检索结果-南通市图书馆

Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis

World Journal of Gastroenterology 2020年第21期26卷 2821-2830页

作者： myung hwan lee Hyun Joo Shin Haesung Yoon Seok Joo Han Hong Koh Mi-Jung lee Department of Radiology Severance HospitalSeverance Pediatric Liver Disease Research GroupResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Surgery Severance HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsSeverance Children’s HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver ***,non-invasive evaluation of hepatic fibrosis is important in infants with *** To investigate the usefulness of periportal thickening(PT)measured on liver magnetic resonance imaging(MRI)for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia(BA).METHODS This retrospective study included infants less than 6 mo who underwent liver MRI and biopsy for the evaluation of infantile *** and spleen size were measured on *** assessment was based on aspartate transaminase to platelet ratio index(APRI).The grade of histopathologic fibrosis was assessed by the METAVIR grading *** and diagnostic performance of PT,normalized spleen size ratio(SR,using the upper normal size limit),and APRI for diagnosing hepatic fibrosis were obtained by receiveroperating characteristic(ROC)curve *** A total of 155 patients were included,110 of which were diagnosed with *** age at the time of MRI was 57.6±34.4 *** were positive correlations between fibrosis grade and PT and SR,even after adjusting age(all,P<0.001).For the diagnosis of significant fibrosis(METAVIR grade F2-F4),the area under the ROC curve was 0.899(95%CI:0.840–0.941)for PT(cutoff,4.2 mm),which was higher than 0.741(95%CI:0.664–0.808)for SR and 0.712(95%CI:0.634–0.782)for APRI(both,P<0.001).For the diagnosis of cirrhosis(F4),the area under the ROC curve was the highest with SR as 0.790(95%CI:0.718–0.852).CONCLUSION Liver MRI findings of PT and SR are useful to assess clinically significant hepatic fibrosis(F2 and higher)in infants with cholestasis including BA.

关键词： Infants Cholestasis Biliary atresia Liver Fibrosis Magnetic resonance imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine-learned wearable sensors for real-time hand-motion recognition: toward practical applications

引用

National Science Review 2024年第2期11卷 231-263页

作者： Kyung Rok Pyun Kangkyu Kwon myung Jin Yoo Kyun Kyu Kim Dohyeon Gong Woon-Hong Yeo Seungyong Han Seung hwan Ko Department of Mechanical Engineering Seoul National University IEN Center for Human-Centric Interfaces and Engineering Institute for Electronics and NanotechnologyGeorgia Institute of Technology School of Electrical and Computer Engineering Georgia Institute of Technology Department of Chemical Engineering Stanford University Department of Mechanical Engineering Ajou University George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National University

Soft electromechanical sensors have led to a new paradigm of electronic devices for novel motion-based wearable applications in our daily lives. However, the vast amount of random and unidentified signals generated by complex body motions has hindered the precise recognition and practical application of this technology. Recent advancements in artificial-intelligence technology have enabled significant strides in extracting features from massive and intricate data sets, thereby presenting a breakthrough in utilizing wearable sensors for practical applications. Beyond traditional machine-learning techniques for classifying simple gestures, advanced machine-learning algorithms have been developed to handle more complex and nuanced motion-based tasks with restricted training data sets. Machine-learning techniques have improved the ability to perceive, and thus machine-learned wearable soft sensors have enabled accurate and rapid human-gesture recognition, providing real-time feedback to users. This forms a crucial component of future wearable electronics, contributing to a robust human–machine interface. In this review, we provide a comprehensive summary covering materials, structures and machine-learning algorithms for hand-gesture recognition and possible practical applications through machine-learned wearable electromechanical sensors.

