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International Journal of Ophthalmology(English edition) 2013年第5期6卷 588-591页

作者： Jae Yong kim Dong Yoon kim Eun-Soon kim myoung joon kim Hungwon Tchah Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIMTo compare the effect of topically administered and subconjunctivally injected bevacizumab on experimental corneal neovascularization in rats for two weeks after treatment.

关键词： corneal neovascularization bevacizumab topical and subconjunctival administration

Visual quality assessment after presbyopic laser in-situ keratomileusis

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 462-469页

作者： Dong Hui Lim Eui-Sang Chung myoung joon kim Tae-Young Chung Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Preventive Medicine Graduate School the Catholic University of Korea Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIM： To assess visual quality after presbyopia correction using an aspheric ablation profile and a micro-monovision protocol. METHODS： This is a retrospective interventional study. Fifty-four eyes of 27 patients （mean age, 50.2±7.5y） who underwent presbyopia correction with an aspheric micro-monovision protocol were enrolled. The values of modulation transfer function （MTF） cutoff frequency, Strehl ratio, objective scattering index （OSI） and accommodation range were quantitatively assessed using the HD analyzer. Preoperative and postoperative contrast sensitivity （CS） at far （2.5 m） and near （40 cm） distance and higher-order aberrations （HOAs） were analyzed. Subjective visual satisfaction was evaluated by self-reported questionnaire regarding optical visual symptoms. RESULTS： One year after presbyopia correction, no significant differences were found in the MTF cutoff frequency, Strehl ratio and OSI, however, the lID analyzer accommodation range significantly differed postoperatively （P=0.004）. Postoperative CS at 12 and 18 cpd at near showed statistically significant improvement （P=0.020 and 0.008, respectively）. Visual performance by self-reported questionnaire revealed satisfactory results in terms of subjective visual quality improvement. CONCLUSION： Objective optical quality parameters show good visual outcomes. Subjective visual quality assessed by self-reported questionnaire in the presbyopia correction group show satisfactory results.

关键词： presbyopia correction laser blended vision visual quality LASIK

A new multiple noncontinuous puncture(pointage)technique for corneal tattooing

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 928-932页

作者： Jin Hyoung Park Taewoong Um myoung joon kim Hungwon Tchah Jae Yong kim Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIMTo assess the safety and cosmetic efficacy of a new multiple noncontinuous transepithelial puncture technique for tattooing a decompensated *** was a non-comparative clinical case series study. The study examines 33 eyes in 33 patients with total corneal opacity due to corneal decompensation, which developed following intraocular surgery. Corneal tattooing was performed using the multiple noncontinuous transepithelial puncture technique (i.e. pointage). The safety of this new surgical strategy was assessed by occurrence of adverse events for the follow-up period. The cosmetic efficacy was determined by the patient's cosmetic satisfaction and independent observer's opinion about patient *** women and 26 men were included in the study. The mean age was 46.4±17.5y (range: 7-67). In total, 30 of 33 patients (91%) reported cosmetic satisfaction within the follow-up period. Only 3 patients (9%) required additional tattooing due to cosmetic unsatisfaction. Cosmetic outcomes were analyzed and classified as excellent or good in 13 (39%) and 17 (52%) patients, respectively. No serious adverse events developed, except delayed epithelial healing in 3 *** cosmetic outcomes of the multiple noncontinuous transepithelial puncture technique for corneal tattooing were good. The safety of this method is higher than conventional procedures. This new procedure also provides improved cost-effectiveness and safety over current corneal tattooing techniques.

关键词： corneal tattooing total corneal opacity corneal decompensation

Diffractive multifocal intraocular lens implantation in patients with monofocal intraocular lens in the contralateral eye

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 737-743页

作者： Jae Yong kim Yunhan Lee Hun Jae Won Hyerin Jeong Jin Hyoung Park myoung joon kim Hungwon Tchah Department of Ophthalmology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea

