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International Journal of Ophthalmology(English edition) 2014年第6期7卷 935-940页

作者： Seong-Jae Kim Hwajin Kim Jeongsook park Inyoung Chung Hyug-Moo Kwon Wan-Sung Choi Ji-myong Yoo Department of Ophthalmology School of MedicineGyeongsang National University Institute of Health Science Gyeongsang National University Department of Anatomy and Neurobiology BK21 Biomedical CenterSchool of MedicineGyeongsang National University School of Nano-Bioscience and Chemical Engineering Ulsan National Institute and Science and Technology

AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METhoDS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were ***: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with ***: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.

关键词： aldose reductase diabetes tonicity response element binding protein retinopathy

Perspective on the critical role of interface for advanced batteries

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Journal of Energy Chemistry 2020年第8期29卷 217-220,I0008页

作者： Chong Yan hong Yuan ho Seok park Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Sungkyunkwan University(SKKU)Jangan-guSuwon 440-746Republic of Korea

As an efficient and environmental friendly energy storage system, lithium battery has been integrated into daily mobile life [1].Lithium batteries are becoming indispensable to all types of electronic products such as laptop computers, mobile phones, digital cameras [2]. A typical lithium battery consists of positive electrode(cathode), negative electrode(anode), electrolyte and other inactive materials(binder, conductive agent, separator) [3].

关键词： Interface Lithium metal Graphite Solid electrolyte interphase(SEI) Solvation Specific absorption

An effective communication and computation model based on a hybridgraph-deeplearning approach for SIoT

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Digital Communications and Networks 2022年第6期8卷 900-910页

作者： M.S.Mekala Gautam Srivastava Ju H.park ho-Youl Jung Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38544South Korea RLRC LAb for Autonomous Vehicle Parts and Materials Innovation Yeungnam UniversityGyeongsan38544South Korea Department of Math and Computer Science Brandon UniversityBrandonCanada Department of Electrical Engineering Yeungnam UniversityGyeongsanSouth Korea Research Centre for Interneural Computing China Medical UniversityTaichungTaiwanChina

Social Edge Service(SES)is an emerging mechanism in the Social Internet of Things(SIoT)orchestration for effective user-centric reliable communication and *** services are affected by active and/or passive attacks such as replay attacks,message tampering because of sharing the same spectrum,as well as inadequate trust measurement methods among intelligent devices(roadside units,mobile edge devices,servers)during computing and *** issues lead to computation and communication overhead of servers and computation *** address this issue,we propose the HybridgrAph-Deep-learning(HAD)approach in two stages for secure communication and ***,the Adaptive Trust Weight(ATW)model with relation-based feedback fusion analysis to estimate the fitness-priority of every node based on directed graph theory to detect malicious nodes and reduce computation and communication ***,a Quotient User-centric Coeval-Learning(QUCL)mechanism to formulate secure channel selection,and Nash equilibrium method for optimizing the communication to share data over edge *** simulation results confirm that our proposed approach has achieved effective communication and computation performance,and enhanced Social Edge Services(SES)reliability than state-of-the-art approaches.

关键词： Edge computing Adaptive trust weight(ATW)model Quotient user-centric coeval-learning(QUCL)mechanism Deep learning Service reliability

Influence of dehydrating agents on the oxidative carbonylation of methanol for dimethyl carbonate synthesis over a Cu/Y-zeolite catalyst

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1059-1063页

作者： Dong-ho Lee Jiin You Je-Min Woo Jung Yoon Seo Young Cheol park Jong-Seop Lee Hyunuk Kim Jong-ho Moon Seung Bin park Greenhouse Gas Laboratory Korea Institute of Energy Research Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology Energy Material Laboratory Korea Institute of Energy Research

