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Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

World Journal of Gastroenterology 2013年第38期19卷 6453-6457页

作者： Dae Hee Choi Sung Joon Lee Chang Don Kang myoung ok park Dong Wook Choi Tae Suk Kim Wonho Lee Byung Ryul Cho Yong Hoon Kim Bong-ki Lee Dong Ryeol Ryu Ji Won Lee Department of Internal Medicine Kangwon National University School of Medicine Department of Radiology Kangwon National University School of Medicine

AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate ***:Patients who underwent coronary angiography were consecutively *** patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel *** ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,*** measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein ***:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed *** the 46 patients with CAD,37(80.4%)had evidence of a fatty *** two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty *** artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent ***,adiponectin might be related to the pathogenesis of NAFLD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease Coronary angiography Adiponectin Insulin resistance

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo park Jong-Seong Bae Taehyun park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

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Femtosecond laser-mediated anchoring of polymer layers on the surface of a biodegradable metal

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Journal of Magnesium and Alloys 2021年第4期9卷 1380-1388页

作者： Jaeho park Bo-In park Young Ju Son Sun Hee Lee Seung-Hoon Um Yu-Chan Kim myoung-Ryul ok Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon Center for Biomaterials Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Materials science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Mg has received much attention as a next-generation implantable material owing to its biocompatibility,bone-like mechanical properties,and biodegradability in physiological *** application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body ***,we propose femtosecond(fs)laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material,which eventually reduces the corrosion *** of the structural,physical,crystallographic,and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating *** on the fs laser conditions,the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO,resulting in a tightly bonded poly(lactic-co-glycolic acid)(PLGA)*** corrosion rate of the PLGA-coated,fs laser-treated Mg is considerably slow compared with the non-treated Mg;the treated Mg is also more biocompatible compared with the non-treated *** fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg;further,it does not require any chemical treatment,thereby overcoming a potential obstacle for its clinical use.

关键词： Femtosecond laser Biodegradable metal Polymer coating Surface modification Surface adhesion

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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji Hun park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong park Jae Ho Shin myoung-Ryul ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

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Early Cretaceous Tectonism and Diatoms in Korea

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1179-1184页

作者： Ki-Hong CHANG Sun-ok park Department of Geology Kyungpook National UniversityDaeguKorea

The Early Cretaceous Sindong Group, a non-marine molasse, unconformably overlies the folded earliest Cretaceous Myogok Formation. The tectonism that folded the Jaseong Synthem including the Myogok and other formations is here called the Nakdong-Jaeryeonggang （N-J） tectonism. The oknyeobong and Dabokni Formations are discussed to show that they belong to the Jaseong Synthem. The Dabokni Formation yielded fossil diatoms whose age has been referred as the ＂earliest Cretaceous＂ based on the geologically constrained age of the fossil-bearing deposit. The age of the N-J tectonism appears Barremian as it is between the Hauterivian Myogok Formation and the Aptian Sindong Group with the TPN （Trigonioides-Plicatounio-Nippononaia） fauna. The N-J tectonism, an orogeny, quite deformed pre-Aptian strata in Korea, but can hardly find its reported equivalent in NE China. A revised correlation table shows that the Jaseong- Sindong sequence corresponds to the Jehol Group of China. The Sindong-Hayang transition was characterized by basin migration and dextral rotation probably caused by the Tan-Lu fault system in a broad sense.

关键词： Early Cretaceous Late Jurassic Dabokni Formation Jaseoung Synthem Nakdong- Jaeryeonggang tectonism Archaic fresh-water diatoms

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Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor:Application in orthopedic implants

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Bioactive Materials 2023年第7期25卷 796-806页

作者： Jaeho park Seung-Hoon Um Youngmin Seo Jaehong Lee Yu-Chan Kim myoung-Ryul ok Suk-Won Hwang Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792South Korea Department of Materials Science and Engineering Seoul National University(SNU)Seoul08826South Korea Division of Biomedical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841South Korea

