关键词：天然气水合物饱和度各向同性各向异性速度电阻率

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Future sea level rise along the coast of China and adjacent region under 1.5℃ and 2.0℃ global warming

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Advances in Climate Change Research 2020年第3期11卷 227-238页

作者： QU Ying LIU Yonggang Svetlana JEVREJEVA luke P.JACKSON Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing100871China National Oceanography Center LiverpoolL35DAUK Programme for Economic Modelling Nuffield CollegeOxford UniversityOX1 INFUK

Although future sea level rise along the China coast has been projected by various studies for different representative concentration pathways(RCPs),the projections for different warming thresholds,e.g.1.5℃ and 2.0℃,have not been done specifically for this region,to the best of our *** provide such a projection here based on the climate projections of Coupled Model Intercomparison Project Phase 5(CMIP5).The projections are given for 20 tide-gauge stations along the coast of China,Korea,Japan,and *** land motion(VLM)is also estimated for stations that have tide gauge records and satellite altimetry both covering the period of *** land motion(LLM)is then estimated by subtracting the land motion due to glacial isostatic adjustment(GIA)from *** considering LLM,sea level rise by 2100 at median probability is projected to be 38-49 cm relative to the average sea level over 1986-2005 under warming of 1.5℃,and increase to 46-57 cm when the warming threshold is increased to 2.0℃.The steric component is the main contributor to this increase in sea *** of LLM will not affect the sea level increase between the two warming thresholds,but it will make the local sea level rise by 2100 at certain locations substantially higher(up to 36 cm)or lower(up to 13 cm).

关键词： sea level rise Coast of China Tide gauge records Vertical land motion Warming of 1.5℃ Warming of 2.0℃

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Characteristics of Algal Succession Following Rock Scraping at Imwon Area in the East Coast of Korea

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Journal of Ocean University of China 2016年第6期15卷 1087-1093页

作者： Young Dae Kim Jung Kwan Alan myung Mo Nam Chu lee Hyun Il Yoo Su Yeoung Yeon Young Hwan Kim Jang Kyun Kim Jae Suk Choi East sea Fisheries Research Institute National Fisheries Research & Development Institute Gangneung 210-860Republic of Korea Korea National Park Service National Park Research Institute Yeosu 550-833 Republic of Korea seaweed Research Center 1rational Fisheries Research & Development lnstituie Mokpo 530-831 Republic of Korea Department of Biology Chungbuk National University Chongju 361-763 Republic Of Korea Department of Marine Science School of Natural Sciences Incheon National University 22012 Yeonsu-gu Incheon Korea Department of Marine Sciences University of Connecticut 06901 Stamford Connecticut USA Division of Bioindustry Silla University Sasang-gu Busan 617-736 Republic of Korea

Abstract This study was conducted to clarify the characteristics high-pressure water sprayer in the period from June 2010 to April 2011 of algal succession following rock scraping using hoe or We divided the research area off the eastern coast of Korean near Imwon into 3 categories depending upon the severity of the barren ground, i.e., the urchin barren-affected, urchin bar- ren-ongoing and urchin barren-free areas. In April 2011, in the urchin barren-affected area with 25 seaweed species, the cover per- centage and importance value （IV） of erustose coralline algae were higher than those of other species. In the urchin barren-ongoing area with 33 seaweed species, crustose coralline algae （mean IV=62%） as well as Sargassum sp. （mean IV=28%）, and Gelidium amansii （mean IV= 19%） were observed following rock scraping. In the urchin barren-free area where seaweed communities were relatively abundant with 42 species, a variety of algal species including G. amansii （mean IV = 32%） underwent algal succession. Overall, it was observed that, as an aspect of algal succession, the weaker the barren ground severity was, the more frequent and di- verse the seaweeds were, and the more complex the succession pattern was in the study. As an aspect of recovering algal community, rock scraping using hoe was shown to be superior to the method using high-pressure water spraying. Therefore, we conclude that rock scraping using hoe is a very effective strategy for recovering the algal community in urchin barren-ongoing area.

