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Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies

Chinese Journal of Integrative Medicine 2022年第3期28卷 263-271页

作者： Chan-Young kwon Hyo-Weon Suh Jong Woo Kim Sun-Yong Chung Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan(47227)Republic of Korea Department of Neuropsychiatry Kyung Hee University KoreanMedicine Hospital at Gangdong892 Dongnam-roGangdong-guSeoul(05278)Republic of Korea

Objective:To analyze the available data on the anti-anger effects of herbal medicines(HMs)as well as their underlying mechanisms in rat ***:From 6 electronic databases[PubMed,EMBASE,China National Knowledge Infrastructure(CNKI),Wanfang,Oriental Medicine Advanced Searching Integrated System(OASIS),and Research Information Sharing Service(RISS)],relevant animal experiments were searched by using"anger,""rats,"and"animal"as search *** last search was conducted on November 22,2019,and all experiments involving rat models of anger and treatment using HMs published until the date of the search were ***:A total of 24 studies with 16 kinds of HMs were *** studies have used the tail irritating method and"social isolation and resident intruder"method to establish anger *** to the included studies,the therapeutic mechanisms of HMs for anger regulation and important herbs by their frequency and/or preclinical evidence mainly incladed regulation of hemorheology(Bupleuri Radix,Paeoniae Radix Alba,and Glycyrrhizae Radix),regulation of sex hormones(Bupleuri Radix,Cyperi Rhizoma,and Paeoniae Radix Alba),regulation of neurotransmitters(Cyperi Rhizoma),regulation of anger-related genes(Bupleuri Radix,Glycyrrhizae Radix,and Paeoniae Radix Alba),and other ***,Liver(Gan)qi-smoothing herbs including Bupleuri Radix and Cyperi Rhizoma were the most frequently ***:This review found the frequent methods to establish an anger model,and major mechanisms of anti-anger effects of ***,some Liver qi-smoothing herbs have been frequently used to investigate the anti-anger effects of *** findings provide insight into the role and relevance of HMs in the field of anger management.

关键词： anger anger management therapy herbal medicine Korean traditional medicine

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Minimum dose path planning for facility inspection based on the discrete Rao-combined ABC algorithm in radioactive environments with obstacles

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Nuclear Science and Techniques 2023年第4期34卷 26-40页

作者： kwon Ryong Hong Su Il O Ryon Hui Kim Tae Song Kim Jang Su Kim Faculty of Energy Science Kim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea High-Tech Research&Development Centre Institute of Information TechnologyKim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea

Workers who conduct regular facility inspections in radioactive environments will inevitably be affected by ***,it is important to optimize the inspection path to ensure that workers are exposed to the least amount of *** study proposes a discrete Rao-combined artificial bee colony(ABC)algorithm for planning inspection paths with minimum exposure doses in radioactive environments with *** this algorithm,retaining the framework of the traditional ABC algorithm,we applied the directional solution update rules of Rao algorithms at the employed bee stage and onlooker bee stage to increase the exploitation ability of the algorithm and implement discretion using the swap operator and swap *** increase the randomness of solution generation,the chaos algorithm was used at the initialization *** K-opt operation technique was introduced at the scout bee stage to increase the exploration ability of the *** path planning in an environment with complex structural obstacles,an obstacle detour technique using a recursive algorithm was *** evaluate the performance of the proposed algorithm,we performed experimental simulations in three hypothetical environments and compared the results with those of improved particle swarm optimization,chaos particle swarm optimization,improved ant colony optimization,and discrete Rao’s *** experimental results show the high performance of the proposed discrete Rao-combined ABC algorithm and its obstacle detour capability.