During the past decade,there has been extensive research toward the possibility of exploring magnesium and its alloys as biocompatible and biodegradable materials for implantable *** practical medical application,however,has been limited to specific areas owing to rapid corrosion in the initial stage and the consequent *** coatings can significantly reduce the initial corrosion of Mg alloys,and several studies have been carried out to improve the adhesion strength of the coating to the surfaces of the *** composition of hydroxyapatite(HAp)is very similar to that of bone tissue;it is one of the most commonly used coating materials for bone-related implants owing to favorable osseointegration *** this study,HAp was coated on Mg using nanosecond laser coating,combining the advantages of chemical and physical *** heat generated in the liquid precursor by the laser improved the adhesion of the coating through the precipitation and growth of HAp at the localized nanosecond laser focal area and increased the corrosion resistance and cell adhesion of *** physical,crystallographic,and chemical bondings were analyzed to explore the mechanism through which the surface adhesion between Mg and the HAp coating layer *** applicability of the coating to Mg screws used for clinical devices and improvement in its corrosion property were *** liquid environment-based laser surface coating technique offers a simple and quick process that does not require any chemical ligands,and therefore,overcomes a potential obstacle in its clinical use.

关键词： Biodegradable metal HAp coating Nanosecond laser Photothermal synthesis Soret effect(thermophoresis)

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α-Lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2005年第31期11卷 4883-4885页

作者： Sung-Joo park Sang-Wan Seo ok-Sun Choi Cheung-Seog park Department of Pharmacology 1 Hoegi-dong

AIM: α-Lipoic acid (ALA) has been used as an *** aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in ***: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 μg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase,amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced ***: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However,the secretion of IL-1β, IL-6, and TNF-α were comparable in CCK octapeptide-induced acute ***: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.

关键词： α-Upoic add AoJte pancreatitis Proinflammatory cytokines Cholecystokinin

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On the global existence of weak solutions for the Cucker-Smale-Navier-Stokes system with shear thickening

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Science China Mathematics 2018年第11期61卷 2033-2052页

作者： Seung-Yeal Ha Hwa Kil Kim Jae-myoung Kim Jinyeong park Department of Mathematical Sciences and Research Institute of Mathematics Seoul National University Seoul 08826 Republic of Korea Korea Institute for Advanced Study Seoul 02455 Republic of Korea Department of Mathematics Education Hannam University Daejeon 34430 Republic of Korea Department of Mathematical Sciences Seoul National University Seoul 08826 Republic of Korea Department of Mathematics and Research Institute of Natural Sciences Hanyang University Seoul 04763 Republic of Korea

We study the large-time dynamics of Cucker-Smale(C-S)flocking particles interacting with nonNewtonian incompressible *** of particles and fluids were modeled using the kinetic Cucker-Smale equation for particles and non-Newtonian Navier-Stokes system for fluids,respectively and these two systems are coupled via the drag force,which is the main flocking(alignment)mechanism between particles and *** present a global existence theory for weak solutions to the coupled Cucker-Smale-Navier-Stokes system with shear *** also use a Lyapunov functional approach to show that sufficiently regular solutions approach flocking states exponentially fast in time.

关键词： emergence flocking Cucker-Smale model Navier-Stokes equation non-Newtonian fluid

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Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up

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World Journal of Gastroenterology 2004年第2期10卷 223-226页

作者： Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young myoung Moon Jin Kyung Kang In-Suh park Chang ok Suh Woo Ik Yang Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Department of Internal Medicine NHIC Ilsan HospitalIlsanSouth Korea Department of Radiation Oncology Yonsei University College of MedicineSeoulSouth Korea Department of Pathology Yonsei University College of MedicineSeoulSouth Korea

AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed. RESULTS:Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (Hpylori) regimen *** duration to reach complete remission was 12 months (85 percentile,2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases. CONCLUSION:Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloriinfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication.

关键词： Adult Aged Endoscopy, Digestive System Follow-Up Studies Gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Lymphoma, Mucosa-Associated Lymphoid Tissue Middle Aged Pyloric Antrum Remission Induction Retrospective Studies Stomach Ulcer

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Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes

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Nano Research 2020年第5期13卷 1347-1353页

作者： Young-Geun park Eunkyung Cha Hyeon Seok An Kyoung-Pil Lee myoung Hoon Song Hong Kyun Kim Jang-Ung park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Department of Ophthalmology School of MedicineKyungpook National UniversityDaegu41944Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases,such as age-related macular degeneration,because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal ***,the current phototherapeutic devices are opaque,bulky,and tethered forms,so they are not feasible for use in continuous treatment during the patient’s daily ***,we report wireless,wearable phototherapeutic devices with red light-emitting diodes for continuous *** light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact ***,fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not ***,these devices were operated wirelessly with control of the light *** addition,in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices.

关键词： transparent electronics wearable healthcare red light-emitting diodes phototherapies

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