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Recurrent giant hemangiomas of liver:Report of two rare cases with literature review

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World Journal of Gastrointestinal Surgery 2012年第11期4卷 262-266页

作者： Hongfa Zhu Khaled Obeidat Jie Ouyang Sasan Roayaie myron e schwartz Swan N Thung The Lillian and Henry M Stratton-Hans Popper Department of Pathology Mount Sinai Medical CenterNew YorkNY 10029United States Division of Surgical Oncology Department of SurgeryThe Mount Sinai Medical CenterNew YorkNY 10029United States

Most hepatic hemangiomas(HHs) are small,asymptomatic and do not require clinical *** resection is only indicated for symptomatic *** report here cases of recurrent HHs in 2 women of 37 and 40 years old,who initially presented with abdominal pain and *** examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter,*** liver segmental resections were performed in both,and the diagnosis of cavernous hemangioma was *** patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial *** the first patient,a 15 cm recurrent hemangioma was resected,but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe,which was not amendable for *** the second patient,a 16 cm hemangioma was seen on radiogram,and because the lesion was not symptomatic,conservative observation was *** after liver resection of giant hemangioma is extremely *** pathogenesis of tumor progression and recurrence is unknown,as is the management of these patients with recurrent hemangioma,particularly when it is extensive and unresectable.

关键词： Liver Giant hemangioma Recurrent hemangioma

Incidence and consequences of varicella in children treated for cancer in Guatemala

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World Journal of Pediatrics 2016年第3期12卷 320-326页

作者： Amy e.Caruso Brown edwin J.Asturias Mario Melgar Federico A.Antillon-Klussmann Pamela Mettler myron J.Levin Center for Bioethics and Humanities and Department of Pediatrics SUNY Upstate Medical University Center for Global Health and Department of epidemiology Colorado School of Public HealthAuroraColoradoUSA National Unit of Pediatric Oncology Guatemala CityGuatemala Department of Biostatistics and Informatics Colorado Biostatistics ConsortiumColorado School of Public HealthAuroraColoradoUSA Section of Pediatric Infectious Diseases Department of PediatricsUniversity of Colorado Denver Anschutz Medical CampusAuroraColoradoUSA

Background:Varicella-zoster virus infection is associated with significant morbidity and mortality in immune-compromised children,despite treatment with antiviral *** varicella vaccine programs have significantly decreased this risk in many highincome countries,but in most low-income and middleincome countries,the burden of varicella in children treated for malignancy is poorly defi ***:We retrospectively reviewed records of children at the National Unit of Pediatric Oncology(UNOP)in Guatemala diagnosed with varicella between January 2009 and March 2013 in order to calculate incidence of varicella and evaluate morbidity,mortality,treatment interruption,and ***:Fifty-nine cases of varicella were *** was 23.4 cases per 1000 person-years(p-y).66.1%of cases occurred in children with leukemia(median age 5.2 years;interquantile range 3.4-7 years)and 41.0%of these occurred during maintenance *** of exposure was identified for 14/59(23.7%)*** were hospitalized(71.2%)and given intravenous acyclovir(64.4%).eight(13.6%)children required critical care,and two(3.4%)died from disseminated varicella with multiorgan *** was delayed or omitted due to varicella in 50%.No signifi cant differences in outcomes based on nutritional and immunologic status were *** minimum average cost of treatment per episode was 598.75 ***:Varicella is a significant problem in children treated for cancer in Guatemala,where effective post-exposure prophylaxis is *** the absence of universal varicella vaccination,strategies to improve recognition of exposure and the future use of novel inactivated vaccines currently under investigation in clinical trials could mitigate this burden.

关键词： cancer developing countries immunocompromised host oncology varicella

Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第41期12卷 6620-6626页

作者： myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey The Liver Center Huntington Medical Research InstitutesPasadenaCaliforniaUnited States The Pfleger Liver InstituteDavid Geffen Schoolof Medicine at the University of California in Los AngelesCaliforniaUnited States Intermune Inc.BrisbaneCaliforniaUnited States The Hepatitis Research Center National TaiwanUniversity HospitalTaipeiTaiwanChina The Liver Center Huntington Medical Research InstitutesPasadenaCaliforniaUnited States

AIM： To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma. MeTHODS： The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA （HBV DNA） level and hepatitis B e antigen （HBeAg） were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. ReSULTS： During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio： 95.74 （12.13-891.31）, P 〈 0.0001], male sex [odds ratio： 7.61 （2.20-47.95）; P = 0.006], and higher Iogzo HBV DNA [odds ratio： 4.69 （1.16-20.43）; P 〈 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio： 26.51 （2.36-381.47）; P = 0.007], presence of precore mutants [odds ratio： 4.23 （1.53-19.58）, P = 0.02] and presence of basal core promoter mutants [odds ratio： 2.93 （1.24-7.57）; P = 0.02] were independent predictors for progression to hepatocellular carcinoma. CONCLUSION： Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma.