关键词： Minimum dose Path planning Nuclear facility inspection ABC algorithm Rao algorithms Swap sequence K-opt operation

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Deep learning for exploring ultra-thin ferroelectrics with highly improved sensitivity of piezoresponse force microscopy

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npj Computational Materials 2023年第1期9卷 2066-2073页

作者： Panithan Sriboriboon Huimin Qiao Owoong kwon Rama K.Vasudevan Stephen Jesse Yunseok Kim School of Advanced Materials and Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Research Center for Advanced Materials Technology Core Research InstituteSuwonRepublic of Korea Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTNUSA

Hafnium oxide-based ferroelectrics have been extensively studied because of their existing ferroelectricity,even in ultra-thin film ***,studying the weak response from ultra-thin film requires improved measurement *** general,resonance-enhanced piezoresponse force microscopy(PFM)has been used to characterize ferroelectricity by fitting a simple harmonic oscillation model with the resonance ***,an iterative approach,such as traditional least squares(LS)fitting,is sensitive to noise and can result in the misunderstanding of weak *** this study,we developed the deep neural network(DNN)hybrid with deep denoising autoencoder(DDA)and principal component analysis(PCA)to extract resonance *** DDA/PCA-DNN improves the PFM sensitivity down to 0.3 pm,allowing measurement of weak piezoresponse with low excitation voltage in 10-nm-thick Hf_(0.5)Zr_(0.5)O_(2) thin *** hybrid approaches could provide more chances to explore the low piezoresponse of the ultra-thin ferroelectrics and could be applied to other microscopic techniques.

关键词： spectrum ferroelectric excitation

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Precise photoelectrochemical tuning of semiconductor microdisk lasers

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Advanced Photonics 2023年第5期5卷 68-76页

作者： Debarghya Sarkar Paul HDannenberg Nicola Martino kwon-Hyeon Kim Yue Wu Seok-Hyun Yun Harvard Medical School BostonMassachusettsUnited States Massachusetts General Hospital Wellman Center for PhotomedicineBostonMassachusettsUnited States Massachusetts Institute of Technology Harvard-MIT Health Sciences and TechnologyCambridgeMassachusettsUnited States

Micro-and nanodisk lasers have emerged as promising optical sources and probes for on-chip and free-space ***,the randomness in disk diameter introduced by standard nanofabrication makes it challenging to obtain deterministic *** address this,we developed a photoelectrochemical(PEC)etching-based technique that enables us to precisely tune the lasing wavelength with subnanometer *** examined the PEC mechanism and compound semiconductor etching rate in diluted sulfuric acid *** this technique,we produced microlasers on a chip and isolated particles with distinct lasing *** precisely tuned disk lasers were then used to tag cells in *** results demonstrate that this scalable technique can be used to produce groups of lasers with precise emission wavelengths for various nanophotonic and biomedical applications.

关键词： microdisk lasers semiconductor precision lasing photoelectrochemical etching laser particle nanophotonics

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Traumatic pancreatic ductal injury treated by endoscopic stenting in a 9-year-old boy:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3885-3890页

作者： Hyung Jun kwon Min Kyu Jung Jinyoung Park Department of Surgery School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Traumatic pancreatic injury is relatively rare in children,accounting for approximately 3%-12%of blunt abdominal trauma *** traumatic pancreatic injuries in boys are related to bicycle *** pancreatic injuries often result in delayed presentation and treatment,leading to high morbidity and *** management of children with traumatic main pancreatic duct injuries is still under *** SUMMARY We report the case of a 9-year-old boy who was presented at our institution with epigastric pain after being stuck with his bicycle handlebar at the upper abdomen and then treated with endoscopic stenting because of a pancreatic ductal *** We believe that endoscopic stenting of pancreatic ductal injuries may be a feasible technique in certain cases of children with traumatic pancreatic duct injuries to avoid unnecessary operations.

关键词： Pancreatic injury Trauma Endoscopic pancreatic stent Pediatrics Case report

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Evaluation of immobilizing agents as soil quality conditioners in addition to their metal(loid) immobilizing effect

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Pedosphere 2022年第2期32卷 307-316页

作者： Chaw Su LWIN Mina LEE Young-Nam KIM Gary OWENS kwon-Rae KIM Department of Soil and Water Science Yezin Agricultural UniversityYezinNaypyitaw 15013Myanmar Department of Smart-Agro Industry Gyeongsang National UniversityJinju 52725Korea Institute of Agriculture and Life Science(IALS) Gyeongsang National UniversityJinju 52828Korea Environmental Contaminants Group Future Industries InstituteUniversity of South AustralianMawson Lakes SA 5095Australia