AIM:To evaluate clinical outcomes of unilateral implantation of a diffractive multifocal intraocular lens(IOL)in patients with contralateral monofocal ***:Twenty-two patients who already had implantation of a monofocal IOL in unilateral eye underwent implantation of a diffractive multifocal IOL in contralateral eye were *** 1,6,and 12 mo,uncorrected and distant corrected distant visual acuity(UCDVA and DCDVA),uncorrected and distant corrected intermediate-visual acuity(UCIVA and DCIVA),uncorrected and distant corrected near visual acuity(UCNVA and DCNVA),and contrast sensitivity were ***/glare symptoms,spectacle dependence,and patient satisfaction were also ***:The mean age was 67.86±7.25 y and the average interval between two IOL implantations was 645.82±878.44 *** 1 mo,binocular UCDVA was lower than 0.20 logMAR in 76%of patients(mean 0.12±0.13 logMAR),which increased to 90%by 6 and 12 *** binocular UCDVA was significantly better than the monocular results(P<0.05)at 1,6,and 12 ***,UCNVA was lower than 0.40 logMAR in 82%of patients,increasing to 90%by 6 and 12 *** UCNVA in the multifocal IOL implanted eye was statistically significantly better than that in the monofocal IOL implanted eye(P<0.05)at 1,6,and 12 *** 5%of patients at 1 and 6 mo,reported"severe glare or halo".Patient satisfaction rates were 95%and 91%at 6 and 12 mo,***:Unilateral implantation of multifocal IOL in patients with a contralateral,monofocal IOL implantation results in high patient satisfaction rate,with low severe glare or halo rate during *** can represent a good option for patients who have previously had a monofocal IOL implantation regardless of two year interval duration between two IOL implantations.

关键词： diffractive multifocal intraocular lens unilateral implantation near vision cataract surgery

Attenuation of corneal neovascularization by topical low-molecular-weight heparin-taurocholate 7 without bleeding complication

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1255-1259页

作者： Jae Yong kim Soo Yeon kim Mi Hyun Cheon Eun-Soon kim In Seok Song myoung joon kim Hungwon Tchah Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center Department of Ophthalmology Hanyang University College of Medicine

AIM：To investigate the antiangiogenic effects and safety of topically administered low-molecular-weight heparintaurocholate 7（LHT7） on corneal neovascularization（CoNV）.METHODS：Twenty-four Sprague-Dawley rats were randomly distributed into four groups of six rats *** central corneas were cauterized using a silver/potassium nitrate *** 2d after cauterization,12.5 mg/mL（low LHT7 group） or 25 mg/mL（high LHT7group） LHT7 was topically administered three times daily;12.5 mg/mL bevacizumab was topically administered as positive control（bevacizumab） group,with normal saline（NS） administered as negative control（NS group）.The corneas were digitally photographed to calculate the CoNV percentage from the neovascularized corneal area at 1 and ***：The 4 study groups did not have different CoNV percentages at 1wk after injury（P〉0.05）.However,the low LHT,high LHT,and bevacizumab groups had significantly lower CoNV percentages than the NS group at 2wk（all P〈0.05）.No significant differences in CoNV percentage were found among the low LHT,high LHT,and bevacizumab groups（all P〉0.05）.All groups except the NS group had lower CoNV percentages at 2wk postinjury than the levels observed at 1wk（all P〈0.05）.CONCLUSION：Topically-administered LHT7 inhibited CoNV without complication after chemical cauterization in the rat.

关键词： bevacizumab chemical cauterization corneal neovascularization low-molecular-weight heparin-taurocholate 7

Effect of atractylenolide Ⅲ on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2081-2092页

作者： Na Yeon kim myoung Ok kim Sangsu Shin Woo‑Sung Kwon Bomi kim joon Yeop Lee Sang In Lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑sangbuk‑do37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National UniversitySangjuGyeongsangbuk‑do 37224Republic of Korea National Institute for Korean Medicine Development Gyeongsan 38540Republic of Korea

Background The intestinal epithelium performs essential physiological functions,such as nutrient absorption,and acts as a barrier to prevent the entry of harmful *** are prevalent contaminants found in ani-mal feed that exert harmful effects on the health of ***(ZEA)is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune system of ***,we evaluated the molecular mechanisms that regulate the effects of ZEA on the porcine intestinal *** Treatment of IPEC-J2 cells with ZEA decreased the expression of E-cadherin and increased the expression of Snai1 and Vimentin,which induced Snail1-mediated epithelial-to-mesenchymal transition(EMT).In addition,ZEA induces Snail-mediated EMT through the activation of TGF-β*** treatment of IPEC-J2 cells with atractyle-nolideⅢ,which were exposed to ZEA,alleviated *** Our findings provide insights into the molecular mechanisms of ZEA toxicity in porcine intestinal epi-thelial cells and ways to mitigate it.

