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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk kim Sung Yong Han Suk kim Nam Kyung Lee Seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Carbon-coated manganese dioxide nanoparticles and their enhanced electrochemical properties for zinc-ion battery applications

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Journal of Energy Chemistry 2017年第4期26卷 815-819页

作者： Saiful Islam Muhammad Hilmy Alfaruqi Jinju Song Sungjin kim Duong Tung Pham Jeonggeun Jo Seokhun kim Vinod Mathew Joseph Paul Baboo Zhiliang Xiu Jaekook kim Department of Materials Science and Engineering Chonnam National University300 Yongbong-dongBukguGwangju 61186Republic of Korea

In this study, we report the cost-effective and simple synthesis of carbon-coated α-MnOnanoparticles(α-MnO@C) for use as cathodes of aqueous zinc-ion batteries(ZIBs) for the first time. α-MnO@C was prepared via a gel formation, using maleic acid(CHO) as the carbon source, followed by annealing at low temperature of 270 °C. A uniform carbon network among the α-MnOnanoparticles was observed by transmission electron microscopy. When tested in a zinc cell, the α-MnO@C exhibited a high initial discharge capacity of 272 m Ah/g under 66 m A/g current density compared to 213 m Ah/g, at the same current density, displayed by the pristine sample. Further, α-MnO@C demonstrated superior cycleability compared to the pristine samples. This study may pave the way for the utilizing carbon-coated MnOelectrodes for aqueous ZIB applications and thereby contribute to realizing high performance eco-friendly batteries.

关键词： Carbon coating Manganese dioxide Zinc-ion battery Electrochemical properties

Effect of vitamin D3 on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes

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The Journal of Biomedical Research 2016年第3期30卷 203-208页

作者： So-Hye Hong Jae-Eon Lee Hong Sung kim Young-Jin Jung DaeYoun Hwang Jae Ho Lee Seung Yun Yang Seung-Chul kim Seong-Keun Cho Beum-Soo An Department of Biomaterials Science College of Natural Resources & Life Science Pusan National University Miryang 50463 Korea Department of Obstetrics and Gynecology Biomedical Research Institute Pusan National University School of Medicine Busan 46269 Korea Department of Animal Science College of Natural Resources & Life Science Pusan National UniversityMiryang 50463 Korea

1,25-dihydroxyvitamin D3 （VD3）, an active form of Vitamin D, is photosynthesized in the skin of vertebrates in response to solar ultraviolet B radiation （UV-B）. VD3 deficiency can cause health problems such as immune disease, metabolic disease, and bone disorders. It has also been demonstrated that VD3 is involved in reproductive functions. Female sex hormones such as estrogen and progesterone are biosynthesized mainly in ovarian granulosa cells as the ovarian follicle develops. The functions of sex hormones include regulation of the estrus cycle and puberty as well as maintenance of pregnancy in females. In this study, we isolated granulosa cells from porcine ovaries and cultured them for experiments. To examine the effects of VD3 on ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by Real-time PCR and Western blotting assay. Production of progesterone from granulosa cells was also measured by ELISA assay. As a result, transcriptional and translational regulation of progesterone biosynthesis-related genes in granulosa cells was significantly altered by VD3. Furthermore, progesterone concen- trations in porcine granulosa cell-cultured media decreased in response to VD3. These results show that VD3 was a strong regulator of sex steroid hormone production in porcine granulosa cells, suggesting that vitamin D deficiency may result in inappropriate sexual development of industrial animals and eventually economic loss.

关键词： Vitamin D3 steroidogenesis progesterone granulosa cell pig

Evaluation of the relationship between two different methods for enumeration fecal indicator bacteria: Colony-forming unit and most probable number

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Journal of Environmental Sciences 2010年第6期22卷 846-850页

作者： Kyung Hwa Cho Dukki Han Yongeun Park Seung Won Lee Sung Min Cha Joo-Hyon Kang Joon Ha kim Department of Environmental Science and Engineering Gwangju Institute of Science and Technology Deparment of Civil and Environmental Engineering Dongguk University-Seoul Sustainable Water Resource Technology Center Gwangju Institute of Science and Technology