The influence of the dehydration by metal oxides on the synthesis of dimethyl carbonate （DMC） via oxidative carbonylation of methanol was studied. A Cu/Y-zeolite catalyst was prepared by the ion exchange method from CuCl2.2H2O and the commercial NH4-form of the Y type zeolite, The catalyst was characterized by X-ray fluorescence （XRF）, N2 adsorption （BET method）, X-ray diffraction （XRD）, and temperature-programmed de- sorption of ammonia （NH3-TPD） to evaluate its Cu and Cl content, surface area, structure, and acidity. Reaction tests were carried out using an autoclave （batch reactor） for 18 h at 403 K and 5.5 MPa （2CH3OH ＋ 1/2O2 ＋ CO （CH3O）2CO ＋ H2O）. The influence of various dehydrating agents （ZnO, MgO, and CaO） was examined with the aim of increasing the methanol conversion （XMeOH, MeOH conversion）. The MeOH conversion increased upon addition of metal oxides in the order CaO 〉〉 MgO 〉 ZnO, with the DMC selectivity （SDMC） following the order MgO 〉 CaO 〉 ZnO. The catalysts and dehydrating agents were characterized before and after the oxidative carbonylation of methanol by thermogravimetric and differential thermogravimetric （TG/DTG）, and XRD to con- firm that the dehydration reaction occurred via the metal oxide （MO ＋ H2O →M（OH）2）. The MeOH conversion increased from 8.7% to 14.6% and DMC selectivity increased from 39.0% to 53.1%, when using the dehydrating azent CaO.

关键词： Carbon monoxide Zeolite Catalyst Dimethyl carbonate Oxidative carbonylation Dehydrating agent

ESR1 mutations:Piece de resistance

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Genes & Diseases 2016年第2期3卷 124-129页

作者： Berry Button Ben ho park The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of MedicineBaltimoreMDUnited States Department of Chemical and Biomolecular Engineering The Whiting School of EngineeringThe Johns Hopkins UniversityBaltimoreMDUnited States

Estrogen and estrogen receptor-alpha(ER)signaling are important factors in the pathogenesis and treatment of ER-positive breast *** targeted therapies against ER,known as endocrine therapies,are widely used in the treatment of ER-positive breast *** these therapies have shown great success,de novo and acquired resistance are *** approach to the problem of endocrine therapy resistance is twofold:identify the mechanisms of resistance and develop alternative treatments to overcome these *** review focuses on the progress and integration of these two aspects of resolving endocrine therapy resistance in ER-positive breast cancer patients.

关键词： Breast cancer Circulating tumor DNA ESR1 Estrogen receptor Mutation Plasma

Optical Gain Analysis of Graded InGaN/GaN Quantum-Well Lasers

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Chinese Physics Letters 2011年第7期28卷 319-322页

作者： Seoung-Hwan park Yong-Tae Moon Jeong Sik Lee ho Ki Kwon Joong Seo park Doyeol Ahn Department of Electronics Engineering Catholic University of DaeguHayangKyeongsanKyeongbuk 712-702Republic of Korea SLED R&D Center LG Innotek16 Woomyeon-dongSeocho-guSeoul 137-140Republic of Korea Department of Electrical and Computer Engineering University of SeoulSeoul 130-743Republic of Korea

Optical properties of graded InGaN/GaN quantum well(QW)lasers are analyzed as improved gain media for laser diodes emitting near 500 *** results are compared with those of conventional InGaN/GaN QW *** heavy-hole effective mass around the topmost valence band is found to nearly not be affected by the inclusion of the graded *** graded InGaN/GaN QW structure shows a much larger matrix element than the conventional InGaN/GaN QW *** radiative current density dependences of the optical gain are similar to each ***,the graded QW structure is expected to have lower threshold current density than the conventional QW structure because the former has a lower threshold carrier density than the latter.

关键词： InGaN/GaN graded Lasers

Castleman's disease of the spleen

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World Journal of Gastroenterology 2015年第5期21卷 1675-1679页

作者： Hee-Jeong Lee ho-Jong Jeon Sang-Gon park Chi-Young park Department of Internal Medicine hemato-oncologyChosun University Hospital501-717 GwangjuSouth Korea Department of Pathology Chosun University Hospital501-717 GwangjuSouth Korea

Castleman's disease(CD) is a rare lymphoproliferative disorder of unknown ***,it occurs as a localized(unicentric) disease or as a systemic(multicentric) *** Castleman's disease(UCD) presents as a solitary mass and primarily affects the mediastinal,retroperitoneal,and cervical lymph *** contrast to multicentric CD,which involves peripheral lymphadenopathy and numerous systemic symptoms,UCD is not typically associated withgeneralized *** main distinct histologic variants are recognized:hyaline-vascular type,plasma cell type,and mixed *** CD is ***,UCD exclusively in the spleen is extremely rare,with only 2 cases described in the literature to ***,we describe an asymptomatic 75-yearold man with a 5.7 cm × 4.5 cm sized heterogenous enhanced mass located in the *** underwent surgical resection for diagnosis and treatment.A pathologic examination indicated the hyaline-vascular type of *** this patient,the preoperative diagnosis was difficult to determine,and therefore,invasive procedures were required.

