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Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum shin Jaewoo Kwon Jae Hoon Lee Seo Young Park Yejong Park Woohyung Lee Ki Byung Song Dae Wook Hwang Song cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Cecal duplication cyst in an infant presenting as shock:A case report

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世界临床病例杂志 2023年第28期11卷 6931-6937页

作者： Seung Mo Kim Sun Hyang Lee Ga Young Park Sung shin Kim cheol Gu Lee Soo Ji Jin Department of Pediatrics Soonchunhyang University Bucheon HospitalSoochunhyang University College of MedicineBucheon 14584Gyeonggi-doSouth Korea Department of General Surgery Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea

BACKGROUND Although intestinal obstruction is one of the most common surgical emergencies in an infant,it is difficult to diagnose neonatal enteric duplication cysts(EDC)preoperatively owing to their rarity as a cause of intestinal *** describe a case report of a neonatal EDC presenting intestinal obstruction and *** SUMMARY A 32-d-old male infant with a prenatal sonographic finding of bladder distension was admitted to our hospital for a severely distended abdomen,fever,and *** first diagnostic hypothesis was septic shock and intestinal *** patient’s symptoms worsened;following an emergency surgical exploratory laparotomy and histopathological findings,the final diagnosis of cecal duplication cyst was *** patient’s postoperative course was uneventful,and on the fifth postoperative day,oral feeding *** days later,the patient was discharged from the *** Although EDC located in the cecum is exceptional,it should be considered when evaluating suspected intestinal obstruction and shock.

关键词： Duplication cyst Cecum Intestinal obstruction Infant Shock Case report

Malicious Node Detection Using Confidence Level Evaluation in a Grid-Based Wireless Sensor Network

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Wireless Sensor Network 2013年第3期5卷 52-60页

作者： Min-cheol shin Yoon-Hwa Choi Department of Computer Engineering Hongik University Seoul Korea

In this paper, we present a malicious node detection scheme using confidence-level evaluation in a grid-based wireless sensor network. The sensor field is divided into square grids, where sensor nodes in each grid form a cluster with a cluster head. Each cluster head maintains the confidence levels of its member nodes based on their readings and reflects them in decision-making. Two thresholds are used to distinguish between false alarms due to malicious nodes and events. In addition, the center of an event region is estimated, if necessary, to enhance the event and malicious node detection accuracy. Experimental results show that the scheme can achieve high malicious node detection accuracy without sacrificing normal sensor nodes.

关键词： Sensor Networks Malicious Node Detection Grid-Based WSN Faults Confidence Levels

T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

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Cellular & Molecular Immunology 2022年第3期19卷 447-448页

作者： Seong Jin Choi Dong-Uk Kim Ji Yun Noh Sangwoo Kim Su-Hyung Park Hye Won Jeong Eui-cheol shin Division of Infectious Disease Department of Internal MedicineSeoul National University HospitalSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)DaejeonRepublic of Korea

In November 2021,the Omicron variant(B.1.1.529)emerged and was designated a variant of concern(VOC)by the World Health ***,Omicron was reported to extensively escape neutralizing antibodies elicited by COVID-19 vaccination or natural infection[1,2,3].However,whether Omicron evades the T cell immunity elicited by COVID-19 vaccination or natural infection remains to be *** address this issue,we analyzed the amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain(Wuhan-Hu-1)in the Omicron variant(hCoV-19/South Africa/CERI-KRISP-K032284/2021).

关键词： neutral conserved elucidated

Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk Yoon cheol Min shin Young Soo Park Nayoung Kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-cheol shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

A Web-based machining process monitoring system for E-manufacturing implementation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1467-1473页

作者： shin Bong-cheol KIM Gun-hee CHOI Jin-hwa JEON Byung-cheol LEE Honghee CHO Myeong-woo HAN Jin-yong PARK Dong-sam Division of Mechanical Engineering Inha University Incheon 402-751 Korea Department of Mechanical Engineering University of Incheon Incheon 402-749 Korea

Recently, with the rapid growth of information technology, many studies have been performed to implement Web-based manufacturing system. Such technologies are expected to meet the need of many manufacturing industries who want to adopt E-manufacturing system for the construction of globalization, agility, and digitalization to cope with the rapid changing market requirements. In this research, a real-time Web-based machine tool and machining process monitoring system is developed as the first step for implementing E-manufacturing system. In this system, the current variations of the main spindle and feeding motors are measured using hall sensors. And the relationship between the cutting force and the spindle motor RMS (Root Mean Square) current at various spindle rotational speeds is obtained. Thermocouples are used to measure temperature variations of important heat sources of a machine tool. Also, a rule-based expert system is applied in order to decide the machining process and machine tool are in normal conditions. Finally, the effectiveness of the developed system is verified through a series of experiments.

关键词： E-manufacturing Web-based system Internet Machining process monitoring Expert system

A Web-based on-machine mould matching and measurement system based on CAD/CAM/CAI integration

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1474-1481页

作者： CHOI Jin-hwa JEON Byung-cheol KIM Gun-hee shin Bong-cheol LEE Honghee CHO Myeong-woo SEONG Eun-je PARK Dong-sam Division of Mechanical Engineering Inha University Incheon 402-751 Korea Department of Mechanical Engineering University of Incheon Incheon 402-749 Korea

The purpose of this study is to develop a Web-based on-machine mould identification and measurement system. The Web-based mould identification system matches obtained vision information with CAD database. Developed Web-based system is to exchange messages between a server and a client by making of ActiveX control, and the result of mould identification is shown on Web-browser at remote site. For effective feature classification and extraction, the signature method is used to make meaningful information from obtained image data. For on-machine measurement of the matched mould, inspection database is constructed from CAD database using developed inspection planning methods. The results are simulated and analyzed using developed system to verify the effectiveness of the proposed methods.

关键词： E-manufacturing CAD/CAM/CAI integration On-machine measurement Mould identification Vision system

Characterization of CD8＋CD57＋ T cells in patients wit acute myocardial infarction

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Cellular & Molecular Immunology 2015年第4期12卷 466-473页

作者： Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee Choi Sungha Park Donghoon Choi Jong-Won Ha Eui-cheol shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and Engineering KAIST Daejeon Republic of Korea Cardiology Division Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Republic of Korea Department of Bio and Brain Engineering KAIST Daejeon Republic of Korea ' ' The first two authors contributed equally to this article

Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction （MI）. We studied the immunological characteristics and clinical impact of CD8＋CD57＋ T cells in acute MI patients. The frequency of CD57＋ cells among CD8＋ T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57＋ cells in the CD8＋ T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8＋CD57＋ T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8＋CD57＋ T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8＋CD57＋ T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8＋ T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8＋ T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

关键词： acute myocardial infarction CD8+CD57+ T cells immunosenescence