关键词： wearable sensor soft electronics artificial intelligence machine learning human–machine interfaces gesture recognition

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Characteristics of damaged layer in micro-machining of copper material

引用

中国有色金属学会会刊：英文版 2009年第B09期19卷 295-300页

作者： Dong-Hee KWON Jeong-Suk KIM myung-Chang KANG Se-Hun KWON Jong-hwan lee School of Mechanical Engineering Pusan National University National Core Research Center for Hybrid Materials Solution Pusan National University Department of Mechatronics Busan College of Korea Polytechnic Ⅶ

The study on damaged layer is necessary for improving the machinability in micro-machining because the damaged layer affects the micro mold life and micro machine parts. This study examined the ultra-precision micro-machining characteristics, such as cutting speed, feed rate and cutting depth, of a micro-damaged layer produced by an ultra-high speed air turbine spindle. The micro cutting force, surface roughness and plastic deformation layer were investigated according to the machining conditions. The damaged layer was measured using optical microscope on samples prepared through metallographic techniques. The scale of the damaged layer depends on the cutting process parameters, particularly, the feed per tooth and axial depth of the cut. According to the experimental results, the depth of the damaged layer is increased by increasing the feed per tooth and cutting depth, also the damaged layer occurs less in down-milling compared with up-milling during the micro-machining operation.

关键词：机械加工性微观特征损伤层铜材样品制备技术微型机器切削速度切削深度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Laser Parameters on Sintered Powder Morphology

引用

Journal of Materials Science & Technology 2010年第4期26卷 375-378页

作者： Byeong-Don Joo Jeong-hwan Jang Jae-Ho lee Young-myung Son Young-Hoon Moon Engineering Research Center for Net Shape and Die Manufacturing School of Mechanical EngineeringPusan National University

Selective laser sintering is a kind of rapid prototyping process whereby a three-dimensional part is built layerwise by laser scanning a powder. This process is highly inffuenced by powder and laser parameters such as laser power, scan rate, spot size and layer thickness. Therefore a study on fabricating a line with Fe-Ni-Cr powder on AISI H13 tool steel has been performed by selective laser sintering. In this study, fabrication was performed by experimental facilities consisting of a 200W fiber laser which can be focused to 0.08 mm and atmospheric chamber which can control atmospheric pressure with argon. The line was fabricated with various laser power, scan rate and layer thickness. Line width and surface quality were investigated. With power increase or layer thickness decrease, line width was decreased and line surface quality was improved with scan rate optimization.

关键词： Selective laser sintering Direct fabrication Fiber laser

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser surface hardening of AISI H13 tool steel

引用

中国有色金属学会会刊：英文版 2009年第4期19卷 917-920页

作者： Jae-Ho lee Jeong-hwan JANG Byeong-Don JOO Young-myung SON Young-Hoon MOON School of Mechanical Engineering Pusan National University

An attempt was made to improve the surface hardness and wear properties of AISI H13 tool steel through solid solution hardening and refinement of microstructures using a 200 W fiber laser as a heat generating *** hardness of laser melted zone was *** order to identify the effect of heat input on the laser melting zone,scanning conditions were *** results show that,the hardness of as-received AISI H13 tool steel is approximately Hv 240,and the hardness after laser surface heat treatment is around Hv *** hardening depth and width are increased with the increase in the heat input *** of experimental results will be considered in tooling industry.

关键词：激光表面硬化工具钢 H13 激光表面热处理表面硬度信息社会光纤激光器固溶强化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective laser melting of Fe-Ni-Cr layer on AISI H13 tool steel

引用

中国有色金属学会会刊：英文版 2009年第4期19卷 921-924页

作者： Byeong-Don JOO Jeong-hwan JANG Jae-Ho lee Young-myung SON Young-Hoon MOON School of Mechanical Engineering Pusan National University

An attempt to fabricate Fe-Ni-Cr coating on AISI H13 tool steel was performed with selective laser ***-Ni-Cr coating was produced by experimental facilities consisting of a 200 W fiber laser which can be focused to 80 μm and atmospheric chamber which can control atmospheric pressure with N2 or *** layer was fabricated with various process parameters such as laser power,scan rate and fill *** quality and coating thickness were measured and *** different surface patterns,such as typeⅠ,typeⅡand type Ⅲ,are shown with various test conditions and smooth regular pattern is obtained under the conditions as 10 μm of fill spacing,50-350 mm/s of scan rate and 40 μm of fill spacing,10-150 mm/s of scan *** maximum coating thickness is increased with power elevation or scan rate drop,and average thickness of 10 μm fill spacing is lower than that of 40 μm fill spacing.