关键词： Atractylenolide III Epithelial–mesenchymal transition IPEC-J2 cells Snail TGF-beta signaling Zearalenone

An Efficient and Spam-Robust Proximity Measure Between Communication Entities

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Journal of Computer Science & Technology 2013年第2期28卷 394-400页

作者： Joo Hyuk Jeon Jihwan Song Jeong Eun Kwon Yoon joon Lee Man Ho Park myoung Ho kim Department of Computer Science Korea Advanced Institute of Science and Technology Biz Solution Team SK Telecom Information Technology R&D Center Mobile Communication Convergence Research Team Electronics and Telecommunications Research Institute

Electronic communication service providers are obliged to retain communication data for a certain amount of time by their local laws. The retained communication data or the communication logs are used in various applications such as crime detection, viral marketing, analytical study, and so on. Many of these applications rely on effective techniques for analyzing communication logs. In this paper, we focus on measuring the proximity between two communication entities, which is a fundamental and important step toward further analysis of communication logs, and propose a new proximity measure called ESP （Efficient and Spam-Robust Proximity measure）. Our proposed measure considers only the （graph- theoretically） shortest paths between two entities and gives small values to those between spam-like entities and others. Thus, it is not only computationally efficient but also spam-robust. By conducting several experiments on real and synthetic datasets, we show that our proposed proximity measure is more accurate, computationally efficient and spam-robust than the existing measures in most cases.

关键词： proximity closeness spam electronic communication

Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung kim Uk-Hee Jung Sung kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

Feasibility of wear reduction for soft nanostructured thin film through enhanced elastic recoverability and contact stress relief

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Friction 2023年第7期11卷 1292-1306页

作者： Kuk-Jin SEO Hyun-joon kim Dae-Eun kim Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Precision Mechanical Engineering Kyungpook National UniversitySangju 37224Republic of Korea Department of Advanced Science and Technology Convergence Kyungpook National UniversitySangju 37224Republic of Korea

This work shows that a soft,thin film comprising randomly aligned carbon nanotubes(CNTs)can reduce surface wear more effectively than a homogeneous thin film because of enhanced elastic recoverability and contact stress relief originating from its mesh *** investigate the wear characteristics of the mesh structure compared to those of the homogeneous thin film,multi-walled CNTs(MWCNTs)and diamond-like carbon(DLC)thin films were prepared to conduct nanoscale tribological experiments using the atomic force microscopy(AFM).The MWCNT thin film showed unmeasurably low wear compared with the DLC thin film under a certain range of normal *** demonstrate the wear reduction mechanism of the MWCNT thin film,its indentation and frictional behaviors were *** indentation behavior of the MWCNT thin film revealed repetitive elastic deformation with a wide strain range and a significantly lower elastic modulus than that of the DLC thin *** permanent deformation of the MWCNT thin film was observed through frictional experiments under relatively high normal load *** results are expected to provide insights into the design of highly wear-resistant surfaces using nanostructures.

关键词： carbon nanotube(CNT) thin film wear friction elastic recovery

Hepatitis B virus mutations related to liver disease progression of Korean patients

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World Journal of Gastroenterology 2014年第2期20卷 460-467页

作者： Bum-joon kim Department of Biomedical Sciences Microbiology and ImmunologyLiver Research Instituteand Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 110-799South Korea

Hepatitis B virus(HBV)infection is a global health problem and more than 350 million people worldwide are chronic carriers of the *** the recent dramatic decline in HBV chronic patients through successful programs of hepatitis B surface antigen vaccination,South Korea is still recognized as an endemic area of HBV *** infections in South Korea exhibit several distinct features in epidemiologic and clinical *** this review paper,we summarize the distinct HBV mutation patterns related to clinical severity and the molecular epidemiologic traits in Korean chronic patients based on previous ***,several lines of evidence,including our previous results,have led to the conclusion that a combination of the exclusive predominance of genotype C2,which is prone to mutations,the high prevalence of basal core promoter double mutations,and the presence of distinct immune responses against HBV proteins in the Korean population may generate the distinct HBV variants rarely or not encountered in other areas,which results in distinct clinical manifestations in Korean chronic *** may provide a novel insight into the relationships between clinical severity,HBV genotype distribution,and HBV naturally occurring variants.

关键词： Hepatitis B virus Mutation South Korea Hepatocellular carcinoma Genotype C2