关键词： algal succession sea-urchin barren ground rock scraping subtidal zone

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky luke P.lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

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Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by fi rst-year medical students

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World Journal of Emergency Medicine 2017年第4期8卷 281-286页

作者： Jonathan B.lee Christina Tse Thomas Keown Michael Louthan Christopher Gabriel Alexander Anshus Bima Hasjim Katrina lee Esther Kim luke Yu Allen Yu Shadi Lahham Steven Bunch Maili Alvarado Abdulatif Gari John C.Fox School of Medicine University of CaliforniaIrvineUSA Department of Emergency Medicine University of CaliforniaIrvineOrangeCalifornia 92868USA

BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, ***: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each ***: We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2%(SD=0.145) with 82.9% of the class passing(score above 75.0%).CONCLUSION: Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for proficiency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound.

关键词： Ultrasound education Ultrasound teaching Indonesia

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THE ESTUARINE COPEPODA OF CHIEKONG AND ZAIKONG RIVERS, KWANGTUNG PROVINCE, CHINA

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Current Zoology 1963年第4期 593-596页

作者： SHEN CHIA-JUI(Institute of Zoology, Academia Sinica)lee FOO-SIANG(South China sea Branch, Institute of Oceanology, Academia Sinica)

This paper is based upon the material collected at the Stations A, B, C at the mouthof the Chiekong River and at the Station D off the mouth of the Zaikong River (bothof which are situated in the northern part of Luichow Peninsula, Kwangtung Province)in every month throughout the year from April, 1961 to March, 1962 by members ofthe Planktology Section, South China sea Branch, Institute of Occanology, AcademiaSinica, and put at our disposal for studies. As a result, 27 species have been identified,

关键词： CHINA KWANGTUNG PROVINCE THE ESTUARINE COPEPODA OF CHIEKONG AND ZAIKONG RIVERS

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Whisky Island

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新高考(英语进阶) 2016年第3期 32-33页

作者： luke Philips

Activity 1Match the word or phrase with a *** together,often food b.a reason which might not be true *** one part of a war was fought d.a place where strong alcohol is made e.a taste *** good or bad something isWater of Life The smell of smoke mixed with the sea air as we stood looking out over the *** us was a group of low,strange-looking *** were visiting the Laphroaig Distillery on the

关键词： Activity Whisky Island

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Characteristics and biological control functions of Bacillus ***8313 as a host-associated probiotic in red sea bream(Pagrus major)aquaculture

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Animal Nutrition 2023年第1期12卷 20-31页

作者： Won Je Jang Kyung-Bon lee Mi-Hyeon Jeon Su-Jeong lee Sang Woo Hur Seunghan lee Bong-Joo lee Jong Min lee Kang-Woong Kim Eun-Woo lee Department of Biotechnology Pukyong National UniversityBusan48513South Korea Department of Biology Education College of Education Chonnam National UniversityGwangju61186South Korea Biopharmaceutical Engineering Major Division of Applied BioengineeringDong-Eui UniversityBusan47340South Korea Aquafeed Research Center National Institute of Fisheries SciencePohang37517South Korea Department of Smart Fisheries Resources College of Industrial SciencesKongju National UniversityYesan32439South Korea

Host-associated probiotics(HAPs)are bacteria originally isolated from rearing water or the host's gastrointestinal tract in order to enhance the host's growth and *** study investigated the HAP potential of Bacillus ***8313,isolated from wild red sea bream(Pagrus major),through characterization and feeding *** based on in vitro tests showed that PM8313 is safe,confirming its hemolytic,cytotoxic,and antibiotic *** addition,PM8313 showed advantages as a probiotic with high viability in the gastrointestinal model and a high cell adhesion ***-genome sequencing demonstrated that PM8313 has a 4,615,871 bp single circular chromosome and a guaninecytosine content of 45.25%.It also showed the absence of genes encoding virulence factors,such as cytotoxin,enterotoxin,hemolysin,sphingomyelinase,and *** the feeding trial,a supplemental diet of 1×10^(8)CFU/g PM8313 positively altered the weight gain,digestive enzyme activity,and intestinal microbiota composition of red sea *** of nonspecific immune parameters and immune-related gene expression,and a challenge test showed that PM8313 supplementation increases immunity and pathogenic bacteria *** findings suggest that PM8313 should be considered for application as a novel HAP to red sea bream aquaculture.

关键词： Host-associated probiotics Immunity Microbiota Probiotics Red sea bream

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Water Boatmen

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英语沙龙（高中） 2015年第5期 26-27页

作者： luke Philips

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