关键词： Basal core promoter mutants Precore mutants Hepatitis B viral genotypes Hepatitis B viral DNA Hepatitis B e antigen Liver failure Hepatocellular carcinoma

Metal intercalation-induced selective adatom mass transport on graphene

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Nano Research 2016年第5期9卷 1434-1441页

作者： Xiaojie Liu Cai-Zhuang Wang myron Hupalo Hai-Qing Lin Kai-Ming Ho Patricia A. Thiel Michael C. Tringides Center for Quantum Science and School of Physics Northeast Normal University Changchun 730777 China Ames Laboratory-U.S. Department of energy and Department of Physics and Astronomy Iowa State University Ames IA 50011 USA Beijing Computational Science Research Center Beijing 100084 China Ames Laboratory-U.S. Department of energy Department of Chemistry and Department of Materials Science and Engineering Iowa State University Ames IA 50011 USA

Recent experiments indicate that metal intercalation is a very effective method to manipulate the graphene-adatom interaction and control metal nanostructure formation on graphene. A key question is mass transport, i.e., how atoms deposited uniformly on graphene populate different areas depending on the local intercalation. Using first-principles calculations, we show that partially intercalated graphene, with a mixture of intercalated and pristine areas, can induce an alternating electric field because of the spatial variations in electron doping, and thus, an oscillatory electrostatic potential. This alternating field can change normal stochastic adatom diffusion to biased diffusion, leading to selective mass transport and consequent nucleation, on either the intercalated or pristine areas, depending on the charge state of the adatoms.

关键词： graphene intercalation electrostatic potential selective adsorption first-principle calculation

Assessing the impact of natural enemies in agroecosystems： toward ＂real＂ IPM or in quest of the Holy Grail？

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Insect Science 2015年第1期22卷 1-5页

作者： myron P. Zalucki Michael J. Furlong Nancy A. Schellhorn Sarina Macfadyen Andrew P. Davies School of Biological Sciences The University of Queensland Brisbane QLD 4072 Australia CSIRO Ecosystem Sciences and Sustain-able Agriculture Flagship Brisbane QLD 4001 Australia CSIRO Ecosystem Sciences and Sustainable Agriculture Flagship CanberraACT 2601 Australia CSIRO Australian Cotton Research Institute (ACRI) Narrabri NSW 2390 Australia Saunders Havill Group Bowen HillsBrisbane QLD 4006 Australia.

Go to virtually any conference or symposium on insect pests and so called ＂Integrated Pest Management,＂ or IPM, is presented as the answer to all management problems. IPM is the textbook paradigm （e.g., Kogan, 1998; Pedigo, 2002; Pedigo ＆ Rice, 2009） that guides all aspects of insect pest management research and implementation （Zalucki et al., 2009）. In most cases the way IPM is put in to practice, as opposed to the textbook jargon could, somewhat cynically, be regarded as ＂incidental＂ to pesticide management. How did it come to this？

关键词： IPM 农业生态系统有害生物综合治理天敌评估管理问题综合防治农药管理

Gastric cancer with peritoneal metastases: efficiency of standard treatment methods

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 569-581页

作者： Roman Yarema МyronОhorchak Petro Hyrya Yuriy Kovalchuk Victor Safiyan Ivan Karelin Severyn Ferneza Markiyan Fetsych myron Matusyak Yuriy Oliynyk Тaras Fetsych Department of oncology and Radiology Danylo Halytsky Lviv National Medical UniversityLviv 79010Ukrain Department of Abdominal Surgery Lviv Oncological Regional Treatment and Diagnostic CenterLviv 79000Ukraine

