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Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 538-545页

作者： Mohamed Bekheit Chloe Audebert Petru Bucur Hans Adriaensen Emilie Bled mylène wartenberg Irene Vignon-Clementel Eric Vibert Inserm Unité 1193 112 Boulevard Paul Valliant CuturierVillejuifFrance Institute of medical sciences University of AberdeenAberdeenUK Centre de recherche Inria de Paris ParisFrance Sorbonne Universités UPMC University of Paris 6Laboratoire Jacques-LouisLionsParisFrance CHRU hopitaux de ToursChirurgie Héato-biliaire et pancréatiqueTransplantation HéatiqueToursFrance Plateforme Chirurgie et Imagerie pour le Recherche et l’Enseignement(CIRE) ImagerieUMR-PRC37380 NouzillyCentre INRA Val de LoireFrance AP-HP Hoital Paul BrousseCentre Héato-BiliaireVillejuifFrance

Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI(PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we compared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75% hepatic resection was performed under a unified protocol. The blood flow was measured in the hepatic artery(Qha), the portal vein(Qpv), and the aorta above the celiac trunk(Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression(PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32%(95% CI:-49% to 15%); Qha 17%(95% CI:-15% to 51%); and Qpv 40%(95% CI:-62% to 18%). The TTUS probe had a higher weight in predicting adverse outcomes after 75% resection compared to the PC-MRI( β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.

关键词： Hepatic blood flow Phase contrast MRI Transit time ultrasound probe Porcine model Liver surgery

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Diagnostic accuracy of MRI and PET/CT for neck staging prior to salvage total laryngectomy

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 1-14页

作者： Jonas Galli Roland Giger Olgun Elicin Martin wartenberg Lukas Anschuetz Lluís Nisa Department of Otorhinolaryngology Head and Neck SurgeryInselspitalBern University Hospitaland University of BernBern 3010Switzerland Department of Radiation Oncology InselspitalBern University Hospitaland University of BernBern 3010Switzerland Institute of Pathology University of BernBern 3008Switzerland

Aim:Lymph node(LN)metastases are associated with poor outcomes in patients with recurrent larynx squamous cell carcinoma(LSCC).neck dissection(ND)is therefore commonly performed along with salvage total laryngectomy(STL).Here,we assess the rate of occult LN metastases and the diagnostic value of MRI and PET/CT for detecting them in recurrent ***:This retrospective study included patients with recurrent LSCC after primary(chemo)radiotherapy[(C)RT]who were re-staged by MRI and/or PET/CT and treated with STL and ND between 2004 and *** histopathology of ND samples was used as the reference ***:Forty-one patients were *** prevalence of occult metastases in MRI-negative and PET/CT-negative neck nodes was between 3.2%and 6.1%.negative predictive values of neck node re-staging were 93.9%for MRI,96.8%for PET/CT,and 96.2%for MRI and PET/CT ***:Both MRI and PET/CT afforded good negative predictive values for nodal staging in patients with recurrent LSCC after(C)RT prior to *** selected patients,these radiological modalities,particularly PET/CT,could help to avoid unnecessary surgery to the neck and its associated morbidity.

关键词： Laryngeal squamous cell carcinoma recurrence salvage total laryngectomy re-staging neck dissection MRI PET/CT occult nodal metastasis

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The impacts of suspended mariculture on coastal zones in China and the scope for Integrated Multi-Trophic Aquaculture

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Ecosystem Health and Sustainability 2017年第6期3卷 32-51页

作者： Reece wartenberg Limin Feng Jia Jun Wu Yim Ling Mak Leo L.Chan Trevor C.Telfer Paul K.S.Lamab.c State Key Laboratory in Marine Pollution City University of Hong KongKowloonHong Kong SARChina Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine BiodiversityCity University of Hong Kong Shenzhen Research Institute BuildingShenzhenGuangdongChina Department of Biology and Chemistry City University of Hong KongKowloonHong Kong SARChina Department of Biomedical Sciences City University of Hong KongKowloonHong Kong SARChina Institute of Aquaculture University of StirlingStirlingUK