关键词： Castleman’s disease Hyaline-vascular type Spleen

Clinical characteristics and treatment of inflammatory bowel disease: A comparison of Eastern and Western perspectives

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World Journal of Gastroenterology 2014年第33期20卷 11525-11537页

作者： Soo Jung park Won ho Kim Jae Hee Cheon Department of Internal Medicine and Institute of Gastroenerology Yonsei University College of Medicine Seoul 120-752 South Korea

Inflammatory bowel disease(IBD) is a chronic, relapsing intestinal inflammatory disorder with unidentified causes. Both environmental factors and genetic aspects are believed to be crucial to the pathogenesis of IBD. The incidence and prevalence of IBD have recently been increasing throughout Asia, presumably secondary to environmental changes. This increasing trend in IBD epidemiology necessitates specific health care planning and education in Asia. To this end, we must gain a precise understanding of the distinctive clinical and therapeutic characteristics of Asian patients with IBD. The phenotypes of IBD reportedly differ considerably between Asians and Caucasians. Thus, use of the same management strategies for these different populations may not be appropriate. Moreover, investigation of the Asian-specific clinical aspects of IBD offers the possibility of identifying causative factors in the pathogenesis of IBD in this geographical area. Accordingly, this review summarizes current knowledge of the phenotypic manifestations and management practices of patients with IBD, with a special focus on a comparisonof Eastern and Western perspectives.

关键词： Crohn's disease Ulcerative colitis Inflam-matory bowel disease Clinical characteristics Treat-ment Asia

Retrieval of Outgoing Longwave Radiation from COMS Narrowband Infrared Imagery

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Advances in Atmospheric Sciences 2015年第3期32卷 375-388页

作者： Myung-Sook park Chang-hoi ho Heeje Cho Yong-Sang ChoI School of Earth and Environmental Sciences Seoul National UniversitySeoul Korea School of Urban and Environmental Engineering Ulsan National Institute of Science & TechnologyUlsan Korea Computational Science and Technology Seoul National UniversitySeoul Korea Computational Science and Technology Seoul National UniversitySeoul Korea Department of Environmental Science and Engineering Ewha Womans UniversitySeoul Korea

hourly outgoing longwave radiation （OLR） from the geostationary satellite Communication Oceanography Meteorological Satellite （COMS） has been retrieved since June *** COMS OLR retrieval algorithms are based on regression analyses of radiative transfer simulations for spectral functions of COMS infrared *** study documents the accuracies of OLRs for future climate applications by making an intercomparison of four OLRs from one single-channel algorithm （OLR12.0 using the 12.0 μm channel） and three multiple-channel algorithms （OLR10.8＋12.0 using the 10.8 and 12.0 pm channels; OLR6.7＋10.8 using the 6.7 and 10.8 μm channels; and OLRAll using the 6.7,10.8,and 12.0 μm channels）.The COMS OLRs from these algorithms were validated with direct measurements of OLR from a broadband radiometer of the Clouds and Earth＇s Radiant Energy System （CERES） over the full COMS field of view [roughly （50°S-50°N,70°-170°E）] during April *** results show that the root-mean-square errors of COMS OLRs are 5-7 W m-2,which indicates good agreement with CERES OLR over the vast ***6.7＋10.8 and OLRAll have much smaller errors （～ 6 W m-2） than OLR12.0 and OLR10.8＋12.0 （～ 8 W m-2）.Moreover,the small errors of OLR6.7＋10.8 and OLRAll are systematic and can be readily reduced through additional mean bias correction and/or radiance *** results indicate a noteworthy role of the 6.7 μm water vapor absorption channel in improving the accuracy of the *** dependence of the accuracy of COMS OLRs on various surface,atmospheric,and observational conditions is also discussed.

关键词： outgoing longwave radiation Communication Oceanography and Meteorological Satellite Cloud and Earth's Radiant Energy System

Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi hongdae Lee Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin park Jiwon Kim Bong Kyun Kang Gun Jang Dae ho Yoon ho Seok park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery