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Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis

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Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan Kim Minjeong Sung myong-suk par. Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung Depar.ment of Internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Depar.ment of Internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial Tumor Immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunotherapy Innovation Center HwasunSouth Korea BioMedical Sciences Graduate Program Chonnam National UniversityHwasunSouth Korea Depar.ment of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Depar.ment of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(TGF-β1)in the emergence of these diseases,the present study tested the hypothesis that LGALS3BP regulates the TGF-β1 signaling ***:The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LGALS3BP-TGF-β1 *** effects of altered TGF-β1 signaling by LGALS3BP were investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:In patients with MASH and HCC,the levels of LGALS3BP and TGFB1 exhibited positive *** of LGALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LGALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LGALS3BP-knockin mice,with increased TGFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active TGF-β1 from extracellular latent complex with the rearranged F-actin *** released TGF-β1 activated JunB transcription factor,which in turn promoted the TGF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated TGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TGF-β***:LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TGF-β1 signaling pathway,making it a promising therapeutic target in TGF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis IntegrinαV Interferonα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-β1

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Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal

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Journal of Environmental Sciences 2019年第6期31卷 58-65页

作者： Jin-Ho Sung Seung-Ki Back Eun-Song Lee Ha-Na Jang Yong-Chil Seo Youn-suk Kang myong-Hwa Lee Depar.ment of Environmental Engineering Yonsei University J-E Tech Co. Ltd Depar.ment of Environmental Engineering Kangwon National University

Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of par.icle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine par.iculates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed.

关键词： Mercury Hybrid filter Activated carbon Coating filter Coal-fired power plant

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Dendritic cell-based immunotherapy for colon cancer using an HLA-A＊0201-restricted cytotoxic T-lymphocyte epitope from tumor-associated antigen 90K

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Cellular & Molecular Immunology 2013年第3期10卷 275-282页

作者： Ji Hee Lee myong-suk par. Jun-Eul Hwang Sang-Hee Cho Woo-Kyun Bae Hyun-Jeong Shim Dae-Eun Kim Ik-Joo Chung Depar.ment of Hematology-Oncology Chonnam National University Medical School Gwangju Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Tumor-associated antigen 90K is implicated in cell-cell and cell-extracellular matrix adhesion through its interaction with galectin-3 and integrin-β 1 and is highly expressed in malignant tissues, making it a novel target for the development of new immunotherapies. We investigated a potential immunotherapy treatment for colon cancer using 90K-specific cytotoxic T lymphocytes induced by autologous dendritic cells and pulsed with 90K peptides. We selected three peptides （90K3s1, 90K5 and 90K523） that bind to HLA-A＊0201 molecules on the basis of their binding affinity, as determined by a peptide-T2 binding assay. Dendritic cells pulsed with 90K peptides resulted in the efficient generation of mature dendritic cells and exhibited enhanced T-cell stimulation and polarization of naive T cells toward Thl. Dendritic cells pulsed with 90K peptides generated potent cytotoxic T-lymphocytes that lysed T2 cells loaded with each 90K peptide, and 90K＋/HLA-A2＋ colon cancer cell lines, including HCT116 and SW480, in a dose-dependent and HLA-A＊O2Ol-restricted manner. No killing was observed in 90K＋/HLA-A2- DLD1 or 90K-/HLA-A2- K562 cells. Therefore, we believe that cytotoxic T-lymphocytes stimulated by 90K peptide-pulsed dendritic cells naturally recognize the 90K peptide presented by colon cancer cells in the context of HLA-A2, and kill 90K-positive tumor cells. Dendritic cells pulsed with 90K peptides led to the induction of granzyme B and perforin positive CD8＋ T cells against HCT116 and SW480 cells, but not DLD1 cells. In conclusion, 90K-specific cytotoxic T lymphocytes, generated by stimulating T cells with 90K peptide-pulsed dendritic cells, could be useful effector cells for the immunotherapv treatment of colon cancer.

关键词： 9OK colon cancer dendritic cells immunotherapy peptide

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Neuronal damage and blood-retinal barrier disruption in retinal ischemia/reperfusion injury:protective effects of Lycium barbarum polysaccharides

Neuronal damage and blood-retinal barrier disruption in reti...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Amy Cheuk Yin Lo suk-Yee Li Chung-Man Yeung Raymond Chuen-Chung Chang Kwok-Fai So David Wong Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong Kong Research Center of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong Kong Depar.ment of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong Kong

＜正＞Objective Neuronal cell death,glial cell activation,retinal swelling and oxidative injury are complications in retinal ischemia/reperfusion（I/R） *** barbarum polysaccharides（LBP）,extracts from the wolfberries, are good for "eye health" in Chinese *** aim of our present study is to explore the use of LBP in retinal I/R *** Retinal I/R injury was induced by surgical occlusion of the internal carotid *** to induction of ischemia,mice were fed orally with either vehicle（PBS） or LBP（1 mg/kg） once a day for 1 week. Ischemia was maintained for 2 hours and reperfusion was then allowed for 22 ***-embedded retinal sections were *** cells were counted while apoptosis was assessed using TUNEL *** levels of glial fibrillary acidic protein（GFAP）,aquaporin-4（AQP4）,poly（ADP-ribose）（par. and nitrotyrosine （NT） were investigated by *** integrity of blood-retinal barrier（BRB） was examined by IgG extravasation *** Decreased viable cell count and apoptosis were found in the ganglion cell layer （GCL） and the inner nuclear layer（INL） of the vehicle-treated I/R ***,increased retinal thickness, GFAP activation,AQP4 up-regulation,IgG extravasation and par.expression level were observed in the vehicletreated I/R *** importantly,many of these changes were diminished or abolished in the LBP-treated I/R *** Pre-treatment with LBP for 1 week effectively protected the retina from neuronal death,apoptosis, glial cell activation,aquaporin water channel up-regulation,disruption of BRB and oxidative *** present study suggests that LBP may have a neuroprotective role in ocular diseases in which I/R is a feature.

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