Introduction:China is responsible for more than 60%of global aquaculture *** the frontiers of food production have expanded,the cultivation of marine organisms in coastal zones and the open ocean has grown *** dominant mariculture industry in China is suspended mariculture,which uses net cages,ropes,or other structures suspended in the water column to cultivate aquatic *** systematic,quantitative review provides a clear and comprehensive account of research that has investigated the adverse impacts of suspended mariculture in China and reviews research that has applied Integrated Multi-Trophic Aquaculture(IMTA)systems for mitigating *** work builds on 218 peer reviewed papers that have been published in English-language ***:Eighteen impacts were identified,including chemical,ecological,physical,and socioeconomic *** measures for improving suspended mariculture were recommended consisting of government department,farm management,and ecological engineering *** was the most frequently recommended *** capabil-ities of IMTA for bioremediation and increased farm production were the most frequently studied *** other benefits have been explored but remain *** current challenges facing the expansion of commercial IMTA include limited use of new technology,limited skills development,decreasing production of low trophic-level species,biogeographic and temporal barriers,and negative system ***:Despite challenges,implementing commercial IMTA is a promising measure for reducing the impacts of sus pended mariculture because it presents a range of secondary benefits that can improve the overall sustainability of aquaculture in the coastal zone.

关键词： Aquaculture bioremediation China impacts Integrated Multi-Trophic Aquaculture pollution suspended mariculture

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小脑病征

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中华神经科杂志 1956年第2期02卷 158-158,163页

作者： Robert wartenberg

下列诸征表示患者有小腦的缺陷,但並无明顯的机能失调,甚至患者没有主诉可供参考。共济失调(Ataxia) 对抗外来阻力時的共济失调——小腦疾患於执行指鼻试验時,开始正常,当手指接近鼻時,震颤渐增,最后手指止於鼻之附近。但亦有指鼻试验...

下列诸征表示患者有小腦的缺陷,但並无明顯的机能失调,甚至患者没有主诉可供参考。共济失调(Ataxia) 对抗外来阻力時的共济失调——小腦疾患於执行指鼻试验時,开始正常,当手指接近鼻時,震颤渐增,最后手指止於鼻之附近。但亦有指鼻试验示正常结果者,因此需用增强方法(即当患者执行指鼻试验時给予轻微的外来阻力)。於患者之腕部繞一橡皮圈,检查者执其一端,当患者作指鼻试验時轻轻给以抗力,检查者亦可置其手指於患者前臂之掌侧,当患

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非连续染色生产的自动化

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国外纺织技术 1986年第6期 30-32+18页

作者： Ulrich wartenberg 孟坚

今天的染色工艺都必须为克服成本上升的压力而竞争,而使生产过程自动化是解决这一问题的方案中最佳的选择。最近在有关会议上的关于小批量和非连续染整工艺过程的讨论表明,多年来,人们忽视了非连续染

关键词：连续染色称量点染色工艺西德德国计算机控制系统微处理机控制系统可编程控制系统

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The Digital Agricultural Knowledge and Information System(DAKIS):Employing digitalisation to encourage diversified and multifunctional agricultural systems

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Environmental Science and Ecotechnology 2023年第4期16卷 177-189页

作者： Ioanna Mouratiadou Nahleen Lemke Cheng Chen Ariani wartenberg Ralf Bloch Marco Donat Thomas Gaiser Deepak Hanike Basavegowda Katharina Helming Seyed Ali Hosseini Yekani Marcos Krull Kai Lingemann Joseph Macpherson Marvin Melzer Claas nendel Annette Piorr Mostafa Shaaban Peter Zander Cornelia Weltzien Sonoko Dorothea Bellingrath-Kimura Leibniz Centre for Agricultural Landscape Research(ZALF) Eberswalder Straße 8415374MünchebergGermany ISARA Laboratory of Rural Studies Research UnitLyon23 Rue Jean Baldassini69364Lyon Cedex 07France Faculty of Landscape Management and Nature Conservation University for Sustainable Development(HNEE)Schickler Straße 516225EberswaldeGermany Institute of Crop Science and Resource Conservation University of Bonn53115BonnGermany Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB) Max-Eyth-Allee 10014469PotsdamGermany German Research Center for Artificial Intelligence(DFKI) Trippstadter Strasse 12267663KaiserslauternGermany Institute of Biochemistry and Biology University of PotsdamAm Mühlenberg 314476Potsdam(Golm)Germany Global Change Research Institute The Czech Academy of ScienceBělidla 986/4a60300BrnoCzech Republic