关键词：镍铬涂层工具钢激光熔融社会扫描速度铁涂层厚度光纤激光器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein

引用

Neural Regeneration Research 2020年第2期15卷 361-368页

作者： Hyun Jin Park Ting Ting Zhao Seung hwan Kim Chong Kil lee Bang Yeon hwang Kyung Eun lee myung Koo lee Department of Pharmacy College of PharmacyChungbuk National UniversityCheongjuRepublic of Korea 2Research Center for Bioresource and Health College of PharmacyChungbuk National UniversityCheongjuRepublic of Korea Department of Social Physical Education Songwon UniversityGwangjuRepublic of Korea

Gynostemma(G.) pentaphyllum(Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum(GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson’s disease(PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-and 6-hydroxydopamine. PD patients exhibit multiple symptoms, so PD-related research should combine neurotoxin models with genetic models. In the present study, we investigated the ameliorative effects of GP-EX, including gypenosides, on the cell death of dopaminergic neurons in the midbrain of A53 T α-synuclein transgenic mouse models of PD(A53 T). Both GP-EX and gypenosides at 50 mg/kg per day were orally administered to the A53 T mice for 20 weeks.α-Synuclein-immunopositive cells and α-synuclein phosphorylation were increased in the midbrain of A53 T mice, which was reduced following treatment with GP-EX. Treatment with GP-EX modulated the reduced phosphorylation of tyrosine hydroxylase, extracellular signal-regulated kinase(ERK1/2), Bcl-2-associated death promoter(Bad) at Ser112, and c-Jun N-terminal kinase(JNK1/2) due to α-synuclein overexpression. In the A53 T group, GP-EX treatment prolonged the latency of the step-through passive avoidance test and shortened the transfer latency of the elevated plus maze test. Gypenosides treatment exhibited the effects and efficacy similar to those of GP-EX. Taken together, GP-EX, including gypenosides, has ameliorative effects on dopaminergic neuronal cell death due to the overexpression of α-synuclein by modulating ERK1/2, Bad at Ser112, and JNK1/2 signaling in the midbrain of A53 T mouse model of PD. Further studies are needed to investigate GP-EX as a treatment for neurodegenerative synucleinopathies, including PD. This study was approved by the Animal Ethics Committee of Chungbuk National University(approval No. CBNUA-956-16-01) on September 21, 2016.

关键词： A53T α-synuclein genetic mice ERK1/2 gynostemma pentaphyllum gypenosides Parkinson’s disease retention transfer latency time

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Material research from the viewpoint of functional motifs

引用

National Science Review 2022年第7期9卷 181-197页

作者： Xiao-Ming Jiang Shuiquan Deng myung-hwan Whangbo Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Department of Chemistry North Carolina State University

As early as 2001,the need for the ’functional motif theory’ was pointed out,to assist the rational design of functional *** properties of materials are determined by their functional motifs and how they are arranged in the *** functional motifs and their arrangements is crucial in understanding the properties of materials and rationally designing new materials of desired *** functional motifs of materials are the critical microstructural units(*** components and building blocks)that play a decisive role in generating certain material functions,and can not be replaced with other structural units without the loss,or significant suppression,of relevant *** role of functional motifs and their arrangement in materials,with representative examples,is *** microscopic structures of these examples can be classified into six types on a length scale smaller than ～10 nm with maximum subatomic resolution,***,magnetic,aperio dic,defect,local and electronic *** motif analysis can be employed in the function-oriented design of materials,as elucidated by taking infrared non-linear optical materials as an *** learning is more efficient in predicting material properties and screening materials with high efficiency than high-throughput experimentation and high-throughput *** order to extract functional motifs and find their quantitative relationships,the development of sufficiently reliable databases for material structures and properties is imperative.