In trace metal (TM)-contaminated agricultural soils,management of TM availability is important for safe crop *** addition,maintenance or improvement of soil quality is vital for sustainable crop *** TM phytoavailability and increased soil quality can be achieved by the application of various immobilizing agents to soil,which can supply both macronutrients and organic *** study investigated the long-term influences of four common immobilizing agents on soil biogeochemical properties and the phytoavailability of TMs in mixed metal-contaminated soil from a cultivated upland near an abandoned mining *** (L),gypsum (G),fly ash (F),and animal manure-based compost (C) were applied to pots containing contaminated soil,either individually or in *** incubation for three years under sequential cultivation of two crops and fallow,soil biogeochemical properties were determined,and Brassica rapa plant bioassay was *** phytoavailability of all TMs (both cationic metals and anionic metalloids) remained significantly lower in soils treated with immobilizing agents even after three years,when compared with the no-agent control (CK) *** addition,the soil quality was significantly improved by treatment with immobilizing *** instance,the C and L+C treatments were the most effective in improving soil physical (bulk density,porosity,and water-resistant aggregate stability),chemical (pH,organic matter,total nitrogen,cation exchange capacity,and plant-available phosphorus,magnesium,and potassium),and biological (microbial biomass carbon and dehydrogenase activity) *** improvement of soil properties and lowering of TM bioavailability were also consistent with the most significant increase in *** biomass production observed in the C treatment,followed by the L+C,G+F,L,G,F,and L+G treatments,as compared with that in *** results indicate that the function of the TM-immobilizing agent as a soil qualit

关键词： crop production metal bioavailability metal immobilization metal phytoavailability soil amendments soil biogeochemical properties soil remediation trace metals

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Absorption-Dominant mmWave EMI Shielding Films with Ultralow Reflection using Ferromagnetic Resonance Frequency Tunable M-Type Ferrites

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Nano-Micro Letters 2023年第6期15卷 1-23页

作者： Horim Lee Seung Han Ryu Suk Jin kwon Jae Ryung Choi Sang‑bok Lee Byeongjin Park Composites Research Division Korea Institute of Materials Science797 ChangwondaeroSeongsan‑GuChangwonGyeongsangnam‑Do 51508Republic of Korea

Although there is a high demand for absorption-dominant electromagnetic interference(EMI) shielding materials for 5G millimeter-wave(mmWave) frequencies, most current shielding materials are based on reflection-dominant conductive materials. While there are few absorption-dominant shielding materials proposed with magnetic materials, their working frequencies are usually limited to under 30 GHz. In this study, a novel multi-band absorption-dominant EMI shielding film with M-type strontium ferrites and a conductive grid is proposed. This film shows ultralow EMI reflection of less than 5% in multiple mmWave frequency bands with sub-millimeter thicknesses, while shielding more than 99.9% of EMI. The ultralow reflection frequency bands are controllable by tuning the ferromagnetic resonance frequency of M-type strontium ferrites and composite layer geometries. Two examples of shielding films with ultralow reflection frequencies, one for 39 and 52 GHz 5G telecommunication bands and the other for 60 and 77 GHz autonomous radar bands, are presented. The remarkably low reflectance and thinness of the proposed films provide an important advancement toward the commercialization of EMI shielding materials for 5G mmWave applications.

关键词： 5G communication MmWave EMI shielding M-type ferrites

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How has the disease course of pediatric ulcerative colitis changed throughout the biologics era?A comparison with the IBSEN study

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World Journal of Gastroenterology 2022年第28期28卷 3666-3681页

作者： Yiyoung kwon Eun Sil Kim Yon Ho Choe Mi Jin Kim Department of Pediatrics Samsung Medical CenterSeoul 06351South Korea Department of Pediatrics Kangbuk Samsung Medical CenterSeoul 03181South Korea

