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Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acid

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International Journal of Oral Science 2014年第3期6卷 150-153页

作者： Jin Man Kim Sang Wook Kang Su-Mi shin Duck Su Kim Kyong-Kyu Choi Eun-cheol Kim Sun-Young Kim Department of Conservative Dentistry School of Dentistry Kyung Hee University Department of Maxillofacial Tissue Regeneration School of Dentistry Kyung Hee University

All-trans retinoic acid（ATRA） inhibits matrix metalloproteinase（MMP）-2 and MMP-9 in synovial fibroblasts, skin fibroblasts,bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pulp cells（HDPCs）. The purpose of this study was to determine the effects of ATRA on the production and secretion of MMP-2 and-9 in HDPCs. The productions and messenger RNA（mRNA） expressions of MMP-2 and-9 were accessed by gelatin zymography and real-time polymerase chain reaction（PCR）, respectively. ATRA was found to decrease MMP-2 level in a dose-dependent manner. Significant reduction in MMP-2 mRNA expression was also observed in HDPCs treated with 25 mmol？L21ATRA. However, HDPCs treated with ATRA had no effect on the pattern of MMP-9 produced or secreted in either cell extracts or conditioned medium fractions. Taken together, ATRA had an inhibitory effect on MMP-2 expression in HDPCs,which suggests that ATRA could be a candidate as a medicament which could control the inflammation of pulp tissue in vital pulp therapy and regenerative endodontics.

关键词： all-trans retinoic acid human dental pulp cell matrix metalloproteinase zymography

Cecal duplication cyst in an infant presenting as shock:A case report

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世界临床病例杂志 2023年第28期11卷 6931-6937页

作者： Seung Mo Kim Sun Hyang Lee Ga Young Park Sung shin Kim cheol Gu Lee Soo Ji Jin Department of Pediatrics Soonchunhyang University Bucheon HospitalSoochunhyang University College of MedicineBucheon 14584Gyeonggi-doSouth Korea Department of General Surgery Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea

BACKGROUND Although intestinal obstruction is one of the most common surgical emergencies in an infant,it is difficult to diagnose neonatal enteric duplication cysts(EDC)preoperatively owing to their rarity as a cause of intestinal *** describe a case report of a neonatal EDC presenting intestinal obstruction and *** SUMMARY A 32-d-old male infant with a prenatal sonographic finding of bladder distension was admitted to our hospital for a severely distended abdomen,fever,and *** first diagnostic hypothesis was septic shock and intestinal *** patient’s symptoms worsened;following an emergency surgical exploratory laparotomy and histopathological findings,the final diagnosis of cecal duplication cyst was *** patient’s postoperative course was uneventful,and on the fifth postoperative day,oral feeding *** days later,the patient was discharged from the *** Although EDC located in the cecum is exceptional,it should be considered when evaluating suspected intestinal obstruction and shock.

关键词： Duplication cyst Cecum Intestinal obstruction Infant Shock Case report

Malicious Node Detection Using Confidence Level Evaluation in a Grid-Based Wireless Sensor Network

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Wireless Sensor Network 2013年第3期5卷 52-60页

作者： Min-cheol shin Yoon-Hwa Choi Department of Computer Engineering Hongik University Seoul Korea

In this paper, we present a malicious node detection scheme using confidence-level evaluation in a grid-based wireless sensor network. The sensor field is divided into square grids, where sensor nodes in each grid form a cluster with a cluster head. Each cluster head maintains the confidence levels of its member nodes based on their readings and reflects them in decision-making. Two thresholds are used to distinguish between false alarms due to malicious nodes and events. In addition, the center of an event region is estimated, if necessary, to enhance the event and malicious node detection accuracy. Experimental results show that the scheme can achieve high malicious node detection accuracy without sacrificing normal sensor nodes.

关键词： Sensor Networks Malicious Node Detection Grid-Based WSN Faults Confidence Levels

T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

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Cellular & Molecular Immunology 2022年第3期19卷 447-448页

作者： Seong Jin Choi Dong-Uk Kim Ji Yun Noh Sangwoo Kim Su-Hyung Park Hye Won Jeong Eui-cheol shin Division of Infectious Disease Department of Internal MedicineSeoul National University HospitalSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)DaejeonRepublic of Korea

In November 2021,the Omicron variant(B.1.1.529)emerged and was designated a variant of concern(VOC)by the World Health ***,Omicron was reported to extensively escape neutralizing antibodies elicited by COVID-19 vaccination or natural infection[1,2,3].However,whether Omicron evades the T cell immunity elicited by COVID-19 vaccination or natural infection remains to be *** address this issue,we analyzed the amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain(Wuhan-Hu-1)in the Omicron variant(hCoV-19/South Africa/CERI-KRISP-K032284/2021).

关键词： neutral conserved elucidated

Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk Yoon cheol Min shin Young Soo Park Nayoung Kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-cheol Son Moon-Jong Han Woo-Jin Kim Soo-Hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-cheol shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

A Web-based machining process monitoring system for E-manufacturing implementation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1467-1473页

作者： shin Bong-cheol KIM Gun-hee CHOI Jin-hwa JEON Byung-cheol LEE Honghee CHO Myeong-woo HAN Jin-yong PARK Dong-sam Division of Mechanical Engineering Inha University Incheon 402-751 Korea Department of Mechanical Engineering University of Incheon Incheon 402-749 Korea

Recently, with the rapid growth of information technology, many studies have been performed to implement Web-based manufacturing system. Such technologies are expected to meet the need of many manufacturing industries who want to adopt E-manufacturing system for the construction of globalization, agility, and digitalization to cope with the rapid changing market requirements. In this research, a real-time Web-based machine tool and machining process monitoring system is developed as the first step for implementing E-manufacturing system. In this system, the current variations of the main spindle and feeding motors are measured using hall sensors. And the relationship between the cutting force and the spindle motor RMS (Root Mean Square) current at various spindle rotational speeds is obtained. Thermocouples are used to measure temperature variations of important heat sources of a machine tool. Also, a rule-based expert system is applied in order to decide the machining process and machine tool are in normal conditions. Finally, the effectiveness of the developed system is verified through a series of experiments.

关键词： E-manufacturing Web-based system Internet Machining process monitoring Expert system

A Web-based on-machine mould matching and measurement system based on CAD/CAM/CAI integration

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1474-1481页

作者： CHOI Jin-hwa JEON Byung-cheol KIM Gun-hee shin Bong-cheol LEE Honghee CHO Myeong-woo SEONG Eun-je PARK Dong-sam Division of Mechanical Engineering Inha University Incheon 402-751 Korea Department of Mechanical Engineering University of Incheon Incheon 402-749 Korea

The purpose of this study is to develop a Web-based on-machine mould identification and measurement system. The Web-based mould identification system matches obtained vision information with CAD database. Developed Web-based system is to exchange messages between a server and a client by making of ActiveX control, and the result of mould identification is shown on Web-browser at remote site. For effective feature classification and extraction, the signature method is used to make meaningful information from obtained image data. For on-machine measurement of the matched mould, inspection database is constructed from CAD database using developed inspection planning methods. The results are simulated and analyzed using developed system to verify the effectiveness of the proposed methods.

关键词： E-manufacturing CAD/CAM/CAI integration On-machine measurement Mould identification Vision system