关键词： functional motif functional motif arrangements microscopic structures structure–property relationship

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Multicenter phase Ⅱ trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer

引用

World Journal of Gastrointestinal Oncology 2018年第12期10卷 505-515页

作者： Moon Jae Chung Huapyong Kang Ho Gak Kim Jong Jin Hyun Jun Kyu lee Kwang Hyuck lee myung hwan Noh Dae hwan Kang Sang Hyub lee Seungmin Bang 无 Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Department of Internal Medicine Daegu Catholic University School of Medicine Daegu 42471 South Korea Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine Ansan 15355 South Korea Department of Internal Medicine Dongguk University Ilsan Hospital Dongguk University College of Medicine Goyang 10326 South Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 06351 South Korea Department of Internal Medicine Dong-A University College of Medicine Busan 49201 South Korea Department of Internal Medicine Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 South Korea Departments of Internal Medicine and Liver Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 03080 South Korea Pancreatobiliary Cancer Study Group of Korean Society of Gastrointestinal Cancer

AIM To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine(GEM)-refractory unresectable pancreatic cancer(PC).METHODS This study was a prospective, multicenter, one-arm, open-label, phase Ⅱ trial. Patients with unresectable PC, who showed disease progression during GEMbased chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin(RIO; irinotecan 120 mg/m^2 and oxaliplatin 60 mg/m^2), which was set according to the phase Ⅰ study of FOLFIRINOX. The objective response rate(ORR), disease control rate(DCR), progressionfree survival(PFS), overall survival(OS), adverse events were evaluated. Additionally, changes in quality of life(QoL) were assessed using a questionnaire on *** Between August 2015 and May 2016, a total of 48 patients were enrolled. The median follow-up time was 259 d with a median of 8.5 cycles. The ORR and DCR were 18.8% and 62.5%, respectively, including one patient who showed complete remission. The median PFS was 5.8 mo [95% confidence interval(CI): 3.7-7.9] and median OS was 9.0 mo(95%CI: 6.4-11.6). Neutropenia(64.6%) was the most common grade 3-4 adverse event, followed by febrile neutropenia(16.7%). Although 14.6% of patients experienced grade 3 fatigue, most non-hematologic AEs were under grade 2. In the QoL analysis, the global health status score before treatment was not different from the score at the last visit after treatment(45.43 ± 22.88 vs 48.66 ± 24.14, P = 0.548).CONCLUSION FOLFIRINOX with RIO showed acceptable toxicity and promising efficacy for GEM-refractory unresectable PC. However, this treatment requires careful observation of treatment-related hematologic toxicities.

关键词： Pancreatic cancer FOLFIRINOX Clinical Trial, Phase Ⅱ Chemotherapy Gemcitabine refractory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Obesity and novel management of inflammatory bowel disease

引用

World Journal of Gastroenterology 2023年第12期29卷 1779-1794页

作者： Jee Hyun Kim Chang-myung Oh Jun hwan Yoo Department of Gastroenterology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13496South Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangju 62465South Korea Institute of Basic Medical Sciences CHA University School of MedicineSeongnam 13496South Korea

Obesity is prevalent within the inflammatory bowel disease(IBD)population,particularly in newly developed *** epidemiological studies have suggested that 15%-40%of IBD patients are obese,and there is a potential role of obesity in the pathogenesis of *** dysfunction of mesenteric fat worsens the inflammatory course of Crohn’s disease and may induce formation of strictures or ***,obesity may affect the disease course or treatment response of *** the increasing data supporting the pathophysiologic and epidemiologic relationship between obesity and IBD,obesity control is being suggested as a novel management for ***,this review aimed to describe the influence of obesity on the outcomes of IBD treatment and to present the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.

关键词： Obesity Inflammatory bowel disease Crohn’s disease Ulcerative colitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：