Most probable number （MPN） and colony-forming unit （CFU） estimates of fecal indicator bacteria （FIB） concentration are common measures of water quality in aquatic environments. Thus, FIB intensively monitored in Yeongsan Watershed in an attempt to compare two different methods and to develop a statistical model to convert from CFU to MPN estimates or vice versa. As a result, the significant difference was found in the MPN and CFU estimates. The enumerated Escherichia coli concentrations in MPN are greater than those in CFU, except for the measurement in winter. Especially in fall, E. coli concentrations in MPN are one order of magnitude greater than that in CFU. Contrarily, enterococci bacteria in MPN are lower than those in CFU. However, in general, a strongly positive relationship are found between MPN and CFU estimates. Therefore, the statistical models were developed, and showed the reasonable converting FIB concentrations from CFU estimates to MPN estimates. We expect this study will provide preliminary information towards future research on whether different analysis methods may result in different water quality standard violation frequencies for the same water sample.

关键词： most probable number colony-forming unit fecal indicator bacteria Escherichia coli enterococci

Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach

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Emerging Contaminants 2024年第2期10卷 76-82页

作者： Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun kim Department of Biology Jeju National UniversityJeju63243South Korea Department of Interdisciplinary Program in Biomedical Science Graduate SchoolSoonchunhyang UniversityAsanChungcheongnam-doSouth Korea Department of Laboratory Medicine Soonchunhyang University Seoul HospitalSeoul04401South Korea

Chromium(III)oxide nanoparticles(NPs)have a wide range of industrial applications,particularly in the production of lithium-ion batteries;however,the toxicity of these NPs has not been studied *** phytotoxicity and genotoxicity of chromium(III)oxide NPs have not been assessed,and only one study reported their cytotoxicity,underscoring the need to perform comprehensive toxicity studies on these ***,we showed that chromium(III)oxide NPs had no effect on germination rates,and only decreased root elongation in *** as determined by root elongation and biomass ***(III)oxide NPs had no phytotoxic effects under environmental realistic conditions,whereas they had cytotoxic effects against HK-2 and Raw 264.7 cells in ***,the cytotoxicity of chromium(III)oxide NPs did not occur under environmentally realistic *** genotoxicity of chromium(III)oxide NPs was not significant in HK-2 cells,suggesting that the potential environmental cytotoxicity of chromium(III)oxide NPs is *** study proposes comprehensive phytotoxicity,cytotoxicity,and genotoxicity testing tools that would be easy,safe,and effective for evaluating the toxicity of *** integrated testing system could be an accurate and stable method for evaluating the toxicity of other nanomaterials.

关键词： Nanoparticle Plant growth Cell viability Chromium(III)oxide Nephrotoxicity

Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 95-102页

作者： Minha kim Stephanie Stroever Krist Aploks Alexander Ostapenko Xiang Da Dong Ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACKGROUND Gallbladder cancer is the most common malignancy of the biliary ***-adjuvant chemotherapy(NACT)has improved overall survival by enabling R0 ***,there is no consensus of guidelines for neoadjuvant therapy in gallbladder *** investigations continue to analyze the regimen and benefit of NACT for ongoing care of gallbladder cancer patients,we examined American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database to determine if there was higher morbidity among the neo-adjuvant group within the 30-day post-operative *** hypothesized patients who underwent NACT were more likely to have higher post-operative *** To investigate the 30-day post-operative morbidity outcomes between patients who received NACT and underwent surgery and patients who only had *** A retrospective analysis of the targeted hepatectomy NSQIP data between 2015 and 2019 was performed to determine if NACT in gallbladder cancer increased the risk for post-operative morbidity(bile leak,infection rate,rate of converting to open surgery,etc.)compared to the group who only had *** calculate the odds ratio for the primary and secondary outcomes,a crude logistic regression was *** Of the 452 patients,52 patients received NACT prior to *** were no statistically significant differences in the odds of morbidity between the two groups,including bile leak[odds ratio(OR),0.69;95%confidence interval(95%CI):0.16-2.10;P=0.55],superficial wound infection(OR,0.58;95%CI:0.03-3.02;P=0.61),and organ space wound infection(OR,0.63;95%CI:0.18-1.63;P=0.61).CONCLUSION There was no significant difference in the risk of 30-day post-operative morbidity between the NACT and surgery group and the surgery only group.