Multifunctional and diversified agriculture can address diverging pressures and demands by simultaneously enhancing productivity,biodiversity,and the provision of ecosystem *** use of digital technologies can support this by designing and managing resource-efficient and context-specific agricultural *** present the Digital Agricultural Knowledge and Information System(DAKIS)to demonstrate an approach that employs digital technologies to enable decision-making towards diversified and sustainable *** develop the DAKIS,we specified,together with stakeholders,requirements for a knowledge-based decision-support tool and reviewed the literature to identify limitations in the current generation of *** results of the review point towards recurring challenges regarding the consideration of ecosystem services and biodiversity,the capacity to foster communication and cooperation between farmers and other actors,and the ability to link multiple spatiotemporal scales and sustainability *** overcome these challenges,the DAKIS provides a digital platform to support farmers'decision-making on land use and management via an integrative spatiotemporally explicit approach that analyses a wide range of data from various *** approach integrates remote and in situ sensors,artificial intelligence,modelling,stakeholder-stated demand for biodiversity and ecosystem services,and participatory sustainability impact assessment to address the diverse drivers affecting agricultural land use and management design,including natural and agronomic factors,economic and policy considerations,and socio-cultural preferences and ***,the DAKIS embeds the consideration of ecosystem services,biodiversity,and sustainability into farmers'decision-making and enables learning and progress towards site-adapted small-scale multifunctional and diversified agriculture while simultaneously supporting farmers'objectives and societal demands.

关键词： Digital agriculture Ecosystem services Decision support system Farming practices Biodiversity Modelling Small-scale management

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VPA对小鼠胚胎干细胞心肌分化的影响

VPA对小鼠胚胎干细胞心肌分化的影响

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中国生理学会第21届全国代表大会暨学术会议

作者：那兰王绍 wartenberg M Hescheler J Sauer H 东北师范大学体育学院吉林大学基础医学院生理学教研室德国科隆大学神经生理学研究所德国科隆大学神经生理学研究所德国科隆大学神经生理学研究所

＜正＞ VPA（丙戊酸）是一种抗癫痫药物。以往的研究表明,VPA在人类和动物引起的胎儿畸形作用主要涉及神经系统、骨骼和骨骼肌。由于研究方法所限,文献对内脏器官,包括心脏的报道较少,其致畸机制不明。本研究采用免疫荧光组织化学,DCF...

＜正＞ VPA（丙戊酸）是一种抗癫痫药物。以往的研究表明,VPA在人类和动物引起的胎儿畸形作用主要涉及神经系统、骨骼和骨骼肌。由于研究方法所限,文献对内脏器官,包括心脏的报道较少,其致畸机制不明。本研究采用免疫荧光组织化学,DCF（二氯荧光素,可表明活性氧水平）测定,配合激光扫描共聚焦显微镜以及先进的小鼠胚胎干细胞（ESc）培养、诱导分化方法,首次研究VPA对小鼠胚胎干细胞生长和心肌分化的影响及致畸的可能机制。

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母亲颗粒物空气污染暴露与足月出生体重:效应与异质性的多国评估

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环境与职业医学 2013年第6期30卷 470-470页

作者： Payam Dadvand Jennifer Parker Michelle L. Bell Matteo Bonzini Michael Brauer Lyndsey A. Darrow Ulrike Gehring Svetlana V. Glinianaia nelson Gouveia Eun-hee Ha Jong Han Leem Edith H. van den Hooven Bin Jalaludin Bill M. Jesdale Johanna Lepeule Rachel Morello-Frosch Geoffrey G. Morgan Angela Cecilia Pesatori Frank H. Pierik Tanja Pless-Mulloli David Q. Rich Sheela Sathyanarayana Juhee Seo Rémy Slama Matthew Strickland Lillian Tamburic Daniel wartenberg Mark J. Nieuwenhuijsen Tracey J. Woodruff

[背景]越来越多的证据显示,母亲空气污染暴露与对胎儿生长的不良影响之间存在关联;但是,现有的文献并不一致。[目的]研究9个国家14个中心的数据,量化母亲颗粒物空气污染暴露与足月出生体重和低出生体重(LBW)之间的关联,并探讨此关联中... 详细信息

