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Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19:a systematic review

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Global Health Research and Policy 2022年第1期7卷 90-100页

作者： Joseph Christian Obnial mystie suzuki Catherine Joy Escuadra Janine Trixia Austria Ma.Jamaica Monique Ponce Elaine Cunanan Faculty of Medicine and Surgery University of Santo TomasManilaPhilip-pines College of Rehabilitation Sciences University of Santo TomasManilaPhilippines Department of Education Graduate SchoolEwha Womans UniversitySeoulRepublic of Korea University of Santo Tomas Hospital ManilaPhilippines

Background:COVID-19 vaccination has been advocated as the most effective way to curb the *** with its inequitable distribution and slow rollout,especially in low-to middle-income countries,it will still take a long time before herd immunity is *** measures must therefore be explored to bolster current COVID-19 vaccination *** particular,the Bacille Calmette-Guerin vaccine has been studied extensively as to its proposed conferment of non-specific immunity against different infections,including *** aim of this study,therefore,is to evaluate the current evidence on the effectiveness of national BCG vaccination policies in reducing infection and mortality of ***:A systematic review was conducted between April to August 2021 following the Preferred Reporting Items for Systematic Reviews and Meta-analysis(PRISMA-P)*** was retrieved from PubMed,Cochrane,HERDIN,Web of Science,EBSCO,and Western Pacific Region Index Medicus(WPRIM).Studies conducted from January 2020 to August 2021 that fell within Level 1A to 2C of the Oxford Center for Evidence-Based Medicine were included in the *** assessment was performed using the appropriate Joanna Briggs Institute critical appraisal tool and a quality assessment checklist for ecological studies adapted from Betran et ***:A total of 13 studies were included in this *** studies reported significant association between BCG vaccination policies and COVID-19 outcomes,even when controlling for confounding *** addition,among other mandated vaccines,such as pneumococcal,influenza,diphtheria-tetanus-pertussis,and measles,only BCG vaccination showed significant association with decreased COVID-19 adverse ***,other factors also showed positive association with COVID-19 outcomes,particularly markers of high economic status of countries,higher median age,and greater population ***:The lower incidence and mortalit

关键词： COVID-19 BCG Vaccination policy Systematic review

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