检索结果-南通市图书馆

Hepatic fat quantification magnetic resonance for monitoring treatment response in pediatric nonalcoholic steatohepatitis

引用

World Journal of Gastroenterology 2015年第33期21卷 9741-9748页

作者： Hong Koh Seung kim myung-joon kim Hyun Gi kim Hyun Joo Shin Mi-Jung Lee Department of Pediatrics Severance Pediatric Liver Disease Research GroupSeverance Children’s HospitalYonsei University College of Medicine Department of Radiology and Research Institute of Radiological Science Severance Pediatric Liver Disease Research GroupSeverance Children’s HospitalYonsei University College of Medicine

AIM: To evaluate the possibility of treatment effect monitoring using hepatic fat quantification magnetic resonance(MR) in pediatric nonalcoholic steatohepatitis(NASH).METHODS: We retrospectively reviewed the medical records of patients who received educational recommendations and vitamin E for NASH and underwent hepatic fat quantification MR from 2011 to *** fat fraction(%) was measured using dual- and triple-echo gradient-recalled-echo sequences at *** compliant and non-compliant groups were compared clinically,biochemically,and ***: Twenty seven patients(M:F = 24:3; mean age: 12 ± 2.3 years) were included(compliant group = 22,non-compliant = 5).None of the baseline findings differed between the 2 groups,except for triglyceride level(compliant vs non-compliant,167.7 mg/d L vs 74.2 mg/d L,P = 0.001).In the compliant group,high-density lipoprotein increased and all other parameters decreased after 1-year ***,there were various changes in the non-compliant *** fat fraction(-19.2% vs 4.6,P < 0.001),tripleecho fat fraction(-13.4% vs 3.5,P < 0.001),alanine aminotransferase(-110.7 IU/L vs-10.6 IU/L,P = 0.047),total cholesterol(-18.1 mg/d L vs 3.8 mg/d L,P = 0.016),and triglyceride levels(-61.3 mg/d L vs 11.2 mg/d L,P = 0.013) were significantly decreased only in the compliant *** change in body mass index and dual-echo fat fraction showed a positive correlation(ρ = 0.418,P = 0.030).CONCLUSION: Hepatic fat quantification MR can be a non-invasive,quantitative and useful tool for monitoring treatment effects in pediatric NASH.

关键词： Nonalcoholic fatty liver disease Steatohepatitis H

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

引用

World Journal of Gastroenterology 2018年第27期24卷 3013-3020页

作者： Hyun Joo Shin Haesung Yoon myung-joon kim Seok Joo Han Hong Koh Seung kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

AIM To evaluate the correlation between intravoxel incoherent motion(IVIM) diffusion-weighted imaging(DWI) parameters and the degree of hepatic steatosis and fibrosis in *** This retrospective study was approved by the institutional review board. The children(≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver(FAT), and fibrotic liver(FIB) groups. The slow diffusion coefficient(D), fast diffusion coefficient(D*), perfusion fraction(f), and apparent diffusion coefficient(ADC) were measured. MR proton density fat fraction(PDFF), MR elastography(MRE), and IVIM values were *** A total of 123 children(median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D* values were lower in the FIB group compared with those of the normal(P = 0.015) and FAT(P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group(P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value(β = 3.194, P < 0.001), and MRE value was negatively correlated with D* value(β =-7.031, P = 0.032). The D and ADC values were not influenced by PDFF or MRE *** In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

关键词： Intravoxel incoherent motion Diffusionweighted imaging Fibrosis Fatty liver Pediatrics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis

引用

World Journal of Gastroenterology 2019年第3期25卷 367-377页

作者： Haesung Yoon Hyun Joo Shin myung-joon kim Seok Joo Han Hong Koh Seung kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

BACKGROUND A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography(MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been *** To assess the utility of splenic stiffness measurements by MRE to predict gastroesophageal varices in *** We retrospectively reviewed abdominal MRE images taken on a 3 T system in pediatric patients. Patients who had undergone Kasai operations for biliary atresia were selected for the Kasai group, and patients with normal livers and spleens were selected for the control group. Two-dimensional spin-echo echoplanar MRE acquisition centered on the liver, with a pneumatic driver at 60 Hz and a low amplitude, was performed to obtain hepatic and splenic stiffness values. Laboratory results for aspartate aminotransferase to platelet ratio index(APRI) were evaluated within six months of MRE, and the normalized spleen size ratio was determined with the upper normal size limit. All Kasai group patients underwent gastroesophageal endoscopy during routine follow-up. The MannWhitney U test, Kendall's tau b correlation and diagnostic performance analysis using the area under the curve(AUC) were performed for statistical *** The median spleen MRE value was 5.5 kPa in the control group(n = 9, age 9-18 years, range 4.7-6.4 kPa) and 8.6 kPa in the Kasai group(n = 22, age 4-18 years,range 5.0-17.8 kPa). In the Kasai group, the APRI, spleen size ratio and spleen MRE values were higher in patients with portal hypertension(n = 11) than in patients without(n =