[背景]越来越多的证据显示,母亲空气污染暴露与对胎儿生长的不良影响之间存在关联;但是,现有的文献并不一致。[目的]研究9个国家14个中心的数据,量化母亲颗粒物空气污染暴露与足月出生体重和低出生体重(LBW)之间的关联,并探讨此关联中地点特征和暴露评估方法对中心之间异质性的影响。[方法]空气污染与妊娠结局国际合作(ICAPPO)的各中心采用共同的分析方案,对PM10和PM2.5(颗粒物≤10和2.5μm)与足月LBW和连续出生体重进行效应评估。采用meta分析将各个中心(~300万例出生)的效应评估结合起来,并采用meta回归分析在报告的效应评估中,中心特征和暴露评估方法对中心之间异质性的影响。[结果]随机效应meta分析显示,调整母亲的社会经济地位后,在整个妊娠期间,足月LBW与PM10[比值比(OR)=1.03;95%CI:1.01~1.05]和PM2.5[OR=1.10;95%CI:1.03~1.18]每增加10μg/m3呈正相关。在充分调整随机效应的meta分析中,作为一个连续性的结果,PM10暴露每增加10μg/m3与足月出生体重呈负相关(-8.9g;95%CI:-13.2^-4.6 g)。meta回归分析显示,具有较高平均PM2.5水平和PM2.5∶PM10比率的中心,以及采用时间暴露评估(与时空相比)的中心,所报告的关联更强。[结论]在研究人群中,母亲颗粒物污染暴露与足月LBW相关联。有3个地点特征和暴露评估方法学方面的不同导致各个中心报告的关联的差异。

关键词：空气污染胎儿生长异质性 ICAPPO 低出生体重 meta分析 meta回归多中心研究颗粒物妊娠

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颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明

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国际脑血管病杂志 2016年第11期24卷 961-985页

作者： Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. wartenberg Cindy L. Zerfoss 杨一萍谢丽丽宁小金季宇腾柯开富 From the Cerebrovascular Center Neurological Institute Cleveland Clinic and Case Western Reserve University 9500 Euclid Ave. S80 Cleveland OH44195 USA The Departments of Pharmacy and Anesthesiology & Critical Care Medicine The Johns Hopkins Hospital and Johns Hopkins University School of Medicine Baltimore MD USA The Department of neurology Mayo Clinic Rochester MN USA Harvard Medical School Brigham and Women's Hospital Boston MA USA The University of Tennessee Health Science Center Memphis TN USA Department of Pharmacy Practice & Science (UK College of Pharmacy) University of Kentucky Lexington KY USA The Departments of Medicine (Hematology) and neurology University of Washington School of Medicine Seattle WA USA The Departments of neurology Neurosurgery Anesthesiology & Critical Care Perelman School of Medicine Hospital of the University of Pennsylvania Philadelphia PA USA The Department of Laboratory Medicine and Pathology Memorial Sloan Kettering Cancer Center and Weill Comell Medical School New York NY USA The Department of neurosurgery Westchester Medical Center New York Medical College Valhalla NY USA Hepital du Sacre-Coeur and University of Montreal and Montreal neurological Institute and McGill University Montreal Quebec Canada Klinik fur neurologie Martin-Luther-Universitat Halle-Wittenberg Halle Germany The neuroscience and neurosurgery Departments Centra Lynchburg General Hospital Lvnchburg VA. USA 南通大学附属医院神经内科 226001

背景抗栓药的使用，包括抗凝药、抗血小板药和溶栓药，在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的，但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美... 详细信息

背景抗栓药的使用，包括抗凝药、抗血小板药和溶栓药，在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的，但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会，涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定，目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索，并对符合标准的研究进行了评价。结果利用GRADE方法学，委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。

关键词：抗凝药抗血小板药抗栓药颅内出血脑出血脑实质出血蛛网膜下腔出血硬膜下出血逆转解药维生素K拮抗药华法林香豆素直接凝血酶抑制药达比加群 Xa因子抑制药阿哌沙班利伐沙班依杜沙班低分子肝素肝素类肝素戊多糖磺达肝素 TPA rtPA 阿替普酶溶栓药纤溶酶原激活物阿司匹林氯吡格雷凝血酶原复合物新鲜冰冻血浆重组因子Ⅶa 鱼精蛋白血小板去氨加压素冷沉淀指南 GRADE标准

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