BACKGROUND In Korea,infliximab was approved for use in children with ulcerative colitis(UC)in October *** To compare the clinical course of UC before and after the introduction of biological agents,and to compare with the IBSEN *** Patients under 18 years of age,who were diagnosed with UC and followed from January 2003 to October 2020,were included in the *** A(n=48)was followed for at least 2 years between January 2003 and October 2012,and Group B(n=62)was followed for at least 2 years between November 2012 and October *** compared endoscopic remission,drug composition,relapse rate,steroidfree period,and the quality of life of each *** plotted the clinical course of the included patients using the pediatric UC activity index score,and compared our patients with those in the IBSEN *** After 2 years of treatment,colonoscopy evaluation revealed different outcomes in the two treatment *** was confirmed in 14 patients(29.2%)of Group A,and in 31 patients(50.0%)of Group B(P<0.012).The median cumulative corticosteroid-free period was 3.0 years in Group A and 4.4 years in Group ***-free period of Group B was significantly longer than that of Group A(P<0.001).There was a statistically significant difference between the two groups in evaluation of the relapse rate during the observation period(P<0.001).The plotted clinical course graphs of Group A showed similar proportions to the graphs in the IBSEN ***,in Group B,the proportion of patients corresponding to curve 1(remission or mild severity after initial high activity)was high at 76%(47/62).CONCLUSION The incidence of relapse has decreased and the steroid-free period has increased after the introduction of the biological *** clinical course also showed a different pattern from that of IBSEN *** active use of biological agents may change the long-term disease course in moderate to severe pediatric UC.

关键词： Colitis Ulcerative Children Infliximab Relapse Steroid

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Energy-Efficient Clustering Using Optimization with Locust Game Theory

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Intelligent Automation & Soft Computing 2023年第6期36卷 2591-2605页

作者： P.Kavitha Rani Hee-kwon Chae Yunyoung Nam Mohamed Abouhawwash Department of Computer Science and Engineering Sri Krishna College of Engineering and TechnologyCoimbatore641008India Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Wireless sensor networks(WSNs)are made up of several sensors located in a specific area and powered by a finite amount of energy to gather environmental *** use sensor nodes(SNs)to collect and transmit ***,the power supplied by the sensor network is ***,SNs must store energy as often as to extend the lifespan of the *** the proposed study,effective clustering and longer network lifetimes are achieved using mul-ti-swarm optimization(MSO)and game theory based on locust search(LS-II).In this research,MSO is used to improve the optimum routing,while the LS-II approach is employed to specify the number of cluster heads(CHs)and select the best *** the CHs are identified,the other sensor components are allo-cated to the closest CHs to them.A game theory-based energy-efficient clustering approach is applied to *** each SN is considered a player in the *** SN can implement beneficial methods for itself depending on the length of the idle listening time in the active phase and then determine to choose whether or not to *** proposed multi-swarm with energy-efficient game theory on locust search(MSGE-LS)efficiently selects CHs,minimizes energy consumption,and improves the lifetime of *** findings of this study indicate that the proposed MSGE-LS is an effective method because its result proves that it increases the number of clusters,average energy consumption,lifespan extension,reduction in average packet loss,and end-to-end delay.

关键词： Wireless sensor network clustering routing cluster head energy consumption network’s lifetime multi swarm optimization game theory

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The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 526-530页

作者： Ryong Kong ok-Hwa Kang Yun-Soo Seo Su-Hyun Mun Tian Zhou Dong-Won Shin Dong-Yeul kwon BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University Department of Oriental Pharmacy College of Pharmacy Wonkwang Oriental Medicines Research Institute Institute of Biotechnology Wonkwang University Department of Oriental Medicine Resources College of Bio Industry Science Sunchon National University

Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam ***:To measure antibacterial activity,we performed a minimum inhibitory concentration(MIC) and synergy *** electron microscopy(TEM) was used in morphological *** analyze gene expression,we conducted reverse transcriptase polymerase chain reaction(PCR).Results:We confirmed a synergy effect between CPZ and β-lactam ***,we observed that CPZ affect the cell envelope of MRS A by using *** the gene level,CPZ reduced the expression of resistance ***:Through this result,we hypothesize that a decrease of resistance factor expressions was caused by CPZ because it disrupts the activity of a sensor protein located in the cell membrane.

关键词： Chlorpromazine PBP2a β-lactamase mecA blaZ MRSA

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