关键词： Biliary atresia Magnetic resonance elastography Kasai operation Splenic stiffness Portal hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model

引用

World Journal of Gastroenterology 2020年第7期26卷 706-716页

作者： Jaeseung Shin Haesung Yoon Yoon Jin Cha Kyunghwa Han Mi-Jung Lee myung-joon kim Hyun Joo Shin Department of Radiology Severance HospitalResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Pathology Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea Department of Radiology Severance HospitalResearch Institute of Radiological ScienceCenter for Clinical Imaging Data ScienceSeoul 03722South Korea

BACKGROUND Hepatic sinusoidal obstruction syndrome(SOS)is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of *** the diagnosis is primarily based on nonspecific clinical features and invasive liver ***,noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic *** To determine the effectiveness of supersonic shear wave imaging(SSI)and dual energy computed tomography(DECT)for diagnosing hepatic SOS using a rabbit *** Among nine New Zealand white rabbits(3-4 kg,male),three in control group ingested normal saline for 20 d and six in the SOS group ingested 6-thioguanine(5 mg/kg/d)for 20 *** stiffness was measured using SSI on days 0,3,10,and *** the same days,liver perfusion was evaluated from virtual monochromatic images of 55 keV and iodine map using *** changes in the liver were assessed using *** pathology scores were compared between the two *** stiffness and perfusion parameters were compared according to the groups,days,and pathology *** Final pathology scores were significantly higher in the SOS than the control group(median 22 vs 2,P=0.024).No gross morphologic changes were seen in *** stiffness,Hounsfield Unit values,and iodine concentrations were higher in the SOS compared to the control group on days 10 and 20(all,P≤0.007).Compared to day 0,liver stiffness and perfusion parameters were higher on day 20 in the SOS group(all,P≤0.001).Correlation coefficients for liver stiffness(r=0.635),Hounsfield Unit values(r=0.587),and iodine concentration(r=0.611)with final pathology scores were positive without significance(all,P>0.05).CONCLUSION Liver stiffness and perfusion parameters were significantly increased in the livers of a rabbit SOS *** and DECT might aid in early diagnosis of hepatic SOS.

关键词： Hepatic sinusoidal obstruction syndrome Elasticity imaging techniques Iodine Computed tomography Liver Animals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

引用

World Journal of Gastroenterology 2015年第9期21卷 2614-2621页

作者： Hyun Joo Shin Eun Young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi kim myung-joon kim Mi-Jung Lee Department of Radiology and Research Institute of Radiological Science Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Department of Pediatric Surgery Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Biostatistics Collaboration Unit Yonsei University College of MedicineSeoul 120-752South Korea Department of Laboratory Animal Resources Avison Bio Medical Research CenterYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal ***:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction *** performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were *** CEUS,signal intensity of liver parenchyma with a time-intensity curve was *** parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to *** grades of liver fibrosis were assessed according to the Metavir score system immediately after *** estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical *** perfusion parameters were measured on the last day and the difference between day 0 and the last day were ***:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two *** the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis ***:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.

关键词： Ultrasonography Contrast enhanced ultrasound Liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extragastrointestinal stromal tumor presenting as a scrotal mass： an unusual case

引用

Asian Journal of Andrology 2007年第2期9卷 275-279页

作者： Seok-Ho Kang myung-joon kim Min-Gu Park Hong-Seok Park Du-Geon Moon Deuk-Jae Sung Hyun-Chul kim Yang-Seok Chae Jun Cheon Je-Jong kim Department of Urology Korea University School of Medicine Seoul 136-705 Korea Department of Radiology Korea University School of Medicine Seoul 136-705 Korea Department of Pathology Korea University School of Medicine Seoul 136-705 Korea

We describe an unusual case of extragastrointestinal stromal tumor （EGIST） presenting as a scrotal mass. A 71- year-old man presented with a gradually enlarging scrotal mass with a 20-year duration. Physical examination re vealed a huge （as large as volleyball）, round, nontender mass occupying the whole scrotum, which was resected completely. Clinical and radiological findings did not comply with any other primary site disease. Under histological examination, the tumor showed a spindle cell pattern with low cellularity, absence of necrotic and mitotic features. Immunohistochemical anlaysis revealed the tumor reactive for CD117 and CD34, while negative for smooth muscle actin, desmin and S-100 protein. To our knowledge, this is the first reported case of an EGIST involving the scrotum.