BACKGROUND Peritoneal metastasis(PM),arising from gastric cancer(GC),is the most common pattern of synchronous and metachronous dissemination and is generally associated with poor *** therapeutic modalities are being increasingly employed for such *** To develop more advanced methods,it becomes necessary to study the results of existing standard treatment methods in patients with PM in order to perform a comparative analysis of the *** A retrospective analysis of the efficiency of standard treatment methods(i.e.,palliative chemotherapy,palliative gastrectomy,and the best supportive care)was performed on 200 GC patients with synchronous *** The overall survival(OS)rate in 200 GC patients with PM under standard treatment was 5.4 ***-year survival occurred in 18.4%of *** multivariate analysis,the survival rate was significantly influenced by the following factors:Presence of extraperitoneal metastases,and stage of PM according to both the Japanese Gastric Cancer Association(JGCA)and the peritoneal cancer index(PCI).The median OS and 1-year survival of patients withР1,P2,and P3(JGCA)carcinomatosis were 9.8 mo,6.7 mo,and 4.0 mo,and 47.2%,18.8%,and 5.1%,*** application of the palliative gastrectomy resulted in an increase in the median OS by up to 17 mo compared to the conservative approach where the value was 8.5 mo(P=0.05)in patients withР1РМ.In patients withР3,palliative chemotherapy increased the OS by up to 5.6 mo compared to the OS of 3.2 mo(P=0.0006)for best supportive *** median OS and 1-year survival of patients withРCI of 1-6,7-12 and 13+points were 8.5 mo,4.2 mo,and 4.1 mo,and 39.8%,6.7%,and 5.5%,*** gastrectomy increased the median OS to 12.6 mo compared to conservative approach of 8.0 mo(P=0.03)in patients withРCI of 1-6 *** patients withРCI 13+points,only palliative chemotherapy increased the OS to 6.0 mo compared to the OS of 3.4 mo for best supportive care(P=0.0

关键词： Gastric cancer Peritoneal metastases Palliative treatment methods Peritoneal cancer index

The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William e.Snyder Angharad M.R.Gatehouse myron P.Zalucki Bruce e.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of entomology and Wildlife ecology University of DelawareNewark 19716USA Department of entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the environment University of QueenslandBrisbane 4072Australia Shandong engineering Research Center for environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of entomology University of ArizonaTucson 85721USA National Center of excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

伤寒减毒TY21a株口服活菌苗智利现场效果观察

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微生物学免疫学进展 1986年第1期 64-67页

作者： myron M Levine ,Robert e Black ,周长全

伤寒病现在仍然是世界上不发达地区的一个重要公共卫生问题,也对来访的发达国家旅游者造成威胁。实际上所有地区的伤寒病,发病率最高是在5—19年龄间的在校儿童。由于学龄儿童是一个容易掌握的人群,根据学校的免疫规划,控制疾病也就有... 详细信息

伤寒病现在仍然是世界上不发达地区的一个重要公共卫生问题,也对来访的发达国家旅游者造成威胁。实际上所有地区的伤寒病,发病率最高是在5—19年龄间的在校儿童。由于学龄儿童是一个容易掌握的人群,根据学校的免疫规划,控制疾病也就有了可能。直到目前,预防伤寒的标准制品是用于

关键词：活菌苗肠衣剂量用药量 TY21a 伤寒沙门氏杆菌病智利效果观察

Pro-Inflammatory Substances and Cognition in the Dallas Heart Study

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Open Journal of Psychiatry 2016年第1期6卷 95-101页

作者： Keith A. Bernardo Heidi C. Rossetti myron F. Weiner Colin Munro Cullum James De Lemos Laura H. Lacritz Department of Psychiatry University of Texas Southwestern Medical Center Dallas TX USA Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX USA Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA

Cognitive decline in late adulthood might be partially mediated by subclinical generalized vascular disease. If so, atherogenic factors such as pro-inflammatory cytokines might be mid-life targets for prevention or treatment. Dallas Heart Study subjects (n = 997;mean age = 42.94 ± 10.2 yrs) underwent blood assays of pro-inflammatory biomarkers associated with atherosclerosis and 8 years later completed a cognitive outcome measure, the Montreal Cognitive Assessment (MoCA). Markers included C-reactive protein (CRP), Interleukin-18 (IL-18), Lipoprotein-associated phospholipase (LP-PLA2), and Monocyte Chemoattractant Protein (MCP-1), with Apolipoprotein e4 (Apoe4) as a potential modifier. We found weak evidence for LP-PLA2 and CRP as predictors of cognitive scores. No relationship was found between elevated MCP-1, IL-18 and cognition. Presence of the Apoe4 allele did not impact the relationship between biomarkers and cognitive function. Levels of atherogenesis-related pro-inflammatory blood biomarkers did not predict cognitive function in middle-aged adults after an interval of 8 years.

关键词： Montreal Cognitive Assessment Cognition Inflammation Dallas Heart Study