关键词： Gallbladder cancer Neoadjuvant chemotherapy Radical cholecystectomy National Surgery Quality Improvement Program Postoperative outcome

A systematic literature review of blockchain cyber security

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Digital Communications and Networks 2020年第2期6卷 147-156页

作者： Paul J.Taylor Tooska Dargahi Ali Dehghantanha Reza M.Parizi kim-Kwang Raymond Choo School of Computing Science&EngineeringUniversity of SalfordManchesterUK Cyber Science Lab School of Computer ScienceUniversity of GuelphOntarioCanada Department of Software Engineering and Game Development Kennesaw State UniversityMariettaGA30060USA Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Since the publication of Satoshi Nakamoto's white paper on Bitcoin in 2008,blockchain has(slowly)become one of the most frequently discussed methods for securing data storage and transfer through decentralized,trustless,peer-to-peer *** research identifies peer-reviewed literature that seeks to utilize blockchain for cyber security purposes and presents a systematic analysis of the most frequently adopted blockchain security *** findings show that the Internet of Things(IoT)lends itself well to novel blockchain applications,as do networks and machine visualization,public-key cryptography,web applications,certification schemes and the secure storage of Personally Identifiable Information(PII).This timely systematic review also sheds light on future directions of research,education and practices in the blockchain and cyber security space,such as security of blockchain in IoT,security of blockchain for AI data,and sidechain security.

关键词： Blockchain Smart contracts Cyber security Distributed ledger technology IoT Cryptocurrency Bitcoin

Two Types of Diurnal Variations in Heavy Rainfall during July over Korea

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Advances in Atmospheric Sciences 2021年第12期38卷 2201-2211页

作者： Chang-Kyun PARK Minhee CHANG Chang-Hoi HO Kyung-Ja HA Jinwon kim Byung-Ju SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea School of Earth and Environmental Systems Pusan National UniversityBusan 46241Korea Center for Climate Physics Institute for Basic ScienceBusan 46241Korea National Institute of Meteorological Sciences Korean Meteorological AdministrationJeju 63568Korea

This study examined the characteristics of the diurnal variations of heavy rainfall(≥110 mm in 12 hours)in Korea and the related atmospheric circulation for July from 1980−*** the analysis period,two dominant pattens of diurnal variation of the heavy rainfall emerged:all-day heavy rainfall(AD)and morning only heavy rainfall(MO)*** the AD-type,the heavy rainfall is caused by abundant moisture content in conjunction with active convection in the morning(0000−1200,LST;LST=UTC+9)and the afternoon hours(1200−2400 LST).These systems are related to the enhanced moisture inflow and upward motion induced by the strengthening of the western North Pacific subtropical high and upper-tropospheric *** the MO-type,heavy rainfall occurs mostly in the morning hours;the associated atmospheric patterns are similar to the *** find that the atmospheric pattern related to severe heavy rainfalls in 2020 corresponds to a typical AD-type and resembles the 1991 heavy-rainfall system in its overall synoptic/mesoscale *** present results imply that extremely heavy rainfall episodes in Korea during the 2020 summer may occur again in the future associated with the recurring atmospheric phenomenon related to the heavy rainfall.

关键词： heavy rainfall diurnal cycle of rainfall 2020 summer summer rainy season Korea

Organic photodiode with dual functions of indoor photovoltaic and high-speed photodetector

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Frontiers of Optoelectronics 2022年第2期15卷 45-51页

作者： Tae Wook kim Sung Hyun kim Jae Won Shim Do Kyung Hwang Center of Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul02841Republic of Korea Division of Nano&Information Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Energy harvesting and light detection are key technologies in various emerging optoelectronic *** high absorption capability and bandgap tunability of organic semiconductors make them promising candidates for such ***,a poly(3-hexylthiophene-2,5-diyl)(P3HT):indene-C60 bisadduct(ICBA)bulk heterojunction-based organic photodiode(OPD)was reported,demonstrating dual functionality as an indoor photovoltaic(PV)and as a high-speed *** OPD demonstrated decent indoor PV performance with a power conversion efficiency(PCE)of(11.6±0.5)%under a light emitting diode(LED)lamp with a luminance of 1000 *** a photodetector,this device exhibited a decent photoresponsivity of 0.15 A/W(green light)with an excellent linear dynamic range(LDR)of over 127 dB within the optical power range of 3.74×10^(−7) to 9.6×10^(−2) W/cm^(2).Furthermore,fast photoswitching behaviors could be observed with the rising/falling times of 14.5/10.4μs and a cutoff(3 dB)frequency of 37 *** results might pave the way for further development of organic optoelectronic applications.

关键词： Organic semiconductor Photodiode Indoor photovoltaics Photodetector