关键词： extragastrointestinal stromal tumor scrotum immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fe_(3)GeTe_(2):a site-differentiated Hund metal

引用

npj Computational Materials 2022年第1期8卷 2355-2360页

作者： Taek Jung kim Siheon Ryee myung joon Han Department of Physics KAISTDaejeon34141Republic of Korea I.Institute of Theoretical Physics University of HamburgNotkestrasse 9-11Hamburg22607Germany

Magnetism in two-dimensional(2D)van der Waals(vdW)materials has lately attracted considerable attention from the point of view of both fundamental science and device ***,establishing a detailed and solid understanding of their magnetism is the key first step toward various *** Fe_(3)GeTe_(2)is a representative ferromagnetic(FM)metal in this family,many aspects of its magnetic and electronic behaviors still remain ***,we report our new finding that Fe_(3)GeTe_(2)is a special type of correlated metal known as“Hund metal”.Furthermore,we demonstrate that Hund metallicity in this material is quite unique by exhibiting remarkable site dependence of Hund correlation strength,hereby dubbed“site-differentiated Hund metal”.Within this new picture,many of the previous experiments can be clearly understood,including the ones that were seemingly contradictory to one another.

关键词： strength establishing metallic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on frictional behavior of carbon nanotube thin films with respect to surface condition

引用

Friction 2018年第4期6卷 432-442页

作者： Youn-Hoo HWANG Byung-Soo myung Hyun-joon kim Department of Precision Mechanical Engineering Kyungpook National University

In this work, tribological characteristics of thin films composed of entangled carbon nanotubes(CNTs) were investigated. The surface roughness of CNT thin films fabricated via a dip‐coating process was controlled by squeezing during the process with an applied normal force ranging from 0 to 5 kgf. Raman spectra and scanning electron microscopy(SEM) images of the thin films were obtained to estimate the influence of the squeezing process on the crystallinity of the CNTs. The analysis revealed that squeezing could reduce surface roughness, while preserving the crystallinity of the CNTs. Moreover, the surface energy of the cover glass used to press the CNT thin film was found to be the critical factor controlling surface roughness. A micro‐tribometer and macro‐tribometer were used to assess the tribological characteristics of the CNT thin film. The results of the tribotest exhibited a correlation between the friction coefficient and surface roughness. Dramatic changes in friction coefficient could be observed in the micro‐tribotest, while changes in friction coefficient in the macro‐tribotest were not significant.

关键词： carbon nanotubes friction surface roughness surface energy squeezing process UV irradiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

引用

中国有色金属学会会刊：英文版 2009年第B09期19卷 271-275页

作者： Jeong-Soo LEE Young-Soo RYU Nam-In kim Bong-joon kim Yoo-Kyung kim myung-Hyun kim Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Grasper type scissors for endoscopic submucosal dissection of gastric epithelial neoplasia

引用

World Journal of Gastroenterology 2013年第37期19卷 6221-6227页

作者： Woo-Chul Chung Byung-Wook kim Chul-Hyun Lim Tae-Ho kim Jae-myung Park joon-Sung kim Division of Gastroenterology Department of Internal MedicineSuwon St.Vincent’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineIncheon St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineBucheon St.Mary’s HospitalThe Catholic University of Korea

AIM:To evaluate the efficacy and safety of grasper type scissors(GTS)for endoscopic submucosal dissection(ESD)of gastric epithelial ***:The study was performed by 4 endoscopists in 4 institutions affiliated to The Catholic University of *** was performed in 76 consecutive patients with gastric epithelial neoplasia by using the GTS(37 patients)or the hook knife plus coagrasper(HKC)(39 patients).The complete resection rate,complication rate,total time elapsed and elapsed time per square centimeter of the dissected specimen were analyzed between the GTS and HKC ***:The mean age of the GTS group was 62.3±11.4 years and mean age of the HKC group was 65.6±10.1 *** adenocarcinoma was found in32.4%in the GTS group and 33.3%in the HKC *** procedures were performed without interruption in every case in both *** en bloc resection rates of both groups were 100%.The total time elapsed during the procedure was 44.54±21.72 min in the GTS group and 43.77±21.84 min in the HKC group(P=0.88)and the time elapsed per square centimeter of the resected lesion was 7.53±6.35 min/cm2in the GTS group and 6.92±5.93 min/cm2in the HKC group(P=0.66).The overall complication rate was not significantly different between the two ***:GTS is a safe and effective device for ESD compared with *** can be performed with GTS alone,which can reduce the costs for ESD.

关键词： Gastric epithelial neoplasia Endoscopic submucosal dissection Grasper type scissors Hook knife Coagrasper

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：